{"id":"https://openalex.org/W152225367","doi":null,"title":"[Effects of calcitonin on osteoclast].","display_name":"[Effects of calcitonin on osteoclast].","publication_year":2001,"publication_date":"2001-09-01","ids":{"openalex":"https://openalex.org/W152225367","mag":"152225367","pmid":"https://pubmed.ncbi.nlm.nih.gov/15741694"},"language":"ja","primary_location":{"id":"pmid:15741694","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15741694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical calcium","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yohei Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195444995","display_name":"Aichi Gakuin University","ror":"https://ror.org/01rwx7470","country_code":"JP","type":"education","lineage":["https://openalex.org/I195444995"]},{"id":"https://openalex.org/I4210102907","display_name":"Asahi Kasei (Japan)","ror":"https://ror.org/018wp0236","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210102907"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yohei Yamamoto","raw_affiliation_strings":["Department of Periodontology, School of Dentistry, Aichi Gakuin University","Scientific Affairs & Sales Promotion Dept, Health Care Company, Asahi Kasei Corporation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, School of Dentistry, Aichi Gakuin University","institution_ids":["https://openalex.org/I195444995"]},{"raw_affiliation_string":"Scientific Affairs & Sales Promotion Dept, Health Care Company, Asahi Kasei Corporation","institution_ids":["https://openalex.org/I4210102907"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Toshihide Noguchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshihide Noguchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Naoyuki Takahashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naoyuki Takahashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"11","issue":"3","first_page":"1158","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcitonin","display_name":"calcitonin","score":1.0},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.9980000257492065},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.949999988079071},{"id":"https://openalex.org/keywords/calcitonin-receptor","display_name":"calcitonin receptor","score":0.9100000262260437},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.8769999742507935},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":1.0},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.8209999799728394},{"id":"https://openalex.org/keywords/podosomes","display_name":"podosomes","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":0.9649999737739563},{"id":"https://openalex.org/keywords/escape-phenomenon","display_name":"escape phenomenon","score":0.7789999842643738},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.9380000233650208}],"concepts":[{"id":"https://openalex.org/C2779627488","wikidata":"https://www.wikidata.org/wiki/Q315860","display_name":"Calcitonin","level":2,"score":0.8336065411567688},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.8312692642211914},{"id":"https://openalex.org/C92316933","wikidata":"https://www.wikidata.org/wiki/Q14905625","display_name":"Calcitonin receptor","level":5,"score":0.6988029479980469},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.6940038204193115},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6269357204437256},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5435410141944885},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.491432785987854},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49054187536239624},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4459479749202728},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.4416349232196808},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.44087663292884827},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4109804332256317},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.31674766540527344},{"id":"https://openalex.org/C163170386","wikidata":"https://www.wikidata.org/wiki/Q419432","display_name":"Calcitonin gene-related peptide","level":4,"score":0.24285122752189636},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20771273970603943},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13654258847236633},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12484627962112427},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.11200892925262451}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002116","descriptor_name":"Calcitonin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:15741694","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15741694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical calcium","raw_type":"English Abstract"},{"id":"pmid:15775626","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15775626","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical calcium","raw_type":"English Abstract"},{"id":"mag:152225367","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15775626","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W41516964","https://openalex.org/W58690323","https://openalex.org/W93053989","https://openalex.org/W1501473386","https://openalex.org/W1547733031","https://openalex.org/W1594144334","https://openalex.org/W2008492357","https://openalex.org/W2014707628","https://openalex.org/W2045562495","https://openalex.org/W2066613071","https://openalex.org/W2098511755","https://openalex.org/W2100604852","https://openalex.org/W2101503666","https://openalex.org/W2105894548","https://openalex.org/W2142099365","https://openalex.org/W2144930991","https://openalex.org/W2150891147","https://openalex.org/W2172421250","https://openalex.org/W2337485820","https://openalex.org/W2409360547","https://openalex.org/W2409679560","https://openalex.org/W2414044484","https://openalex.org/W2508997451","https://openalex.org/W2520211681","https://openalex.org/W2542822064","https://openalex.org/W2769671204","https://openalex.org/W2791309620","https://openalex.org/W2895903821","https://openalex.org/W2909894833","https://openalex.org/W2981617674","https://openalex.org/W2990840371","https://openalex.org/W3016852213","https://openalex.org/W3016940380","https://openalex.org/W3025259451","https://openalex.org/W3028330817","https://openalex.org/W3034225365","https://openalex.org/W3035467903","https://openalex.org/W3036451283","https://openalex.org/W3092541624","https://openalex.org/W3147479802","https://openalex.org/W6776928405"],"related_works":["https://openalex.org/W2019086342","https://openalex.org/W1988699977","https://openalex.org/W1985821514","https://openalex.org/W4249503707","https://openalex.org/W1987472712","https://openalex.org/W2023876136","https://openalex.org/W2414911475","https://openalex.org/W2087769364","https://openalex.org/W2061271074","https://openalex.org/W3147152868"],"abstract_inverted_index":{"Osteoclasts":[0],"are":[1,51],"the":[2,44,84,90,96],"only":[3],"cells":[4],"that":[5,72],"destroy":[6],"and":[7,41,56],"resorb":[8],"bone.":[9],"Calcitonin,":[10],"a":[11],"calcium":[12],"regulatory":[13],"hormone,":[14],"strongly":[15],"inhibits":[16],"bone-resorbing":[17],"activity":[18],"of":[19,24,34,38,43,47,75,92,98],"osteoclasts.":[20,48],"The":[21],"calcitonin-induced":[22],"inhibition":[23],"osteoclast":[25,99],"function":[26],"is":[27,70,80],"believed":[28],"to":[29,32,53],"be":[30],"due":[31],"disruption":[33],"cytoskeletal":[35],"organization":[36],"(distraction":[37],"actin":[39],"rings)":[40],"disappearance":[42],"cellular":[45],"polarity":[46],"Calcitonin":[49],"receptors":[50],"coupled":[52],"both":[54],"cAMP-PKA-":[55],"Ca(2+)-PKC":[57],"(protein":[58],"kinase":[59],"C)-mediated":[60],"signaling":[61],"pathways.":[62],"Using":[63],"mouse":[64],"osteoclasts":[65],"formed":[66],"in":[67,95],"vitro,":[68],"it":[69],"shown":[71],"inhibitory":[73],"effects":[74],"calcitonin":[76,93],"on":[77],"bone":[78],"resorption":[79],"mainly":[81],"mediated":[82],"by":[83],"cAMP-PKA":[85],"signal.":[86],"This":[87],"article":[88],"describes":[89],"mechanism":[91],"action":[94],"suppression":[97],"function.":[100]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
