{"id":"https://openalex.org/W1522012490","doi":"https://doi.org/10.1385/cbb:40:3:209","title":"Protein Tyrosine Phosphatases: Potential Role in \u03b2-Cell Insulin Signal Transduction","display_name":"Protein Tyrosine Phosphatases: Potential Role in \u03b2-Cell Insulin Signal Transduction","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W1522012490","doi":"https://doi.org/10.1385/cbb:40:3:209","mag":"1522012490","pmid":"https://pubmed.ncbi.nlm.nih.gov/15289656"},"language":"en","primary_location":{"id":"doi:10.1385/cbb:40:3:209","doi":"https://doi.org/10.1385/cbb:40:3:209","is_oa":false,"landing_page_url":"https://doi.org/10.1385/cbb:40:3:209","pdf_url":null,"source":{"id":"https://openalex.org/S188545443","display_name":"Cell Biochemistry and Biophysics","issn_l":"1085-9195","issn":["1085-9195","1559-0283"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biochemistry and Biophysics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075258877","display_name":"Michel Bernier","orcid":"https://orcid.org/0000-0002-5948-368X","observed_orcids":["https://orcid.org/0000-0002-5948-368X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michel Bernier","raw_affiliation_strings":["Diabetes Section, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD","Diabetes Section, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Section, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Diabetes Section, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075258877"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.07685769,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"3S","first_page":"209","last_page":"217"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-tyrosine-phosphatase","display_name":"protein tyrosine phosphatase","score":1.0},{"id":"https://openalex.org/keywords/insulin-receptor-signaling","display_name":"insulin receptor signaling","score":0.9039999842643738},{"id":"https://openalex.org/keywords/beta-cell-function","display_name":"beta-cell function","score":0.7699999809265137},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.652999997138977},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/first-phase-insulin-secretion","display_name":"first-phase insulin secretion","score":0.8159999847412109},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.5249999761581421},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.8029999732971191},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.7440904974937439},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.7424042224884033},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6697184443473816},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6470295190811157},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6255167126655579},{"id":"https://openalex.org/C82183700","wikidata":"https://www.wikidata.org/wiki/Q14914347","display_name":"GRB10","level":5,"score":0.5980554223060608},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.5184709429740906},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5146282911300659},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.4533518850803375},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.43994730710983276},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.43725645542144775},{"id":"https://openalex.org/C185967709","wikidata":"https://www.wikidata.org/wiki/Q101433828","display_name":"Insulin receptor substrate","level":5,"score":0.4111909866333008},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41117414832115173},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3918835520744324},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3769489526748657},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27730974555015564},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09217843413352966}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1385/cbb:40:3:209","doi":"https://doi.org/10.1385/cbb:40:3:209","is_oa":false,"landing_page_url":"https://doi.org/10.1385/cbb:40:3:209","pdf_url":null,"source":{"id":"https://openalex.org/S188545443","display_name":"Cell Biochemistry and Biophysics","issn_l":"1085-9195","issn":["1085-9195","1559-0283"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biochemistry and Biophysics","raw_type":"journal-article"},{"id":"doi:10.1385/cbb:40:3s:209","doi":"https://doi.org/10.1385/cbb:40:3s:209","is_oa":false,"landing_page_url":"https://doi.org/10.1385/cbb:40:3s:209","pdf_url":null,"source":{"id":"https://openalex.org/S188545443","display_name":"Cell Biochemistry and Biophysics","issn_l":"1085-9195","issn":["1085-9195","1559-0283"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biochemistry and Biophysics","raw_type":"journal-article"},{"id":"pmid:15289656","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15289656","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell biochemistry and biophysics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1508156998","https://openalex.org/W1512072195","https://openalex.org/W1556383867","https://openalex.org/W1577599606","https://openalex.org/W1697523131","https://openalex.org/W1908445283","https://openalex.org/W1978002465","https://openalex.org/W1992002046","https://openalex.org/W1992968276","https://openalex.org/W1994914276","https://openalex.org/W1995088117","https://openalex.org/W1999286346","https://openalex.org/W1999683959","https://openalex.org/W2003177585","https://openalex.org/W2003949849","https://openalex.org/W2006835948","https://openalex.org/W2007551386","https://openalex.org/W2013355944","https://openalex.org/W2013499465","https://openalex.org/W2014129040","https://openalex.org/W2022786966","https://openalex.org/W2025474326","https://openalex.org/W2037028566","https://openalex.org/W2037226098","https://openalex.org/W2040692229","https://openalex.org/W2044980718","https://openalex.org/W2050818286","https://openalex.org/W2054519142","https://openalex.org/W2054575721","https://openalex.org/W2054704723","https://openalex.org/W2055162678","https://openalex.org/W2056424732","https://openalex.org/W2059576139","https://openalex.org/W2065685149","https://openalex.org/W2070582535","https://openalex.org/W2076964520","https://openalex.org/W2078941335","https://openalex.org/W2080778772","https://openalex.org/W2082449959","https://openalex.org/W2082828361","https://openalex.org/W2086752996","https://openalex.org/W2087482176","https://openalex.org/W2088075259","https://openalex.org/W2095949497","https://openalex.org/W2107050190","https://openalex.org/W2115681043","https://openalex.org/W2120413507","https://openalex.org/W2123229219","https://openalex.org/W2135896596","https://openalex.org/W2150388470","https://openalex.org/W2150630317","https://openalex.org/W2160421139","https://openalex.org/W2161144814","https://openalex.org/W2163101309","https://openalex.org/W2169218609","https://openalex.org/W2169654877","https://openalex.org/W2172039316","https://openalex.org/W4239070823","https://openalex.org/W4321429164"],"related_works":["https://openalex.org/W2053746471","https://openalex.org/W1996908796","https://openalex.org/W2135896596","https://openalex.org/W2307042160","https://openalex.org/W1577599606","https://openalex.org/W4238669558","https://openalex.org/W2114396018","https://openalex.org/W1496740734","https://openalex.org/W2078121507","https://openalex.org/W2042897481"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}