{"id":"https://openalex.org/W1522010565","doi":"https://doi.org/10.1007/bf03401797","title":"CD39 Modulates Endothelial Cell Activation and Apoptosis","display_name":"CD39 Modulates Endothelial Cell Activation and Apoptosis","publication_year":2000,"publication_date":"2000-07-01","ids":{"openalex":"https://openalex.org/W1522010565","doi":"https://doi.org/10.1007/bf03401797","mag":"1522010565","pmid":"https://pubmed.ncbi.nlm.nih.gov/10997340","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1949966"},"language":"en","primary_location":{"id":"doi:10.1007/bf03401797","doi":"https://doi.org/10.1007/bf03401797","is_oa":true,"landing_page_url":"https://doi.org/10.1007/bf03401797","pdf_url":"https://molmed.biomedcentral.com/track/pdf/10.1007/BF03401797","source":{"id":"https://openalex.org/S6769275","display_name":"Molecular Medicine","issn_l":"1076-1551","issn":["1076-1551","1528-3658"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://molmed.biomedcentral.com/track/pdf/10.1007/BF03401797","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053929827","display_name":"Christian Goepfert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian Goepfert","raw_affiliation_strings":["Center for Immunobiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunobiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050854410","display_name":"Masato Imai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masato Imai","raw_affiliation_strings":["Center for Immunobiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunobiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065386977","display_name":"Sophie Brouard","orcid":"https://orcid.org/0000-0002-6398-1315","observed_orcids":["https://orcid.org/0000-0002-6398-1315"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sophie Brouard","raw_affiliation_strings":["Center for Immunobiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunobiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085873910","display_name":"Eva Csizmadia","orcid":"https://orcid.org/0000-0003-1996-0370","observed_orcids":["https://orcid.org/0000-0003-1996-0370"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eva Csizmadia","raw_affiliation_strings":["Center for Immunobiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunobiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019777904","display_name":"El\u017cbieta Kaczmarek","orcid":"https://orcid.org/0000-0001-5773-7167","observed_orcids":["https://orcid.org/0000-0001-5773-7167"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elzbieta Kaczmarek","raw_affiliation_strings":["Center for Immunobiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunobiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041621533","display_name":"Simon Christopher Robson","orcid":"https://orcid.org/0000-0001-6374-0194","observed_orcids":["https://orcid.org/0000-0001-6374-0194","https://orcid.org/0000-0001-5419-622X"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Simon C. Robson","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Rm. 370 H, Research North, 99 Brookline Avenue, Boston, MA, 02215, USA","Center for Immunobiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Rm. 370 H, Research North, 99 Brookline Avenue, Boston, MA, 02215, USA","institution_ids":["https://openalex.org/I1316535847"]},{"raw_affiliation_string":"Center for Immunobiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5041621533"],"corresponding_institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":2.4188,"has_fulltext":true,"cited_by_count":106,"citation_normalized_percentile":{"value":0.87336878,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"6","issue":"7","first_page":"591","last_page":"603"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd39","display_name":"CD39","score":1.0},{"id":"https://openalex.org/keywords/ntpdase","display_name":"NTPDase","score":0.8700000047683716},{"id":"https://openalex.org/keywords/endothelial-activation","display_name":"endothelial activation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/endothelial-cell-apoptosis","display_name":"endothelial cell apoptosis","score":0.953000009059906},{"id":"https://openalex.org/keywords/purinergic-receptors","display_name":"purinergic receptors","score":0.7390000224113464},{"id":"https://openalex.org/keywords/p2y-receptors","display_name":"P2Y receptors","score":0.9049999713897705},{"id":"https://openalex.org/keywords/p2x7-receptor","display_name":"P2X7 receptor","score":0.9049999713897705},{"id":"https://openalex.org/keywords/extracellular-atp","display_name":"extracellular ATP","score":0.9279999732971191},{"id":"https://openalex.org/keywords/von-willebrand-factor-secretion","display_name":"von Willebrand factor secretion","score":0.9210000038146973},{"id":"https://openalex.org/keywords/nf-kappab-nuclear-translocation","display_name":"NF-\u03baB nuclear translocation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/e-selectin","display_name":"E-selectin","score":0.8740000128746033},{"id":"https://openalex.org/keywords/adenoviral-gene-transfer","display_name":"adenoviral gene transfer","score":0.8090000152587891},{"id":"https://openalex.org/keywords/vascular-protection","display_name":"vascular protection","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7498292922973633},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.6668248176574707},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6439819931983948},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.46195343136787415},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4511246085166931},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4045320451259613},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37807825207710266},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37776505947113037},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3233984708786011},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.28969383239746094},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1165902316570282},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08831736445426941}],"mesh":[{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001081","descriptor_name":"Apyrase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001081","descriptor_name":"Apyrase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006490","descriptor_name":"Hemostatics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014471","descriptor_name":"Umbilical Veins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016895","descriptor_name":"Culture Media, Serum-Free","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019040","descriptor_name":"E-Selectin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019040","descriptor_name":"E-Selectin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020302","descriptor_name":"Weibel-Palade Bodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/bf03401797","doi":"https://doi.org/10.1007/bf03401797","is_oa":true,"landing_page_url":"https://doi.org/10.1007/bf03401797","pdf_url":"https://molmed.biomedcentral.com/track/pdf/10.1007/BF03401797","source":{"id":"https://openalex.org/S6769275","display_name":"Molecular Medicine","issn_l":"1076-1551","issn":["1076-1551","1528-3658"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1949966","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1949966","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Med","raw_type":"Text"},{"id":"pmid:10997340","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10997340","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular medicine (Cambridge, Mass.)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.222.6769","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.222.6769","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.molmed.org/content/2000/591.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1007/bf03401797","doi":"https://doi.org/10.1007/bf03401797","is_oa":true,"landing_page_url":"https://doi.org/10.1007/bf03401797","pdf_url":"https://molmed.biomedcentral.com/track/pdf/10.1007/BF03401797","source":{"id":"https://openalex.org/S6769275","display_name":"Molecular Medicine","issn_l":"1076-1551","issn":["1076-1551","1528-3658"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5520316217","display_name":null,"funder_award_id":"NIH-R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7630150625","display_name":"VASCULAR NTPDASES AND TRANSPLANTATION","funder_award_id":"R01HL057307","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1522010565.pdf","grobid_xml":"https://content.openalex.org/works/W1522010565.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W860300","https://openalex.org/W17992636","https://openalex.org/W124719744","https://openalex.org/W1491069537","https://openalex.org/W1565285014","https://openalex.org/W1567363998","https://openalex.org/W1582754633","https://openalex.org/W1792542720","https://openalex.org/W1798670049","https://openalex.org/W1811799314","https://openalex.org/W1815757713","https://openalex.org/W1870523313","https://openalex.org/W1893431894","https://openalex.org/W1957977306","https://openalex.org/W1965656874","https://openalex.org/W1972546896","https://openalex.org/W1974204965","https://openalex.org/W1976342357","https://openalex.org/W1977594248","https://openalex.org/W1983577961","https://openalex.org/W1997076203","https://openalex.org/W2002451448","https://openalex.org/W2004696602","https://openalex.org/W2005037642","https://openalex.org/W2007472940","https://openalex.org/W2014023264","https://openalex.org/W2016217548","https://openalex.org/W2017504260","https://openalex.org/W2018204952","https://openalex.org/W2023204231","https://openalex.org/W2030569295","https://openalex.org/W2033580900","https://openalex.org/W2033981667","https://openalex.org/W2036029448","https://openalex.org/W2036750318","https://openalex.org/W2038370680","https://openalex.org/W2043638000","https://openalex.org/W2044014719","https://openalex.org/W2045074917","https://openalex.org/W2045503814","https://openalex.org/W2045680940","https://openalex.org/W2046425380","https://openalex.org/W2048443303","https://openalex.org/W2049110705","https://openalex.org/W2051148897","https://openalex.org/W2065009203","https://openalex.org/W2085567480","https://openalex.org/W2086670738","https://openalex.org/W2100994529","https://openalex.org/W2104892506","https://openalex.org/W2117204128","https://openalex.org/W2117571952","https://openalex.org/W2142541950","https://openalex.org/W2143854154","https://openalex.org/W2144373920","https://openalex.org/W2147537177","https://openalex.org/W2149700343","https://openalex.org/W2151892297","https://openalex.org/W2158029079","https://openalex.org/W2164116575","https://openalex.org/W2166703079","https://openalex.org/W2171678969","https://openalex.org/W2231894365","https://openalex.org/W2409772411","https://openalex.org/W2414813949","https://openalex.org/W2436464685"],"related_works":["https://openalex.org/W7098239068","https://openalex.org/W2057784185","https://openalex.org/W1997888150","https://openalex.org/W2981027029","https://openalex.org/W2095336107","https://openalex.org/W1510165700","https://openalex.org/W2133348699","https://openalex.org/W2058768349","https://openalex.org/W2040797703","https://openalex.org/W2092509331"],"abstract_inverted_index":{"BACKGROUND:":[0],"CD39":[1,48,122,148,176],"is":[2],"the":[3,18,52,128,134,151],"dominant":[4],"vascular":[5,179],"nucleoside":[6],"triphosphate":[7],"diphosphohydrolase":[8],"(NTPDase)":[9],"that":[10],"exerts":[11],"major":[12],"effects":[13,26,181],"on":[14,29],"platelet":[15],"reactivity":[16],"by":[17,156],"regulated":[19],"hydrolysis":[20],"of":[21,27,127,140,153,167,175],"extracellular":[22,118,168],"adenine":[23],"nucleotides.":[24],"The":[25],"NTPDases":[28],"endothelial":[30],"cell":[31,135],"(EC)":[32],"activation":[33,108],"and":[34,68,88,137,144],"apoptosis":[35,154],"remain":[36],"unexplored.":[37],"MATERIAL":[38],"AND":[39],"METHODS:":[40],"Recombinant":[41],"replication-deficient":[42],"adenoviruses":[43],"were":[44],"constructed":[45],"with":[46,64,82,182],"human":[47,58],"cDNA":[49],"(rAdCD39)":[50],"or":[51],"bacterial":[53],"beta-galactosidase":[54],"(rAdbetagal).":[55],"RESULTS:":[56],"Intact":[57],"umbilical":[59],"vein":[60],"EC":[61,107],"cultures":[62],"infected":[63,90],"rAdCD39":[65],"had":[66],"substantial":[67],"stable":[69],"increases":[70],"in":[71,115,162,170],"NTPDase":[72,97],"biochemical":[73],"activity":[74,98],"(14.50":[75],"+/-":[76,86,93],"3.50":[77],"Pi":[78],"nmole/well/min),":[79],"when":[80],"contrasted":[81],"noninfected":[83],"cells":[84,91],"(0.95":[85],"0.002)":[87],"rAdbetagal":[89],"(1.01":[92],"0.02;":[94],"p<0.005).":[95],"Increased":[96],"efficiently":[99],"inhibited":[100],"immediate":[101],"type":[102],"2Y":[103],"purinergic":[104,159],"receptor":[105],"(P2Y)-mediated":[106],"responses":[109],"viz.":[110],"von":[111],"Willebrand":[112],"factor":[113,131],"secretion":[114],"response":[116,163],"to":[117,133,164],"ATP.":[119],"In":[120],"addition,":[121],"up-regulation":[123],"blocked":[124],"ATP-induced":[125],"translocation":[126],"transcription":[129,139],"nuclear":[130],"(NF)-kappaB":[132],"nucleus,":[136],"abrogated":[138],"mRNA":[141],"encoding":[142],"E-selectin,":[143],"consequent":[145],"protein":[146],"synthesis.":[147],"also":[149],"decreased":[150],"extent":[152],"triggered":[155],"putative":[157],"type-2X":[158],"(P2X7)":[160],"receptors":[161],"high":[165],"concentrations":[166],"ATP":[169],"vitro.":[171],"CONCLUSION:":[172],"These":[173],"properties":[174],"indicate":[177],"primary":[178],"protective":[180],"potential":[183],"therapeutic":[184],"applications.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}