{"id":"https://openalex.org/W1521966843","doi":null,"title":"Modulation of signal transducer and activator of transcription 3 activities by p53 tumor suppressor in breast cancer cells.","display_name":"Modulation of signal transducer and activator of transcription 3 activities by p53 tumor suppressor in breast cancer cells.","publication_year":2002,"publication_date":"2002-01-15","ids":{"openalex":"https://openalex.org/W1521966843","mag":"1521966843","pmid":"https://pubmed.ncbi.nlm.nih.gov/11809683"},"language":"en","primary_location":{"id":"pmid:11809683","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11809683","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022526482","display_name":"Jiayuh Lin","orcid":"https://orcid.org/0000-0002-5618-8781","observed_orcids":["https://orcid.org/0000-0002-5618-8781"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiayuh Lin","raw_affiliation_strings":["Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109-0936, USA. linjia@umich.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109-0936, USA. linjia@umich.edu","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103942068","display_name":"Xiaohong Jin","orcid":"https://orcid.org/0009-0003-9918-446X","observed_orcids":["https://orcid.org/0009-0003-9918-446X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaohong Jin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015057397","display_name":"Kori Rothman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kori Rothman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113539342","display_name":"Huey-Jen Lin","orcid":"https://orcid.org/0000-0003-1726-6385","observed_orcids":["https://orcid.org/0000-0003-1726-6385"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huey-Jen Lin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103034037","display_name":"Huaijing Tang","orcid":"https://orcid.org/0000-0003-4885-6863","observed_orcids":["https://orcid.org/0000-0003-4885-6863"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huaijing Tang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5079268091","display_name":"William M. Burke","orcid":"https://orcid.org/0000-0002-1288-4590","observed_orcids":["https://orcid.org/0000-0002-1288-4590"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William Burke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.054,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.73704702,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"62","issue":"2","first_page":"376","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.042500000447034836,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9570000171661377},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9539999961853027},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9440000057220459},{"id":"https://openalex.org/keywords/stat3-phosphorylation","display_name":"STAT3 phosphorylation","score":0.968999981880188},{"id":"https://openalex.org/keywords/stat3-dna-binding","display_name":"STAT3 DNA binding","score":0.7770000100135803},{"id":"https://openalex.org/keywords/transcriptional-activity","display_name":"transcriptional activity","score":0.6439999938011169},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.5920000076293945},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.9890000224113464},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.906000018119812},{"id":"https://openalex.org/keywords/p21-waf-1","display_name":"p21WAF-1","score":0.9039999842643738},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/tumor-suppressor-regulation","display_name":"tumor suppressor regulation","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.8166388273239136},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.769248366355896},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6576539278030396},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5496793389320374},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.535261869430542},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5347757339477539},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5245271325111389},{"id":"https://openalex.org/C171958077","wikidata":"https://www.wikidata.org/wiki/Q419333","display_name":"STAT protein","level":4,"score":0.5232343077659607},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5223787426948547},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.46752265095710754},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3583598732948303},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3469083309173584},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.2392462193965912},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09103655815124512}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11809683","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11809683","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1521966843","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11809683","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W35717447","https://openalex.org/W61326834","https://openalex.org/W1483520515","https://openalex.org/W1531836615","https://openalex.org/W1550808631","https://openalex.org/W1558123369","https://openalex.org/W1884415617","https://openalex.org/W1892740436","https://openalex.org/W1976385326","https://openalex.org/W1981799488","https://openalex.org/W2024282024","https://openalex.org/W2030283142","https://openalex.org/W2040712355","https://openalex.org/W2043912950","https://openalex.org/W2046958356","https://openalex.org/W2051638902","https://openalex.org/W2054208935","https://openalex.org/W2078581194","https://openalex.org/W2097767970","https://openalex.org/W2107631090","https://openalex.org/W2108266755","https://openalex.org/W2118310862","https://openalex.org/W2154013099"],"related_works":["https://openalex.org/W2136397000","https://openalex.org/W2114445658","https://openalex.org/W2070824623","https://openalex.org/W7154783060","https://openalex.org/W2062129127","https://openalex.org/W2012970644","https://openalex.org/W2326494428","https://openalex.org/W2053841000","https://openalex.org/W263963459","https://openalex.org/W2329662539"],"abstract_inverted_index":{"The":[0],"constitutive":[1],"activation":[2],"of":[3,10,32,42,52,73,84,104,106,114,153,156],"the":[4,11,82,112,115,146,151],"Stat3":[5,33,55,127,172],"oncogene":[6],"product":[7],"and":[8,59,99,159,174],"mutation":[9],"p53":[12,75,116,130],"tumor":[13],"suppressor":[14],"are":[15],"both":[16],"frequently":[17],"detected":[18],"in":[19,64,81,89,135,150],"human":[20],"breast":[21,65,136],"cancer.":[22],"We":[23,38],"sought":[24],"to":[25],"determine":[26],"whether":[27],"there":[28],"is":[29],"functional":[30],"regulation":[31],"by":[34],"wild-type":[35],"(wt)":[36],"p53.":[37],"demonstrate":[39,164],"that":[40,140,170],"expression":[41,113],"wt":[43,74],"p53,":[44,48],"but":[45],"not":[46,77,121],"mutant":[47],"significantly":[49],"diminished":[50],"phosphorylation":[51,83,105,173],"Stat3,":[53],"reduced":[54],"DNA":[56],"binding":[57],"activity,":[58],"inhibited":[60],"Stat3-dependent":[61],"transcriptional":[62],"activity":[63],"cancer":[66,137],"cells":[67],"expressing":[68],"constitutively":[69,142],"active":[70,143],"Stat3.":[71,144],"Expression":[72],"did":[76,120],"cause":[78],"a":[79,102,165],"reduction":[80,103],"three":[85],"unrelated":[86],"protein":[87],"kinases":[88],"other":[90],"signal":[91],"transduction":[92],"pathways,":[93],"AKT,":[94],"extracellular":[95],"signal-regulated":[96],"kinase":[97],"(ERK)1,":[98],"ERK2":[100],"or":[101],"epidermal":[107],"growth":[108],"factor":[109],"receptor.":[110],"Furthermore,":[111],"downstream":[117],"target,":[118],"p21(WAF-1),":[119],"have":[122],"an":[123],"inhibitory":[124],"effect":[125],"on":[126],"phosphorylation.":[128],"Wt":[129],"also":[131],"induced":[132],"significant":[133],"apoptosis":[134,148],"cell":[138],"lines":[139],"express":[141],"Interestingly,":[145],"p53-dependent":[147,167],"occurred":[149],"presence":[152],"high":[154],"levels":[155],"phosphorylated":[157],"AKT":[158],"ERK1/2.":[160],"Therefore,":[161],"these":[162],"findings":[163],"novel":[166],"cellular":[168],"process":[169],"regulates":[171],"activity.":[175]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}