{"id":"https://openalex.org/W152196452","doi":null,"title":"Molecular Mechanisms of Zebrafish Photoreceptor Regeneration.","display_name":"Molecular Mechanisms of Zebrafish Photoreceptor Regeneration.","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W152196452","mag":"152196452"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/78976","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/78976","pdf_url":"https://hdl.handle.net/2027.42/78976","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2027.42/78976","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071966047","display_name":"Zhao Qin","orcid":"https://orcid.org/0000-0003-1709-0818","observed_orcids":["https://orcid.org/0000-0003-1709-0818"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Zhao Qin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1709-0818","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5071966047"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photoreceptor-regeneration","display_name":"photoreceptor regeneration","score":0.968999981880188},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.7760000228881836},{"id":"https://openalex.org/keywords/muller-cells","display_name":"M\u00fcller cells","score":0.8659999966621399},{"id":"https://openalex.org/keywords/retinal-stem-cells","display_name":"retinal stem cells","score":0.9520000219345093},{"id":"https://openalex.org/keywords/retinal-regeneration","display_name":"retinal regeneration","score":0.7490000128746033},{"id":"https://openalex.org/keywords/homeodomain-transcription-factor","display_name":"homeodomain transcription factor","score":0.8870000243186951},{"id":"https://openalex.org/keywords/fgf-signaling","display_name":"FGF signaling","score":0.9760000109672546},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7900000214576721},{"id":"https://openalex.org/keywords/tissue-regeneration","display_name":"tissue regeneration","score":0.6769999861717224},{"id":"https://openalex.org/keywords/glial-reprogramming","display_name":"glial reprogramming","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.9484423398971558},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.85639488697052},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48741772770881653},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4778689742088318},{"id":"https://openalex.org/C177275483","wikidata":"https://www.wikidata.org/wiki/Q7316769","display_name":"Retinal regeneration","level":3,"score":0.411370187997818},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3379806876182556},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21972200274467468},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15806326270103455}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/78976","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/78976","pdf_url":"https://hdl.handle.net/2027.42/78976","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:152196452","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/78976","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Deep Blue (University of Michigan)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/78976","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/78976","pdf_url":"https://hdl.handle.net/2027.42/78976","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W152196452.pdf","grobid_xml":"https://content.openalex.org/works/W152196452.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1483456468","https://openalex.org/W1965128951","https://openalex.org/W1966898852","https://openalex.org/W1976995280","https://openalex.org/W1992178400","https://openalex.org/W1994869619","https://openalex.org/W2004307784","https://openalex.org/W2013821266","https://openalex.org/W2016508121","https://openalex.org/W2022753721","https://openalex.org/W2023501279","https://openalex.org/W2029150089","https://openalex.org/W2030575757","https://openalex.org/W2044914889","https://openalex.org/W2065532397","https://openalex.org/W2068995182","https://openalex.org/W2080569117","https://openalex.org/W2081607263","https://openalex.org/W2088130353","https://openalex.org/W2105824459","https://openalex.org/W2107125023","https://openalex.org/W2114967857","https://openalex.org/W2116718309","https://openalex.org/W2117283769","https://openalex.org/W2128736049","https://openalex.org/W2138980520","https://openalex.org/W2159555560"],"related_works":["https://openalex.org/W1855794268","https://openalex.org/W6980925375","https://openalex.org/W67938594","https://openalex.org/W4385303512","https://openalex.org/W1967576174","https://openalex.org/W2072170174","https://openalex.org/W2520964346","https://openalex.org/W1970092966","https://openalex.org/W2528959174","https://openalex.org/W2411060299"],"abstract_inverted_index":{"Unlike":[0],"mammals,":[1],"which":[2,74,159],"have":[3,230],"only":[4],"limited":[5],"capabilities":[6],"to":[7,41,204],"replace":[8],"damaged":[9],"tissues":[10,139],"and":[11,29,115,164,187],"organs,":[12],"teleost":[13],"fishes,":[14],"such":[15],"as":[16,110,183],"zebrafish,":[17],"are":[18,75,123,160],"highly":[19],"regenerative.":[20],"Adult":[21],"zebrafish":[22,47,65,95,154,180,224,258],"can":[23],"regenerate":[24,205],"retinal":[25,61,71,127,206,241],"neurons":[26,62,254],"following":[27],"damage":[28],"thereby":[30],"restore":[31],"visual":[32],"function.":[33],"The":[34],"objective":[35],"of":[36,46,55,60,70,86,94,99,137,152,173,179,220,234,252],"this":[37],"dissertation":[38],"research":[39],"was":[40],"investigate":[42],"the":[43,68,76,91,100,176,218,235,256],"molecular":[44,133,236],"basis":[45],"photoreceptor":[48,96,181,225,253],"regeneration":[49,59,136,182,251],"by":[50,185,210],"using":[51,211],"a":[52,131,197,212,240],"diverse":[53,138],"range":[54],"genetic":[56],"techniques.":[57],"Since":[58],"in":[63,103,140,145,167,188,200,245,250,255],"adult":[64,257],"depends":[66],"on":[67],"activation":[69],"stem":[72,242],"cells,":[73,79,248],"M\u00fcller":[77,88,105,147,202],"glial":[78,247],"I":[80,118,216],"first":[81],"generated":[82],"gene":[83,143,214],"expression":[84],"profiles":[85],"isolated":[87],"glia":[89,106,203],"during":[90,175,223],"early":[92,177],"stages":[93,178],"regeneration.":[97,117,226],"Two":[98],"genes":[101,122],"up-regulated":[102,144],"injury-activated":[104,146],"were":[107],"previously":[108],"identified":[109],"essential":[111],"factors":[112],"for":[113,126,162],"fin":[114],"heart":[116],"showed":[119],"that":[120,130,192,238],"these":[121,228],"also":[124,195],"required":[125,161],"regeneration,":[128],"suggesting":[129],"common":[132],"program":[134,244],"triggers":[135],"zebrafish.":[141],"Another":[142],"glia,":[148],"six3b,":[149],"is":[150],"one":[151],"three":[153],"six3-related":[155],"homeobox":[156],"transcription":[157],"factors,":[158],"forebrain":[163],"eye":[165],"development":[166],"all":[168],"vertebrates":[169],"studied.":[170],"Expression":[171],"patterns":[172],"six3b":[174],"shown":[184],"qRT-PCR":[186],"situ":[189],"hybridization":[190],"suggested":[191],"it":[193],"might":[194],"play":[196],"central":[198],"role":[199,219],"reprogramming":[201],"neurons.":[207],"In":[208],"addition,":[209],"candidate":[213],"approach,":[215],"tested":[217],"Fgf":[221],"signaling":[222],"Together,":[227],"studies":[229],"advanced":[231],"our":[232],"understanding":[233],"mechanisms":[237],"activate":[239],"cell":[243],"mature":[246],"resulting":[249],"retina.":[259]},"counts_by_year":[],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2016-06-24T00:00:00"}