{"id":"https://openalex.org/W1521897480","doi":"https://doi.org/10.1016/s0021-9258(18)47439-x","title":"The human interferon-gamma receptor. Purification, characterization, and preparation of antibodies.","display_name":"The human interferon-gamma receptor. Purification, characterization, and preparation of antibodies.","publication_year":1987,"publication_date":"1987-06-01","ids":{"openalex":"https://openalex.org/W1521897480","doi":"https://doi.org/10.1016/s0021-9258(18)47439-x","mag":"1521897480","pmid":"https://pubmed.ncbi.nlm.nih.gov/2954953"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(18)47439-x","doi":"https://doi.org/10.1016/s0021-9258(18)47439-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)47439-x","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(18)47439-x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074793894","display_name":"Daniela Novick","orcid":"https://orcid.org/0000-0003-2020-1750","observed_orcids":["https://orcid.org/0000-0003-2020-1750"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"D Novick","raw_affiliation_strings":["From the Department of Virology, Weizmann Institute of Science, Rehouot 76110, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Virology, Weizmann Institute of Science, Rehouot 76110, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010061511","display_name":"Patricia L. Orchansky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"P Orchansky","raw_affiliation_strings":["From the Department of Virology, Weizmann Institute of Science, Rehouot 76110, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Virology, Weizmann Institute of Science, Rehouot 76110, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111441256","display_name":"M Revel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"M Revel","raw_affiliation_strings":["From the Department of Virology, Weizmann Institute of Science, Rehouot 76110, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Virology, Weizmann Institute of Science, Rehouot 76110, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004647809","display_name":"Menachem Rubinstein","orcid":"https://orcid.org/0000-0002-3472-6614","observed_orcids":["https://orcid.org/0000-0002-3472-6614"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"M Rubinstein","raw_affiliation_strings":["From the Department of Virology, Weizmann Institute of Science, Rehouot 76110, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Virology, Weizmann Institute of Science, Rehouot 76110, Israel","institution_ids":["https://openalex.org/I53964585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I53964585"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.8291,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.95520352,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"262","issue":"18","first_page":"8483","last_page":"8487"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.8008000254631042,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.8008000254631042,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.19470000267028809,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-gamma-receptor","display_name":"interferon-gamma receptor","score":0.9879999756813049},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8199999928474426},{"id":"https://openalex.org/keywords/receptor-purification","display_name":"receptor purification","score":0.9459999799728394},{"id":"https://openalex.org/keywords/foreskin-fibroblasts","display_name":"foreskin fibroblasts","score":0.8199999928474426},{"id":"https://openalex.org/keywords/antibody-preparation","display_name":"antibody preparation","score":0.6610000133514404},{"id":"https://openalex.org/keywords/receptor-binding-affinity","display_name":"receptor binding affinity","score":0.6909999847412109},{"id":"https://openalex.org/keywords/receptor-complex","display_name":"receptor complex","score":0.5239999890327454},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.9110000133514404},{"id":"https://openalex.org/keywords/lectin-affinity-chromatography","display_name":"lectin affinity chromatography","score":0.8029999732971191},{"id":"https://openalex.org/keywords/steric-exclusion","display_name":"steric exclusion","score":0.9229999780654907}],"concepts":[{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6498444676399231},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6122804284095764},{"id":"https://openalex.org/C71829478","wikidata":"https://www.wikidata.org/wiki/Q901305","display_name":"Immunoprecipitation","level":3,"score":0.556921124458313},{"id":"https://openalex.org/C116084860","wikidata":"https://www.wikidata.org/wiki/Q48255","display_name":"Gel electrophoresis","level":2,"score":0.5363814234733582},{"id":"https://openalex.org/C197462201","wikidata":"https://www.wikidata.org/wiki/Q2476074","display_name":"Cell surface receptor","level":3,"score":0.5126344561576843},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4940193295478821},{"id":"https://openalex.org/C179247698","wikidata":"https://www.wikidata.org/wiki/Q382799","display_name":"Affinity chromatography","level":3,"score":0.4856952130794525},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.48281368613243103},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.4784800410270691},{"id":"https://openalex.org/C49382859","wikidata":"https://www.wikidata.org/wiki/Q286498","display_name":"Lymphokine","level":3,"score":0.4548393785953522},{"id":"https://openalex.org/C101660505","wikidata":"https://www.wikidata.org/wiki/Q898301","display_name":"Polyacrylamide gel electrophoresis","level":3,"score":0.4534951150417328},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3900381028652191},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3269193470478058},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.21172577142715454},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.10224714875221252},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07294023036956787}],"mesh":[{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002846","descriptor_name":"Chromatography, Affinity","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017471","descriptor_name":"Receptors, Interferon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(18)47439-x","doi":"https://doi.org/10.1016/s0021-9258(18)47439-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)47439-x","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:2954953","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2954953","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(18)47439-x","doi":"https://doi.org/10.1016/s0021-9258(18)47439-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)47439-x","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W258376682","https://openalex.org/W1422881997","https://openalex.org/W1483645952","https://openalex.org/W1490800426","https://openalex.org/W1542531015","https://openalex.org/W1550576044","https://openalex.org/W1550814250","https://openalex.org/W1558985378","https://openalex.org/W1567059382","https://openalex.org/W1589391550","https://openalex.org/W1975676125","https://openalex.org/W1982093100","https://openalex.org/W2008854654","https://openalex.org/W2016540239","https://openalex.org/W2022961230","https://openalex.org/W2043813981","https://openalex.org/W2061817244","https://openalex.org/W2061883989","https://openalex.org/W2068472838","https://openalex.org/W2072522791","https://openalex.org/W2100837269"],"related_works":["https://openalex.org/W28728343","https://openalex.org/W2095657538","https://openalex.org/W1983075519","https://openalex.org/W1980751318","https://openalex.org/W2034308851","https://openalex.org/W2084169036","https://openalex.org/W1971817469","https://openalex.org/W1518941550","https://openalex.org/W2067995205","https://openalex.org/W1589391550"],"abstract_inverted_index":{"The":[0,66],"receptor":[1,68,112],"for":[2],"human":[3],"interferon-gamma":[4,27],"(IFN-gamma)":[5],"was":[6,57,102,121,125],"purified":[7,67,111],"from":[8,15],"foreskin":[9],"fibroblasts.":[10],"Triton":[11],"X-100":[12],"extracts":[13],"obtained":[14,58,88,122],"either":[16],"intact":[17,90,128],"cells":[18],"or":[19],"membrane":[20],"preparations":[21],"were":[22],"passed":[23],"through":[24],"an":[25],"immobilized":[26],"column.":[28],"Sodium":[29],"dodecyl":[30],"sulfate-polyacrylamide":[31],"gel":[32],"electrophoresis":[33],"(SDS-PAGE)":[34],"of":[35,42,49,78,98,106,131,138,149,156],"eluted":[36],"fractions":[37],"revealed":[38],"a":[39,76,83],"major":[40],"band":[41,137],"Mr":[43,50,99,139],"=":[44,51,100,140],"95,000":[45,141],"and":[46,53,62,116,151,158],"minor":[47],"bands":[48],"80,000":[52],"60,000.":[54],"Further":[55],"purification":[56],"by":[59,63,104,114],"steric":[60],"exclusion":[61],"lectin":[64],"chromatography.":[65],"retained":[69],"the":[70,110,134,146,153],"ability":[71],"to":[72,86,109,127],"bind":[73],"125I-IFN-gamma":[74,107,124,157],"with":[75,89,133],"Kd":[77],"2.2":[79],"X":[80,93],"10(-10)":[81,94],"M,":[82],"value":[84],"close":[85],"that":[87,144],"fibroblasts":[91],"(5":[92],"M).":[95],"A":[96,118],"complex":[97,120,155],"105,000-125,000":[101],"visualized":[103],"immunoprecipitation":[105],"cross-linked":[108,126,154],"followed":[113],"SDS-PAGE":[115,136],"autoradiography.":[117],"similar":[119],"when":[123],"cells.":[129],"Immunization":[130],"mice":[132],"excised":[135],"elicited":[142],"antibodies":[143],"blocked":[145],"antiviral":[147],"activity":[148],"IFN-gamma":[150],"immunoprecipitated":[152],"its":[159],"receptor.":[160]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
