{"id":"https://openalex.org/W152178485","doi":null,"title":"A randomised, double-blind study of cicaprost, an oral prostacyclin analogue, in the treatment of Raynaud's phenomenon secondary to systemic sclerosis.","display_name":"A randomised, double-blind study of cicaprost, an oral prostacyclin analogue, in the treatment of Raynaud's phenomenon secondary to systemic sclerosis.","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W152178485","mag":"152178485","pmid":"https://pubmed.ncbi.nlm.nih.gov/8453795"},"language":"en","primary_location":{"id":"pmid:8453795","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8453795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004488408","display_name":"Chak Sing Lau","orcid":"https://orcid.org/0000-0001-6698-8355","observed_orcids":["https://orcid.org/0000-0001-6698-8355"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C S Lau","raw_affiliation_strings":["University Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I2802526638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033515344","display_name":"J. J. F. Belch","orcid":"https://orcid.org/0000-0001-8280-6689","observed_orcids":["https://orcid.org/0000-0001-8280-6689"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J J Belch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044824382","display_name":"Rajan Madhok","orcid":"https://orcid.org/0000-0002-8396-9508","observed_orcids":["https://orcid.org/0000-0002-8396-9508"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Madhok","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078012543","display_name":"Howard Cappell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Cappell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056447660","display_name":"Ariane L. Herrick","orcid":"https://orcid.org/0000-0003-4941-7926","observed_orcids":["https://orcid.org/0000-0003-4941-7926"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Herrick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113668386","display_name":"Malcolm I. V. Jayson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Jayson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086922990","display_name":"John Thompson","orcid":"https://orcid.org/0000-0001-6944-381X","observed_orcids":["https://orcid.org/0000-0001-6944-381X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Thompson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2907,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.75803336,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"11","issue":"1","first_page":"35","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13313","display_name":"Dupuytren's Contracture and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cicaprost","display_name":"cicaprost","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prostacyclin-analogues","display_name":"prostacyclin analogues","score":0.9860000014305115},{"id":"https://openalex.org/keywords/raynaud-s-phenomenon","display_name":"Raynaud's phenomenon","score":0.9900000095367432},{"id":"https://openalex.org/keywords/systemic-sclerosis","display_name":"systemic sclerosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/digital-vasospasm","display_name":"digital vasospasm","score":0.9240000247955322},{"id":"https://openalex.org/keywords/vasodilation","display_name":"vasodilation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/antiplatelet-activity","display_name":"antiplatelet activity","score":0.8259999752044678},{"id":"https://openalex.org/keywords/digital-ulcers","display_name":"digital ulcers","score":0.9210000038146973},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.5230000019073486},{"id":"https://openalex.org/keywords/patient-tolerance","display_name":"patient tolerance","score":0.48100000619888306},{"id":"https://openalex.org/keywords/dose-comparison","display_name":"dose comparison","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8738850355148315},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7078340649604797},{"id":"https://openalex.org/C2781103887","wikidata":"https://www.wikidata.org/wiki/Q20817139","display_name":"Iloprost","level":3,"score":0.6002114415168762},{"id":"https://openalex.org/C2781128415","wikidata":"https://www.wikidata.org/wiki/Q412050","display_name":"Prostacyclin","level":2,"score":0.537817120552063},{"id":"https://openalex.org/C2777583614","wikidata":"https://www.wikidata.org/wiki/Q7916877","display_name":"Vasomotion","level":3,"score":0.4183225631713867},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4134730100631714},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.36453673243522644},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.34296512603759766},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011928","descriptor_name":"Raynaud Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011928","descriptor_name":"Raynaud Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:8453795","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8453795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Clinical Trial"},{"id":"pmh:oai:discovery.dundee.ac.uk:openaire_cris_publications/87b92650-1973-4c59-8bdf-edabe2066b28","doi":null,"is_oa":false,"landing_page_url":"https://discovery.dundee.ac.uk/en/publications/87b92650-1973-4c59-8bdf-edabe2066b28","pdf_url":null,"source":{"id":"https://openalex.org/S4306400523","display_name":"Discovery Research Portal (University of Dundee)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177639307","host_organization_name":"University of Dundee","host_organization_lineage":["https://openalex.org/I177639307"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:hub.hku.hk:10722/161994","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10722/161994","pdf_url":null,"source":{"id":"https://openalex.org/S4377196271","display_name":"The HKU Scholars Hub (University of Hong Kong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I889458895","host_organization_name":"University of Hong Kong","host_organization_lineage":["https://openalex.org/I889458895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"mag:152178485","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8453795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2242207743","https://openalex.org/W1981031097","https://openalex.org/W2401971453","https://openalex.org/W2166493507","https://openalex.org/W2130371595","https://openalex.org/W22849435","https://openalex.org/W2126076519","https://openalex.org/W2109323195","https://openalex.org/W1547026755","https://openalex.org/W2070986045"],"abstract_inverted_index":{"Cicaprost":[0],"is":[1,8],"a":[2,67,84,93,133,138,190],"new":[3],"synthetic":[4],"prostacylin":[5],"analogue":[6],"which":[7],"metabolically":[9],"stable":[10],"and":[11,38,50,101,116,142,152,189,221,256],"bioavailable":[12],"after":[13],"oral":[14],"administration;":[15],"in":[16,54,164,180,196,228,249],"previous":[17],"studies":[18,233],"it":[19],"has":[20],"been":[21],"shown":[22],"to":[23,41,61,216,240,254],"have":[24],"vasodilator":[25],"antiplatelet":[26],"effects.":[27],"In":[28],"this":[29,229],"pilot":[30],"study,":[31],"we":[32],"investigated":[33],"the":[34,55,113,121,125,127,143,147,150,173,175,181,197,217,242],"clinical":[35,151],"efficacy":[36],"of":[37,45,57,74,86,118,124,129,135,146,155,177,210,225,247],"patient":[39],"tolerance":[40],"two":[42],"dosage":[43],"levels":[44],"cicaprost":[46,97,104,168,185,226,248],"(2.5":[47],"micrograms":[48,52,99,106,187],"tds":[49,100],"5":[51,105,186],"tds)":[53],"treatment":[56,219],"Raynaud's":[58,119,252],"phenomenon":[59],"secondary":[60,253],"systemic":[62],"sclerosis":[63],"(SSc).":[64],"This":[65],"was":[66,109,194,213],"three":[68],"centre,":[69],"double-blind,":[70],"placebo":[71],"controlled":[72],"study":[73],"49":[75],"patients":[76,90,182,250],"carried":[77],"out":[78],"over":[79],"four":[80],"winter":[81],"months.":[82],"For":[83],"period":[85,220],"10":[87],"days,":[88],"16":[89,95],"were":[91],"given":[92],"placebo,":[94,174],"received":[96,103,167,184],"2.5":[98],"17":[102],"tds.":[107],"Response":[108],"assessed":[110],"based":[111],"on":[112,172],"total":[114],"number":[115,128],"duration":[117],"attacks,":[120,126,137],"average":[122,198],"severity":[123,176,199],"painful":[130],"attacks":[131,178],"as":[132],"proportion":[134],"all":[136],"digital":[139,156],"ulcer":[140],"count,":[141],"patients'":[144],"opinion":[145],"treatment.":[148],"Although":[149],"laboratory":[153],"parameters":[154],"vasospasm":[157],"did":[158],"not":[159],"show":[160],"statistically":[161,191],"significant":[162,192],"improvement":[163],"those":[165,171],"who":[166,183],"compared":[169],"with":[170,234,251],"lessened":[179],"tds,":[188],"difference":[193],"seen":[195],"at":[200],"week":[201],"2":[202],"post-treatment":[203],"(p":[204],"=":[205],"0.02).":[206],"The":[207],"apparent":[208],"lack":[209],"overall":[211],"significance":[212],"probably":[214,238],"related":[215],"short":[218],"relatively":[222],"low":[223],"doses":[224],"used":[227],"exploratory":[230],"study.":[231],"Longer":[232],"dose":[235],"titration":[236],"are":[237,258],"needed":[239],"demonstrate":[241],"beneficial":[243],"effects,":[244],"if":[245],"any,":[246],"SSc,":[255],"these":[257],"being":[259],"planned.":[260]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}