{"id":"https://openalex.org/W1521673497","doi":"https://doi.org/10.1002/cyto.b.21261","title":"Reactive T cells by flow cytometry distinguish Hodgkin lymphomas from T cell/histiocyte\u2010rich large B cell lymphoma","display_name":"Reactive T cells by flow cytometry distinguish Hodgkin lymphomas from T cell/histiocyte\u2010rich large B cell lymphoma","publication_year":2015,"publication_date":"2015-06-17","ids":{"openalex":"https://openalex.org/W1521673497","doi":"https://doi.org/10.1002/cyto.b.21261","mag":"1521673497","pmid":"https://pubmed.ncbi.nlm.nih.gov/26084540"},"language":"en","primary_location":{"id":"doi:10.1002/cyto.b.21261","doi":"https://doi.org/10.1002/cyto.b.21261","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cyto.b.21261","pdf_url":null,"source":{"id":"https://openalex.org/S87401112","display_name":"Cytometry Part B Clinical Cytometry","issn_l":"1552-4949","issn":["1552-4949","1552-4957"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytometry Part B: Clinical Cytometry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103186489","display_name":"David Wu","orcid":"https://orcid.org/0000-0001-7729-5730","observed_orcids":["https://orcid.org/0000-0001-7729-5730"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Wu","raw_affiliation_strings":["Department of Laboratory Medicine, University of Washington, Seattle, Washington 98109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of Washington, Seattle, Washington 98109","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104096034","display_name":"Anju Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anju Thomas","raw_affiliation_strings":["Department of Laboratory Medicine, University of Washington, Seattle, Washington 98109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of Washington, Seattle, Washington 98109","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020858509","display_name":"Jonathan R. Fromm","orcid":"https://orcid.org/0000-0002-2287-5284","observed_orcids":["https://orcid.org/0000-0002-2287-5284"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jonathan R. Fromm","raw_affiliation_strings":["Department of Laboratory Medicine University of Washington Seattle Washington 98109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine University of Washington Seattle Washington 98109","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020858509"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":2.6321,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.89732957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"90","issue":"5","first_page":"424","last_page":"432"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hodgkin-lymphoma","display_name":"Hodgkin's disease","score":0.9200000166893005},{"id":"https://openalex.org/keywords/nodular-lymphocyte-predominant-hodgkin-lymphoma","display_name":"nodular lymphocyte predominant Hodgkin lymphoma","score":0.9670000076293945},{"id":"https://openalex.org/keywords/t-cell-histiocyte-rich-large-b-cell-lymphoma","display_name":"T-cell/histiocyte-rich large B-cell lymphoma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cd4-cd8-ratio","display_name":"CD4/CD8 ratio","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cd4-cd8-t-cells","display_name":"CD4+CD8+ T cells","score":0.878000020980835},{"id":"https://openalex.org/keywords/b-cell-depletion","display_name":"B-cell depletion","score":0.6620000004768372},{"id":"https://openalex.org/keywords/plasma-cells","display_name":"plasma cells","score":0.6010000109672546},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.5879999995231628},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.5559999942779541},{"id":"https://openalex.org/keywords/b-cell-non-hodgkin-lymphoma","display_name":"B-cell non-Hodgkin lymphoma","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6590002179145813},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.6065430641174316},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5648691058158875},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5548485517501831},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5442661046981812},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.48371392488479614},{"id":"https://openalex.org/C43100952","wikidata":"https://www.wikidata.org/wiki/Q654612","display_name":"Histiocyte","level":2,"score":0.45872896909713745},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4487704634666443},{"id":"https://openalex.org/C196166836","wikidata":"https://www.wikidata.org/wiki/Q902926","display_name":"Immunophenotyping","level":3,"score":0.4467259347438812},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.4354206323623657},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.4284045696258545},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40932202339172363},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34384095668792725},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3303226828575134},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2760401666164398},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.14835789799690247},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.09852546453475952},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006644","descriptor_name":"Histiocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016131","descriptor_name":"Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/cyto.b.21261","doi":"https://doi.org/10.1002/cyto.b.21261","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cyto.b.21261","pdf_url":null,"source":{"id":"https://openalex.org/S87401112","display_name":"Cytometry Part B Clinical Cytometry","issn_l":"1552-4949","issn":["1552-4949","1552-4957"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytometry Part B: Clinical Cytometry","raw_type":"journal-article"},{"id":"pmid:26084540","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26084540","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytometry. Part B, Clinical cytometry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320310094","display_name":"University of Washington","ror":"https://ror.org/00cvxb145"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W150951851","https://openalex.org/W189250228","https://openalex.org/W1968101362","https://openalex.org/W1970031375","https://openalex.org/W1980755899","https://openalex.org/W1981058274","https://openalex.org/W1985563120","https://openalex.org/W1990204754","https://openalex.org/W1991579717","https://openalex.org/W1993584210","https://openalex.org/W2007369295","https://openalex.org/W2007398050","https://openalex.org/W2008432104","https://openalex.org/W2008577378","https://openalex.org/W2011404703","https://openalex.org/W2027556826","https://openalex.org/W2029629769","https://openalex.org/W2037899664","https://openalex.org/W2047677821","https://openalex.org/W2069366928","https://openalex.org/W2079160828","https://openalex.org/W2080843242","https://openalex.org/W2094798767","https://openalex.org/W2104594943","https://openalex.org/W2117692326","https://openalex.org/W2137286147","https://openalex.org/W2137546302","https://openalex.org/W2154021280","https://openalex.org/W2163079212","https://openalex.org/W2163086758","https://openalex.org/W2171775292","https://openalex.org/W2335104352","https://openalex.org/W2402687606","https://openalex.org/W2418296467","https://openalex.org/W2495058436","https://openalex.org/W2503110302","https://openalex.org/W4232182676","https://openalex.org/W4365787130"],"related_works":["https://openalex.org/W2069366928","https://openalex.org/W2197160731","https://openalex.org/W2027556826","https://openalex.org/W4381893493","https://openalex.org/W4365787130","https://openalex.org/W2029629769","https://openalex.org/W4292560335","https://openalex.org/W1980755899","https://openalex.org/W2041297402","https://openalex.org/W4200339490"],"abstract_inverted_index":{"BACKGROUND:":[0],"Classical":[1],"Hodgkin":[2,8],"lymphoma":[3,9,16],"(CHL),":[4],"nodular":[5],"lymphocyte":[6],"predominant":[7],"(NLPHL),":[10],"and":[11,65,79,86,105,108,128,170,176,200,212,214,229],"T-cell/histiocyte":[12],"rich":[13],"large":[14],"B-cell":[15,19],"(T/HRLBCL)":[17],"are":[18,25],"lymphomas":[20],"in":[21,121,133,154,195,204,220],"which":[22],"tumor":[23],"cells":[24,73,102,110,164,192],"rare":[26],"as":[27],"compared":[28],"with":[29,74,185],"the":[30,39,122,146,179,188,205],"background":[31],"reactive":[32,40,67,123,206],"infiltrate.":[33],"We":[34],"hypothesized":[35],"that":[36],"characterization":[37],"of":[38,77,88,125,143,161,190,209],"infiltrates":[41],"can":[42,215],"provide":[43],"information":[44],"to":[45,198,222,233],"help":[46],"diagnose":[47],"these":[48,217],"lymphomas.":[49],"METHODS:":[50],"Lymphocyte":[51],"subsets":[52],"by":[53],"flow":[54],"cytometry":[55],"were":[56,111,183],"analyzed":[57],"for":[58,167],"27":[59],"NLPHL,":[60,211],"20":[61],"T/HRLBCL,":[62,174],"34":[63],"CHL,":[64,175,210],"49":[66],"lymph":[68],"nodes":[69],"(RLN).":[70],"CD4+":[71,95],"T":[72,89,96,99,101,163],"bright":[75],"expression":[76],"CD7":[78],"CD45":[80],"(CD3+CD4+CD7(bright)":[81],"CD45(bright)":[82,116,148],"),":[83],"CD4:CD8":[84,181],"ratio,":[85],"percentage":[87,160,189],"cells,":[90,92,94,97,100],"B":[91,191],"NK":[93],"CD8+":[98],"coexpressing":[103],"CD4,":[104],"CD8":[106,234],"(CD4+CD8+),":[107],"plasma":[109],"measured.":[112],"RESULTS:":[113],"The":[114,158],"CD3+CD4+CD7(bright)":[115,147],"T-cell":[117,149,235],"population":[118,150],"was":[119,151,165],"present":[120],"infiltrate":[124,208],"CHL":[126,199],"(76.5%)":[127],"T/HRLBCL":[129,196,213,225],"(92.3%)":[130],"but":[131],"not":[132],"NLPHL":[134,168],"(8.3%)":[135],"or":[136],"RLN":[137],"(4.1%).":[138],"In":[139],"a":[140],"separate":[141],"analysis":[142],"387":[144],"samples,":[145],"also":[152],"observed":[153],"some":[155],"CD10+":[156],"B-NHL.":[157],"mean":[159],"CD4+CD8+":[162],"highest":[166,180],"(11.7%)":[169],"differed":[171],"significantly":[172],"from":[173],"RLN.":[177],"Interestingly,":[178],"ratios":[182],"seen":[184],"T/HRLBCL.":[186],"Finally,":[187],"is":[193],"decreased":[194],"relative":[197],"NLPHL.":[201],"CONCLUSIONS:":[202],"Differences":[203],"inflammatory":[207],"suggest":[216],"diagnoses.":[218],"Additionally,":[219],"contrast":[221],"published":[223],"studies,":[224],"demonstrates":[226],"both":[227],"low":[228],"very":[230],"high":[231],"CD4":[232],"ratios.":[236],"\u00a9":[237],"2015":[238],"International":[239],"Clinical":[240],"Cytometry":[241],"Society.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
