{"id":"https://openalex.org/W1521283013","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1074.7","title":"Inhibition of high salt\u2010induced activation of NLRP3 inflammasome by mesenchymal stem cell transplantation in the renal medulla in Dahl S rats (1074.7)","display_name":"Inhibition of high salt\u2010induced activation of NLRP3 inflammasome by mesenchymal stem cell transplantation in the renal medulla in Dahl S rats (1074.7)","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W1521283013","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1074.7","mag":"1521283013"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.28.1_supplement.1074.7","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1074.7","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.1074.7","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100365948","display_name":"Xiaoxue Li","orcid":"https://orcid.org/0000-0002-9484-3409","observed_orcids":["https://orcid.org/0000-0002-9484-3409","https://orcid.org/0000-0003-0579-1342","https://orcid.org/0009-0008-7377-4046"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoxue Li","raw_affiliation_strings":["Pharmacology and Toxicology Virginia Commonwealth University Richmond VA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and Toxicology Virginia Commonwealth University Richmond VA United States","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038841883","display_name":"Qing Zhu","orcid":"https://orcid.org/0000-0002-8611-189X","observed_orcids":["https://orcid.org/0000-0002-8611-189X"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qing Zhu","raw_affiliation_strings":["Pharmacology and Toxicology Virginia Commonwealth University Richmond VA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and Toxicology Virginia Commonwealth University Richmond VA United States","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023502750","display_name":"Sabena M. Conley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sabena Conley","raw_affiliation_strings":["Pharmacology and Toxicology Virginia Commonwealth University Richmond VA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and Toxicology Virginia Commonwealth University Richmond VA United States","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027053936","display_name":"Junping Hu","orcid":"https://orcid.org/0000-0002-4265-9538","observed_orcids":["https://orcid.org/0000-0002-4265-9538"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junping Hu","raw_affiliation_strings":["Pharmacology and Toxicology Virginia Commonwealth University Richmond VA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and Toxicology Virginia Commonwealth University Richmond VA United States","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003769038","display_name":"Pin\u2010Lan Li","orcid":"https://orcid.org/0000-0002-0797-8947","observed_orcids":["https://orcid.org/0000-0002-0797-8947"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pin\u2010Lan Li","raw_affiliation_strings":["Pharmacology and Toxicology Virginia Commonwealth University Richmond VA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and Toxicology Virginia Commonwealth University Richmond VA United States","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090650646","display_name":"Ningjun Li","orcid":"https://orcid.org/0000-0001-5371-3790","observed_orcids":["https://orcid.org/0000-0001-5371-3790","https://orcid.org/0009-0007-0084-005X","https://orcid.org/0009-0001-4172-0085"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ningjun Li","raw_affiliation_strings":["Pharmacology and Toxicology vcu Richmond VA United States","1Pharmacology and Toxicology vcu Richmond VA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and Toxicology vcu Richmond VA United States","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]},{"raw_affiliation_string":"1Pharmacology and Toxicology vcu Richmond VA United States","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04062527,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12075","display_name":"Sodium Intake and Health","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mesenchymal-stem-cell-transplantation","display_name":"mesenchymal stem cell transplantation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/high-salt-diet","display_name":"high-salt diet","score":0.9900000095367432},{"id":"https://openalex.org/keywords/dahl-salt-sensitive-rats","display_name":"Dahl salt-sensitive rats","score":0.9419999718666077},{"id":"https://openalex.org/keywords/renal-medulla","display_name":"renal medulla","score":0.9919999837875366},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.8740000128746033},{"id":"https://openalex.org/keywords/asc","display_name":"ASC","score":0.9160000085830688},{"id":"https://openalex.org/keywords/nlrp3","display_name":"NLRP3","score":0.8709999918937683},{"id":"https://openalex.org/keywords/distal-tubule","display_name":"distal tubule","score":0.6679999828338623},{"id":"https://openalex.org/keywords/collecting-duct","display_name":"collecting duct","score":0.9700000286102295}],"concepts":[{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.9653228521347046},{"id":"https://openalex.org/C162157009","wikidata":"https://www.wikidata.org/wiki/Q14905618","display_name":"NALP3","level":4,"score":0.7429136037826538},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6195645928382874},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5190256834030151},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5022966861724854},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.49384838342666626},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.48545771837234497},{"id":"https://openalex.org/C2780512574","wikidata":"https://www.wikidata.org/wiki/Q2409399","display_name":"Renal medulla","level":3,"score":0.45711448788642883},{"id":"https://openalex.org/C195121873","wikidata":"https://www.wikidata.org/wiki/Q1131385","display_name":"Medullary cavity","level":2,"score":0.42881539463996887},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42506468296051025},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4033293128013611},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1805773675441742},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.13131630420684814}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.28.1_supplement.1074.7","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1074.7","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.1074.7","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.49000000953674316}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2116317088","https://openalex.org/W2009800174","https://openalex.org/W3144262249","https://openalex.org/W1986731647","https://openalex.org/W2012633036","https://openalex.org/W4385798904","https://openalex.org/W85928981","https://openalex.org/W1975563740","https://openalex.org/W4283319341","https://openalex.org/W4297229765"],"abstract_inverted_index":{"Activation":[0],"of":[1,42,52,64,75,90,116,146,175,193,199,206],"NALP3":[2,20,43,65,92],"inflammasome":[3,21,44,66,82,118,149,178,194],"has":[4],"been":[5],"shown":[6],"to":[7,29,47,67,128,181],"be":[8,197],"involved":[9],"in":[10,24,33,102,126,132,140,164,186,209],"various":[11],"renal":[12,19,27,49,110,147,158,176,183,211],"pathological":[13],"conditions.":[14],"It":[15],"remains":[16],"unknown":[17],"whether":[18,40],"activation":[22,45,174,195],"participates":[23],"the":[25,48,62,73,91,109,157,182,200,203,210],"abnormal":[26],"response":[28,63,127],"high":[30,68,129,172],"salt":[31,35,69,130],"diet":[32],"Dahl":[34,133,165,187],"sensitive":[36],"rats.":[37,142,167],"In":[38],"addition,":[39],"inhibition":[41,192],"contributes":[46],"protective":[50,204],"actions":[51],"stem":[53,77,207],"cells":[54,208],"is":[55],"not":[56],"clear.":[57],"The":[58],"present":[59,101],"study":[60],"detected":[61],"intake":[70,131],"and":[71,96,105,113,190,218],"determined":[72],"effect":[74],"mesenchymal":[76],"cell":[78,163],"(MSC)":[79],"transplantation":[80,155],"on":[81],"activation.":[83],"Immunostaining":[84],"showed":[85],"that":[86,171,191],"3":[87],"essential":[88],"components":[89,119],"inflammasome,":[93],"NALP3,":[94],"ASC":[95],"caspase\u20101,":[97],"were":[98,120,150],"all":[99],"mainly":[100],"distal":[103],"tubules":[104],"collecting":[106],"ducts.":[107],"Interestingly,":[108],"medullary":[111,177,184],"mRNA":[112],"protein":[114],"levels":[115],"these":[117],"remarkably":[121],"increased":[122],"by":[123,153],"2\u20104":[124],"fold":[125],"S":[134,166,188],"rats,":[135],"while":[136],"remained":[137],"no":[138],"change":[139],"normal":[141],"High":[143],"salt\u2010induced":[144,173],"increases":[145],"medullar":[148],"significantly":[151],"blocked":[152],"MSC":[154],"into":[156],"medulla":[159],"compared":[160],"with":[161],"control":[162],"These":[168],"data":[169],"suggested":[170],"may":[179,196],"contribute":[180],"dysfunction":[185],"rats":[189],"one":[198],"mechanisms":[201],"for":[202],"effects":[205],"medulla.":[212],"Grant":[213],"Funding":[214],"Source":[215],":":[216],"HL089563":[217],"HL106042":[219]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2025-10-10T00:00:00"}