{"id":"https://openalex.org/W1521279639","doi":"https://doi.org/10.1096/fasebj.7.1.7678559","title":"Mis-splicing yields circular RNA molecules.","display_name":"Mis-splicing yields circular RNA molecules.","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W1521279639","doi":"https://doi.org/10.1096/fasebj.7.1.7678559","mag":"1521279639","pmid":"https://pubmed.ncbi.nlm.nih.gov/7678559"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.7.1.7678559","doi":"https://doi.org/10.1096/fasebj.7.1.7678559","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.7.1.7678559","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039806595","display_name":"Claude Cocquerelle","orcid":"https://orcid.org/0000-0001-5203-8594","observed_orcids":["https://orcid.org/0000-0001-5203-8594"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210105941","display_name":"Institut pour la Recherche sur le Cancer de Lille","ror":"https://ror.org/01c8cwz57","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210105941"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C Cocquerelle","raw_affiliation_strings":["Unit\u00e9 124 INSERM, Institut de Recherches sur le Cancer, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 124 INSERM, Institut de Recherches sur le Cancer, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210105941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044283101","display_name":"B\u00e9n\u00e9dicte Mascrez","orcid":"https://orcid.org/0000-0002-9495-8556","observed_orcids":["https://orcid.org/0000-0002-9495-8556"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210105941","display_name":"Institut pour la Recherche sur le Cancer de Lille","ror":"https://ror.org/01c8cwz57","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210105941"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B Mascrez","raw_affiliation_strings":["Unit\u00e9 124 INSERM, Institut de Recherches sur le Cancer, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 124 INSERM, Institut de Recherches sur le Cancer, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210105941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043699093","display_name":"Dominique H\u00e9tuin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210105941","display_name":"Institut pour la Recherche sur le Cancer de Lille","ror":"https://ror.org/01c8cwz57","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210105941"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"D H\u00e9tuin","raw_affiliation_strings":["Unit\u00e9 124 INSERM, Institut de Recherches sur le Cancer, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 124 INSERM, Institut de Recherches sur le Cancer, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210105941"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014337680","display_name":"Bernard Bailleul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210105941","display_name":"Institut pour la Recherche sur le Cancer de Lille","ror":"https://ror.org/01c8cwz57","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210105941"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"B Bailleul","raw_affiliation_strings":["Unit\u00e9 124 INSERM, Institut de Recherches sur le Cancer, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 124 INSERM, Institut de Recherches sur le Cancer, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210105941"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014337680"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210105941"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":1.5248,"has_fulltext":false,"cited_by_count":1189,"citation_normalized_percentile":{"value":0.82195608,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"7","issue":"1","first_page":"155","last_page":"160"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.6478999853134155,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.6478999853134155,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.34940001368522644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circular-rna","display_name":"circular RNA","score":0.9879999756813049},{"id":"https://openalex.org/keywords/ets1","display_name":"ETS1","score":0.5019999742507935},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.6809999942779541},{"id":"https://openalex.org/keywords/pre-mrna-processing","display_name":"pre-mRNA processing","score":0.7289999723434448},{"id":"https://openalex.org/keywords/cytoplasmic-rna","display_name":"cytoplasmic RNA","score":0.5960000157356262},{"id":"https://openalex.org/keywords/rna-stability","display_name":"RNA stability","score":0.5400000214576721},{"id":"https://openalex.org/keywords/splicing-mechanism","display_name":"splicing mechanism","score":0.7559999823570251},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.8802639245986938},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.8645740747451782},{"id":"https://openalex.org/C2775893923","wikidata":"https://www.wikidata.org/wiki/Q17113455","display_name":"Circular RNA","level":4,"score":0.6912791728973389},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6485143899917603},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.6018643975257874},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5683081746101379},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5643704533576965},{"id":"https://openalex.org/C17757408","wikidata":"https://www.wikidata.org/wiki/Q4135516","display_name":"genomic DNA","level":3,"score":0.5614007711410522},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5478945374488831},{"id":"https://openalex.org/C42576000","wikidata":"https://www.wikidata.org/wiki/Q5420618","display_name":"Exonic splicing enhancer","level":5,"score":0.4785759449005127},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4648531675338745},{"id":"https://openalex.org/C47124935","wikidata":"https://www.wikidata.org/wiki/Q468289","display_name":"Trans-splicing","level":5,"score":0.4246801733970642},{"id":"https://openalex.org/C73758832","wikidata":"https://www.wikidata.org/wiki/Q7578564","display_name":"Splicing factor","level":5,"score":0.4163011312484741},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36430126428604126}],"mesh":[{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002451","descriptor_name":"Cell Compartmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011519","descriptor_name":"Proto-Oncogenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D012322","descriptor_name":"RNA Precursors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050783","descriptor_name":"Proto-Oncogene Proteins c-ets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050784","descriptor_name":"Proto-Oncogene Protein c-ets-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1096/fasebj.7.1.7678559","doi":"https://doi.org/10.1096/fasebj.7.1.7678559","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.7.1.7678559","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmid:7678559","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7678559","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W7669837","https://openalex.org/W974346466","https://openalex.org/W1537551718","https://openalex.org/W1576472122","https://openalex.org/W1984487835","https://openalex.org/W1988271866","https://openalex.org/W1996449685","https://openalex.org/W2013014592","https://openalex.org/W2035241051","https://openalex.org/W2035607209","https://openalex.org/W2076892293","https://openalex.org/W2083886945","https://openalex.org/W2089745440","https://openalex.org/W2097114054","https://openalex.org/W2153405631","https://openalex.org/W2421374720","https://openalex.org/W2431859774","https://openalex.org/W2979538372"],"related_works":["https://openalex.org/W7096142130","https://openalex.org/W7099389529","https://openalex.org/W2034305079","https://openalex.org/W2100759026","https://openalex.org/W4241689820","https://openalex.org/W2130417316","https://openalex.org/W1993529637","https://openalex.org/W1969320072","https://openalex.org/W2157327258","https://openalex.org/W2029989907"],"abstract_inverted_index":{"We":[0],"previously":[1],"identified":[2],"novel":[3,53,108],"human":[4],"ets-1":[5],"transcripts":[6,70,92],"in":[7,27,39,66,75,98],"which":[8],"the":[9,20,28,49,76,80,87,119],"normal":[10],"order":[11,21,37],"of":[12,22,32,36,51,79,90,103,110],"exons":[13,23,34,65],"is":[14,24,86],"inverted,":[15],"and":[16,113],"demonstrated":[17],"that":[18,56],"although":[19],"different":[25],"than":[26],"genomic":[29,67],"DNA,":[30],"splicing":[31,120],"these":[33,52],"out":[35],"occurs":[38],"pairs":[40],"using":[41],"genuine":[42],"splice":[43],"sites":[44],"(1).":[45],"Here":[46],"we":[47],"determine":[48],"structure":[50],"transcripts,":[54],"showing":[55],"they":[57],"correspond":[58],"to":[59],"circular":[60,91],"RNA":[61],"molecules":[62],"containing":[63],"only":[64],"order.":[68],"These":[69],"are":[71],"stable":[72],"molecules,":[73],"localized":[74],"cytoplasmic":[77],"component":[78],"cells.":[81],"To":[82],"our":[83],"knowledge,":[84],"this":[85],"first":[88],"case":[89],"being":[93],"processed":[94],"from":[95],"nuclear":[96],"pre-mRNA":[97],"eukaryotes.":[99],"This":[100],"new":[101],"type":[102],"transcript":[104],"might":[105],"represent":[106],"a":[107],"aspect":[109],"gene":[111],"expression":[112],"hold":[114],"some":[115],"interesting":[116],"clues":[117],"about":[118],"mechanism.":[121]},"counts_by_year":[{"year":2026,"cited_by_count":25},{"year":2025,"cited_by_count":55},{"year":2024,"cited_by_count":91},{"year":2023,"cited_by_count":95},{"year":2022,"cited_by_count":154},{"year":2021,"cited_by_count":160},{"year":2020,"cited_by_count":196},{"year":2019,"cited_by_count":118},{"year":2018,"cited_by_count":97},{"year":2017,"cited_by_count":76},{"year":2016,"cited_by_count":38},{"year":2015,"cited_by_count":30},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
