{"id":"https://openalex.org/W1520184724","doi":"https://doi.org/10.1002/hbm.22584","title":"BDNFVal66Met genotype interacts with childhood adversity and influences the formation of hippocampal subfields","display_name":"BDNFVal66Met genotype interacts with childhood adversity and influences the formation of hippocampal subfields","publication_year":2014,"publication_date":"2014-07-10","ids":{"openalex":"https://openalex.org/W1520184724","doi":"https://doi.org/10.1002/hbm.22584","mag":"1520184724","pmid":"https://pubmed.ncbi.nlm.nih.gov/25044977","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6869047"},"language":"en","primary_location":{"id":"doi:10.1002/hbm.22584","doi":"https://doi.org/10.1002/hbm.22584","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hbm.22584","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hbm.22584?download=true","source":{"id":"https://openalex.org/S121666818","display_name":"Human Brain Mapping","issn_l":"1065-9471","issn":["1065-9471","1097-0193"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Brain Mapping","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hbm.22584?download=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043918876","display_name":"Thomas Frodl","orcid":"https://orcid.org/0000-0002-8113-6959","observed_orcids":["https://orcid.org/0000-0002-8113-6959"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","IE"],"is_corresponding":false,"raw_author_name":"Thomas Frodl","raw_affiliation_strings":["Centre of Advanced Medical Imaging; St. James's Hospital & Trinity College Dublin; Dublin Ireland","Department of Psychiatry and Institute of Neuroscience, University of Dublin, Trinity College Dublin, Dublin, Ireland","Department of Psychiatry and Psychotherapy; University of Regensburg; Regensburg Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre of Advanced Medical Imaging; St. James's Hospital & Trinity College Dublin; Dublin Ireland","institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210154619"]},{"raw_affiliation_string":"Department of Psychiatry and Institute of Neuroscience, University of Dublin, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]},{"raw_affiliation_string":"Department of Psychiatry and Psychotherapy; University of Regensburg; Regensburg Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102790343","display_name":"Norbert Skokauskas","orcid":"https://orcid.org/0000-0002-9352-3489","observed_orcids":["https://orcid.org/0000-0002-9352-3489"]},"institutions":[{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]},{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE","NO"],"is_corresponding":false,"raw_author_name":"Norbert Skokauskas","raw_affiliation_strings":["Centre for Child and Youth Mental Health and Child Protection, Department of Medicine, NTNU, Trondheim, Norway","Department of Psychiatry and Institute of Neuroscience, University of Dublin, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Child and Youth Mental Health and Child Protection, Department of Medicine, NTNU, Trondheim, Norway","institution_ids":["https://openalex.org/I204778367"]},{"raw_affiliation_string":"Department of Psychiatry and Institute of Neuroscience, University of Dublin, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063399834","display_name":"Eva-Maria Frey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eva-Maria Frey","raw_affiliation_strings":["Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054219365","display_name":"Derek W. Morris","orcid":"https://orcid.org/0000-0002-3413-570X","observed_orcids":["https://orcid.org/0000-0002-3413-570X"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Derek Morris","raw_affiliation_strings":["Department of Psychiatry and Institute of Neuroscience; University of Dublin, Trinity College Dublin; Dublin Ireland","Neuropsychiatric Genetics Research Group; Department of Psychiatry & Institute of Molecular Medicine; University of Dublin, Trinity College Dublin; Dublin Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Institute of Neuroscience; University of Dublin, Trinity College Dublin; Dublin Ireland","institution_ids":["https://openalex.org/I205274468"]},{"raw_affiliation_string":"Neuropsychiatric Genetics Research Group; Department of Psychiatry & Institute of Molecular Medicine; University of Dublin, Trinity College Dublin; Dublin Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106497970","display_name":"Michael Gill","orcid":"https://orcid.org/0000-0003-0206-5337","observed_orcids":["https://orcid.org/0000-0003-0206-5337"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Michael Gill","raw_affiliation_strings":["Department of Psychiatry and Institute of Neuroscience; University of Dublin, Trinity College Dublin; Dublin Ireland","Neuropsychiatric Genetics Research Group; Department of Psychiatry & Institute of Molecular Medicine; University of Dublin, Trinity College Dublin; Dublin Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Institute of Neuroscience; University of Dublin, Trinity College Dublin; Dublin Ireland","institution_ids":["https://openalex.org/I205274468"]},{"raw_affiliation_string":"Neuropsychiatric Genetics Research Group; Department of Psychiatry & Institute of Molecular Medicine; University of Dublin, Trinity College Dublin; Dublin Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032377052","display_name":"Angela Carballedo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Angela Carballedo","raw_affiliation_strings":["Centre of Advanced Medical Imaging; St. James's Hospital & Trinity College Dublin; Dublin Ireland","Department of Psychiatry and Institute of Neuroscience; University of Dublin, Trinity College Dublin; Dublin Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre of Advanced Medical Imaging; St. James's Hospital & Trinity College Dublin; Dublin Ireland","institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210154619"]},{"raw_affiliation_string":"Department of Psychiatry and Institute of Neuroscience; University of Dublin, Trinity College Dublin; Dublin Ireland","institution_ids":["https://openalex.org/I205274468"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3520,"currency":"USD","value_usd":3520},"apc_paid":null,"fwci":4.0463,"has_fulltext":true,"cited_by_count":78,"citation_normalized_percentile":{"value":0.95347432,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"35","issue":"12","first_page":"5776","last_page":"5783"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.5429999828338623,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.5429999828338623,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.09600000083446503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10426","display_name":"Child Abuse and Trauma","score":0.07069999724626541,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bdnf-val66met-polymorphism","display_name":"BDNF Val66Met polymorphism","score":0.9580000042915344},{"id":"https://openalex.org/keywords/childhood-adversity","display_name":"childhood adversity","score":0.8299999833106995},{"id":"https://openalex.org/keywords/childhood-stress","display_name":"childhood stress","score":0.6320000290870667},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9139999747276306},{"id":"https://openalex.org/keywords/hippocampal-subfields","display_name":"hippocampal subfields","score":0.984000027179718},{"id":"https://openalex.org/keywords/dentate-gyrus","display_name":"dentate gyrus","score":0.9380000233650208},{"id":"https://openalex.org/keywords/ca2-3","display_name":"CA2/3","score":0.8019999861717224},{"id":"https://openalex.org/keywords/ca4","display_name":"CA4","score":0.7829999923706055},{"id":"https://openalex.org/keywords/hippocampal-volume","display_name":"hippocampal volume","score":0.7799999713897705},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.972000002861023},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.9064548015594482},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7611484527587891},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5652546882629395},{"id":"https://openalex.org/C2778163459","wikidata":"https://www.wikidata.org/wiki/Q7375573","display_name":"rs6265","level":5,"score":0.5540951490402222},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.5190287828445435},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5023243427276611},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.4890073537826538},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4733861982822418},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.4712653160095215},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.42068466544151306},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40378886461257935},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3467869162559509},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3433380722999573},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27699410915374756},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1680164635181427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1338564157485962},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12884750962257385},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.08112451434135437},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07777148485183716}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002649","descriptor_name":"Child Abuse","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/hbm.22584","doi":"https://doi.org/10.1002/hbm.22584","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hbm.22584","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hbm.22584?download=true","source":{"id":"https://openalex.org/S121666818","display_name":"Human Brain Mapping","issn_l":"1065-9471","issn":["1065-9471","1097-0193"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Brain Mapping","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6869047","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6869047","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hum Brain Mapp","raw_type":"Text"},{"id":"pmid:25044977","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25044977","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human brain mapping","raw_type":"Journal Article"},{"id":"pmh:oai:epub.uni-regensburg.de:60935","doi":null,"is_oa":false,"landing_page_url":"http://orcid.org/0000-0002-8113-6959>,","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:http://www.rian.ie/119407/","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2262/75606","pdf_url":null,"source":{"id":"https://openalex.org/S4306400033","display_name":"Arrow@dit (Dublin Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210144925","host_organization_name":"Technological University Dublin","host_organization_lineage":["https://openalex.org/I4210144925"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frodl T, Skokauskas N, Frey EM, Morris D, Gill M, Carballedo A, BDNF Val66Met genotype interacts with childhood adversity and influences the formation of hippocampal subfields., Human brain mapping, 35, 12, 2014, 5776-83","raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1002/hbm.22584","doi":"https://doi.org/10.1002/hbm.22584","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hbm.22584","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hbm.22584?download=true","source":{"id":"https://openalex.org/S121666818","display_name":"Human Brain Mapping","issn_l":"1065-9471","issn":["1065-9471","1097-0193"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Brain Mapping","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G8467100454","display_name":null,"funder_award_id":"G20330","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"}],"funders":[{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1520184724.pdf","grobid_xml":"https://content.openalex.org/works/W1520184724.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W31370813","https://openalex.org/W1571837886","https://openalex.org/W1826521770","https://openalex.org/W1966460145","https://openalex.org/W1976711431","https://openalex.org/W1977419693","https://openalex.org/W1979125819","https://openalex.org/W1994950269","https://openalex.org/W1998030239","https://openalex.org/W2008113854","https://openalex.org/W2012237001","https://openalex.org/W2013373204","https://openalex.org/W2020751391","https://openalex.org/W2031269976","https://openalex.org/W2034761715","https://openalex.org/W2040912840","https://openalex.org/W2045960341","https://openalex.org/W2050716480","https://openalex.org/W2051550544","https://openalex.org/W2061196406","https://openalex.org/W2062682953","https://openalex.org/W2067535960","https://openalex.org/W2073884643","https://openalex.org/W2083312379","https://openalex.org/W2093541378","https://openalex.org/W2099280287","https://openalex.org/W2104386846","https://openalex.org/W2106106014","https://openalex.org/W2106623141","https://openalex.org/W2110763068","https://openalex.org/W2111477880","https://openalex.org/W2112262501","https://openalex.org/W2116584334","https://openalex.org/W2129705910","https://openalex.org/W2130417276","https://openalex.org/W2134268790","https://openalex.org/W2139984345","https://openalex.org/W2146505604","https://openalex.org/W2155962001","https://openalex.org/W2159040523","https://openalex.org/W2160589013","https://openalex.org/W2170990401","https://openalex.org/W2474753552"],"related_works":["https://openalex.org/W2073884643","https://openalex.org/W2111477880","https://openalex.org/W2414781743","https://openalex.org/W2980556096","https://openalex.org/W2087761877","https://openalex.org/W2129705910","https://openalex.org/W2085594304","https://openalex.org/W2160589013","https://openalex.org/W6944199621","https://openalex.org/W2099280287"],"abstract_inverted_index":{"Childhood":[0,114],"stress":[1,181],"and":[2,29,47,59,69,76,102,117,133,150,155,166,172,197],"genetic":[3],"factors":[4],"like":[5],"the":[6,10,65,88,95,113,118,194],"Val66MET":[7],"polymorphism":[8,68],"of":[9,37,106,147],"brain":[11],"derived":[12],"neurotrophic":[13],"factor":[14],"(BDNF)":[15],"gene":[16,183],"are":[17,51,62],"associated":[18],"with":[19,74,127,167],"a":[20,143],"higher":[21],"risk":[22],"for":[23,187,193],"developing":[24],"major":[25],"depressive":[26],"disorder":[27],"(MDD)":[28],"might":[30],"also":[31],"influence":[32],"hippocampal":[33,44,96,188],"changes.":[34],"The":[35,104],"aim":[36],"this":[38],"study":[39],"was":[40,91,110,142],"to":[41,56,93,137],"determine":[42],"which":[43,60],"dentate":[45,98,198],"gyrus":[46,99],"cornu":[48],"ammonis":[49],"subfields":[50,61,97],"altered":[52],"in":[53,191],"MDD":[54,75,128],"compared":[55,136],"healthy":[57,77,138],"controls":[58,79],"affected":[63],"by":[64,182],"BDNF":[66,120,148],"Val66Met":[67,119],"child":[70],"adversity.":[71],"Adult":[72],"patients":[73],"matched":[78],"underwent":[80],"high-resolution":[81],"magnetic":[82],"resonance":[83],"imaging.":[84],"Automatic":[85],"segmentation":[86],"using":[87,112],"programme":[89],"FreeSurfer":[90],"used":[92],"segment":[94],"(DG/CA4),":[100],"CA1":[101],"CA2/3.":[103],"history":[105],"possible":[107],"childhood":[108,151,162,168],"adversity":[109,152,163,169],"assessed":[111],"Trauma":[115],"Questionnaire":[116],"SNP":[121],"(rs6265)":[122],"genotypes":[123],"were":[124],"obtained.":[125],"Patients":[126],"had":[129,164],"significantly":[130],"smaller":[131,170],"CA4/DG":[132,156,171],"CA2/3":[134,154,173,196],"volumes":[135,174],"controls.":[139],"Furthermore,":[140],"there":[141],"significant":[144],"interactive":[145],"effect":[146],"allele":[149,159],"on":[153],"volumes.":[157],"Met":[158],"carriers":[160],"without":[161],"larger":[165],"than":[175],"Val-allele":[176],"homozygotes.":[177],"Our":[178],"results":[179],"highlight":[180],"interactions":[184],"as":[185],"relevant":[186],"volume":[189],"reductions,":[190],"particular":[192],"subfield":[195],"gyrus.":[199]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":9}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}