{"id":"https://openalex.org/W1520167064","doi":null,"title":"Expression and regulation of the leukemia inhibitory factor/D factor gene in human T-cell leukemia virus type 1 infected T-cell lines.","display_name":"Expression and regulation of the leukemia inhibitory factor/D factor gene in human T-cell leukemia virus type 1 infected T-cell lines.","publication_year":1992,"publication_date":"1992-12-15","ids":{"openalex":"https://openalex.org/W1520167064","mag":"1520167064","pmid":"https://pubmed.ncbi.nlm.nih.gov/1458488"},"language":"en","primary_location":{"id":"pmid:1458488","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1458488","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039378017","display_name":"Tomoyo Umemiya\u2010Okada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Umemiya-Okada","raw_affiliation_strings":["Department of Medicine, Kobe University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Kobe University School of Medicine, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049575471","display_name":"Toshiki Natazuka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Natazuka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101711253","display_name":"Toshimitsu Matsui","orcid":"https://orcid.org/0000-0002-2536-7584","observed_orcids":["https://orcid.org/0000-0002-2536-7584"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Matsui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101847759","display_name":"Masahiko Ito","orcid":"https://orcid.org/0000-0001-7020-7312","observed_orcids":["https://orcid.org/0000-0001-7020-7312"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Ito","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T Taniguchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Taniguchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5017684570","display_name":"Y Nakao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Nakao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1611,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.4116587,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"52","issue":"24","first_page":"6961","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leukemia-inhibitory-factor","display_name":"leukemia inhibitory factor","score":0.9750000238418579},{"id":"https://openalex.org/keywords/d-factor","display_name":"D-factor","score":0.796999990940094},{"id":"https://openalex.org/keywords/htlv-1","display_name":"HTLV-1","score":0.8199999928474426},{"id":"https://openalex.org/keywords/adult-t-cell-leukemia-lymphoma","display_name":"adult T-cell leukemia/lymphoma","score":0.9259999990463257},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.8309999704360962},{"id":"https://openalex.org/keywords/phorbol-ester","display_name":"phorbol ester","score":0.8429999947547913},{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d3","display_name":"1,25-dihydroxyvitamin D3","score":0.8989999890327454},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hypercalcemia","display_name":"hypercalcemia","score":0.8859999775886536},{"id":"https://openalex.org/keywords/immunological-abnormalities","display_name":"immune abnormalities","score":0.5889999866485596},{"id":"https://openalex.org/keywords/t-cell-lines","display_name":"T cell lines","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C27284151","wikidata":"https://www.wikidata.org/wiki/Q6534502","display_name":"Leukemia inhibitory factor","level":4,"score":0.9252424240112305},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.6963946223258972},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.673566460609436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5512179732322693},{"id":"https://openalex.org/C106825092","wikidata":"https://www.wikidata.org/wiki/Q14914453","display_name":"Leukemia inhibitory factor receptor","level":5,"score":0.5085004568099976},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5030645728111267},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.44801563024520874},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.41132932901382446},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3364174962043762},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3238431215286255},{"id":"https://openalex.org/C11988809","wikidata":"https://www.wikidata.org/wiki/Q412889","display_name":"Interleukin 6","level":3,"score":0.2577957212924957},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23637181520462036},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.224532812833786},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.17479372024536133},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06336668133735657},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.04713374376296997}],"mesh":[{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006131","descriptor_name":"Growth Inhibitors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006131","descriptor_name":"Growth Inhibitors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006934","descriptor_name":"Hypercalcemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D015490","descriptor_name":"HTLV-I Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053605","descriptor_name":"Leukemia Inhibitory Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1458488","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1458488","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1520167064","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1458488","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W147399175","https://openalex.org/W175589755","https://openalex.org/W1492535969","https://openalex.org/W1501821322","https://openalex.org/W1514275127","https://openalex.org/W1521392303","https://openalex.org/W1597356743","https://openalex.org/W1672550237","https://openalex.org/W1968199996","https://openalex.org/W1968814677","https://openalex.org/W1993686365","https://openalex.org/W1999098419","https://openalex.org/W2004585436","https://openalex.org/W2005988457","https://openalex.org/W2013956239","https://openalex.org/W2037118546","https://openalex.org/W2041566569","https://openalex.org/W2066415387","https://openalex.org/W2066797016","https://openalex.org/W2070208938","https://openalex.org/W2098491997","https://openalex.org/W2134812217","https://openalex.org/W2154192444","https://openalex.org/W2209705202","https://openalex.org/W2336865896","https://openalex.org/W2367306869","https://openalex.org/W2404234309"],"related_works":["https://openalex.org/W7099776436","https://openalex.org/W2014464617","https://openalex.org/W2408364956","https://openalex.org/W258065988","https://openalex.org/W1993605266","https://openalex.org/W2401476896","https://openalex.org/W2059027587","https://openalex.org/W2461519271","https://openalex.org/W2105888542","https://openalex.org/W2020375873"],"abstract_inverted_index":{"The":[0,62,79],"expression":[1,51,80,97],"of":[2,65,81,98,107,111],"the":[3,41,96,99,105,112],"leukemia":[4,13,24],"inhibitory":[5],"factor/D":[6],"factor":[7],"(LIF)":[8],"gene":[9,101],"in":[10,59,69,76,104,116],"human":[11],"T-cell":[12,18,23,29,42,120],"virus":[14,25],"type":[15,26],"1":[16,27,87],"infected":[17,28],"lines":[19,30,43],"was":[20,52,67,84],"examined.":[21],"Human":[22],"MT-1,":[31],"MT-2,":[32],"H89-59,":[33],"H89-79,":[34],"and":[35,45,90,109],"H109":[36],"expressed":[37],"LIF":[38,49,66,82,100],"mRNA,":[39],"but":[40],"MOLT-4":[44],"TALL-1":[46],"did":[47],"not.":[48],"mRNA":[50,83],"enhanced":[53,72],"by":[54,73,86],"interleukin":[55,74],"2":[56,75],"or":[57],"12-O-tetradecanoylphorbol-13-acetate":[58],"MT-2":[60,77],"cells.":[61,78],"biological":[63],"activity":[64],"detected":[68],"culture":[70],"medium":[71],"suppressed":[85],"alpha,25-dihydroxyvitamin":[88],"D3":[89],"dexamethasone.":[91],"These":[92],"results":[93],"imply":[94],"that":[95],"is":[102],"involved":[103],"development":[106],"hypercalcemia":[108],"abnormalities":[110],"immune":[113],"system":[114],"observed":[115],"patients":[117],"with":[118],"adult":[119],"leukemia.":[121]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}