{"id":"https://openalex.org/W1520072571","doi":"https://doi.org/10.1097/01213011-199912000-00011","title":"Characterization of a novel variant (S145C/L311V) of 3 ??-hydroxysteroid/dihydrodiol dehydrogenase in human liver","display_name":"Characterization of a novel variant (S145C/L311V) of 3 ??-hydroxysteroid/dihydrodiol dehydrogenase in human liver","publication_year":1999,"publication_date":"1999-12-01","ids":{"openalex":"https://openalex.org/W1520072571","doi":"https://doi.org/10.1097/01213011-199912000-00011","mag":"1520072571"},"language":"en","primary_location":{"id":"doi:10.1097/01213011-199912000-00011","doi":"https://doi.org/10.1097/01213011-199912000-00011","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01213011-199912000-00011","pdf_url":null,"source":{"id":"https://openalex.org/S192301155","display_name":"Pharmacogenetics and Genomics","issn_l":"1744-6872","issn":["1744-6872","1744-6880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenetics and Genomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112539020","display_name":"Toshiyuki Kume","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]},{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4210141669","display_name":"Hokkaido University Hospital","ror":"https://ror.org/0419drx70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210141669"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiyuki Kume","raw_affiliation_strings":["aLaboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido","bDiscovery Research Laboratory, Tanabe Seiyaku Co., Ltd, Toda, Saitama","cBiochemistry Laboratory, Gifu Pharmaceutical University. Mitahora-higashi, Gifu","dDepartment of Pathology. Hokkaido University Hospital, Sapporo, Hokkaido","eLaboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Osaka University, Sulta, Osaka","fGenome Information Research Center, Osaka University, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aLaboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"bDiscovery Research Laboratory, Tanabe Seiyaku Co., Ltd, Toda, Saitama","institution_ids":[]},{"raw_affiliation_string":"cBiochemistry Laboratory, Gifu Pharmaceutical University. Mitahora-higashi, Gifu","institution_ids":["https://openalex.org/I173865709"]},{"raw_affiliation_string":"dDepartment of Pathology. Hokkaido University Hospital, Sapporo, Hokkaido","institution_ids":["https://openalex.org/I4210141669"]},{"raw_affiliation_string":"eLaboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Osaka University, Sulta, Osaka","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"fGenome Information Research Center, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111811690","display_name":"Harunori Iwasa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]},{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4210141669","display_name":"Hokkaido University Hospital","ror":"https://ror.org/0419drx70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210141669"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Harunori Iwasa","raw_affiliation_strings":["aLaboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido","bDiscovery Research Laboratory, Tanabe Seiyaku Co., Ltd, Toda, Saitama","cBiochemistry Laboratory, Gifu Pharmaceutical University. Mitahora-higashi, Gifu","dDepartment of Pathology. Hokkaido University Hospital, Sapporo, Hokkaido","eLaboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Osaka University, Sulta, Osaka","fGenome Information Research Center, Osaka University, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aLaboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"bDiscovery Research Laboratory, Tanabe Seiyaku Co., Ltd, Toda, Saitama","institution_ids":[]},{"raw_affiliation_string":"cBiochemistry Laboratory, Gifu Pharmaceutical University. Mitahora-higashi, Gifu","institution_ids":["https://openalex.org/I173865709"]},{"raw_affiliation_string":"dDepartment of Pathology. Hokkaido University Hospital, Sapporo, Hokkaido","institution_ids":["https://openalex.org/I4210141669"]},{"raw_affiliation_string":"eLaboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Osaka University, Sulta, Osaka","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"fGenome Information Research Center, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064255737","display_name":"Hiroaki Shiraishi","orcid":"https://orcid.org/0009-0006-0016-631X","observed_orcids":["https://orcid.org/0009-0006-0016-631X"]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]},{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4210141669","display_name":"Hokkaido University Hospital","ror":"https://ror.org/0419drx70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210141669"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroaki Shiraishi","raw_affiliation_strings":["aLaboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido","bDiscovery Research Laboratory, Tanabe Seiyaku Co., Ltd, Toda, Saitama","cBiochemistry Laboratory, Gifu Pharmaceutical University. Mitahora-higashi, Gifu","dDepartment of Pathology. Hokkaido University Hospital, Sapporo, Hokkaido","eLaboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Osaka University, Sulta, Osaka","fGenome Information Research Center, Osaka University, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aLaboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"bDiscovery Research Laboratory, Tanabe Seiyaku Co., Ltd, Toda, Saitama","institution_ids":[]},{"raw_affiliation_string":"cBiochemistry Laboratory, Gifu Pharmaceutical University. Mitahora-higashi, Gifu","institution_ids":["https://openalex.org/I173865709"]},{"raw_affiliation_string":"dDepartment of Pathology. Hokkaido University Hospital, Sapporo, Hokkaido","institution_ids":["https://openalex.org/I4210141669"]},{"raw_affiliation_string":"eLaboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Osaka University, Sulta, Osaka","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"fGenome Information Research Center, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089297113","display_name":"Tsuyoshi Yokoi","orcid":"https://orcid.org/0000-0002-3239-2817","observed_orcids":["https://orcid.org/0000-0002-3239-2817"]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]},{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4210141669","display_name":"Hokkaido University Hospital","ror":"https://ror.org/0419drx70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210141669"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuyoshi Yokoi","raw_affiliation_strings":["aLaboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido","bDiscovery Research Laboratory, Tanabe Seiyaku Co., Ltd, Toda, Saitama","cBiochemistry Laboratory, Gifu Pharmaceutical University. Mitahora-higashi, Gifu","dDepartment of Pathology. Hokkaido University Hospital, Sapporo, Hokkaido","eLaboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Osaka University, Sulta, Osaka","fGenome Information Research Center, Osaka University, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aLaboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"bDiscovery Research Laboratory, Tanabe Seiyaku Co., Ltd, Toda, Saitama","institution_ids":[]},{"raw_affiliation_string":"cBiochemistry Laboratory, Gifu Pharmaceutical University. Mitahora-higashi, Gifu","institution_ids":["https://openalex.org/I173865709"]},{"raw_affiliation_string":"dDepartment of Pathology. Hokkaido University Hospital, Sapporo, Hokkaido","institution_ids":["https://openalex.org/I4210141669"]},{"raw_affiliation_string":"eLaboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Osaka University, Sulta, Osaka","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"fGenome Information Research Center, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111840696","display_name":"Kazuo Nagashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]},{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4210141669","display_name":"Hokkaido University Hospital","ror":"https://ror.org/0419drx70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210141669"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuo Nagashima","raw_affiliation_strings":["aLaboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido","bDiscovery Research Laboratory, Tanabe Seiyaku Co., Ltd, Toda, Saitama","cBiochemistry Laboratory, Gifu Pharmaceutical University. Mitahora-higashi, Gifu","dDepartment of Pathology. Hokkaido University Hospital, Sapporo, Hokkaido","eLaboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Osaka University, Sulta, Osaka","fGenome Information Research Center, Osaka University, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aLaboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"bDiscovery Research Laboratory, Tanabe Seiyaku Co., Ltd, Toda, Saitama","institution_ids":[]},{"raw_affiliation_string":"cBiochemistry Laboratory, Gifu Pharmaceutical University. Mitahora-higashi, Gifu","institution_ids":["https://openalex.org/I173865709"]},{"raw_affiliation_string":"dDepartment of Pathology. Hokkaido University Hospital, Sapporo, Hokkaido","institution_ids":["https://openalex.org/I4210141669"]},{"raw_affiliation_string":"eLaboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Osaka University, Sulta, Osaka","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"fGenome Information Research Center, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113972421","display_name":"Minezo OTSUKA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]},{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4210141669","display_name":"Hokkaido University Hospital","ror":"https://ror.org/0419drx70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210141669"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Minezo Otsuka","raw_affiliation_strings":["aLaboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido","bDiscovery Research Laboratory, Tanabe Seiyaku Co., Ltd, Toda, Saitama","cBiochemistry Laboratory, Gifu Pharmaceutical University. Mitahora-higashi, Gifu","dDepartment of Pathology. Hokkaido University Hospital, Sapporo, Hokkaido","eLaboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Osaka University, Sulta, Osaka","fGenome Information Research Center, Osaka University, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aLaboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"bDiscovery Research Laboratory, Tanabe Seiyaku Co., Ltd, Toda, Saitama","institution_ids":[]},{"raw_affiliation_string":"cBiochemistry Laboratory, Gifu Pharmaceutical University. Mitahora-higashi, Gifu","institution_ids":["https://openalex.org/I173865709"]},{"raw_affiliation_string":"dDepartment of Pathology. Hokkaido University Hospital, Sapporo, Hokkaido","institution_ids":["https://openalex.org/I4210141669"]},{"raw_affiliation_string":"eLaboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Osaka University, Sulta, Osaka","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"fGenome Information Research Center, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078962603","display_name":"Tomoyuki Terada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]},{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4210141669","display_name":"Hokkaido University Hospital","ror":"https://ror.org/0419drx70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210141669"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoyuki Terada","raw_affiliation_strings":["aLaboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido","bDiscovery Research Laboratory, Tanabe Seiyaku Co., Ltd, Toda, Saitama","cBiochemistry Laboratory, Gifu Pharmaceutical University. Mitahora-higashi, Gifu","dDepartment of Pathology. Hokkaido University Hospital, Sapporo, Hokkaido","eLaboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Osaka University, Sulta, Osaka","fGenome Information Research Center, Osaka University, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aLaboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"bDiscovery Research Laboratory, Tanabe Seiyaku Co., Ltd, Toda, Saitama","institution_ids":[]},{"raw_affiliation_string":"cBiochemistry Laboratory, Gifu Pharmaceutical University. Mitahora-higashi, Gifu","institution_ids":["https://openalex.org/I173865709"]},{"raw_affiliation_string":"dDepartment of Pathology. Hokkaido University Hospital, Sapporo, Hokkaido","institution_ids":["https://openalex.org/I4210141669"]},{"raw_affiliation_string":"eLaboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Osaka University, Sulta, Osaka","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"fGenome Information Research Center, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tetsuya Takagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]},{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4210141669","display_name":"Hokkaido University Hospital","ror":"https://ror.org/0419drx70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210141669"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuya Takagi","raw_affiliation_strings":["aLaboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido","bDiscovery Research Laboratory, Tanabe Seiyaku Co., Ltd, Toda, Saitama","cBiochemistry Laboratory, Gifu Pharmaceutical University. Mitahora-higashi, Gifu","dDepartment of Pathology. Hokkaido University Hospital, Sapporo, Hokkaido","eLaboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Osaka University, Sulta, Osaka","fGenome Information Research Center, Osaka University, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aLaboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"bDiscovery Research Laboratory, Tanabe Seiyaku Co., Ltd, Toda, Saitama","institution_ids":[]},{"raw_affiliation_string":"cBiochemistry Laboratory, Gifu Pharmaceutical University. Mitahora-higashi, Gifu","institution_ids":["https://openalex.org/I173865709"]},{"raw_affiliation_string":"dDepartment of Pathology. Hokkaido University Hospital, Sapporo, Hokkaido","institution_ids":["https://openalex.org/I4210141669"]},{"raw_affiliation_string":"eLaboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Osaka University, Sulta, Osaka","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"fGenome Information Research Center, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015424874","display_name":"Akira Hara","orcid":"https://orcid.org/0000-0002-5554-8060","observed_orcids":["https://orcid.org/0000-0002-5554-8060"]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]},{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4210141669","display_name":"Hokkaido University Hospital","ror":"https://ror.org/0419drx70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210141669"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Hara","raw_affiliation_strings":["aLaboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido","bDiscovery Research Laboratory, Tanabe Seiyaku Co., Ltd, Toda, Saitama","cBiochemistry Laboratory, Gifu Pharmaceutical University. Mitahora-higashi, Gifu","dDepartment of Pathology. Hokkaido University Hospital, Sapporo, Hokkaido","eLaboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Osaka University, Sulta, Osaka","fGenome Information Research Center, Osaka University, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aLaboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"bDiscovery Research Laboratory, Tanabe Seiyaku Co., Ltd, Toda, Saitama","institution_ids":[]},{"raw_affiliation_string":"cBiochemistry Laboratory, Gifu Pharmaceutical University. Mitahora-higashi, Gifu","institution_ids":["https://openalex.org/I173865709"]},{"raw_affiliation_string":"dDepartment of Pathology. Hokkaido University Hospital, Sapporo, Hokkaido","institution_ids":["https://openalex.org/I4210141669"]},{"raw_affiliation_string":"eLaboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Osaka University, Sulta, Osaka","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"fGenome Information Research Center, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021070991","display_name":"Tetsuya Kamataki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]},{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4210141669","display_name":"Hokkaido University Hospital","ror":"https://ror.org/0419drx70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210141669"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuya Kamataki","raw_affiliation_strings":["aLaboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido","bDiscovery Research Laboratory, Tanabe Seiyaku Co., Ltd, Toda, Saitama","cBiochemistry Laboratory, Gifu Pharmaceutical University. Mitahora-higashi, Gifu","dDepartment of Pathology. Hokkaido University Hospital, Sapporo, Hokkaido","eLaboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Osaka University, Sulta, Osaka","fGenome Information Research Center, Osaka University, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aLaboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"bDiscovery Research Laboratory, Tanabe Seiyaku Co., Ltd, Toda, Saitama","institution_ids":[]},{"raw_affiliation_string":"cBiochemistry Laboratory, Gifu Pharmaceutical University. Mitahora-higashi, Gifu","institution_ids":["https://openalex.org/I173865709"]},{"raw_affiliation_string":"dDepartment of Pathology. Hokkaido University Hospital, Sapporo, Hokkaido","institution_ids":["https://openalex.org/I4210141669"]},{"raw_affiliation_string":"eLaboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Osaka University, Sulta, Osaka","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"fGenome Information Research Center, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"9","issue":"6","first_page":"763","last_page":"772"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp2c8","display_name":"CYP2C8","score":0.5400000214576721},{"id":"https://openalex.org/keywords/amino-acid-substitutions","display_name":"amino acid substitutions","score":0.6890000104904175},{"id":"https://openalex.org/keywords/enzyme-activity","display_name":"enzyme activity","score":0.7850000262260437},{"id":"https://openalex.org/keywords/substrate-binding","display_name":"substrate binding","score":0.8550000190734863},{"id":"https://openalex.org/keywords/steroid-hormone-metabolism","display_name":"steroid hormone metabolism","score":0.7630000114440918},{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbon-metabolism","display_name":"polycyclic aromatic hydrocarbon metabolism","score":0.953000009059906},{"id":"https://openalex.org/keywords/ketone-reduction","display_name":"ketone reduction","score":0.6919999718666077},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.675000011920929},{"id":"https://openalex.org/keywords/recombinant-enzyme-production","display_name":"recombinant enzyme expression","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6212148666381836},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6013699769973755},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.568614661693573},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.5495737791061401},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.5256308913230896},{"id":"https://openalex.org/C108305142","wikidata":"https://www.wikidata.org/wiki/Q3062286","display_name":"Heterologous expression","level":4,"score":0.5164211392402649},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4977436363697052},{"id":"https://openalex.org/C2781067048","wikidata":"https://www.wikidata.org/wiki/Q5955660","display_name":"Hydroxysteroid dehydrogenase","level":4,"score":0.46993571519851685},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.41651085019111633},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.3966888189315796},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2878798246383667}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01213011-199912000-00011","doi":"https://doi.org/10.1097/01213011-199912000-00011","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01213011-199912000-00011","pdf_url":null,"source":{"id":"https://openalex.org/S192301155","display_name":"Pharmacogenetics and Genomics","issn_l":"1744-6872","issn":["1744-6872","1744-6880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenetics and Genomics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7208578808","https://openalex.org/W2401471962","https://openalex.org/W2396439345","https://openalex.org/W1914173493","https://openalex.org/W1598526550","https://openalex.org/W2011236458","https://openalex.org/W2278670715","https://openalex.org/W2233338100","https://openalex.org/W2396256496","https://openalex.org/W1976263676"],"abstract_inverted_index":{"Human":[0],"liver":[1,44,105,176],"3\u03b1-hydroxysteroid/dihydrodiol":[2],"dehydrogenase":[3],"(DD)":[4],"is":[5,18],"involved":[6],"in":[7,33,101,131,141],"the":[8,22,30,34,42,49,54,61,96,118,121,127,162,169,181,184,193],"metabolism":[9],"of":[10,24,48,68,95,103,117,136,161,171,183],"steroid":[11],"hormones":[12],"and":[13,17,38,75,87,149,178],"polycyclic":[14],"aromatic":[15],"hydrocarbons,":[16],"also":[19,179],"responsible":[20],"for":[21,29,41,53,60,147,174,189],"reduction":[23],"ketone-containing":[25],"drugs.":[26],"To":[27],"account":[28],"interindividual":[31],"difference":[32],"activity,":[35],"we":[36],"isolated":[37],"characterized":[39],"clones":[40],"human":[43,175],"enzymes.":[45],"The":[46,92,115,134,166],"sequence":[47],"cDNA":[50],"clone":[51],"coding":[52,59],"variant":[55,97],"differed":[56],"from":[57,107],"that":[58],"wild-type":[62],"DD":[63],"by":[64,109,158],"two":[65,79],"nucleotides":[66],"(substitutions":[67],"C":[69],"with":[70,126],"G":[71],"at":[72,186],"positions":[73],"434":[74],"931)":[76],"which":[77],"caused":[78],"amino":[80],"acid":[81],"replacements,":[82],"Ser145":[83],"to":[84,89,143,192],"Cys":[85],"(S145C)":[86],"Leu311":[88],"Val":[90],"(L311V).":[91],"heterologous":[93],"expression":[94],"mRNA":[98],"was":[99,156],"confirmed":[100],"four":[102],"31":[104],"samples":[106],"Japanese":[108],"an":[110,159],"allele-specific":[111],"polymerase":[112],"chain":[113],"reaction.":[114],"effects":[116],"mutations":[119,139],"on":[120],"catalytic":[122],"properties":[123],"were":[124],"examined":[125],"recombinant":[128],"enzymes":[129],"expressed":[130],"Escherichia":[132],"coli.":[133],"introduction":[135,160],"S145C/L311V":[137],"double":[138],"resulted":[140],"three-":[142],"five-fold":[144],"decreased":[145],"activities":[146],"xenobiotic":[148],"steroidal":[150],"substrates,":[151],"whereas":[152],"no":[153],"significant":[154],"change":[155],"observed":[157],"S145C":[163],"mutation":[164],"alone.":[165],"results":[167],"substantiate":[168],"existence":[170],"polymorphic":[172],"forms":[173],"DD,":[177],"suggest":[180],"importance":[182],"residue":[185],"position":[187],"311":[188],"substrate":[190],"binding":[191],"enzyme.":[194]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}
