{"id":"https://openalex.org/W1519847653","doi":"https://doi.org/10.1016/s0021-9258(17)44160-3","title":"In vivo and in vitro uptake and degradation of acetylated low density lipoprotein by rat liver endothelial, Kupffer, and parenchymal cells.","display_name":"In vivo and in vitro uptake and degradation of acetylated low density lipoprotein by rat liver endothelial, Kupffer, and parenchymal cells.","publication_year":1983,"publication_date":"1983-10-01","ids":{"openalex":"https://openalex.org/W1519847653","doi":"https://doi.org/10.1016/s0021-9258(17)44160-3","mag":"1519847653","pmid":"https://pubmed.ncbi.nlm.nih.gov/6313644"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(17)44160-3","doi":"https://doi.org/10.1016/s0021-9258(17)44160-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)44160-3","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1519847653"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(17)44160-3","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113537177","display_name":"J. Fred Nagelkerke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J F Nagelkerke","raw_affiliation_strings":["From the Department of Biochemistry I, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biochemistry I, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025036332","display_name":"K P Barto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"K P Barto","raw_affiliation_strings":["From the Department of Biochemistry I, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biochemistry I, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024733637","display_name":"Theo J.C. van Berkel","orcid":"https://orcid.org/0000-0003-1548-440X","observed_orcids":["https://orcid.org/0000-0003-1548-440X"]},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"T J van Berkel","raw_affiliation_strings":["From the Department of Biochemistry I, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biochemistry I, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I913958620"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":8.6607,"has_fulltext":false,"cited_by_count":386,"citation_normalized_percentile":{"value":0.99325794,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"258","issue":"20","first_page":"12221","last_page":"12227"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acetylated-low-density-lipoprotein","display_name":"acetylated low density lipoprotein","score":0.984000027179718},{"id":"https://openalex.org/keywords/lipoprotein-uptake","display_name":"lipoprotein uptake","score":0.7450000047683716},{"id":"https://openalex.org/keywords/lipoprotein-degradation","display_name":"lipoprotein degradation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/liver-endothelial-cells","display_name":"liver endothelial cells","score":0.847000002861023},{"id":"https://openalex.org/keywords/kupffer-cells","display_name":"Kupffer cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.9829999804496765},{"id":"https://openalex.org/keywords/receptor-mediated-uptake","display_name":"receptor-mediated uptake","score":0.5400000214576721},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.9559999704360962},{"id":"https://openalex.org/keywords/lysosomotropic-agents","display_name":"lysosomotropic agents","score":0.8460000157356262},{"id":"https://openalex.org/keywords/chloroquine","display_name":"chloroquine","score":0.8389999866485596},{"id":"https://openalex.org/keywords/ammonium-chloride","display_name":"ammonium chloride","score":0.8949999809265137},{"id":"https://openalex.org/keywords/rat-liver","display_name":"rat liver","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C2778904781","wikidata":"https://www.wikidata.org/wiki/Q513486","display_name":"Kupffer cell","level":2,"score":0.7242655754089355},{"id":"https://openalex.org/C2778394429","wikidata":"https://www.wikidata.org/wiki/Q304956","display_name":"Collagenase","level":3,"score":0.6549712419509888},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.6433999538421631},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.5564061403274536},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5070369243621826},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4997527599334717},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.4954437017440796},{"id":"https://openalex.org/C2779620165","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Low-density lipoprotein","level":3,"score":0.48512089252471924},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4822281301021576},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.47883298993110657},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.46502116322517395},{"id":"https://openalex.org/C195521686","wikidata":"https://www.wikidata.org/wiki/Q17152676","display_name":"Liver cytology","level":3,"score":0.44671863317489624},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4275239109992981},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.4248766005039215},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4218023121356964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39624541997909546},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.32174819707870483},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.24151647090911865},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.152504563331604},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.137330561876297},{"id":"https://openalex.org/C2908801736","wikidata":"https://www.wikidata.org/wiki/Q9368","display_name":"Liver metabolism","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004727","descriptor_name":"Endothelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007728","descriptor_name":"Kupffer Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011770","descriptor_name":"Pyruvate Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(17)44160-3","doi":"https://doi.org/10.1016/s0021-9258(17)44160-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)44160-3","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:6313644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6313644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(17)44160-3","doi":"https://doi.org/10.1016/s0021-9258(17)44160-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)44160-3","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W236822603","https://openalex.org/W274281445","https://openalex.org/W1487164341","https://openalex.org/W1490154674","https://openalex.org/W1775749144","https://openalex.org/W1968072927","https://openalex.org/W1983065772","https://openalex.org/W2004410658","https://openalex.org/W2016974672","https://openalex.org/W2040579726","https://openalex.org/W2042819132","https://openalex.org/W2045235472","https://openalex.org/W2047132669","https://openalex.org/W2049401036","https://openalex.org/W2057955349","https://openalex.org/W2067400204","https://openalex.org/W2071891566","https://openalex.org/W2076907924","https://openalex.org/W2093927588","https://openalex.org/W2123228131","https://openalex.org/W2141839354","https://openalex.org/W2149921847","https://openalex.org/W2149960019","https://openalex.org/W2171563035","https://openalex.org/W2402704282"],"related_works":["https://openalex.org/W2092883171","https://openalex.org/W1608488562","https://openalex.org/W2398175483","https://openalex.org/W236822603","https://openalex.org/W2956940695","https://openalex.org/W572843245","https://openalex.org/W2065790541","https://openalex.org/W139712472","https://openalex.org/W2006336005","https://openalex.org/W2107030474"],"abstract_inverted_index":{"Isolation":[0],"and":[1,10,33,73,109,131,195,239,274],"separation":[2],"of":[3,21,35,66,84,92,107,167,172,197,201,218,241,251,281],"rat":[4,150,297],"liver":[5,151,298],"cells":[6,57,72,111,115,134,261],"into":[7],"endothelial,":[8],"Kupffer,":[9],"parenchymal":[11],"cell":[12,40,67,87,153,234,237,252,300,304],"fractions":[13],"were":[14,116,138],"performed":[15],"at":[16,122,244],"different":[17,86],"times":[18,60,75,247],"after":[19,53,98],"injection":[20],"human":[22,181],"125I-acetyl":[23],"low":[24,43],"density":[25],"lipoproteins":[26],"(LDL).":[27],"In":[28],"order":[29],"to":[30,186,192,272],"minimize":[31],"degradation":[32,196,240],"redistribution":[34],"the":[36,70,78,85,90,103,114,149,161,173,187,198,202,219,228,231,236,256,264,282,289,296,302],"injected":[37],"lipoprotein":[38],"during":[39,288],"isolation,":[41],"a":[42,119,141,155,164],"temperature":[44],"(8":[45],"degrees":[46,124],"C)":[47],"procedure":[48],"was":[49,94,243],"applied.":[50],"Ten":[51],"min":[52,97],"injection,":[54],"isolated":[55,117,262],"endothelial":[56,108,127,152,258,299],"contained":[58],"5":[59],"more":[61,76,214],"acetyl-LDL":[62,93,162,169,188,242,308],"apoprotein":[63],"per":[64,249],"mg":[65,250],"protein":[68,253],"than":[69,77,129,136,215,254],"Kupffer":[71,110,133,233],"31":[74],"hepatocytes.":[79],"A":[80],"similar":[81],"relative":[82],"importance":[83],"types":[88],"in":[89,104,213,227],"uptake":[91,194],"observed":[95],"30":[96],"injection.":[99],"For":[100],"studies":[101],"on":[102],"vitro":[105],"interaction":[106],"with":[112,118,255,263],"acetyl-LDL,":[113,276],"collagenase":[120],"perfusion":[121],"37":[123],"C.":[125],"Pure":[126],"(greater":[128,135],"95%)":[130],"purified":[132,232],"70%)":[137],"obtained":[139],"by":[140],"two-step":[142],"elutriation":[143],"method.":[144],"It":[145,292],"is":[146,183,190,293,301],"demonstrated":[147],"that":[148,224,279,295],"possesses":[154],"high":[156,220],"affinity":[157,221],"receptor":[158,189],"specific":[159],"for":[160,176,307],"because":[163],"35-fold":[165],"excess":[166],"unlabeled":[168,179],"inhibits":[170],"association":[171,238],"labeled":[174],"compound":[175],"70%,":[177],"whereas":[178],"native":[180],"LDL":[182],"ineffective.":[184],"Binding":[185],"coupled":[191],"rapid":[193],"apolipoprotein.":[199],"Addition":[200],"lysosomotropic":[203],"agents":[204],"chloroquine":[205],"(50":[206],"microM)":[207],"or":[208,286],"NH4Cl":[209],"(10":[210],"mM)":[211],"resulted":[212],"90%":[216],"inhibition":[217],"degradation,":[222],"indicating":[223],"this":[225],"occurs":[226],"lysosomes.":[229],"With":[230],"fraction,":[235],"least":[245],"4":[246],"less":[248],"pure":[257],"cells.":[259],"Although":[260],"cold":[265],"pronase":[266],"technique":[267],"are":[268,284],"also":[269],"still":[270],"able":[271],"bind":[273],"degrade":[275],"it":[277],"appeared":[278],"40-60%":[280],"receptors":[283],"destroyed":[285],"inactivated":[287],"isolation":[290],"procedure.":[291],"concluded":[294],"main":[303],"type":[305],"responsible":[306],"uptake.":[309]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
