{"id":"https://openalex.org/W1518368751","doi":"https://doi.org/10.1111/j.1939-1676.2011.0709.x","title":"Concentration of Lipocalin Region of Collagen XXVII Alpha 1 in the Serum of Dogs with Hemangiosarcoma","display_name":"Concentration of Lipocalin Region of Collagen XXVII Alpha 1 in the Serum of Dogs with Hemangiosarcoma","publication_year":2011,"publication_date":"2011-03-21","ids":{"openalex":"https://openalex.org/W1518368751","doi":"https://doi.org/10.1111/j.1939-1676.2011.0709.x","mag":"1518368751","pmid":"https://pubmed.ncbi.nlm.nih.gov/21418324"},"language":"en","primary_location":{"id":"doi:10.1111/j.1939-1676.2011.0709.x","doi":"https://doi.org/10.1111/j.1939-1676.2011.0709.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1939-1676.2011.0709.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1939-1676.2011.0709.x","source":{"id":"https://openalex.org/S69093139","display_name":"Journal of Veterinary Internal Medicine","issn_l":"0891-6640","issn":["0891-6640","1939-1676"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1939-1676.2011.0709.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019043711","display_name":"Grant Kirby","orcid":"https://orcid.org/0000-0002-3363-9973","observed_orcids":["https://orcid.org/0000-0002-3363-9973"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"G.M. Kirby","raw_affiliation_strings":["McMaster University, Hamilton Department of Biomedical Sciences, , ON,","Department of Biomedical Sciences, McMaster University, Hamilton, ON Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McMaster University, Hamilton Department of Biomedical Sciences, , ON,","institution_ids":["https://openalex.org/I98251732"]},{"raw_affiliation_string":"Department of Biomedical Sciences, McMaster University, Hamilton, ON Canada","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Mackay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"A. Mackay","raw_affiliation_strings":["McMaster University, Hamilton Department of Biomedical Sciences, , ON,","Department of Biomedical Sciences, McMaster University, Hamilton, ON Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McMaster University, Hamilton Department of Biomedical Sciences, , ON,","institution_ids":["https://openalex.org/I98251732"]},{"raw_affiliation_string":"Department of Biomedical Sciences, McMaster University, Hamilton, ON Canada","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111610232","display_name":"A GRANT","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"A. Grant","raw_affiliation_strings":["McMaster University, Hamilton Department of Biomedical Sciences, , ON,","Department of Biomedical Sciences, McMaster University, Hamilton, ON Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McMaster University, Hamilton Department of Biomedical Sciences, , ON,","institution_ids":["https://openalex.org/I98251732"]},{"raw_affiliation_string":"Department of Biomedical Sciences, McMaster University, Hamilton, ON Canada","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046426757","display_name":"J. Paul Woods","orcid":"https://orcid.org/0000-0002-7268-6764","observed_orcids":["https://orcid.org/0000-0002-7268-6764"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"P. Woods","raw_affiliation_strings":["McMaster University, Hamilton Department of Clinical Studies, , ON,","Department of Clinical Studies, McMaster University, Hamilton, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McMaster University, Hamilton Department of Clinical Studies, , ON,","institution_ids":["https://openalex.org/I98251732"]},{"raw_affiliation_string":"Department of Clinical Studies, McMaster University, Hamilton, ON, Canada","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":null,"display_name":"B. McEwen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"B. McEwen","raw_affiliation_strings":["Animal Health Laboratory, McMaster University, Hamilton , ON,","Animal Health Laboratory, McMaster University, Hamilton, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Health Laboratory, McMaster University, Hamilton , ON,","institution_ids":["https://openalex.org/I98251732"]},{"raw_affiliation_string":"Animal Health Laboratory, McMaster University, Hamilton, ON, Canada","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111500859","display_name":"C. Khanna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Khanna","raw_affiliation_strings":["Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025258103","display_name":"Joseph Macri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76442945","display_name":"Hamilton Health Sciences","ror":"https://ror.org/02dqdxm48","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I76442945"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J. Macri","raw_affiliation_strings":["Clinical Proteomics Facility, Hamilton Health Sciences , Department of Pathology and Laboratory Medicine, McMaster University, Hamilton, ON,","Clinical Proteomics Facility, Hamilton Health Sciences, Department of Pathology and Laboratory Medicine, McMaster University, Hamilton, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Proteomics Facility, Hamilton Health Sciences , Department of Pathology and Laboratory Medicine, McMaster University, Hamilton, ON,","institution_ids":["https://openalex.org/I76442945","https://openalex.org/I98251732"]},{"raw_affiliation_string":"Clinical Proteomics Facility, Hamilton Health Sciences, Department of Pathology and Laboratory Medicine, McMaster University, Hamilton, ON, Canada","institution_ids":["https://openalex.org/I76442945","https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105523435","display_name":"M. Anthony Hayes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M.A. Hayes","raw_affiliation_strings":["University of Guelph, Guelph Department of Pathobiology, , ON,","Department of Pathobiology,University of Guelph,Guelph,ON,Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Guelph, Guelph Department of Pathobiology, , ON,","institution_ids":["https://openalex.org/I79817857"]},{"raw_affiliation_string":"Department of Pathobiology,University of Guelph,Guelph,ON,Canada","institution_ids":["https://openalex.org/I79817857"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110135209","display_name":"Margaret Stalker","orcid":"https://orcid.org/0000-0001-9493-7221","observed_orcids":["https://orcid.org/0000-0001-9493-7221"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M. Stalker","raw_affiliation_strings":["Animal Health Laboratory, McMaster University, Hamilton , ON,","Animal Health Laboratory, McMaster University, Hamilton, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Health Laboratory, McMaster University, Hamilton , ON,","institution_ids":["https://openalex.org/I98251732"]},{"raw_affiliation_string":"Animal Health Laboratory, McMaster University, Hamilton, ON, Canada","institution_ids":["https://openalex.org/I98251732"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":null,"fwci":3.2036,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.89638448,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"25","issue":"3","first_page":"497","last_page":"503"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11580","display_name":"Veterinary Medicine and Surgery","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemangiosarcoma","display_name":"hemangiosarcoma","score":0.9620000123977661},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.8479999899864197},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cancer-diagnosis","display_name":"cancer diagnosis","score":0.5809999704360962},{"id":"https://openalex.org/keywords/cancer-recurrence-monitoring","display_name":"tumor recurrence monitoring","score":0.6859999895095825},{"id":"https://openalex.org/keywords/splenectomy","display_name":"splenectomy","score":0.7570000290870667},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.75},{"id":"https://openalex.org/keywords/lymphoma","display_name":"lymphoma","score":0.7799999713897705},{"id":"https://openalex.org/keywords/canine-cancer","display_name":"canine cancer","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9016909599304199},{"id":"https://openalex.org/C2781082889","wikidata":"https://www.wikidata.org/wiki/Q539728","display_name":"Hemangiosarcoma","level":3,"score":0.6735612154006958},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.661974310874939},{"id":"https://openalex.org/C20299238","wikidata":"https://www.wikidata.org/wiki/Q363928","display_name":"Lipocalin","level":2,"score":0.5490638017654419},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40440914034843445},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3437785804271698},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.11481204628944397},{"id":"https://openalex.org/C2779217266","wikidata":"https://www.wikidata.org/wiki/Q2619091","display_name":"Angiosarcoma","level":2,"score":0.09511035680770874},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006394","descriptor_name":"Hemangiosarcoma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006394","descriptor_name":"Hemangiosarcoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006394","descriptor_name":"Hemangiosarcoma","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024022","descriptor_name":"Fibrillar Collagens","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D024022","descriptor_name":"Fibrillar Collagens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054834","descriptor_name":"Lipocalins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D054834","descriptor_name":"Lipocalins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1939-1676.2011.0709.x","doi":"https://doi.org/10.1111/j.1939-1676.2011.0709.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1939-1676.2011.0709.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1939-1676.2011.0709.x","source":{"id":"https://openalex.org/S69093139","display_name":"Journal of Veterinary Internal Medicine","issn_l":"0891-6640","issn":["0891-6640","1939-1676"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Internal Medicine","raw_type":"journal-article"},{"id":"pmid:21418324","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21418324","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of veterinary internal medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1939-1676.2011.0709.x","doi":"https://doi.org/10.1111/j.1939-1676.2011.0709.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1939-1676.2011.0709.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1939-1676.2011.0709.x","source":{"id":"https://openalex.org/S69093139","display_name":"Journal of Veterinary Internal Medicine","issn_l":"0891-6640","issn":["0891-6640","1939-1676"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Internal Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337859","display_name":"OVC Pet Trust","ror":"https://ror.org/02stdqb15"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1518368751.pdf","grobid_xml":"https://content.openalex.org/works/W1518368751.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W206113937","https://openalex.org/W1574853204","https://openalex.org/W1972982788","https://openalex.org/W1977240640","https://openalex.org/W2000206516","https://openalex.org/W2013454191","https://openalex.org/W2039562896","https://openalex.org/W2044536504","https://openalex.org/W2069792308","https://openalex.org/W2075241233","https://openalex.org/W2111265971","https://openalex.org/W2129477987","https://openalex.org/W2162850849","https://openalex.org/W4255434939"],"related_works":["https://openalex.org/W3135727782","https://openalex.org/W2508716579","https://openalex.org/W7062183620","https://openalex.org/W2062845977","https://openalex.org/W7137641962","https://openalex.org/W7027812829","https://openalex.org/W7134175309","https://openalex.org/W4408672476","https://openalex.org/W3161620661","https://openalex.org/W2028179069"],"abstract_inverted_index":{"BACKGROUND:":[0],"Hemangiosarcoma":[1],"(HSA)":[2],"is":[3,17],"a":[4],"common":[5],"malignancy":[6],"of":[7,15,20,22,36,44,107,173,234],"dogs":[8,37,49,55,71,108,127,134,212],"with":[9,38,50,72,109,135,213],"characteristic":[10,164],"early,":[11],"aggressive":[12],"metastasis.":[13],"Diagnosis":[14],"HSA":[16,39,51,73,112,176],"challenging":[18],"because":[19],"lack":[21],"sensitive":[23],"and":[24,52,74,85,90,148,183,206,232],"specific":[25],"diagnostic":[26],"tests.":[27],"HYPOTHESIS:":[28],"Specific":[29],"proteins":[30,69],"that":[31,99],"are":[32],"increased":[33,209],"in":[34,70,105,125,210],"serum":[35,68,100,106],"might":[40,227],"represent":[41],"useful":[42,229],"biomarkers":[43],"the":[45,57,171],"disease.":[46],"ANIMALS:":[47],"Thirty-four":[48],"42":[53],"healthy":[54,75,126],"from":[56],"Ontario":[58],"Veterinary":[59],"College":[60],"Teaching":[61],"Hospital.":[62],"METHODS:":[63],"This":[64],"case-control":[65],"study":[66],"compared":[67],"dogs.":[76],"Proteins":[77],"were":[78,151,155,186],"separated":[79],"by":[80,87],"2-dimensional":[81],"difference":[82],"gel":[83],"electrophoresis":[84],"identified":[86],"liquid":[88],"chromatography":[89],"tandem":[91],"mass":[92],"spectrometry.":[93],"RESULTS:":[94],"Western":[95],"blot":[96],"analysis":[97],"showed":[98],"collagen":[101,189],"XXVII":[102,190,225],"peptide":[103,191,226],"concentration":[104,192],"large":[110],"metastatic":[111],"burdens":[113],"(1,488,":[114],"231-3,754":[115],"DU;":[116,217],"median,":[117],"minimum-maximum);":[118],"was,":[119],"on":[120],"average,":[121],"9.5-fold":[122],"higher":[123],"than":[124,158],"(156;":[128],"46-2,101":[129],"DU).":[130,219],"While":[131],"concentrations":[132],"for":[133,160,175,180,230],"osteosarcomas":[136],"(678;":[137],"124-3,251":[138],"DU),":[139,143,147],"lymphomas":[140],"(423;":[141],"92-2,777":[142],"carcinomas":[144],"(1,022;":[145],"177-3,448":[146],"inflammatory":[149],"disease":[150],"also":[152],"increased,":[153],"values":[154],"consistently":[156],"lower":[157],"those":[159],"HSA.":[161,236],"Receiver":[162],"operating":[163],"curves":[165],"revealed":[166],"an":[167],"estimated":[168],"area":[169],"under":[170],"curve":[172],"83%":[174],"cases":[177],"whereas":[178],"areas":[179],"other":[181],"neoplastic":[182],"nonneoplastic":[184],"diseases":[185],"nondiscriminatory.":[187],"Serum":[188],"before":[193],"splenectomy":[194],"(1,350;":[195],"1,156-1,929":[196],"DU)":[197,205],"was":[198],"reduced":[199],"after":[200],"tumor":[201,214],"removal":[202],"(529;":[203],"452-562":[204],"chemotherapy":[207],"but":[208],"2":[211],"recurrence":[215],"(511-945":[216],"493-650":[218],"CONCLUSIONS":[220],"AND":[221],"CLINICAL":[222],"IMPORTANCE:":[223],"Collagen":[224],"be":[228],"diagnosis":[231],"monitoring":[233],"advanced":[235]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
