{"id":"https://openalex.org/W1516780915","doi":null,"title":"Trans-generational influence of tetracycline on Drosophila melanogaster","display_name":"Trans-generational influence of tetracycline on Drosophila melanogaster","publication_year":2010,"publication_date":"2010-02-27","ids":{"openalex":"https://openalex.org/W1516780915","mag":"1516780915"},"language":"en","primary_location":{"id":"pmh:oai:edoc.mpg.de:452785","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mpg.de/452785","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008517093","display_name":"Hagen M\u00fcller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hagen M\u00fcller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027271022","display_name":"Marianne Krefft","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marianne Krefft","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129421772","display_name":"Gregory Adam Reeves","orcid":"https://orcid.org/0000-0002-4384-7207","observed_orcids":["https://orcid.org/0000-0002-4384-7207"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Reeves","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4384-7207","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5054295296","display_name":"Floyd A. Reed","orcid":"https://orcid.org/0000-0003-4703-530X","observed_orcids":["https://orcid.org/0000-0003-4703-530X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Floyd A. Reed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12043","display_name":"Insect behavior and control techniques","score":0.19779999554157257,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12043","display_name":"Insect behavior and control techniques","score":0.19779999554157257,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.12020000070333481,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11075","display_name":"Insect Resistance and Genetics","score":0.11680000275373459,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetracycline","display_name":"tetracycline","score":0.9980000257492065},{"id":"https://openalex.org/keywords/transgenerational-effects","display_name":"transgenerational effects","score":0.7480000257492065},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.9919999837875366},{"id":"https://openalex.org/keywords/oviposition","display_name":"oviposition","score":0.6029999852180481},{"id":"https://openalex.org/keywords/developmental-delay","display_name":"developmental delay","score":0.9890000224113464},{"id":"https://openalex.org/keywords/maternal-inheritance","display_name":"maternal inheritance","score":0.6150000095367432},{"id":"https://openalex.org/keywords/paternal-inheritance","display_name":"paternal inheritance","score":0.9869999885559082},{"id":"https://openalex.org/keywords/mitochondrial-metabolism","display_name":"mitochondrial metabolism","score":0.6520000100135803},{"id":"https://openalex.org/keywords/antibiotic-exposure","display_name":"antibiotic exposure","score":0.4620000123977661},{"id":"https://openalex.org/keywords/sterile-insect-technique","display_name":"sterile insect technique","score":0.8970000147819519}],"concepts":[{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.8086555004119873},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4032911956310272},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3942241966724396},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.38504403829574585},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13422927260398865}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:edoc.mpg.de:452785","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mpg.de/452785","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:pure.mpg.de:item_1505197","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11858/00-001M-0000-000F-D4BF-5","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/bachelorThesis"},{"id":"mag:1516780915","doi":null,"is_oa":false,"landing_page_url":"http://pubman.mpdl.mpg.de/pubman/item/escidoc:1505197","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"},{"score":0.40450000762939453,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4403632755","https://openalex.org/W4412432044","https://openalex.org/W4320723527","https://openalex.org/W2020114667","https://openalex.org/W2073889929","https://openalex.org/W2762710278","https://openalex.org/W7213408130","https://openalex.org/W2910872223","https://openalex.org/W3113184072","https://openalex.org/W2927123197"],"abstract_inverted_index":{"Tetracycline":[0],"is":[1,13,124,137],"widely":[2],"used":[3,15,48],"as":[4,16,185],"an":[5,96],"antibiotic":[6],"for":[7,49,177,189],"medial":[8],"and":[9,27,35,128,156,180],"research":[10,50],"purposes.":[11],"It":[12],"also":[14],"a":[17,53,110],"dietary":[18],"additive":[19],"to":[20,44,154,168],"control":[21],"conditional":[22],"promoter":[23],"expression":[24],"from":[25,76],"Tet-On":[26],"Tet-Off":[28],"constructs.":[29],"A":[30],"previous":[31],"study":[32,65],"by":[33,139,163],"Ballard":[34],"Melvin":[36],"(2007)":[37],"in":[38,95,100,109,149],"Drosophila":[39],"melanogaster":[40,80],"determined":[41],"that":[42,58,196],"exposure":[43,164],"tetracycline":[45,82,89,106,155,169,201],"concentrations,":[46],"commonly":[47],"purposes,":[51],"caused":[52],"disruption":[54],"of":[55,70,78,91,113,165],"mitochondrial":[56],"metabolism":[57],"was":[59],"detectable":[60],"two":[61,71],"generations":[62,167],"post-exposure.\\nIn":[63],"this":[64],"we":[66],"describe":[67],"the":[68,150,172,178],"identification":[69],"previously":[72],"unknown":[73],"phenotypes":[74,144,179],"resulting":[75],"development":[77,136],"D.":[79],"on":[81,88,105,115,200],"containing":[83,202],"food":[84,90,107,117],"(100\uf06dg/ml).":[85],"(1)":[86],"Development":[87,104],"both":[92,126,131,143],"parents":[93,132],"results":[94,108],"approximately":[97],"40%":[98],"reduction":[99],"egg":[101],"laying.":[102],"(2)":[103],"developmental":[111,119,122],"delay":[112,123],"offspring":[114],"standard":[116],"(trans-generational":[118],"delay).":[120],"This":[121],"inherited":[125],"maternally":[127],"paternally.":[129],"When":[130],"are":[133,183,186],"exposed":[134,153],"normal":[135],"extended":[138],"\uf07e2":[140],"days":[141],"(15%).\\nUnexpectedly,":[142],"were":[145],"always":[146],"most":[147],"extreme":[148],"first":[151],"generation":[152],"could":[157],"be":[158],"completely":[159],"or":[160],"partially":[161],"rescued":[162],"preceding":[166,174],"(not":[170],"necessarily":[171],"immediately":[173],"generation).\\nPossible":[175],"explanations":[176],"their":[181,187],"rescue":[182],"discussed,":[184],"implications":[188],"transgenic":[190],"sterile":[191],"insect":[192],"technique":[193],"(SIT)":[194],"approaches":[195],"maintain":[197],"stocks":[198],"permanently":[199],"food.":[203]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}