{"id":"https://openalex.org/W1516639618","doi":"https://doi.org/10.1046/j.1471-4159.2003.01742.x","title":"Co\u2010ordinate transcriptional regulation of dopamine synthesis genes by \u03b1\u2010synuclein in human neuroblastoma cell lines","display_name":"Co\u2010ordinate transcriptional regulation of dopamine synthesis genes by \u03b1\u2010synuclein in human neuroblastoma cell lines","publication_year":2003,"publication_date":"2003-04-23","ids":{"openalex":"https://openalex.org/W1516639618","doi":"https://doi.org/10.1046/j.1471-4159.2003.01742.x","mag":"1516639618","pmid":"https://pubmed.ncbi.nlm.nih.gov/12716427"},"language":"en","primary_location":{"id":"doi:10.1046/j.1471-4159.2003.01742.x","doi":"https://doi.org/10.1046/j.1471-4159.2003.01742.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1471-4159.2003.01742.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111370875","display_name":"Melisa J. Baptista","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melisa J. Baptista","raw_affiliation_strings":["Laboratory of Neurogenetics, National Institute on Aging/NIH, Building 10 Room 6C103, MSC 1589, 9000 Rockville Pike, Bethesda, MD 20892, USA. baptista@mail.nih.gov","Laboratory of Neurogenetics, National Institute on Aging/NIH, Building 10 Room 6C103, MSC 1589, 9000 Rockville Pike, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurogenetics, National Institute on Aging/NIH, Building 10 Room 6C103, MSC 1589, 9000 Rockville Pike, Bethesda, MD 20892, USA. baptista@mail.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Laboratory of Neurogenetics, National Institute on Aging/NIH, Building 10 Room 6C103, MSC 1589, 9000 Rockville Pike, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070907726","display_name":"Casey O\u2019Farrell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Casey O'Farrell","raw_affiliation_strings":["Neurogenetics laboratory, Birdsall Building, Mayo Clinic, Jacksonville, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurogenetics laboratory, Birdsall Building, Mayo Clinic, Jacksonville, Florida, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022066412","display_name":"Sneha Daya","orcid":"https://orcid.org/0000-0002-8866-5538","observed_orcids":["https://orcid.org/0000-0002-8866-5538"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sneha Daya","raw_affiliation_strings":["Laboratory of Neurogenetics, NIA/NIH, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurogenetics, NIA/NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047656045","display_name":"Rili Ahmad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rili Ahmad","raw_affiliation_strings":["Laboratory of Neurogenetics, NIA/NIH, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurogenetics, NIA/NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009284638","display_name":"David W. Miller","orcid":"https://orcid.org/0000-0002-4634-5819","observed_orcids":["https://orcid.org/0000-0002-4634-5819"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David W. Miller","raw_affiliation_strings":["Laboratory of Neurogenetics, NIA/NIH, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurogenetics, NIA/NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020514779","display_name":"John Hardy","orcid":"https://orcid.org/0000-0002-3122-0423","observed_orcids":["https://orcid.org/0000-0002-3122-0423"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Hardy","raw_affiliation_strings":["Laboratory of Neurogenetics, NIA/NIH, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurogenetics, NIA/NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050824228","display_name":"Matthew James Farrer","orcid":"https://orcid.org/0000-0003-1159-5321","observed_orcids":["https://orcid.org/0000-0003-1159-5321"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew J. Farrer","raw_affiliation_strings":["Neurogenetics laboratory, Birdsall Building, Mayo Clinic, Jacksonville, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurogenetics laboratory, Birdsall Building, Mayo Clinic, Jacksonville, Florida, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064191051","display_name":"Mark Cookson","orcid":"https://orcid.org/0000-0002-1058-3831","observed_orcids":["https://orcid.org/0000-0002-1058-3831"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark R. Cookson","raw_affiliation_strings":["Laboratory of Neurogenetics, NIA/NIH, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurogenetics, NIA/NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":5.5265,"has_fulltext":false,"cited_by_count":151,"citation_normalized_percentile":{"value":0.9601464,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"85","issue":"4","first_page":"957","last_page":"968"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.04639999940991402,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.9959999918937683},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.949999988079071},{"id":"https://openalex.org/keywords/dopamine-synthesis","display_name":"dopamine synthesis","score":0.8320000171661377},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/neuroblastoma-cell-lines","display_name":"neuroblastoma cell lines","score":0.9340000152587891},{"id":"https://openalex.org/keywords/dihydropteridine-reductase","display_name":"dihydropteridine reductase","score":0.8650000095367432},{"id":"https://openalex.org/keywords/gtp-cyclohydrolase","display_name":"GTP cyclohydrolase","score":0.9739999771118164},{"id":"https://openalex.org/keywords/sepiapterin-reductase","display_name":"sepiapterin reductase","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":1.0},{"id":"https://openalex.org/keywords/nurr1","display_name":"Nurr1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dopaminergic-neuron-degeneration","display_name":"dopaminergic neuron loss","score":0.847000002861023},{"id":"https://openalex.org/keywords/lewy-bodies","display_name":"Lewy bodies","score":0.8619999885559082}],"concepts":[{"id":"https://openalex.org/C159167319","wikidata":"https://www.wikidata.org/wiki/Q420766","display_name":"Tyrosine hydroxylase","level":3,"score":0.571220338344574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5658657550811768},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5625698566436768},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5049331784248352},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.4359549880027771},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39710748195648193},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3948467969894409},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3575436472892761},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20898696780204773},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.18901342153549194}],"mesh":[{"descriptor_ui":"D000429","descriptor_name":"Alcohol Oxidoreductases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000429","descriptor_name":"Alcohol Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001142","descriptor_name":"Aromatic-L-Amino-Acid Decarboxylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001142","descriptor_name":"Aromatic-L-Amino-Acid Decarboxylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006136","descriptor_name":"GTP Cyclohydrolase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006136","descriptor_name":"GTP Cyclohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020218","descriptor_name":"Response Elements","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051843","descriptor_name":"Synucleins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057126","descriptor_name":"Nuclear Receptor Subfamily 4, Group A, Member 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1046/j.1471-4159.2003.01742.x","doi":"https://doi.org/10.1046/j.1471-4159.2003.01742.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1471-4159.2003.01742.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:12716427","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12716427","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:29782","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/29782/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JOURNAL OF NEUROCHEMISTRY , 85 (4) pp. 957-968. (2003)","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3464757233","display_name":null,"funder_award_id":"NS 40256","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1502551601","https://openalex.org/W1504584187","https://openalex.org/W1517096773","https://openalex.org/W1521854746","https://openalex.org/W1527671059","https://openalex.org/W1637321639","https://openalex.org/W1708468382","https://openalex.org/W1930159471","https://openalex.org/W1970082985","https://openalex.org/W1972939055","https://openalex.org/W1976148085","https://openalex.org/W1976316003","https://openalex.org/W1976345822","https://openalex.org/W1978793403","https://openalex.org/W1982928559","https://openalex.org/W1985009927","https://openalex.org/W1989651985","https://openalex.org/W1997071370","https://openalex.org/W1998902445","https://openalex.org/W2005833530","https://openalex.org/W2025266279","https://openalex.org/W2025441398","https://openalex.org/W2025922492","https://openalex.org/W2027547004","https://openalex.org/W2030600721","https://openalex.org/W2030748454","https://openalex.org/W2046014998","https://openalex.org/W2052974495","https://openalex.org/W2060449537","https://openalex.org/W2061259632","https://openalex.org/W2066433054","https://openalex.org/W2073135755","https://openalex.org/W2074920372","https://openalex.org/W2075997185","https://openalex.org/W2081355012","https://openalex.org/W2088514983","https://openalex.org/W2088851040","https://openalex.org/W2091265794","https://openalex.org/W2093388612","https://openalex.org/W2104912043","https://openalex.org/W2109628664","https://openalex.org/W2112659765","https://openalex.org/W2116753046","https://openalex.org/W2127031542","https://openalex.org/W2132181394","https://openalex.org/W2137476312","https://openalex.org/W2139606799","https://openalex.org/W2140557689","https://openalex.org/W2145050029","https://openalex.org/W2150656456","https://openalex.org/W2153348456","https://openalex.org/W2171281715","https://openalex.org/W2400982232","https://openalex.org/W4210995338","https://openalex.org/W4295689620","https://openalex.org/W4295994768","https://openalex.org/W4297407199","https://openalex.org/W4319425454"],"related_works":["https://openalex.org/W2900318172","https://openalex.org/W2062732021","https://openalex.org/W2043099576","https://openalex.org/W7056393307","https://openalex.org/W2089019351","https://openalex.org/W2030748454","https://openalex.org/W1967905541","https://openalex.org/W2111543406","https://openalex.org/W2075281870","https://openalex.org/W1923453730"],"abstract_inverted_index":{"Abnormal":[0],"accumulation":[1],"of":[2,11,62,80,101,104,112,115,118,126,138,172,186],"alpha-synuclein":[3,22,57],"in":[4,21,26,44,120,131],"Lewy":[5],"bodies":[6],"is":[7,189],"a":[8],"neuropathological":[9],"hallmark":[10],"both":[12],"sporadic":[13],"and":[14,94,149,168],"familial":[15],"Parkinson's":[16],"disease":[17],"(PD).":[18],"Although":[19],"mutations":[20],"have":[23],"been":[24],"identified":[25],"autosomal":[27],"dominant":[28],"PD,":[29,121],"the":[30,110,116,124,128,163,173,183],"mechanism":[31],"by":[32,65,153],"which":[33,107],"dopaminergic":[34],"cell":[35,46],"death":[36],"occurs":[37],"remains":[38],"unknown.":[39],"We":[40,97,134],"investigated":[41,123],"transcriptional":[42],"changes":[43],"neuroblastoma":[45],"lines":[47],"transfected":[48],"with":[49,60],"either":[50],"normal":[51],"or":[52,55],"mutant":[53,157],"(A30P":[54],"A53T)":[56],"using":[58],"microarrays,":[59],"confirmation":[61],"selected":[63],"genes":[64,130],"quantitative":[66],"RT-PCR.":[67],"Gene":[68],"products":[69],"whose":[70],"expression":[71,103,125,171],"was":[72,178],"found":[73,99,135],"to":[74],"be":[75],"significantly":[76],"altered":[77,102],"included":[78],"members":[79],"diverse":[81],"functional":[82],"groups":[83],"such":[84],"as":[85],"stress":[86],"response,":[87],"transcription":[88,92,193],"regulators,":[89],"apoptosis-inducing":[90],"molecules,":[91],"factors":[93],"membrane-bound":[95],"proteins.":[96],"also":[98,179],"evidence":[100],"dihydropteridine":[105],"reductase,":[106],"indirectly":[108],"regulates":[109],"synthesis":[111,188],"dopamine.":[113],"Because":[114],"importance":[117],"dopamine":[119,132,187],"we":[122],"all":[127],"known":[129],"synthesis.":[133],"co-ordinated":[136],"downregulation":[137],"mRNA":[139],"for":[140,166],"GTP":[141],"cyclohydrolase,":[142],"sepiapterin":[143],"reductase":[144],"(SR),":[145],"tyrosine":[146],"hydroxylase":[147],"(TH)":[148],"aromatic":[150],"acid":[151],"decarboxylase":[152],"wild-type":[154],"but":[155],"not":[156],"alpha-synuclein.":[158],"These":[159],"were":[160],"confirmed":[161],"at":[162],"protein":[164],"level":[165],"SR":[167],"TH.":[169],"Reduced":[170],"orphan":[174],"nuclear":[175],"receptor":[176],"Nurr1":[177],"noted,":[180],"suggesting":[181],"that":[182],"co-ordinate":[184],"regulation":[185],"regulated":[190],"through":[191],"this":[192],"factor.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
