{"id":"https://openalex.org/W1516631422","doi":"https://doi.org/10.1038/nrg862","title":"Genetic approaches to studying energy balance: perception and integration","display_name":"Genetic approaches to studying energy balance: perception and integration","publication_year":2002,"publication_date":"2002-08-01","ids":{"openalex":"https://openalex.org/W1516631422","doi":"https://doi.org/10.1038/nrg862","mag":"1516631422","pmid":"https://pubmed.ncbi.nlm.nih.gov/12154382"},"language":"en","primary_location":{"id":"doi:10.1038/nrg862","doi":"https://doi.org/10.1038/nrg862","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrg862","pdf_url":null,"source":{"id":"https://openalex.org/S8553189","display_name":"Nature Reviews Genetics","issn_l":"1471-0056","issn":["1471-0056","1471-0064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Genetics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033517921","display_name":"Gregory S. Barsh","orcid":"https://orcid.org/0000-0002-0838-1042","observed_orcids":["https://orcid.org/0000-0002-0838-1042"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gregory S. Barsh","raw_affiliation_strings":["[1] Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305-5208, USA. gbarsh@pmgm2.stanford.edu","Department of Pediatrics, Stanford University School of Medicine, Stanford, 94305-5208, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[1] Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305-5208, USA. gbarsh@pmgm2.stanford.edu","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Pediatrics, Stanford University School of Medicine, Stanford, 94305-5208, California, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053926256","display_name":"Michael W. Schwartz","orcid":"https://orcid.org/0000-0003-1619-0331","observed_orcids":["https://orcid.org/0000-0003-1619-0331"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael W. Schwartz","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle, 98195-6420, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, 98195-6420, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5033517921"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":3.1922,"has_fulltext":false,"cited_by_count":416,"citation_normalized_percentile":{"value":1.0,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"3","issue":"8","first_page":"589","last_page":"600"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/energy-balance","display_name":"energy balance","score":0.9789999723434448},{"id":"https://openalex.org/keywords/homeostatic-regulation","display_name":"homeostatic regulation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/humoral-factors","display_name":"humoral factors","score":0.6790000200271606},{"id":"https://openalex.org/keywords/neuronal-receptors","display_name":"neuronal receptors","score":0.6039999723434448},{"id":"https://openalex.org/keywords/positional-cloning","display_name":"positional cloning","score":0.9940000176429749},{"id":"https://openalex.org/keywords/body-fat-stores","display_name":"body fat stores","score":0.6869999766349792},{"id":"https://openalex.org/keywords/metabolic-response","display_name":"metabolic response","score":0.4309999942779541},{"id":"https://openalex.org/keywords/behavioral-responses","display_name":"behavioral responses","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8412543535232544},{"id":"https://openalex.org/C121050878","wikidata":"https://www.wikidata.org/wiki/Q5135020","display_name":"Cloning (programming)","level":2,"score":0.5367421507835388},{"id":"https://openalex.org/C3020804800","wikidata":"https://www.wikidata.org/wiki/Q5050812","display_name":"Positional cloning","level":4,"score":0.5091385245323181},{"id":"https://openalex.org/C26760741","wikidata":"https://www.wikidata.org/wiki/Q160402","display_name":"Perception","level":2,"score":0.5029177069664001},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.46432772278785706},{"id":"https://openalex.org/C168031717","wikidata":"https://www.wikidata.org/wiki/Q1530280","display_name":"Balance (ability)","level":2,"score":0.41255998611450195},{"id":"https://openalex.org/C2491326","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy homeostasis","level":3,"score":0.41015443205833435},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.4074706435203552},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4014494717121124},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.36468297243118286},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35311901569366455},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2793984115123749},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.21239548921585083},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18337345123291016},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.14097198843955994},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.07039454579353333},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002001","descriptor_name":"Adipose Tissue, Brown","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002001","descriptor_name":"Adipose Tissue, Brown","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002001","descriptor_name":"Adipose Tissue, Brown","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/nrg862","doi":"https://doi.org/10.1038/nrg862","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrg862","pdf_url":null,"source":{"id":"https://openalex.org/S8553189","display_name":"Nature Reviews Genetics","issn_l":"1471-0056","issn":["1471-0056","1471-0064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Genetics","raw_type":"journal-article"},{"id":"pmid:12154382","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12154382","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Genetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"sustainable_development_goals_aurora":[{"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7","score":0.6499999761581421}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":104,"referenced_works":["https://openalex.org/W137153859","https://openalex.org/W1260067689","https://openalex.org/W1481893565","https://openalex.org/W1488596761","https://openalex.org/W1490643348","https://openalex.org/W1499189927","https://openalex.org/W1506453366","https://openalex.org/W1512875938","https://openalex.org/W1528557493","https://openalex.org/W1561443084","https://openalex.org/W1572502886","https://openalex.org/W1616806865","https://openalex.org/W1623365227","https://openalex.org/W1631449371","https://openalex.org/W1639930240","https://openalex.org/W1653273172","https://openalex.org/W1866620858","https://openalex.org/W1886546158","https://openalex.org/W1915373236","https://openalex.org/W1971764800","https://openalex.org/W1975977959","https://openalex.org/W1976978438","https://openalex.org/W1980335383","https://openalex.org/W1980856647","https://openalex.org/W1987942547","https://openalex.org/W1995491925","https://openalex.org/W1996713062","https://openalex.org/W1999352359","https://openalex.org/W2002294810","https://openalex.org/W2007800906","https://openalex.org/W2007829947","https://openalex.org/W2010142606","https://openalex.org/W2010610426","https://openalex.org/W2011762116","https://openalex.org/W2012853250","https://openalex.org/W2014163208","https://openalex.org/W2014508988","https://openalex.org/W2016261339","https://openalex.org/W2016381466","https://openalex.org/W2018814167","https://openalex.org/W2023398079","https://openalex.org/W2024794762","https://openalex.org/W2031316620","https://openalex.org/W2037226098","https://openalex.org/W2037447899","https://openalex.org/W2038370141","https://openalex.org/W2038432598","https://openalex.org/W2041114226","https://openalex.org/W2045948521","https://openalex.org/W2045988370","https://openalex.org/W2052722944","https://openalex.org/W2053604903","https://openalex.org/W2053807193","https://openalex.org/W2058390591","https://openalex.org/W2059035261","https://openalex.org/W2061128822","https://openalex.org/W2061225746","https://openalex.org/W2062316965","https://openalex.org/W2065389660","https://openalex.org/W2067096633","https://openalex.org/W2067175577","https://openalex.org/W2067431283","https://openalex.org/W2069302715","https://openalex.org/W2070304988","https://openalex.org/W2075019242","https://openalex.org/W2085184474","https://openalex.org/W2087759102","https://openalex.org/W2088777766","https://openalex.org/W2091087465","https://openalex.org/W2093908453","https://openalex.org/W2094554392","https://openalex.org/W2097378006","https://openalex.org/W2098181391","https://openalex.org/W2102590502","https://openalex.org/W2105470099","https://openalex.org/W2106397535","https://openalex.org/W2110147982","https://openalex.org/W2112202133","https://openalex.org/W2114207481","https://openalex.org/W2114389815","https://openalex.org/W2118192748","https://openalex.org/W2120635941","https://openalex.org/W2127398512","https://openalex.org/W2130935482","https://openalex.org/W2135621257","https://openalex.org/W2137113565","https://openalex.org/W2140634320","https://openalex.org/W2147888023","https://openalex.org/W2153867200","https://openalex.org/W2159953069","https://openalex.org/W2160064508","https://openalex.org/W2162716270","https://openalex.org/W2163865122","https://openalex.org/W2170269651","https://openalex.org/W2171999724","https://openalex.org/W2183215072","https://openalex.org/W2214744960","https://openalex.org/W2260664110","https://openalex.org/W2267586012","https://openalex.org/W2288477535","https://openalex.org/W2409908980","https://openalex.org/W2432263744","https://openalex.org/W2463943727","https://openalex.org/W4256464866"],"related_works":["https://openalex.org/W2362782207","https://openalex.org/W2109007429","https://openalex.org/W2030283002","https://openalex.org/W1987653914","https://openalex.org/W1514682894","https://openalex.org/W2388174443","https://openalex.org/W2079167097","https://openalex.org/W2368788590","https://openalex.org/W2086180371","https://openalex.org/W1594182106"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":19}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}