{"id":"https://openalex.org/W1515799994","doi":"https://doi.org/10.1016/0022-2836(91)90022-x","title":"X-ray analysis of the single chain B29-A1 peptide-linked insulin molecule","display_name":"X-ray analysis of the single chain B29-A1 peptide-linked insulin molecule","publication_year":1991,"publication_date":"1991-07-01","ids":{"openalex":"https://openalex.org/W1515799994","doi":"https://doi.org/10.1016/0022-2836(91)90022-x","mag":"1515799994","pmid":"https://pubmed.ncbi.nlm.nih.gov/1856866"},"language":"en","primary_location":{"id":"doi:10.1016/0022-2836(91)90022-x","doi":"https://doi.org/10.1016/0022-2836(91)90022-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0022-2836(91)90022-x","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112472751","display_name":"Urszula Derewenda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"U. Derewenda","raw_affiliation_strings":["Department of Chemistry, University of York, Heslington, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of York, Heslington, U.K","institution_ids":["https://openalex.org/I52099693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055855625","display_name":"Zygmunt S. Derewenda","orcid":"https://orcid.org/0000-0003-1748-9992","observed_orcids":["https://orcid.org/0000-0003-1748-9992"]},"institutions":[{"id":"https://openalex.org/I4210159963","display_name":"Novo Holdings (Denmark)","ror":"https://ror.org/04sfxgz72","country_code":"DK","type":"company","lineage":["https://openalex.org/I2801134892","https://openalex.org/I4210159963"]},{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["DK","GB"],"is_corresponding":false,"raw_author_name":"Z. Derewenda","raw_affiliation_strings":["Department of Chemistry University of York, Heslington, York, YO1 5DD, U.K","Novo Research Institute, Bagsvaerd, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry University of York, Heslington, York, YO1 5DD, U.K","institution_ids":["https://openalex.org/I52099693"]},{"raw_affiliation_string":"Novo Research Institute, Bagsvaerd, Denmark","institution_ids":["https://openalex.org/I4210159963"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074423495","display_name":"Eleanor Joy Dodson","orcid":"https://orcid.org/0000-0002-8968-9814","observed_orcids":["https://orcid.org/0000-0002-8968-9814"]},"institutions":[{"id":"https://openalex.org/I4210159963","display_name":"Novo Holdings (Denmark)","ror":"https://ror.org/04sfxgz72","country_code":"DK","type":"company","lineage":["https://openalex.org/I2801134892","https://openalex.org/I4210159963"]},{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["DK","GB"],"is_corresponding":false,"raw_author_name":"E.J. Dodson","raw_affiliation_strings":["Department of Chemistry University of York, Heslington, York, YO1 5DD, U.K","Novo Research Institute, Bagsvaerd, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry University of York, Heslington, York, YO1 5DD, U.K","institution_ids":["https://openalex.org/I52099693"]},{"raw_affiliation_string":"Novo Research Institute, Bagsvaerd, Denmark","institution_ids":["https://openalex.org/I4210159963"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081915088","display_name":"George Guy Dodson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159963","display_name":"Novo Holdings (Denmark)","ror":"https://ror.org/04sfxgz72","country_code":"DK","type":"company","lineage":["https://openalex.org/I2801134892","https://openalex.org/I4210159963"]},{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["DK","GB"],"is_corresponding":false,"raw_author_name":"G.G. Dodson","raw_affiliation_strings":["Department of Chemistry University of York, Heslington, York, YO1 5DD, U.K","Novo Research Institute, Bagsvaerd, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry University of York, Heslington, York, YO1 5DD, U.K","institution_ids":["https://openalex.org/I52099693"]},{"raw_affiliation_string":"Novo Research Institute, Bagsvaerd, Denmark","institution_ids":["https://openalex.org/I4210159963"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiao Bing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159963","display_name":"Novo Holdings (Denmark)","ror":"https://ror.org/04sfxgz72","country_code":"DK","type":"company","lineage":["https://openalex.org/I2801134892","https://openalex.org/I4210159963"]},{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["DK","GB"],"is_corresponding":false,"raw_author_name":"Xiao Bing","raw_affiliation_strings":["Department of Chemistry University of York, Heslington, York, YO1 5DD, U.K","Novo Research Institute, Bagsvaerd, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry University of York, Heslington, York, YO1 5DD, U.K","institution_ids":["https://openalex.org/I52099693"]},{"raw_affiliation_string":"Novo Research Institute, Bagsvaerd, Denmark","institution_ids":["https://openalex.org/I4210159963"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041310836","display_name":"Jan Markussen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159963","display_name":"Novo Holdings (Denmark)","ror":"https://ror.org/04sfxgz72","country_code":"DK","type":"company","lineage":["https://openalex.org/I2801134892","https://openalex.org/I4210159963"]},{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["DK","GB"],"is_corresponding":false,"raw_author_name":"Jan Markussen","raw_affiliation_strings":["Department of Chemistry University of York, Heslington, York, YO1 5DD, U.K","Novo Research Institute, Bagsvaerd, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry University of York, Heslington, York, YO1 5DD, U.K","institution_ids":["https://openalex.org/I52099693"]},{"raw_affiliation_string":"Novo Research Institute, Bagsvaerd, Denmark","institution_ids":["https://openalex.org/I4210159963"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":10.1506,"has_fulltext":false,"cited_by_count":204,"citation_normalized_percentile":{"value":0.98845158,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"220","issue":"2","first_page":"425","last_page":"433"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.054099999368190765,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.04769999906420708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.8230000138282776},{"id":"https://openalex.org/keywords/insulin-crystal-structure","display_name":"insulin crystal structure","score":0.5899999737739563},{"id":"https://openalex.org/keywords/insulin-dimer","display_name":"insulin dimer","score":0.4959999918937683},{"id":"https://openalex.org/keywords/insulin-hexamer","display_name":"insulin hexamer","score":0.5730000138282776},{"id":"https://openalex.org/keywords/insulin-conformation","display_name":"insulin conformation","score":0.453000009059906},{"id":"https://openalex.org/keywords/insulin-receptor-binding","display_name":"insulin receptor binding","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.7278602123260498},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.7109925150871277},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.7057870030403137},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.6969857215881348},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5920236110687256},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.4812714457511902},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4181610643863678},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2872796058654785},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1908402144908905},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.07728582620620728},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0022-2836(91)90022-x","doi":"https://doi.org/10.1016/0022-2836(91)90022-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0022-2836(91)90022-x","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},{"id":"pmid:1856866","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1856866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W76488434","https://openalex.org/W112136519","https://openalex.org/W611162094","https://openalex.org/W964503500","https://openalex.org/W1499490706","https://openalex.org/W1501630033","https://openalex.org/W1637173362","https://openalex.org/W1937983574","https://openalex.org/W1966041739","https://openalex.org/W1968241822","https://openalex.org/W1986749099","https://openalex.org/W2010828278","https://openalex.org/W2028864844","https://openalex.org/W2030093057","https://openalex.org/W2044156690","https://openalex.org/W2053795827","https://openalex.org/W2061119810","https://openalex.org/W2114621223","https://openalex.org/W2135113990","https://openalex.org/W2155836823","https://openalex.org/W2327959646","https://openalex.org/W4323517667","https://openalex.org/W6604531561","https://openalex.org/W6666035383"],"related_works":["https://openalex.org/W2327959646","https://openalex.org/W2019872290","https://openalex.org/W2030795694","https://openalex.org/W2463941497","https://openalex.org/W4239171687","https://openalex.org/W2057084950","https://openalex.org/W4301478031","https://openalex.org/W2243572913","https://openalex.org/W1977673722","https://openalex.org/W2942548888"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
