{"id":"https://openalex.org/W151558970","doi":null,"title":"Facial tolerability of topical retinoid therapy.","display_name":"Facial tolerability of topical retinoid therapy.","publication_year":2004,"publication_date":"2004-11-01","ids":{"openalex":"https://openalex.org/W151558970","mag":"151558970","pmid":"https://pubmed.ncbi.nlm.nih.gov/15624747"},"language":"en","primary_location":{"id":"pmid:15624747","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15624747","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of drugs in dermatology : JDD","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"James Leyden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800191209","display_name":"Pennsylvania Hospital","ror":"https://ror.org/03mvdc478","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800191209","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4210143392","display_name":"University of Pennsylvania Health System","ror":"https://ror.org/04h81rw26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Leyden","raw_affiliation_strings":["Department of Dermatology, University of Pennsylvania Hospital, Philadelphia, PA 19104, USA. jjleyden@mindspring.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Pennsylvania Hospital, Philadelphia, PA 19104, USA. jjleyden@mindspring.com","institution_ids":["https://openalex.org/I2800191209","https://openalex.org/I4210143392","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103581990","display_name":"Gary L. Grove","orcid":"https://orcid.org/0009-0009-2553-4870","observed_orcids":["https://orcid.org/0009-0009-2553-4870"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary Grove","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088442211","display_name":"Charles R. Zerweck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles Zerweck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4965,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.79841662,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"3","issue":"6","first_page":"641","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11553","display_name":"Acne and Rosacea Treatments and Effects","score":0.47360000014305115,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11553","display_name":"Acne and Rosacea Treatments and Effects","score":0.47360000014305115,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.365200012922287,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.061799999326467514,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/topical-retinoids","display_name":"topical retinoids","score":0.9980000257492065},{"id":"https://openalex.org/keywords/skin-irritation","display_name":"skin irritation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/tazarotene","display_name":"tazarotene","score":0.8700000047683716},{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.8870000243186951},{"id":"https://openalex.org/keywords/adapalene","display_name":"adapalene","score":1.0},{"id":"https://openalex.org/keywords/sensitive-skin","display_name":"sensitive skin","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C2779306117","wikidata":"https://www.wikidata.org/wiki/Q3981685","display_name":"Tazarotene","level":3,"score":0.9822114706039429},{"id":"https://openalex.org/C2777140388","wikidata":"https://www.wikidata.org/wiki/Q352348","display_name":"Adapalene","level":5,"score":0.9761584997177124},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.9585907459259033},{"id":"https://openalex.org/C2775954498","wikidata":"https://www.wikidata.org/wiki/Q420418","display_name":"Retinoid","level":4,"score":0.84798264503479},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.844926655292511},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.7382619976997375},{"id":"https://openalex.org/C2779963572","wikidata":"https://www.wikidata.org/wiki/Q29417","display_name":"Tretinoin","level":4,"score":0.5544247627258301},{"id":"https://openalex.org/C2780576536","wikidata":"https://www.wikidata.org/wiki/Q7451065","display_name":"Sensitive skin","level":2,"score":0.5100374817848206},{"id":"https://openalex.org/C2777063393","wikidata":"https://www.wikidata.org/wiki/Q77776","display_name":"Irritation","level":2,"score":0.4386083781719208},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38410210609436035},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.2569621801376343},{"id":"https://openalex.org/C2777673923","wikidata":"https://www.wikidata.org/wiki/Q79928","display_name":"Acne","level":2,"score":0.1319037675857544},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.11218109726905823},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.07522442936897278},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.06887447834014893},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.054041892290115356},{"id":"https://openalex.org/C44228677","wikidata":"https://www.wikidata.org/wiki/Q181898","display_name":"Polymerization","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C2778885487","wikidata":"https://www.wikidata.org/wiki/Q411424","display_name":"Benzoyl peroxide","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000068816","descriptor_name":"Adapalene","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004643","descriptor_name":"Emollients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005145","descriptor_name":"Face","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009281","descriptor_name":"Naphthalenes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009281","descriptor_name":"Naphthalenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009539","descriptor_name":"Nicotinic Acids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009539","descriptor_name":"Nicotinic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012176","descriptor_name":"Retinoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012176","descriptor_name":"Retinoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15624747","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15624747","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of drugs in dermatology : JDD","raw_type":"Clinical Trial"},{"id":"mag:151558970","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15624747","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2401391580","https://openalex.org/W2410358064","https://openalex.org/W4324057621","https://openalex.org/W4235723194","https://openalex.org/W1828582648","https://openalex.org/W2411097831","https://openalex.org/W4396778632","https://openalex.org/W2002964676","https://openalex.org/W4292925555","https://openalex.org/W1979667759"],"abstract_inverted_index":{"The":[0],"facial":[1,138],"tolerability":[2,58],"of":[3,16],"various":[4],"topical":[5],"retinoids":[6],"was":[7,66,75,88,122],"evaluated":[8,33],"in":[9,13],"253":[10],"healthy":[11],"volunteers":[12],"a":[14,61],"series":[15],"split-face,":[17],"randomized,":[18],"investigator-masked":[19],"studies-all":[20],"conducted":[21],"at":[22],"the":[23,27,144],"same":[24,28],"site":[25],"by":[26],"investigator.":[29],"Four":[30],"variables":[31],"were":[32,51,100,113],"to":[34,72],"determine":[35],"if":[36],"they":[37],"influenced":[38,57],"tolerability-retinoid":[39],"concentration,":[40,129],"formulation":[41,65],"vehicle,":[42,130],"skin":[43,79,131],"sensitivity,":[44,132],"and":[45,96,110,133],"individual":[46],"retinoid.":[47,73],"Lower":[48],"retinoid":[49,71,134],"concentrations":[50],"associated":[52],"with":[53],"less":[54],"irritation.":[55],"Vehicle":[56],"but":[59],"whether":[60],"gel":[62,121],"or":[63],"cream":[64,87,93,118],"better":[67,89,101,114,123],"tolerated":[68,90,102,115,124],"varied":[69],"from":[70],"Tolerability":[74],"superior":[76],"on":[77],"normal":[78,84],"than":[80,91,103,116,125],"\"sensitive":[81],"skin.\"":[82],"On":[83,106],"skin,":[85,108],"tazarotene":[86,104,109,126],"tretinoin":[92,97,117],"whereas":[94,119],"adapalene":[95,111,120],"microsponge":[98],"gels":[99],"gel.":[105,127],"sensitive":[107],"creams":[112],"Retinoid":[128],"can":[135],"all":[136],"affect":[137],"tolerability.":[139],"Skin":[140],"vulnerability":[141],"may":[142],"be":[143],"most":[145],"important":[146],"factor.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}