{"id":"https://openalex.org/W1515485698","doi":null,"title":"Molekular- und zellbiologische Studien zur Evolution und subzellul\u00e4ren Lokalisation humaner Parvulin-Proteine","display_name":"Molekular- und zellbiologische Studien zur Evolution und subzellul\u00e4ren Lokalisation humaner Parvulin-Proteine","publication_year":2007,"publication_date":"2007-12-17","ids":{"openalex":"https://openalex.org/W1515485698","mag":"1515485698"},"language":"de","primary_location":{"id":"pmh:oai:duepublico.uni-duisburg-essen.de:17046","doi":null,"is_oa":true,"landing_page_url":"http://duepublico.uni-duisburg-essen.de/servlets/DocumentServlet?id=17046","pdf_url":"http://duepublico.uni-duisburg-essen.de/servlets/DocumentServlet?id=17046","source":{"id":"https://openalex.org/S4306400212","display_name":"DuEPublico (University of Duisburg-Essen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62318514","host_organization_name":"University of Duisburg-Essen","host_organization_lineage":["https://openalex.org/I62318514"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Wissenschaftliche Abschlussarbeiten \u00bb Dissertation"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://duepublico.uni-duisburg-essen.de/servlets/DocumentServlet?id=17046","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Daniel S. Kessler","orcid":"https://orcid.org/0000-0002-3557-2434","observed_orcids":["https://orcid.org/0000-0002-3557-2434"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Daniel S. Kessler","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3557-2434","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.1664000004529953,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.1664000004529953,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.1151999980211258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.07729999721050262,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alternative-transcription-initiation","display_name":"alternative transcription initiation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/mitochondrial-targeting-signal","display_name":"mitochondrial targeting signal","score":0.8230000138282776},{"id":"https://openalex.org/keywords/mitochondrial-localization","display_name":"mitochondrial localization","score":0.7070000171661377},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.859000027179718},{"id":"https://openalex.org/keywords/phylogenetic-analysis","display_name":"phylogenetic analysis","score":0.6959999799728394},{"id":"https://openalex.org/keywords/hominid-evolution","display_name":"hominid evolution","score":0.6370000243186951},{"id":"https://openalex.org/keywords/primate-evolution","display_name":"primate evolution","score":0.5210000276565552},{"id":"https://openalex.org/keywords/dna-binding","display_name":"DNA binding","score":0.6959999799728394},{"id":"https://openalex.org/keywords/at-rich-dna","display_name":"AT-rich DNA","score":0.9350000023841858},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.8360000252723694},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/pin1","display_name":"Pin1","score":0.5440000295639038},{"id":"https://openalex.org/keywords/high-mobility-group-proteins","display_name":"high mobility group proteins","score":0.9649999737739563},{"id":"https://openalex.org/keywords/protein-evolution","display_name":"protein evolution","score":0.4189999997615814},{"id":"https://openalex.org/keywords/gene-duplication","display_name":"gene duplication","score":0.32899999618530273},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.3619999885559082}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.737541913986206},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4542378783226013},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3259541392326355},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3246902525424957}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:duepublico.uni-duisburg-essen.de:17046","doi":null,"is_oa":true,"landing_page_url":"http://duepublico.uni-duisburg-essen.de/servlets/DocumentServlet?id=17046","pdf_url":"http://duepublico.uni-duisburg-essen.de/servlets/DocumentServlet?id=17046","source":{"id":"https://openalex.org/S4306400212","display_name":"DuEPublico (University of Duisburg-Essen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62318514","host_organization_name":"University of Duisburg-Essen","host_organization_lineage":["https://openalex.org/I62318514"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Wissenschaftliche Abschlussarbeiten \u00bb Dissertation"},{"id":"pmh:oai:duepublico2.uni-due.de:duepublico_mods_00017046","doi":null,"is_oa":true,"landing_page_url":"https://duepublico2.uni-due.de/receive/duepublico_mods_00017046","pdf_url":"https://nbn-resolving.org/urn:nbn:de:hbz:465-20080104-152349-5","source":{"id":"https://openalex.org/S4306400212","display_name":"DuEPublico (University of Duisburg-Essen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62318514","host_organization_name":"University of Duisburg-Essen","host_organization_lineage":["https://openalex.org/I62318514"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"dissertation"},{"id":"mag:1515485698","doi":null,"is_oa":false,"landing_page_url":"https://duepublico2.uni-due.de/receive/duepublico_mods_00017046","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:duepublico.uni-duisburg-essen.de:17046","doi":null,"is_oa":true,"landing_page_url":"http://duepublico.uni-duisburg-essen.de/servlets/DocumentServlet?id=17046","pdf_url":"http://duepublico.uni-duisburg-essen.de/servlets/DocumentServlet?id=17046","source":{"id":"https://openalex.org/S4306400212","display_name":"DuEPublico (University of Duisburg-Essen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62318514","host_organization_name":"University of Duisburg-Essen","host_organization_lineage":["https://openalex.org/I62318514"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Wissenschaftliche Abschlussarbeiten \u00bb Dissertation"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1515485698.pdf","grobid_xml":"https://content.openalex.org/works/W1515485698.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W1240112909","https://openalex.org/W1535704580","https://openalex.org/W1573941143","https://openalex.org/W1592169576","https://openalex.org/W1598431212","https://openalex.org/W1630273828","https://openalex.org/W1635667563","https://openalex.org/W1650619559","https://openalex.org/W1737511844","https://openalex.org/W1754378627","https://openalex.org/W1965976660","https://openalex.org/W1967044193","https://openalex.org/W1967590676","https://openalex.org/W1968069432","https://openalex.org/W1977010040","https://openalex.org/W1980492916","https://openalex.org/W1982177944","https://openalex.org/W1983216661","https://openalex.org/W1983608874","https://openalex.org/W1985131241","https://openalex.org/W1986144447","https://openalex.org/W1987774012","https://openalex.org/W1992744933","https://openalex.org/W1993849345","https://openalex.org/W1999054269","https://openalex.org/W2006155021","https://openalex.org/W2006211612","https://openalex.org/W2006786379","https://openalex.org/W2008083733","https://openalex.org/W2008959358","https://openalex.org/W2009367440","https://openalex.org/W2009391528","https://openalex.org/W2011854711","https://openalex.org/W2012900360","https://openalex.org/W2017639307","https://openalex.org/W2019269201","https://openalex.org/W2024334974","https://openalex.org/W2025438577","https://openalex.org/W2027253705","https://openalex.org/W2029747645","https://openalex.org/W2029873987","https://openalex.org/W2038335468","https://openalex.org/W2039473698","https://openalex.org/W2043035995","https://openalex.org/W2044098205","https://openalex.org/W2044586246","https://openalex.org/W2045906806","https://openalex.org/W2048882194","https://openalex.org/W2049952527","https://openalex.org/W2052686632","https://openalex.org/W2057312381","https://openalex.org/W2058426472","https://openalex.org/W2061134113","https://openalex.org/W2061630866","https://openalex.org/W2063394559","https://openalex.org/W2067627520","https://openalex.org/W2067678211","https://openalex.org/W2070894669","https://openalex.org/W2079325078","https://openalex.org/W2081740580","https://openalex.org/W2081807421","https://openalex.org/W2084748297","https://openalex.org/W2093258807","https://openalex.org/W2096049852","https://openalex.org/W2099451735","https://openalex.org/W2107947829","https://openalex.org/W2113675798","https://openalex.org/W2126946512","https://openalex.org/W2127901454","https://openalex.org/W2134278790","https://openalex.org/W2144634347","https://openalex.org/W2150164439","https://openalex.org/W2152100426","https://openalex.org/W2152458080","https://openalex.org/W2154854793","https://openalex.org/W2160090073","https://openalex.org/W2163989297","https://openalex.org/W2418598064","https://openalex.org/W2479475902"],"related_works":["https://openalex.org/W7095833500","https://openalex.org/W1737511844","https://openalex.org/W2084666192","https://openalex.org/W2070894669","https://openalex.org/W2157183303","https://openalex.org/W1974318500","https://openalex.org/W2040402888","https://openalex.org/W1981886968","https://openalex.org/W2145678852","https://openalex.org/W2022054645"],"abstract_inverted_index":{"Die":[0,64,254],"beiden":[1],"menschlichen":[2],"Parvuline":[3,198,320],"Par14":[4,37,195,225,240,265,280],"und":[5,23,60,114,154,226,234,241,266,281,322],"Par17":[6,35,100,127,173,185,227,242,282],"werden":[7],"durch":[8,32],"das":[9,146,298],"gleiche":[10,244],"Gen":[11],"codiert.":[12],"Durch":[13],"alternative":[14],"Transkrikptionsinitiation":[15],"kommt":[16],"es":[17,164],"zur":[18,24,315],"Bildung":[19],"unterschiedlich":[20],"langer":[21],"mRNAs":[22],"Expression":[25],"eines":[26,166],"25":[27],"Aminos\u00e4uren":[28],"langen":[29],"N-terminalen":[30],"Pr\u00e4-Peptids,":[31],"welches":[33,110,134],"sich":[34,69,145,270],"von":[36,54,76,224,274,279,304],"unterscheidet.":[38],"In":[39],"einer":[40,77],"phylogenetischen":[41],"Analyse":[42],"des":[43,48,126,179,232,332],"Parvulin-Gens":[44],"konnte":[45,96,174],"diese":[46],"Erweiterung":[47],"Leserahmens":[49,67],"nur":[50],"in":[51,83,92,101,138,249,341],"den":[52,84,93,102,136],"Genomen":[53],"Gro\u00dfen":[55],"Menschenaffen":[56,153],"(Mensch,":[57],"Schimpanse,":[58],"Gorilla":[59],"Orang-Utan)":[61],"nachgewiesen":[62,190],"werden.":[63,183],"Entwicklung":[65],"dieses":[66],"l\u00e4sst":[68],"anhand":[70],"der":[71,73,150,152,167,213,230,235,252,291,295,302,317,319,345],"Phylogenie":[72],"Anthropoiden":[74],"nachvollziehen,":[75],"vorgeformten,":[78],"jedoch":[79,248],"nicht":[80],"codierenden":[81],"Sequenz":[82],"Neuweltaffen":[85],"bis":[86],"hin":[87],"zu":[88,108,115,121,216,264],"seiner":[89],"funktionalen":[90],"Form":[91],"Hominiden.":[94],"Es":[95],"gezeigt":[97],"werden,":[98,191],"dass":[99],"Mitochondrien":[103,140,296],"lokalisiert":[104],"ist,":[105],"im":[106,112,119,228],"Gegensatz":[107],"Par14,":[109],"haupts\u00e4chlich":[111],"Zellkern":[113],"einem":[116],"kleineren":[117],"Teil":[118],"Cytoplasma":[120],"finden":[122],"ist.":[123],"Das":[124],"Pr\u00e4-Peptid":[125,147],"wurde":[128],"dabei":[129],"als":[130],"mitochondriales":[131],"Targeting-Signal":[132],"identifiziert,":[133],"f\u00fcr":[135,194,261],"Transport":[137],"die":[139,187,289,293,306,330,335,342],"unbedingt":[141],"ben\u00f6tigt":[142],"wird.":[143],"Da":[144],"erst":[148],"nach":[149],"Auftrennung":[151],"Altweltaffen":[155],"vor":[156],"etwa":[157],"23":[158],"Millionen":[159],"Jahren":[160],"entwickelt":[161],"hat,":[162],"stellt":[163],"phylogenetisch":[165],"j\u00fcngsten":[168],"Targeting-Peptide":[169],"dar.":[170],"Mit":[171],"dem":[172,272],"somit":[175,258,323],"ein":[176],"hominiden-spezifischer":[177],"Bestandteil":[178],"mitochondrialen":[180],"Proteoms":[181],"identifiziert":[182],"F\u00fcr":[184],"konnten":[186],"gleichen":[188],"DNA-Bindungseigenschaften":[189],"wie":[192,329],"zuvor":[193],"beschrieben.":[196],"Beide":[197],"binden":[199],"mit":[200,271,307],"hoher":[201],"Affinit\u00e4t":[202],"an":[203],"AT-reiche,":[204],"gebogene,":[205],"doppelstr\u00e4ngige":[206],"DNA":[207],"Abschnitte.":[208],"Aufgrund":[209],"dieser":[210],"Eigenschaften":[211],"sowie":[212,301,338],"strukturellen":[214],"\u00c4hnlichkeit":[215],"anderen":[217],"Proteinen":[218],"(PIN1,":[219],"HMG-Proteine)":[220],"wird":[221],"eine":[222,243,259],"Funktion":[223,318],"Bereich":[229],"Regulation":[231,331],"Zellzyklus":[233,333],"Chromatin-Remodellierung":[236],"vermutet.":[237],"Offenbar":[238],"erf\u00fcllen":[239],"oder":[245,277,297,334],"\u00e4hnliche":[246],"Funktion,":[247],"verschiedenen":[250],"Kompartimenten":[251],"Zelle.":[253],"vorliegende":[255],"Arbeit":[256],"liefert":[257],"Grundlage":[260],"weiterf\u00fchrende":[262],"Arbeiten":[263,312],"Par17.":[267],"Diese":[268,311],"sollten":[269],"Einfluss":[273],"knock":[275],"outs":[276],"\u00dcberexpression":[278],"auf":[283,288],"verschiedene":[284],"Parameter":[285],"(zum":[286],"Beispiel":[287],"Vitalit\u00e4t":[290],"Zellen,":[292],"Morphologie":[294],"mitochondriale":[299],"Membranpotenzial),":[300],"Identifizierung":[303],"Proteinen,":[305],"Par14/Par17":[308],"interagieren,":[309],"besch\u00e4ftigen.":[310],"k\u00f6nnten":[313],"weiter":[314],"Kl\u00e4rung":[316],"beitragen":[321],"wichtige":[324],"Erkenntnisse":[325],"\u00fcber":[326],"zellul\u00e4re":[327],"Prozesse":[328],"Mitochondrien-Teilung":[336],"liefern,":[337],"interessante":[339],"Einblicke":[340],"molekularen":[343],"Grundlagen":[344],"Hominiden-Evolution":[346],"bieten.":[347]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}