{"id":"https://openalex.org/W1515371019","doi":"https://doi.org/10.1161/circ.130.suppl_2.18901","title":"Abstract 18901: Calgranulins S100A8, S100A9 and S100A12 are Novel Genes Modified by n-3 PUFA Supplementation and Evoked Endotoxemia in Humans","display_name":"Abstract 18901: Calgranulins S100A8, S100A9 and S100A12 are Novel Genes Modified by n-3 PUFA Supplementation and Evoked Endotoxemia in Humans","publication_year":2014,"publication_date":"2014-11-25","ids":{"openalex":"https://openalex.org/W1515371019","doi":"https://doi.org/10.1161/circ.130.suppl_2.18901","mag":"1515371019"},"language":"en","primary_location":{"id":"doi:10.1161/circ.130.suppl_2.18901","doi":"https://doi.org/10.1161/circ.130.suppl_2.18901","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.130.suppl_2.18901","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078392652","display_name":"Jane F. Ferguson","orcid":"https://orcid.org/0000-0001-6896-1025","observed_orcids":["https://orcid.org/0000-0001-6896-1025"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane F Ferguson","raw_affiliation_strings":["Perelman Sch of Medicine, Univ of Pennsylvania, Philadelphia, PA","Perelman School of Medicine University of Pennsylvania Philadelphia PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Perelman Sch of Medicine, Univ of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Perelman School of Medicine University of Pennsylvania Philadelphia PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022420096","display_name":"Chenyi Xue","orcid":"https://orcid.org/0000-0002-8829-7659","observed_orcids":["https://orcid.org/0000-0002-8829-7659"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chenyi Xue","raw_affiliation_strings":["Perelman Sch of Medicine, Univ of Pennsylvania, Philadelphia, PA","Perelman School of Medicine University of Pennsylvania Philadelphia PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Perelman Sch of Medicine, Univ of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Perelman School of Medicine University of Pennsylvania Philadelphia PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001685590","display_name":"Mingyao Li","orcid":"https://orcid.org/0000-0003-2422-9494","observed_orcids":["https://orcid.org/0000-0003-2422-9494","https://orcid.org/0000-0001-8180-0621"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingyao Li","raw_affiliation_strings":["Perelman Sch of Medicine, Univ of Pennsylvania, Philadelphia, PA","Perelman School of Medicine University of Pennsylvania Philadelphia PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Perelman Sch of Medicine, Univ of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Perelman School of Medicine University of Pennsylvania Philadelphia PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011993136","display_name":"Rachana D. Shah","orcid":"https://orcid.org/0000-0001-7866-557X","observed_orcids":["https://orcid.org/0000-0001-7866-557X"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachana Shah","raw_affiliation_strings":["Div of Pediatric Endocrinology, Children\u2019s Hosp of Philadelphia, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Div of Pediatric Endocrinology, Children\u2019s Hosp of Philadelphia, Philadelphia, PA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026776682","display_name":"Muredach P. Reilly","orcid":"https://orcid.org/0000-0002-3035-9386","observed_orcids":["https://orcid.org/0000-0002-3035-9386"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muredach P Reilly","raw_affiliation_strings":["Perelman Sch of Medicine, Univ of Pennsylvania, Philadelphia, PA","Perelman School of Medicine University of Pennsylvania Philadelphia PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Perelman Sch of Medicine, Univ of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Perelman School of Medicine University of Pennsylvania Philadelphia PA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"130","issue":"suppl_2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calgranulins","display_name":"calgranulins","score":0.9039999842643738},{"id":"https://openalex.org/keywords/s100a8","display_name":"S100A8","score":0.9990000128746033},{"id":"https://openalex.org/keywords/s100a9","display_name":"S100A9","score":1.0},{"id":"https://openalex.org/keywords/s100a12","display_name":"S100A12","score":1.0},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.9490000009536743},{"id":"https://openalex.org/keywords/omega-3-supplementation","display_name":"omega-3 supplementation","score":0.824999988079071},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9200000166893005},{"id":"https://openalex.org/keywords/adipose-tissue-transcriptome","display_name":"adipose tissue transcriptome","score":0.9549999833106995},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5479999780654907},{"id":"https://openalex.org/keywords/inflammasome","display_name":"inflammasome","score":0.8159999847412109},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.7049999833106995},{"id":"https://openalex.org/keywords/adipocytes","display_name":"adipocytes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/epa","display_name":"EPA","score":0.4129999876022339},{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":0.9900000095367432}],"concepts":[{"id":"https://openalex.org/C2776307749","wikidata":"https://www.wikidata.org/wiki/Q18031354","display_name":"S100A9","level":3,"score":0.7928246259689331},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.7232879400253296},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.7007734179496765},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6969955563545227},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6508240699768066},{"id":"https://openalex.org/C2778557267","wikidata":"https://www.wikidata.org/wiki/Q20969990","display_name":"S100A8","level":3,"score":0.6065325736999512},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5817477703094482},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.46857118606567383},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4674939215183258},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.465279757976532},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32203608751296997},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31433579325675964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31096774339675903},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2834553122520447},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1793193519115448},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.08236420154571533}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.130.suppl_2.18901","doi":"https://doi.org/10.1161/circ.130.suppl_2.18901","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.130.suppl_2.18901","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1790439830","https://openalex.org/W2582550466","https://openalex.org/W2237030959","https://openalex.org/W2031866738","https://openalex.org/W2034816376","https://openalex.org/W2561465802","https://openalex.org/W4405310402","https://openalex.org/W2510559395","https://openalex.org/W2032969984","https://openalex.org/W4400145821"],"abstract_inverted_index":{"Introduction:":[0],"We":[1,57,137,169,225],"have":[2],"previously":[3],"identified":[4],"genes":[5,175,202,304],"involved":[6,205],"in":[7,15,34,44,66,74,86,143,155,176,206,216,231,233,241,244,256,259,280,294,305],"the":[8,217,281],"adipose":[9,30,64,99,223],"transcriptomic":[10,159],"response":[11,144,160,306],"to":[12,51,62,145,161,222,267,307],"evoked":[13,77,130,274],"endotoxemia":[14,78],"humans.":[16],"Long-chain":[17],"omega-3":[18],"polyunsaturated":[19],"fatty":[20],"acids":[21],"(n-3":[22,252],"PUFA)":[23],"may":[24,203,212,296],"modulate":[25],"chronic":[26],"low-grade":[27],"systemic":[28],"and":[29,109,148,153,208,211,235,249,273],"inflammation,":[31],"conferring":[32],"protection":[33],"cardiometabolic":[35],"disease.":[36],"However,":[37],"given":[38],"subtle":[39],"effects":[40,53,293],"of":[41,90,98,173,219,283,289,300,302],"n-3":[42,72,87,111,146,166,177,238,263,290],"PUFA":[43,73,88,112,147,167,178,239,253,291],"vivo,":[45],"intervention":[46],"studies":[47],"often":[48],"lack":[49],"power":[50],"detect":[52],"on":[54],"resting":[55],"biomarkers.":[56],"applied":[58],"unbiased":[59],"transcriptomics":[60,272],"(RNASeq)":[61],"human":[63,151],"tissue":[65,100],"healthy":[67,103],"individuals":[68,104],"following":[69],"supplementation":[70,113],"with":[71,76,121,189,262],"combination":[75],"(LPS)":[79],"as":[80,124,126],"a":[81,128,214],"unique":[82],"genomic":[83,278],"discovery":[84,279],"model":[85],"modulation":[89,299],"inflammation.":[91],"Methods:":[92],"Using":[93],"RNASeq":[94],"we":[95],"analyzed":[96],"transcriptomes":[97],"biopsies":[101],"from":[102],"at":[105],"three":[106],"timepoints:":[107],"before":[108],"after":[110,237],"(n=7;":[114],"3600mg/day":[115],"EPA/DHA)":[116],"for":[117],"6-8":[118],"weeks":[119],"compared":[120,188],"placebo":[122,190],"(n=6),":[123],"well":[125],"during":[127],"subsequent":[129],"inflammatory":[131,209,220,268],"challenge":[132],"(LPS":[133],"0.6":[134],"ng/kg":[135],"I.V.).":[136],"further":[138],"explored":[139],"candidate":[140],"gene":[141,229],"expression":[142,230,301],"LPS":[149,162,250],"using":[150],"monocytes":[152,236],"adipocytes":[154,234,245],"vitro.":[156],"Results:":[157],"The":[158],"was":[163],"altered":[164],"by":[165],"supplementation.":[168],"found":[170,226],"increased":[171],"up-regulation":[172],"calgranulin":[174,228,303],"(S100A8":[179,191],"16-fold,":[180],"p=0.002;":[181,184],"S100A9":[182,194],"8-fold,":[183],"S100A12":[185,197],"32-fold,":[186],"p=0.01)":[187],"2-fold,":[192],"p=0.003;":[193],"1.4-fold,":[195],"p=0.4;":[196],"5-fold,":[198],"p=0.04).":[199],"These":[200],"inflammasome-activating":[201],"be":[204,297],"atherogenesis":[207],"diseases,":[210],"play":[213],"role":[215],"recruitment":[218],"cells":[221],"tissue.":[224],"differing":[227],"vitro":[232],"(up":[240],"monocytes,":[242,257],"down":[243],"post":[246],"DHA":[247],"p<0.001)":[248],"treatment":[251],"dependent":[254],"decrease":[255],"increase":[258],"adipocytes)":[260],"consistent":[261],"PUFA-dependent":[264],"cell-type-specific":[265],"responses":[266],"activation.":[269,310],"Conclusions:":[270],"Unbiased":[271],"inflammation":[275],"permits":[276],"enhanced":[277],"context":[282],"nutritional":[284],"intervention.":[285],"A":[286],"novel":[287],"mechanism":[288],"protective":[292],"vivo":[295],"through":[298],"innate":[308],"immune":[309]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}
