{"id":"https://openalex.org/W1514867115","doi":null,"title":"Virus-host interactions in early HIV-1 infection","display_name":"Virus-host interactions in early HIV-1 infection","publication_year":2015,"publication_date":"2015-03-28","ids":{"openalex":"https://openalex.org/W1514867115","mag":"1514867115"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1463445","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1463445/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J. Carter Rowley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"J. Carter Rowley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.984000027179718},{"id":"https://openalex.org/keywords/early-infection","display_name":"early infection","score":0.5600000023841858},{"id":"https://openalex.org/keywords/capsid-protein","display_name":"capsid protein","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cpsf6","display_name":"CPSF6","score":0.9769999980926514},{"id":"https://openalex.org/keywords/virus-host-interactions","display_name":"host-virus interaction","score":0.7160000205039978},{"id":"https://openalex.org/keywords/integration-site-selection","display_name":"integration site selection","score":0.8299999833106995},{"id":"https://openalex.org/keywords/ctl-escape-mutations","display_name":"CTL escape mutations","score":0.8840000033378601},{"id":"https://openalex.org/keywords/bax-inhibitor-1","display_name":"Bax inhibitor-1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/host-cofactors","display_name":"host cofactors","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.6479513645172119},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6156677007675171},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6114639639854431},{"id":"https://openalex.org/C59157529","wikidata":"https://www.wikidata.org/wiki/Q994741","display_name":"Nuclear transport","level":4,"score":0.5490026473999023},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3527459502220154},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.2575937807559967}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1463445","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1463445/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:1514867115","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1463445/","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4406511764","https://openalex.org/W2003527687","https://openalex.org/W6990096966","https://openalex.org/W2559214085","https://openalex.org/W2889370079","https://openalex.org/W2067128869","https://openalex.org/W1985849199","https://openalex.org/W4407991962","https://openalex.org/W2436469904","https://openalex.org/W2050963564"],"abstract_inverted_index":{"After":[0],"entry":[1,62,98,140,216,247],"into":[2,19],"a":[3,32,188,224,228,236,244],"target":[4],"cell,":[5],"HIV-1":[6,135,268],"must":[7],"traverse":[8],"the":[9,13,24,42,69,75,84,95,124,132,137,160,170,179,196,210,214,240,254,262,275,280],"cytoplasm":[10,43],"and":[11,88,100,130,178,184,201,235,260,270],"enter":[12],"nucleus":[14],"in":[15,35,111,155,256],"order":[16],"to":[17,30,41,53,193,212,242],"integrate":[18],"host":[20,76],"chromatin.":[21],"Until":[22],"recently,":[23],"viral":[25,109,251],"CA":[26,48,72,87,129,200],"core":[27],"was":[28],"thought":[29],"play":[31],"passive":[33],"role":[34,263],"infection,":[36],"simply":[37],"delivering":[38],"its":[39],"contents":[40],"soon":[44],"after":[45],"entry.":[46],"However,":[47],"has":[49],"recently":[50],"been":[51],"found":[52],"interact":[54,194],"with":[55,59,74,136,195],"and/or":[56],"determine":[57],"interaction":[58,85,277],"several":[60],"nuclear":[61,97,139,215,246],"cofactors.":[63],"In":[64,166],"this":[65,151,257],"study,":[66],"we":[67,168],"investigate":[68],"consequences":[70],"of":[71,104,128,134,144,150,173,176,190,199,218,264],"interacting":[73],"mRNA-processing":[77],"factor":[78],"CPSF6.":[79],"We":[80,114,186],"provide":[81],"evidence":[82],"that":[83,121,148,159,226,238,272],"between":[86,163],"cytoplasmic":[89],"CPSF6":[90,125,177,181,265],"during":[91],"early":[92],"infection":[93],"dictates":[94],"downstream":[96],"pathway":[99,152,161,217,248],"integration":[101],"site":[102],"selection":[103],"HIV-1,":[105],"despite":[106],"not":[107],"affecting":[108],"titre":[110],"cell":[112,164],"lines.":[113],"identify":[115],"clinically":[116],"relevant":[117],"CTL":[118],"escape":[119],"mutations":[120],"lie":[122],"within":[123],"binding":[126],"pocket":[127,198],"alter":[131,213],"relationship":[133],"CPSF6-dependent":[138],"pathway.":[141],"The":[142],"phenotypes":[143],"these":[145],"mutants":[146],"suggest":[147],"conservation":[149],"is":[153],"important":[154],"vivo":[156],"but":[157],"also":[158],"differs":[162],"types.":[165],"addition,":[167],"examine":[169],"antiviral":[171,205],"mechanisms":[172],"C-terminal":[174],"truncations":[175],"small-molecule":[180],"peptidomimetics":[182],"PF74":[183],"BI-1.":[185],"design":[187],"series":[189],"compounds":[191],"predicted":[192],"CPSF6-binding":[197],"screen":[202],"them":[203],"for":[204],"activity":[206],"as":[207,209,266],"well":[208],"ability":[211],"HIV-1.":[219],"Of":[220],"particular":[221],"interest":[222],"are":[223],"compound":[225,237],"exhibits":[227],"very":[229],"different":[230,284],"inhibition":[231],"profile":[232],"from":[233],"PF74/BI-1":[234],"causes":[239],"virus":[241,281],"use":[243],"CPSF6-independent":[245],"without":[249],"reducing":[250],"titre.":[252],"Together,":[253],"findings":[255],"study":[258],"confirm":[259],"characterise":[261],"an":[267],"cofactor":[269],"demonstrate":[271],"drugs":[273],"targeting":[274],"CA-CPSF6":[276],"could":[278],"inhibit":[279],"through":[282],"multiple":[283],"mechanisms.":[285]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}