{"id":"https://openalex.org/W1513048819","doi":"https://doi.org/10.4049/jimmunol.163.1.448","title":"Repeated Administration of Adenoviral Vectors in Lungs of Human CD4 Transgenic Mice Treated with a Nondepleting CD4 Antibody","display_name":"Repeated Administration of Adenoviral Vectors in Lungs of Human CD4 Transgenic Mice Treated with a Nondepleting CD4 Antibody","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W1513048819","doi":"https://doi.org/10.4049/jimmunol.163.1.448","mag":"1513048819","pmid":"https://pubmed.ncbi.nlm.nih.gov/10384148"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.163.1.448","doi":"https://doi.org/10.4049/jimmunol.163.1.448","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.163.1.448","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070314915","display_name":"Narendra B. Chirmule","orcid":"https://orcid.org/0000-0003-2177-2248","observed_orcids":["https://orcid.org/0000-0003-2177-2248"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Narendra Chirmule","raw_affiliation_strings":["Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute , Philadelphia, PA 19104","*Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute, Philadelphia, PA 19104; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I79576946"]},{"raw_affiliation_string":"*Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute, Philadelphia, PA 19104; and","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022073916","display_name":"Alemseged Truneh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alemseged Truneh","raw_affiliation_strings":["\u2020Department of Immunology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Department of Immunology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057194147","display_name":"Sarah Ehlen Haecker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Ehlen Haecker","raw_affiliation_strings":["Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute , Philadelphia, PA 19104","*Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute, Philadelphia, PA 19104; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I79576946"]},{"raw_affiliation_string":"*Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute, Philadelphia, PA 19104; and","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034773524","display_name":"John Tazelaar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John Tazelaar","raw_affiliation_strings":["Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute , Philadelphia, PA 19104","*Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute, Philadelphia, PA 19104; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I79576946"]},{"raw_affiliation_string":"*Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute, Philadelphia, PA 19104; and","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009470292","display_name":"Guangping Gao","orcid":"https://orcid.org/0000-0003-0097-9012","observed_orcids":["https://orcid.org/0000-0003-0097-9012"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guang-ping Gao","raw_affiliation_strings":["Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute , Philadelphia, PA 19104","*Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute, Philadelphia, PA 19104; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I79576946"]},{"raw_affiliation_string":"*Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute, Philadelphia, PA 19104; and","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108437486","display_name":"Steven E. Raper","orcid":"https://orcid.org/0000-0001-9191-4681","observed_orcids":["https://orcid.org/0000-0001-9191-4681"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven E Raper","raw_affiliation_strings":["Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute , Philadelphia, PA 19104","*Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute, Philadelphia, PA 19104; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I79576946"]},{"raw_affiliation_string":"*Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute, Philadelphia, PA 19104; and","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110096707","display_name":"Joseph V. Hughes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph V Hughes","raw_affiliation_strings":["Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute , Philadelphia, PA 19104","*Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute, Philadelphia, PA 19104; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I79576946"]},{"raw_affiliation_string":"*Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute, Philadelphia, PA 19104; and","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051344823","display_name":"James M. Wilson","orcid":"https://orcid.org/0000-0002-9630-3131","observed_orcids":["https://orcid.org/0000-0002-9630-3131","https://orcid.org/0000-0002-7988-0201"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James M Wilson","raw_affiliation_strings":["Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute , Philadelphia, PA 19104","*Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute, Philadelphia, PA 19104; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I79576946"]},{"raw_affiliation_string":"*Institute for Human Gene Therapy and Departments of Medicine and of Molecular and Cellular Engineering, University of Pennsylvania, and Wistar Institute, Philadelphia, PA 19104; and","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034773524","https://openalex.org/A5070314915"],"corresponding_institution_ids":["https://openalex.org/I102322052","https://openalex.org/I79576946"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":2.5702,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.8918561,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"163","issue":"1","first_page":"448","last_page":"455"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8600000143051147},{"id":"https://openalex.org/keywords/intratracheal-administration","display_name":"intratracheal administration","score":0.6269999742507935},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.5379999876022339},{"id":"https://openalex.org/keywords/neutralizing-antibody-response","display_name":"neutralizing antibody response","score":0.5789999961853027},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.8920000195503235},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.7490000128746033},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.8939999938011169},{"id":"https://openalex.org/keywords/lung","display_name":"lung","score":0.367000013589859}],"concepts":[{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.7458022832870483},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7253322005271912},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.6265826225280762},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.6180593967437744},{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.5891897082328796},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5866044759750366},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5765179991722107},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5221226811408997},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5218818783760071},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.5160731673240662},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.4703626334667206},{"id":"https://openalex.org/C2776954459","wikidata":"https://www.wikidata.org/wiki/Q193447","display_name":"Adenoviridae","level":4,"score":0.4679388403892517},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4500562846660614},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.440576434135437},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.4261441230773926},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20297124981880188},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.11351555585861206},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.08158835768699646},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007442","descriptor_name":"Intubation, Intratracheal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008212","descriptor_name":"Lymphocyte Depletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008811","descriptor_name":"Mice, Inbred DBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4049/jimmunol.163.1.448","doi":"https://doi.org/10.4049/jimmunol.163.1.448","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.163.1.448","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:10384148","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10384148","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"mag:2493876915","doi":null,"is_oa":false,"landing_page_url":"https://eurekamag.com/research/035/649/035649718.php","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1532724727","display_name":null,"funder_award_id":"P30 DK47757-06","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2931682885","display_name":"GENE THERAPY FOR CF-SPECIALIZED CENTER OF RESEARCH","funder_award_id":"P50DK049136","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3682178382","display_name":"Molecular Therapy for Cystic Fibrosis","funder_award_id":"P30DK047757","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G935178316","display_name":null,"funder_award_id":"P50DK49136-05","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W32929286","https://openalex.org/W1507518053","https://openalex.org/W1509412469","https://openalex.org/W1580532757","https://openalex.org/W1945938648","https://openalex.org/W1969309166","https://openalex.org/W2008785883","https://openalex.org/W2011909031","https://openalex.org/W2015617337","https://openalex.org/W2021116207","https://openalex.org/W2053944961","https://openalex.org/W2060095976","https://openalex.org/W2076558278","https://openalex.org/W2079720213","https://openalex.org/W2081085309","https://openalex.org/W2083556128","https://openalex.org/W2090781939","https://openalex.org/W2090864647","https://openalex.org/W2091993406","https://openalex.org/W2110911021","https://openalex.org/W2117802323","https://openalex.org/W2131095976","https://openalex.org/W2132256212","https://openalex.org/W2134352843","https://openalex.org/W2140066663","https://openalex.org/W2140905192","https://openalex.org/W2151902657","https://openalex.org/W2156119419","https://openalex.org/W2273876198"],"related_works":["https://openalex.org/W2171021135","https://openalex.org/W2068831259","https://openalex.org/W1965813064","https://openalex.org/W1990328511","https://openalex.org/W1967228746","https://openalex.org/W2016006434","https://openalex.org/W2021116207","https://openalex.org/W2072981634","https://openalex.org/W2164338855","https://openalex.org/W2493876915"],"abstract_inverted_index":{"The":[0,89],"central":[1],"role":[2],"of":[3,9,25,41,57,74,82,100,115,131,135,144],"CD4+":[4],"T":[5,118],"cells":[6],"in":[7,18,44,149],"regulation":[8],"adenovirus":[10,124],"vector-mediated":[11],"immune":[12,36,67],"responses":[13,68,103,122],"has":[14],"been":[15],"documented":[16],"previously":[17],"murine":[19,45],"models.":[20],"We":[21],"analyzed":[22],"the":[23,116,129,141],"effects":[24,130],"a":[26,50,132,145],"nondepleting":[27,146],"mAb":[28],"to":[29,69,91,104,123],"human":[30,51],"CD4":[31,52,147],"(CD4":[32],"mAb;":[33],"Clenoliximab)":[34],"on":[35],"functions":[37],"following":[38],"intratracheal":[39],"administration":[40],"adenoviral":[42,70,83,154],"vectors":[43,84,94],"CD4-deficient":[46],"mice":[47,59,76],"(muCD4KO)":[48],"expressing":[49],"transgene":[53],"(HuCD4":[54],"mice).":[55],"Treatment":[56],"HuCD4":[58,75],"with":[60,77,97],"Clenoliximab":[61,78,108,136],"inhibited":[62,110],"both":[63],"cell-mediated":[64],"and":[65,112],"humoral":[66],"Ags.":[71],"Chronic":[72],"treatment":[73],"permitted":[79],"successful":[80],"readministration":[81],"at":[85],"least":[86],"four":[87],"times.":[88],"ability":[90],"readminister":[92],"these":[93],"is":[95],"associated":[96],"marked":[98],"suppression":[99],"neutralizing":[101],"Ab":[102,148],"viral":[105],"capsid":[106],"proteins.":[107],"also":[109],"CTL":[111],"prolonged":[113],"expression":[114],"transgene.":[117],"or":[119],"B":[120],"cell":[121],"did":[125],"not":[126],"emerge":[127],"after":[128],"short":[133],"course":[134],"diminished.":[137],"These":[138],"data":[139],"illustrate":[140],"potential":[142],"utility":[143],"facilitating":[150],"gene":[151],"therapy":[152],"using":[153],"vectors.":[155]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
