{"id":"https://openalex.org/W1512909172","doi":null,"title":"Differential induction of Toll-like receptors & type 1 interferons by Sabin attenuated & wild type 1 polioviruses in human neuronal cells.","display_name":"Differential induction of Toll-like receptors & type 1 interferons by Sabin attenuated & wild type 1 polioviruses in human neuronal cells.","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W1512909172","mag":"1512909172","pmid":"https://pubmed.ncbi.nlm.nih.gov/24056597","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3788206"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2783033","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3788206","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3788206","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031793661","display_name":"Madhu Chhanda Mohanty","orcid":"https://orcid.org/0000-0001-6942-2875","observed_orcids":["https://orcid.org/0000-0001-6942-2875"]},"institutions":[{"id":"https://openalex.org/I37048141","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28","country_code":"IN","type":"government","lineage":["https://openalex.org/I37048141"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Madhu C Mohanty","raw_affiliation_strings":["Enterovirus Research Centre, ICMR, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Enterovirus Research Centre, ICMR, Mumbai, India","institution_ids":["https://openalex.org/I37048141"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037477467","display_name":"Jagadish Mohanrao Deshpande","orcid":"https://orcid.org/0000-0001-5194-0375","observed_orcids":["https://orcid.org/0000-0001-5194-0375"]},"institutions":[{"id":"https://openalex.org/I37048141","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28","country_code":"IN","type":"government","lineage":["https://openalex.org/I37048141"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jagadish M Deshpande","raw_affiliation_strings":["Enterovirus Research Centre, ICMR, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Enterovirus Research Centre, ICMR, Mumbai, India","institution_ids":["https://openalex.org/I37048141"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I37048141"],"apc_list":null,"apc_paid":null,"fwci":0.2874,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.57032018,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"138","issue":null,"first_page":"209","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.5234000086784363,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.5234000086784363,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.3869999945163727,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.055799998342990875,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/poliovirus","display_name":"poliovirus","score":0.8059999942779541},{"id":"https://openalex.org/keywords/wild-type-poliovirus","display_name":"wild-type poliovirus","score":0.8029999732971191},{"id":"https://openalex.org/keywords/toll-like-receptors","display_name":"Toll-like receptors","score":0.7639999985694885},{"id":"https://openalex.org/keywords/tlr3","display_name":"TLR3","score":0.8569999933242798},{"id":"https://openalex.org/keywords/tlr7","display_name":"TLR7","score":1.0},{"id":"https://openalex.org/keywords/mda5","display_name":"MDA5","score":0.9300000071525574},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.9860000014305115},{"id":"https://openalex.org/keywords/innate-immune-response","display_name":"innate immune response","score":0.8700000047683716},{"id":"https://openalex.org/keywords/neurons","display_name":"neurons","score":0.9179999828338623},{"id":"https://openalex.org/keywords/sk-n-sh-cells","display_name":"SK-N-SH cells","score":0.8289999961853027},{"id":"https://openalex.org/keywords/rna-helicase","display_name":"RNA helicase","score":0.8270000219345093},{"id":"https://openalex.org/keywords/oral-polio-vaccine","display_name":"oral polio vaccine","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C134474686","wikidata":"https://www.wikidata.org/wiki/Q21111069","display_name":"MDA5","level":5,"score":0.8670365810394287},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.7492674589157104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7418988943099976},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7199463844299316},{"id":"https://openalex.org/C2779631682","wikidata":"https://www.wikidata.org/wiki/Q12438936","display_name":"Poliovirus","level":3,"score":0.6445275545120239},{"id":"https://openalex.org/C2779836521","wikidata":"https://www.wikidata.org/wiki/Q14914081","display_name":"TLR7","level":5,"score":0.5571825504302979},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5414862632751465},{"id":"https://openalex.org/C2778420691","wikidata":"https://www.wikidata.org/wiki/Q14866230","display_name":"TLR3","level":5,"score":0.5068603157997131},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4963551163673401},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.47176769375801086},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.4410226047039032},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.43018850684165955},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.4301174283027649},{"id":"https://openalex.org/C111289621","wikidata":"https://www.wikidata.org/wiki/Q418772","display_name":"Pattern recognition receptor","level":4,"score":0.4123561382293701},{"id":"https://openalex.org/C2776954689","wikidata":"https://www.wikidata.org/wiki/Q21100537","display_name":"RIG-I","level":4,"score":0.4112378656864166},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3841693699359894},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.35453301668167114},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23854398727416992},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22146478295326233},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.20897600054740906},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07470712065696716},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017955","descriptor_name":"Poliovirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:2783033","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3788206","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24056597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24056597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Indian journal of medical research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3788206","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3788206/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian J Med Res","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a7ac8f72e00544829212d481ac25a7ae","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a7ac8f72e00544829212d481ac25a7ae","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Indian Journal of Medical Research, Vol 138, Iss 2, Pp 209-218 (2013)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2783033","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3788206","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.979200005531311,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1503511302","https://openalex.org/W1583867858","https://openalex.org/W1606976916","https://openalex.org/W1798984988","https://openalex.org/W1958691693","https://openalex.org/W1965390534","https://openalex.org/W1973386916","https://openalex.org/W1978447714","https://openalex.org/W1981498390","https://openalex.org/W2004670971","https://openalex.org/W2005884645","https://openalex.org/W2022160170","https://openalex.org/W2027498268","https://openalex.org/W2040589516","https://openalex.org/W2041562506","https://openalex.org/W2063826038","https://openalex.org/W2090829965","https://openalex.org/W2102097271","https://openalex.org/W2127290428","https://openalex.org/W2132127444","https://openalex.org/W2136052329","https://openalex.org/W2137198892","https://openalex.org/W2144611757","https://openalex.org/W2162560584","https://openalex.org/W2165413779","https://openalex.org/W2167799993","https://openalex.org/W2168113266","https://openalex.org/W3109449877"],"related_works":["https://openalex.org/W2042317304","https://openalex.org/W2156425828","https://openalex.org/W2017965946","https://openalex.org/W1980586890","https://openalex.org/W2146108501","https://openalex.org/W2002196074","https://openalex.org/W1892143279","https://openalex.org/W1958691693","https://openalex.org/W2373186948","https://openalex.org/W2274000592"],"abstract_inverted_index":{"BACKGROUND":[0],"&":[1,190],"OBJECTIVES:":[2],"Polioviruses":[3],"are":[4],"the":[5,27,43,86,141,159],"causative":[6],"agent":[7],"of":[8,88,118,128,143,161,168,173,213],"paralytic":[9],"poliomyelitis.":[10],"Attenuated":[11],"polioviruses":[12,30,201],"(Sabin":[13,61],"oral":[14],"poliovirus":[15,52,60],"vaccine":[16],"strains)":[17],"do":[18,33],"not":[19,34],"replicate":[20],"efficiently":[21],"in":[22,63,97,137,180,223,231],"neurons":[23],"as":[24,149],"compared":[25,85,150],"to":[26,41,48,146,151,197,227],"wild":[28,49,108,152,200],"type":[29,50,58,209],"and":[31,55,73,84,93,107,131,199,208,216,219],"therefore":[32],"cause":[35],"disease.":[36],"This":[37],"study":[38],"was":[39],"aimed":[40],"investigate":[42],"differential":[44],"host":[45,80],"immune":[46,82,195],"response":[47,196],"1":[51,59,210],"(wild":[53],"PV)":[54,62],"Sabin":[56,105,121,155,178,198,220],"attenuated":[57],"cultured":[64,98],"human":[65,99],"neuronal":[66,100,112,138,181,224],"cells.":[67],"METHODS:":[68],"By":[69],"using":[70],"flow":[71],"cytometry":[72],"real":[74],"time":[75,166],"PCR":[76],"methods":[77],"we":[78],"examined":[79],"innate":[81,194],"responses":[83],"role":[87],"toll":[89],"like":[90],"receptors":[91],"(TLRs)":[92],"cytoplasmic":[94],"RNA":[95],"helicases":[96],"cells":[101,113,139,182,225],"(SK-N-SH)":[102],"infected":[103],"with":[104],"PV":[106,122,156,179],"PV.":[109,153],"RESULTS:":[110],"Human":[111],"expressed":[114],"very":[115],"low":[116],"levels":[117],"TLRs":[119],"constitutively.":[120],"infection":[123,144],"induced":[124,158,171],"significantly":[125,203],"higher":[126],"expression":[127,160,172],"TLR3,":[129,205],"TLR7":[130,214],"melanoma":[132],"differentiation-associated":[133],"protein-5":[134],"(MDA-5)":[135],"m-RNA":[136],"at":[140,164],"beginning":[142],"(up":[145],"4":[147],"h)":[148],"Further,":[154],"also":[157],"interferon":[162,217],"\u03b1/\u03b2":[163,175],"early":[165],"point":[167],"infection.":[169],"The":[170],"IFN":[174],"gene":[176],"by":[177,186],"could":[183],"be":[184,228],"suppressed":[185],"inhibiting":[187],"TLR7.":[188],"INTERPRETATION":[189],"CONCLUSIONS:":[191],"Neuronal":[192],"cell":[193],"differ":[202],"for":[204],"TLR7,":[206],"MDA5":[207],"interferons.":[211],"Effects":[212],"activation":[215],"production":[218],"virus":[221],"replication":[222],"need":[226],"actively":[229],"investigated":[230],"future":[232],"studies.":[233]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}