{"id":"https://openalex.org/W1512898564","doi":null,"title":"The ability of chemotactic factors to induce lysosomal enzyme release. I. The characteristics of the release, the importance of surfaces and the relation of enzyme release to chemotactic responsiveness.","display_name":"The ability of chemotactic factors to induce lysosomal enzyme release. I. The characteristics of the release, the importance of surfaces and the relation of enzyme release to chemotactic responsiveness.","publication_year":1974,"publication_date":"1974-06-01","ids":{"openalex":"https://openalex.org/W1512898564","mag":"1512898564","pmid":"https://pubmed.ncbi.nlm.nih.gov/4596695"},"language":"en","primary_location":{"id":"pmid:4596695","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4596695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112152311","display_name":"Elmer L. Becker","orcid":"https://orcid.org/0000-0002-8817-3533","observed_orcids":["https://orcid.org/0000-0002-8817-3533"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E L Becker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028582089","display_name":"Henry J. Showell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H J Showell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030906578","display_name":"Peter M. Henson","orcid":"https://orcid.org/0000-0003-1934-8405","observed_orcids":["https://orcid.org/0000-0003-1934-8405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P M Henson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"L S Hsu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L S Hsu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.1967,"has_fulltext":false,"cited_by_count":218,"citation_normalized_percentile":{"value":0.96904987,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"112","issue":"6","first_page":"2047","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.04399999976158142,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemoattractants","display_name":"chemoattractants","score":0.9480000138282776},{"id":"https://openalex.org/keywords/lysosomal-enzyme-release","display_name":"lysosomal enzyme release","score":0.9049999713897705},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.7680000066757202},{"id":"https://openalex.org/keywords/complement-c3a","display_name":"complement C3a","score":0.8949999809265137},{"id":"https://openalex.org/keywords/c5a","display_name":"C5a","score":0.9959999918937683},{"id":"https://openalex.org/keywords/peritoneal-neutrophils","display_name":"peritoneal neutrophils","score":0.7739999890327454},{"id":"https://openalex.org/keywords/filter-pore-size","display_name":"filter pore size","score":0.7950000166893005},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.6190000176429749},{"id":"https://openalex.org/keywords/lysozyme","display_name":"lysozyme","score":0.8299999833106995},{"id":"https://openalex.org/keywords/beta-glucuronidase","display_name":"beta-glucuronidase","score":0.9539999961853027},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":0.9340000152587891}],"concepts":[{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.9269670844078064},{"id":"https://openalex.org/C2776966407","wikidata":"https://www.wikidata.org/wiki/Q24779410","display_name":"Lysozyme","level":2,"score":0.7082998752593994},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.7053321003913879},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.7008830308914185},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4710804224014282},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4682926535606384},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.43609100580215454},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37005263566970825},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32527393102645874},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0527033805847168}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001202","descriptor_name":"Ascitic Fluid","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002250","descriptor_name":"Carbon Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005374","descriptor_name":"Filtration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005966","descriptor_name":"Glucuronidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014020","descriptor_name":"Tissue Extracts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:4596695","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4596695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"mag:1512898564","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4596695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4313309063","https://openalex.org/W108484141","https://openalex.org/W1593552287","https://openalex.org/W2266909637","https://openalex.org/W1999393262","https://openalex.org/W7096233225","https://openalex.org/W2059009993","https://openalex.org/W2414232798","https://openalex.org/W1506198910","https://openalex.org/W1990791863"],"abstract_inverted_index":{"The":[0,61,106],"complement-derived":[1],"chemotactics":[2],"factors,":[3],"C3a,":[4],"C5a,":[5],"and":[6,28,146,179],"C567,":[7],"as":[8,10],"well":[9],"the":[11,24,35,45,52,70,86,90,100,138,157,172],"chemotactic":[12,117,139,159],"factor":[13],"obtained":[14],"from":[15,30,92,143],"culture":[16],"filtrates":[17],"of":[18,23,44,57,75,79,89,102,122,141,182],"Escherichia":[19],"coli,":[20],"induce":[21],"release":[22,43,53,62,115,153],"lysosomal":[25,103,151,183],"enzymes,":[26],"\u03b2-glucuronidase":[27],"lysozyme,":[29],"rabbit":[31],"peritoneal":[32],"neutrophils.":[33],"Under":[34],"same":[36,158],"circumstances,":[37],"there":[38],"is":[39,54,119,187],"little":[40],"or":[41,82,169,175,189],"no":[42],"cytoplasmic":[46],"marker,":[47],"lactic":[48],"dehydrogenase,":[49],"indicating":[50],"that":[51,113,165],"a":[55,120,166,191],"form":[56,121],"induced":[58,123,180],"secretion.":[59,105],"occurs":[63],"to":[64,94,149],"an":[65,109],"appreciable":[66],"extent":[67],"only":[68],"when":[69,154],"neutrophils":[71,142,186],"settle":[72],"on":[73,125],"filters":[74,91],"average":[76],"pore":[77,87],"size":[78,88],"0.60":[80,93],"\u00b5m":[81,96],"greater;":[83],"however,":[84],"increasing":[85],"5":[95],"does":[97],"not":[98],"increase":[99],"amount":[101],"enzyme":[104,114,152],"requirement":[107],"for":[108],"appropriate":[110],"surface":[111],"suggests":[112],"by":[116,156],"factors":[118],"secretion":[124,181],"non-phagocytosable":[126],"surfaces":[127],"studied":[128],"previously.":[129],"No":[131],"statistically":[132],"significant":[133],"correlation":[134],"was":[135],"found":[136],"between":[137],"responsiveness":[140],"different":[144,188,192],"rabbits":[145],"their":[147],"ability":[148],"give":[150],"stimulated":[155],"factor.":[160],"This":[161],"suggests,":[162],"at":[163],"least,":[164],"critical":[167],"step":[168],"steps":[170],"in":[171,185],"biochemical":[173],"sequence":[174],"sequences":[176],"governing":[177],"chemotaxis":[178],"enzymes":[184],"has":[190],"quantitative":[193],"importance.":[194]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}