{"id":"https://openalex.org/W1512434836","doi":null,"title":"In-vitro infection of pupae with Israeli Acute Paralysis Virus suggests variation for susceptibility and disturbance of transcriptional homeostasis in honey bees (Apis mellifera)","display_name":"In-vitro infection of pupae with Israeli Acute Paralysis Virus suggests variation for susceptibility and disturbance of transcriptional homeostasis in honey bees (Apis mellifera)","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W1512434836","mag":"1512434836"},"language":"en","primary_location":{"id":"pmh:oai:libres.uncg.edu/15152","doi":null,"is_oa":true,"landing_page_url":"http://libres.uncg.edu/ir/uncg/f/O_Rueppell_In-Vitro2013.pdf","pdf_url":"http://libres.uncg.edu/ir/uncg/f/O_Rueppell_In-Vitro2013.pdf","source":{"id":"https://openalex.org/S4306401856","display_name":"NC Digital Online Collection of Knowledge and Scholarship (The University of North Carolina at Greensboro)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169335092","host_organization_name":"University of North Carolina at Greensboro","host_organization_lineage":["https://openalex.org/I169335092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://libres.uncg.edu/ir/uncg/f/O_Rueppell_In-Vitro2013.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022289352","display_name":"Olav Rueppell","orcid":"https://orcid.org/0000-0001-5370-4229","observed_orcids":["https://orcid.org/0000-0001-5370-4229"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Olav Rueppell","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5370-4229","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5022289352"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3553,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.63034188,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11641","display_name":"Insect and Pesticide Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11641","display_name":"Insect and Pesticide Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10702","display_name":"Insect and Arachnid Ecology and Behavior","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11386","display_name":"Bee Products Chemical Analysis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/israeli-acute-paralysis-virus","display_name":"Israeli acute paralysis virus","score":0.9039999842643738},{"id":"https://openalex.org/keywords/apis-mellifera","display_name":"Apis mellifera","score":0.9990000128746033},{"id":"https://openalex.org/keywords/virus-resistance","display_name":"virus resistance","score":0.47699999809265137},{"id":"https://openalex.org/keywords/virus-host-interactions","display_name":"host-virus interaction","score":0.6069999933242798},{"id":"https://openalex.org/keywords/ribosome-biogenesis","display_name":"ribosome biogenesis","score":0.8640000224113464},{"id":"https://openalex.org/keywords/colony-collapse-disorder","display_name":"colony collapse disorder","score":0.6470000147819519},{"id":"https://openalex.org/keywords/in-vitro-infection","display_name":"in vitro infection","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8877036571502686},{"id":"https://openalex.org/C2777907900","wikidata":"https://www.wikidata.org/wiki/Q102857","display_name":"Honey bee","level":2,"score":0.8563330173492432},{"id":"https://openalex.org/C2778204363","wikidata":"https://www.wikidata.org/wiki/Q3500128","display_name":"Deformed wing virus","level":4,"score":0.8456272482872009},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5051963925361633},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.424821138381958},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.3800473213195801},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3638755679130554},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3548641502857208},{"id":"https://openalex.org/C2779381614","wikidata":"https://www.wikidata.org/wiki/Q48564","display_name":"Varroa destructor","level":3,"score":0.33961111307144165}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:libres.uncg.edu/15152","doi":null,"is_oa":true,"landing_page_url":"http://libres.uncg.edu/ir/uncg/f/O_Rueppell_In-Vitro2013.pdf","pdf_url":"http://libres.uncg.edu/ir/uncg/f/O_Rueppell_In-Vitro2013.pdf","source":{"id":"https://openalex.org/S4306401856","display_name":"NC Digital Online Collection of Knowledge and Scholarship (The University of North Carolina at Greensboro)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169335092","host_organization_name":"University of North Carolina at Greensboro","host_organization_lineage":["https://openalex.org/I169335092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:1512434836","doi":null,"is_oa":false,"landing_page_url":"https://libres.uncg.edu/ir/uncg//listing.aspx?id=15152","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:libres.uncg.edu/15152","doi":null,"is_oa":true,"landing_page_url":"http://libres.uncg.edu/ir/uncg/f/O_Rueppell_In-Vitro2013.pdf","pdf_url":"http://libres.uncg.edu/ir/uncg/f/O_Rueppell_In-Vitro2013.pdf","source":{"id":"https://openalex.org/S4306401856","display_name":"NC Digital Online Collection of Knowledge and Scholarship (The University of North Carolina at Greensboro)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169335092","host_organization_name":"University of North Carolina at Greensboro","host_organization_lineage":["https://openalex.org/I169335092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407},{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.40450000762939453}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4066104549","display_name":null,"funder_award_id":"2010-65104-20533","funder_id":"https://openalex.org/F4320332605","funder_display_name":"Agricultural Research Service"},{"id":"https://openalex.org/G6504078871","display_name":null,"funder_award_id":"2010-65104-20533","funder_id":"https://openalex.org/F4320332299","funder_display_name":"National Institute of Food and Agriculture"}],"funders":[{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320332299","display_name":"National Institute of Food and Agriculture","ror":"https://ror.org/05qx3fv49"},{"id":"https://openalex.org/F4320332605","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044"},{"id":"https://openalex.org/F4320333244","display_name":"University of North Carolina at Greensboro","ror":"https://ror.org/04fnxsj42"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1512434836.pdf","grobid_xml":"https://content.openalex.org/works/W1512434836.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2154997065","https://openalex.org/W2152922135","https://openalex.org/W4205118547","https://openalex.org/W3087837446","https://openalex.org/W3119674039","https://openalex.org/W2081131958","https://openalex.org/W2804607182","https://openalex.org/W2161102160","https://openalex.org/W1992647991","https://openalex.org/W2031587711"],"abstract_inverted_index":{"The":[0,70],"ongoing":[1],"decline":[2,20],"of":[3,35,55,78,85,91,96,137,144,147,155,168,176],"honey":[4,25,62,122,177,197],"bee":[5,26,36,63,123,198],"health":[6],"worldwide":[7],"is":[8,30],"a":[9,97,173,192],"serious":[10],"economic":[11],"and":[12,38,119,184],"ecological":[13],"concern.":[14],"One":[15],"major":[16],"contributor":[17],"to":[18,47,93,116],"the":[19,33,100,156,166,187],"are":[21],"pathogens,":[22],"including":[23,152],"several":[24,148],"viruses.":[27],"However,":[28],"information":[29],"limited":[31],"on":[32],"biology":[34],"viruses":[37,190],"molecular":[39],"interactions":[40],"with":[41,87,180],"their":[42],"hosts.":[43],"An":[44],"experimental":[45],"protocol":[46],"test":[48],"these":[49],"systems":[50],"was":[51],"developed,":[52],"using":[53],"injections":[54],"Israeli":[56],"Acute":[57],"Paralysis":[58],"Virus":[59],"(IAPV)":[60],"into":[61,165],"pupae":[64,72],"reared":[65],"ex-situ":[66],"under":[67],"laboratory":[68],"conditions.":[69],"infected":[71],"developed":[73],"pronounced":[74],"but":[75],"variable":[76],"patterns":[77],"disease.":[79],"Symptoms":[80],"varied":[81],"from":[82],"complete":[83],"cessation":[84],"development":[86],"no":[88],"visual":[89],"evidence":[90],"disease":[92],"rapid":[94],"darkening":[95],"part":[98],"or":[99],"entire":[101],"body.":[102],"Considerable":[103],"differences":[104],"in":[105,114,195],"IAPV":[106,117,142,169],"titer":[107],"dynamics":[108],"were":[109],"observed,":[110],"suggesting":[111],"significant":[112],"variation":[113],"resistance":[115,130],"among":[118],"possibly":[120],"within":[121],"colonies.":[124],"Thus,":[125],"selective":[126],"breeding":[127],"for":[128],"virus":[129],"should":[131],"be":[132],"possible.":[133],"Gene":[134],"expression":[135],"analyses":[136],"three":[138],"separate":[139],"experiments":[140],"suggest":[141],"disruption":[143],"transcriptional":[145,174],"homeostasis":[146],"fundamental":[149],"cellular":[150],"functions,":[151],"an":[153],"up-regulation":[154],"ribosomal":[157],"biogenesis":[158],"pathway.":[159],"These":[160],"results":[161],"provide":[162],"first":[163],"insights":[164],"mechanisms":[167],"pathogenicity.":[170],"They":[171],"mirror":[172],"survey":[175],"bees":[178],"afflicted":[179],"Colony":[181],"Collapse":[182],"Disorder":[183],"thus":[185],"support":[186],"hypothesis":[188],"that":[189],"play":[191],"critical":[193],"role":[194],"declining":[196],"health.":[199]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2016-06-24T00:00:00"}
