{"id":"https://openalex.org/W1511749080","doi":null,"title":"Major clinical events, signs and severity assessment scores related to actual survival in patients who died from primary biliary cirrhosis. A long-term historical cohort study.","display_name":"Major clinical events, signs and severity assessment scores related to actual survival in patients who died from primary biliary cirrhosis. A long-term historical cohort study.","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W1511749080","mag":"1511749080","pmid":"https://pubmed.ncbi.nlm.nih.gov/10228773"},"language":"en","primary_location":{"id":"pmid:10228773","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10228773","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028689548","display_name":"Gooitzen M. van Dam","orcid":"https://orcid.org/0000-0002-7248-8696","observed_orcids":["https://orcid.org/0000-0002-7248-8696"]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"G M van Dam","raw_affiliation_strings":["International School of Hepatology and Tropical Medicine GISH-T, Faculty of Medical Sciences, State University Groningen, The Netherlands. govandam@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International School of Hepatology and Tropical Medicine GISH-T, Faculty of Medical Sciences, State University Groningen, The Netherlands. govandam@hotmail.com","institution_ids":["https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110409294","display_name":"Ch Gips","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C H Gips","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084954787","display_name":"Yacov Reisman","orcid":"https://orcid.org/0000-0002-1513-6360","observed_orcids":["https://orcid.org/0000-0002-1513-6360","https://orcid.org/0000-0001-6052-4058"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Reisman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091244100","display_name":"K W Maas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K W Maas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034639874","display_name":"I M Purmer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I M Purmer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052411600","display_name":"J.R. Huizenga","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J R Huizenga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5069059163","display_name":"Bart W. Verbaan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B W Verbaan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"46","issue":"25","first_page":"108","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-biliary-cholangitis","display_name":"primary biliary cirrhosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/survival-prediction","display_name":"survival prediction","score":0.6489999890327454},{"id":"https://openalex.org/keywords/mayo-risk-score","display_name":"Mayo risk score","score":0.671999990940094},{"id":"https://openalex.org/keywords/child-pugh-score","display_name":"Child-Pugh score","score":0.8640000224113464},{"id":"https://openalex.org/keywords/ascites","display_name":"ascites","score":0.6899999976158142},{"id":"https://openalex.org/keywords/hepatic-encephalopathy","display_name":"hepatic encephalopathy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/upper-gastrointestinal-bleeding","display_name":"upper gastrointestinal bleeding","score":0.7540000081062317},{"id":"https://openalex.org/keywords/spider-naevi","display_name":"spider naevi","score":0.8500000238418579},{"id":"https://openalex.org/keywords/prothrombin-time","display_name":"prothrombin time","score":0.7789999842643738},{"id":"https://openalex.org/keywords/serum-albumin","display_name":"serum albumin","score":0.9340000152587891},{"id":"https://openalex.org/keywords/nutritional-status","display_name":"nutritional status","score":0.6119999885559082},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6029999852180481},{"id":"https://openalex.org/keywords/mortality-risk-stratification","display_name":"mortality risk stratification","score":0.5509999990463257},{"id":"https://openalex.org/keywords/long-term-follow-up","display_name":"long-term follow-up","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8375163078308105},{"id":"https://openalex.org/C2780496750","wikidata":"https://www.wikidata.org/wiki/Q193889","display_name":"Ascites","level":2,"score":0.745667040348053},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6552143096923828},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6244062781333923},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5195903778076172},{"id":"https://openalex.org/C2780366471","wikidata":"https://www.wikidata.org/wiki/Q1072420","display_name":"Primary biliary cirrhosis","level":2,"score":0.5177792310714722},{"id":"https://openalex.org/C2780325230","wikidata":"https://www.wikidata.org/wiki/Q642548","display_name":"Hepatic encephalopathy","level":3,"score":0.4969933331012726},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4729846715927124},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.4571745991706848},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.4306715428829193},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3799740672111511},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.328505277633667},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008105","descriptor_name":"Liver Cirrhosis, Biliary","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:10228773","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10228773","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.rug.nl:openaire_cris_publications/709fddb6-55f5-4dba-b4f7-9a131c44afbb","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11370/709fddb6-55f5-4dba-b4f7-9a131c44afbb","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"van Dam, G M, Gips, C H, Reisman, Y, Maas, K W, Purmer, I M, Huizenga, J R & Verbaan, B W 1999, 'Major clinical events, signs and severity assessment scores related to actual survival in patients who died from primary biliary cirrhosis. A long-term historical cohort study', HEPATO-GASTROENTEROLOGY, vol. 46, no. 25, pp. 108-115.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/709fddb6-55f5-4dba-b4f7-9a131c44afbb","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/709fddb6-55f5-4dba-b4f7-9a131c44afbb","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"HEPATO-GASTROENTEROLOGY, 46(25), 108 - 115. H G E UPDATE MEDICAL PUBLISHING S A","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:1511749080","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10228773","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7024729156","https://openalex.org/W2495314092","https://openalex.org/W55762658","https://openalex.org/W2149834061","https://openalex.org/W2148674881","https://openalex.org/W2102301083","https://openalex.org/W2275314297","https://openalex.org/W2141861294","https://openalex.org/W6966843525","https://openalex.org/W2020104402"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"One":[1],"of":[2,26,65,96,109,196,415],"the":[3,14,239,269,273,384,408,461],"prognostic":[4],"methods":[5,40,116],"for":[6,358,369,383,457,459],"survival":[7,43,141,253,266,275,313,332,351,380,422,441],"in":[8,46,227],"primary":[9],"biliary":[10],"cirrhosis":[11],"(PBC)":[12],"is":[13],"Mayo":[15,42,124,146,270,432],"model,":[16],"with":[17,47,119,311,328,349,439],"a":[18,199,242,251,416],"time-scale":[19],"limited":[20],"to":[21,30,74,87,238,278,291,302,354,378,386,401,420],"7":[22],"years.":[23,425],"The":[24,262,389,413],"aim":[25],"our":[27,449],"study":[28],"was":[29,224,381,453],"assess":[31],"how":[32],"major":[33,200,417],"clinical":[34],"events,":[35],"signs,":[36,106],"several":[37],"severity":[38,304],"assessment":[39,115,149],"and":[41,105,121,134,185,206,216,231,244,257,318,327,374,391,396,433,442],"probabilities":[44],"fit":[45],"actual":[48,274,312,350,379,405,440],"patient":[49,59],"survival,":[50,406],"by":[51,268],"using":[52],"yearly":[53],"observations":[54],"until":[55],"0.5":[56],"years":[57,81,208,218,233,280,293],"before":[58],"death":[60,75],"from":[61,69,145,276,289,352],"PBC.":[62],"METHODOLOGY:":[63],"Data":[64],"32":[66,197],"patients":[67,198],"dying":[68],"PBC":[70,450],"were":[71,143,466],"collected":[72],"prior":[73],"at":[76],"-0.5,":[77],"-1,":[78],"-2":[79,235],"etc.":[80],"(median:":[82,209,234],"-5":[83],"years,":[84,356,430],"range:":[85],"-16":[86,215,290,353],"-0.5":[88,207,232,279],"years).":[89,236],"Major":[90],"events":[91],"registered":[92],"were:":[93,123,152],"first":[94,107,225],"occurrence":[95,414],"ascites,":[97],"upper":[98],"gastrointestinal":[99],"bleeding":[100],"or":[101,112],"manifest":[102],"hepatic":[103],"encephalopathy":[104,159],"observation":[108],"spider":[110],"naevi":[111],"purpura.":[113],"Severity":[114,148],"applied":[117],"(all":[118],"scores":[120,305,376,435],"classes)":[122],"(M),":[125,169,171],"Child-Campbell":[126],"(C),":[127],"Pugh-Child":[128],"(P),":[129],"Pugh-Child-PBC":[130],"(PP),":[131],"'Child-Pugh'":[132],"(CP),":[133],"Ascites":[135],"Nutritional":[136],"State-Child":[137],"(ANS).":[138],"Fifty":[139],"percent":[140],"estimates":[142],"calculated":[144],"scores.":[147],"method":[150],"variables":[151],"ascites":[153],"(C,":[154,160,166,180,333],"P,":[155,161,176,182,189,316,334],"PP,":[156,162,177,183,190,317,335],"CP,":[157,372],"ANS),":[158,167],"CP),":[163,178,184],"nutritional":[164],"state":[165],"edema":[168],"age":[170],"serum":[172],"albumin":[173],"(M,":[174,188,314],"C,":[175,315,371],"bilirubin":[179],"M,":[181,359],"prothrombin":[186],"time":[187],"CP).":[191],"RESULTS:":[192],"In":[193,426,448],"27":[194],"out":[195],"event":[201,249,418],"occurred,":[202],"always":[203],"between":[204,214,229],"-6":[205,277,301,385],"-1":[210],"year)":[211],"and,":[212],"never":[213],"-7":[217,292,355],"(p":[219,254,307],"<":[220,285,308],"0.0001).":[221],"A":[222,367],"sign":[223],"observed":[226],"30/32":[228],"-14":[230],"Compared":[237],"total":[240],"population,":[241],"sign,":[243],"even":[245],"more":[246],"so,":[247],"an":[248,454],"indicated":[250],"shorter":[252],"=":[255,259,282,295,298,321,325,338,342,362,365],"0.004":[256],"p":[258,284,297,364],"0.0002,":[260],"respectively).":[261],"median":[263],"50%":[264,331],"estimated":[265,329],"(predicted":[267],"model)":[271],"fitted":[272],"(r":[281,294,361],"-0.7,":[283],"0.0001),":[286],"but":[287,347],"not":[288,399],"-0.1,":[296],"0.4).":[299],"All":[300],"-0.5-year":[303,387],"correlated":[306,436],"0.0001)":[309],"both":[310],"CP":[319,336,392],"r":[320,324,337,341],"0.7;":[322],"ANS":[323,340,375],"0.5)":[326],"M":[330,344,373,409],"-0.9;":[339],"-0.6;":[343],"score:":[345],"-0.99),":[346],"none":[348],"except":[357],"slightly":[360],"-0.3,":[363],"0.04).":[366],"nomogram":[368],"mean":[370],"related":[377],"constructed":[382],"period.":[388],"C":[390,397],"classes":[393,410],"A,":[394],"B,":[395],"did":[398],"appear":[400],"distinguish":[402],"sufficiently":[403],"into":[404],"whereas":[407],"did.":[411],"CONCLUSIONS:":[412],"appeared":[419],"exclude":[421],"over":[423],"6":[424,429],"these":[427],"final":[428],"Child-Campbell,":[431],"Pugh":[434],"equally":[437],"well":[438],"better":[443],"than":[444],"Ascites/Nutritional":[445],"State":[446],"score.":[447],"patients,":[451],"Campbell":[452],"excellent":[455],"alternative":[456],"Pugh;":[458],"Pugh,":[460],"original":[462],"Child-Turcotte":[463],"variable":[464],"limits":[465],"fully":[467],"sufficient.":[468]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
