{"id":"https://openalex.org/W1511046785","doi":null,"title":"Caract\u00e9risation clinique et biologique d'une population de l'arc alpin pr\u00e9sum\u00e9e atteinte d'un n\u00e9oplasme my\u00e9loprolif\u00e9ratif Philadelphie n\u00e9gatif : apport respectif des diff\u00e9rents marqueurs biologiques","display_name":"Caract\u00e9risation clinique et biologique d'une population de l'arc alpin pr\u00e9sum\u00e9e atteinte d'un n\u00e9oplasme my\u00e9loprolif\u00e9ratif Philadelphie n\u00e9gatif : apport respectif des diff\u00e9rents marqueurs biologiques","publication_year":2011,"publication_date":"2011-10-28","ids":{"openalex":"https://openalex.org/W1511046785","mag":"1511046785"},"language":"fr","primary_location":{"id":"pmh:hdl:10068/863623","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/863623","pdf_url":"http://hdl.handle.net/10068/863623","source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10068/863623","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029449586","display_name":"Julie Mondet","orcid":"https://orcid.org/0000-0002-0765-1100","observed_orcids":["https://orcid.org/0000-0002-0765-1100"]},"institutions":[{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Julie Mondet","raw_affiliation_strings":["Universit\u00e9 Grenoble Alpes - UFR Pharmacie"],"raw_orcid":"https://orcid.org/0000-0002-0765-1100","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Grenoble Alpes - UFR Pharmacie","institution_ids":["https://openalex.org/I899635006"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5029449586"],"corresponding_institution_ids":["https://openalex.org/I899635006"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"117","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/philadelphia-chromosome-negative-myeloproliferative-neoplasms","display_name":"Philadelphia-negative myeloproliferative neoplasms","score":0.972000002861023},{"id":"https://openalex.org/keywords/polycythemia-vera","display_name":"polycythemia vera","score":0.9049999713897705},{"id":"https://openalex.org/keywords/essential-thrombocythemia","display_name":"essential thrombocythemia","score":0.9829999804496765},{"id":"https://openalex.org/keywords/primary-myelofibrosis","display_name":"primary myelofibrosis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/jak2-v617f-mutation","display_name":"JAK2 V617F mutation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/mpl-mutation","display_name":"MPL mutation","score":0.6320000290870667},{"id":"https://openalex.org/keywords/jak2-exon-12-mutation","display_name":"JAK2 exon 12 mutation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/hematopoietic-progenitor-proliferation","display_name":"hematopoietic progenitor proliferation","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3494902551174164},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.33918264508247375},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3352099657058716}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:hdl:10068/863623","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/863623","pdf_url":"http://hdl.handle.net/10068/863623","source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:HAL:dumas-00641042v1","doi":null,"is_oa":false,"landing_page_url":"https://dumas.ccsd.cnrs.fr/dumas-00641042","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sciences pharmaceutiques. 2011","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"mag:1511046785","doi":null,"is_oa":false,"landing_page_url":"https://dumas.ccsd.cnrs.fr/dumas-00641042","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:hdl:10068/863623","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/863623","pdf_url":"http://hdl.handle.net/10068/863623","source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1511046785.pdf","grobid_xml":"https://content.openalex.org/works/W1511046785.grobid-xml"},"referenced_works_count":229,"referenced_works":["https://openalex.org/W46453237","https://openalex.org/W53178620","https://openalex.org/W88994664","https://openalex.org/W110936782","https://openalex.org/W168904253","https://openalex.org/W173976910","https://openalex.org/W266774159","https://openalex.org/W593805313","https://openalex.org/W653801100","https://openalex.org/W1421162947","https://openalex.org/W1503652716","https://openalex.org/W1532208000","https://openalex.org/W1545261698","https://openalex.org/W1545484310","https://openalex.org/W1569117791","https://openalex.org/W1571744234","https://openalex.org/W1582747898","https://openalex.org/W1599549049","https://openalex.org/W1769562272","https://openalex.org/W1910376846","https://openalex.org/W1948504681","https://openalex.org/W1963736125","https://openalex.org/W1966948071","https://openalex.org/W1967870955","https://openalex.org/W1968468753","https://openalex.org/W1968802616","https://openalex.org/W1970101456","https://openalex.org/W1970553871","https://openalex.org/W1971236510","https://openalex.org/W1971383697","https://openalex.org/W1971487953","https://openalex.org/W1972837140","https://openalex.org/W1972850303","https://openalex.org/W1973034846","https://openalex.org/W1975825540","https://openalex.org/W1977174953","https://openalex.org/W1977590248","https://openalex.org/W1978463385","https://openalex.org/W1978972655","https://openalex.org/W1979648944","https://openalex.org/W1980568348","https://openalex.org/W1983494536","https://openalex.org/W1985177017","https://openalex.org/W1985619207","https://openalex.org/W1986364120","https://openalex.org/W1986595955","https://openalex.org/W1987362547","https://openalex.org/W1987966047","https://openalex.org/W1988019098","https://openalex.org/W1989188541","https://openalex.org/W1989940026","https://openalex.org/W1991277248","https://openalex.org/W1991452357","https://openalex.org/W1993230181","https://openalex.org/W1994580828","https://openalex.org/W1995653573","https://openalex.org/W1996502308","https://openalex.org/W1997560018","https://openalex.org/W1998393353","https://openalex.org/W1998608957","https://openalex.org/W1998721150","https://openalex.org/W1999274448","https://openalex.org/W1999608888","https://openalex.org/W2000429990","https://openalex.org/W2001006614","https://openalex.org/W2001477292","https://openalex.org/W2001901845","https://openalex.org/W2002926644","https://openalex.org/W2003413140","https://openalex.org/W2003597939","https://openalex.org/W2007748242","https://openalex.org/W2007928677","https://openalex.org/W2008970948","https://openalex.org/W2009902838","https://openalex.org/W2010527821","https://openalex.org/W2010992436","https://openalex.org/W2011253478","https://openalex.org/W2012509591","https://openalex.org/W2012686883","https://openalex.org/W2014508866","https://openalex.org/W2014544221","https://openalex.org/W2015629513","https://openalex.org/W2016692566","https://openalex.org/W2017085228","https://openalex.org/W2018005597","https://openalex.org/W2018983791","https://openalex.org/W2019264445","https://openalex.org/W2019870759","https://openalex.org/W2021726932","https://openalex.org/W2022750639","https://openalex.org/W2023311627","https://openalex.org/W2025109100","https://openalex.org/W2025348347","https://openalex.org/W2025614458","https://openalex.org/W2026310796","https://openalex.org/W2027192831","https://openalex.org/W2027343725","https://openalex.org/W2027613124","https://openalex.org/W2027789412","https://openalex.org/W2028331311","https://openalex.org/W2028390656","https://openalex.org/W2028500440","https://openalex.org/W2028961479","https://openalex.org/W2029050314","https://openalex.org/W2029548336","https://openalex.org/W2029743397","https://openalex.org/W2030569551","https://openalex.org/W2032882684","https://openalex.org/W2036058848","https://openalex.org/W2038114785","https://openalex.org/W2040074923","https://openalex.org/W2040159352","https://openalex.org/W2041062474","https://openalex.org/W2041108026","https://openalex.org/W2043387647","https://openalex.org/W2045452136","https://openalex.org/W2045477530","https://openalex.org/W2049145190","https://openalex.org/W2049202208","https://openalex.org/W2049793290","https://openalex.org/W2049965335","https://openalex.org/W2052033797","https://openalex.org/W2053584669","https://openalex.org/W2056777053","https://openalex.org/W2057109647","https://openalex.org/W2057129764","https://openalex.org/W2057360098","https://openalex.org/W2058330063","https://openalex.org/W2058342200","https://openalex.org/W2058604302","https://openalex.org/W2059244652","https://openalex.org/W2059511422","https://openalex.org/W2059729544","https://openalex.org/W2060859484","https://openalex.org/W2060988701","https://openalex.org/W2061882623","https://openalex.org/W2061956129","https://openalex.org/W2062083070","https://openalex.org/W2062131191","https://openalex.org/W2063731736","https://openalex.org/W2064766264","https://openalex.org/W2065161568","https://openalex.org/W2066249318","https://openalex.org/W2068898856","https://openalex.org/W2069651950","https://openalex.org/W2070839556","https://openalex.org/W2071765672","https://openalex.org/W2073726802","https://openalex.org/W2075125336","https://openalex.org/W2075979948","https://openalex.org/W2078504876","https://openalex.org/W2079532825","https://openalex.org/W2079681891","https://openalex.org/W2079841451","https://openalex.org/W2084127158","https://openalex.org/W2085128863","https://openalex.org/W2085287321","https://openalex.org/W2086511628","https://openalex.org/W2087061122","https://openalex.org/W2088045605","https://openalex.org/W2089430949","https://openalex.org/W2091572860","https://openalex.org/W2094186176","https://openalex.org/W2094456737","https://openalex.org/W2095024333","https://openalex.org/W2097692898","https://openalex.org/W2097743943","https://openalex.org/W2098142432","https://openalex.org/W2100293053","https://openalex.org/W2100840054","https://openalex.org/W2101502003","https://openalex.org/W2102895132","https://openalex.org/W2105621586","https://openalex.org/W2107139993","https://openalex.org/W2107184174","https://openalex.org/W2107398329","https://openalex.org/W2110210855","https://openalex.org/W2111141291","https://openalex.org/W2111148790","https://openalex.org/W2112129429","https://openalex.org/W2112316414","https://openalex.org/W2115400483","https://openalex.org/W2116533231","https://openalex.org/W2116878961","https://openalex.org/W2118562509","https://openalex.org/W2119941797","https://openalex.org/W2121216306","https://openalex.org/W2121462692","https://openalex.org/W2121742833","https://openalex.org/W2123587611","https://openalex.org/W2123633897","https://openalex.org/W2126102155","https://openalex.org/W2126665281","https://openalex.org/W2127237359","https://openalex.org/W2127559749","https://openalex.org/W2129629467","https://openalex.org/W2130983069","https://openalex.org/W2133633030","https://openalex.org/W2136097944","https://openalex.org/W2143039662","https://openalex.org/W2144097507","https://openalex.org/W2144664431","https://openalex.org/W2144806169","https://openalex.org/W2145829737","https://openalex.org/W2146505525","https://openalex.org/W2149373649","https://openalex.org/W2150100099","https://openalex.org/W2150409186","https://openalex.org/W2150694022","https://openalex.org/W2153174477","https://openalex.org/W2157477083","https://openalex.org/W2158669800","https://openalex.org/W2159205187","https://openalex.org/W2162617912","https://openalex.org/W2163235060","https://openalex.org/W2166708161","https://openalex.org/W2168082317","https://openalex.org/W2169505204","https://openalex.org/W2229971338","https://openalex.org/W2242619563","https://openalex.org/W2257078289","https://openalex.org/W2263869051","https://openalex.org/W2397873541","https://openalex.org/W2401960958","https://openalex.org/W2404783736","https://openalex.org/W2419191023","https://openalex.org/W2519637987","https://openalex.org/W2531854041","https://openalex.org/W2585555667"],"related_works":["https://openalex.org/W1602453267","https://openalex.org/W4392203022","https://openalex.org/W7094848846","https://openalex.org/W7057783482","https://openalex.org/W2980820253","https://openalex.org/W7163727758","https://openalex.org/W6989537018","https://openalex.org/W1985856430","https://openalex.org/W7027268202","https://openalex.org/W4289045737"],"abstract_inverted_index":{"Les":[0],"n\u00e9oplasmes":[1],"my\u00e9loprolif\u00e9ratifs":[2],"Philadelphie":[3],"n\u00e9gatif":[4],"(NMP":[5],"Ph-)":[6],"sont":[7,196],"des":[8,49,64,67,70,122,165,203,248,251,258],"h\u00e9mopathies":[9],"clonales":[10],"caract\u00e9ris\u00e9es":[11],"par":[12,42],"la":[13,30,35,46,53,58,192,201,239,245],"prolif\u00e9ration":[14],"de":[15,20,27,45,52,96,105,108,110,113,116,124,132,135,155,161,171,194,218,228,230,235,255,262],"lign\u00e9es":[16],"my\u00e9lo\u00efdes":[17],"sans":[18],"blocage":[19],"maturation":[21],"ni":[22],"signe":[23],"dysplasique.":[24],"La":[25,169,215],"polyglobulie":[26],"Vaquez":[28],"(PV),":[29],"thrombocyt\u00e9mie":[31],"essentielle":[32],"(TE)":[33],"et":[34,69,131,145,160,191,250],"my\u00e9lofibrose":[36],"primitive":[37],"(MFP)":[38],"se":[39],"caract\u00e9risent":[40],"sch\u00e9matiquement":[41],"une":[43,102],"augmentation":[44],"masse":[47],"sanguine,":[48],"plaquettes":[50],"ou":[51],"fibrose":[54],"m\u00e9dullaire.":[55],"En":[56],"2008,":[57],"mutation":[59,114],"JAK2V617F,":[60],"pr\u00e9sente":[61],"dans":[62,119,225,238,244],"90%":[63],"PV,":[65,182,189],"50%":[66],"TE":[68,249],"MFP,":[71],"ainsi":[72],"que":[73,211],"d":[74,92,129],"autres":[75,93],"analyses":[76],"mol\u00e9culaires":[77],"(MPL,":[78],"JAK2":[79],"exon":[80],"12..)":[81],"ont":[82,265],"\u00e9t\u00e9":[83,174,266],"int\u00e9gr\u00e9s":[84],"comme":[85],"crit\u00e8res":[86],"diagnostiques":[87],"selon":[88],"l":[89,120,125,163,233],"OMS":[90],"parmi":[91],"techniques":[94],"(culture":[95],"prog\u00e9niteurs":[97,111,195,204,219],"h\u00e9matopo\u00ef\u00e9tiques...).":[98],"Ce":[99,150],"travail":[100],"est":[101,207],"\u00e9tude":[103],"r\u00e9trospective":[104],"882":[106],"r\u00e9sultats":[107],"cultures":[109],"et/ou":[112],"JAK2V617F":[115,172,190,212,236],"patients":[117,259],"suivis":[118],"un":[121,223],"sites":[123],"arc":[126],"alpin":[127],"(CH":[128],"Annecy":[130],"Chamb\u00e9ry,":[133],"CHU":[134],"Grenoble,":[136],"Institut":[137],"Daniel":[138],"Hollard)":[139],"entre":[140],"le":[141,146,226],"1er":[142],"Janvier":[143],"2007":[144],"31":[147],"D\u00e9cembre":[148],"2010.":[149],"recensement":[151],"nous":[152],"a":[153,173,221],"permis":[154],"caract\u00e9riser":[156],"les":[157,188,199],"NMP":[158,178,263],"Ph-":[159,179,264],"red\u00e9finir":[162],"int\u00e9r\u00eat":[164,224],"divers":[166],"marqueurs":[167],"biologiques.":[168],"fr\u00e9quence":[170],"\u00e9tablie":[175],"chez":[176],"410":[177],"dont":[180],"141":[181],"234":[183],"TE,":[184,200],"32":[185],"MFP.":[186],"Dans":[187,198],"pousse":[193,202,216],"corr\u00e9l\u00e9es.":[197],"h\u00e9matopo\u00ef\u00e9tiques":[205],"s":[206],"r\u00e9v\u00e9l\u00e9e":[208],"plus":[209],"sensible":[210],"(p":[213],"value<0.05).":[214],"spontan\u00e9e":[217],"m\u00e9gacaryocytaires":[220],"montr\u00e9":[222],"screening":[227],"mutations":[229],"MPL":[231],"en":[232],"absence":[234],"(40.9%":[237],"population":[240,246],"s\u00e9lectionn\u00e9e":[241],"versus":[242],"3-15%":[243],"globale":[247],"MFP).":[252],"Des":[253],"algorithmes":[254],"prescription":[256],"pour":[257],"pr\u00e9sum\u00e9s":[260],"atteints":[261],"propos\u00e9s.":[267]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}