{"id":"https://openalex.org/W1510716670","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1000.1","title":"Induction of VEGF expression in monocytes by alpha\u2010tocopherol and alpha\u2010tocopheryl phosphate via PI3Kgamma/Akt and hTAP1/SEC14L2\u2010mediated lipid exchange (1000.1)","display_name":"Induction of VEGF expression in monocytes by alpha\u2010tocopherol and alpha\u2010tocopheryl phosphate via PI3Kgamma/Akt and hTAP1/SEC14L2\u2010mediated lipid exchange (1000.1)","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W1510716670","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1000.1","mag":"1510716670"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.28.1_supplement.1000.1","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1000.1","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.1000.1","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075026169","display_name":"Jean-Marc A Zingg","orcid":"https://orcid.org/0000-0001-8345-2616","observed_orcids":["https://orcid.org/0000-0001-8345-2616"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean\u2010Marc Zingg","raw_affiliation_strings":["Vascular Biology Laboratory Tufts University Boston MA United States","1Vascular Biology Laboratory Tufts University Boston MA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Biology Laboratory Tufts University Boston MA United States","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"1Vascular Biology Laboratory Tufts University Boston MA United States","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042840198","display_name":"Angelo Azzi","orcid":"https://orcid.org/0000-0002-0737-4430","observed_orcids":["https://orcid.org/0000-0002-0737-4430"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angelo Azzi","raw_affiliation_strings":["Vascular Biology Laboratory Tufts University Boston MA United States","1Vascular Biology Laboratory Tufts University Boston MA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Biology Laboratory Tufts University Boston MA United States","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"1Vascular Biology Laboratory Tufts University Boston MA United States","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001814538","display_name":"Mohsen Meydani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohsen Meydani","raw_affiliation_strings":["Vascular Biology Laboratory Tufts University Boston MA United States","1Vascular Biology Laboratory Tufts University Boston MA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Biology Laboratory Tufts University Boston MA United States","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"1Vascular Biology Laboratory Tufts University Boston MA United States","institution_ids":["https://openalex.org/I121934306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I121934306"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.1258,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.43315794,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"28","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.6942999958992004,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.6942999958992004,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.21660000085830688,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.017899999395012856,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-tocopherol","display_name":"alpha-tocopherol","score":0.8389999866485596},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.9559999704360962},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8790000081062317},{"id":"https://openalex.org/keywords/vegf-expression","display_name":"VEGF expression","score":0.796999990940094},{"id":"https://openalex.org/keywords/pi3kgamma","display_name":"PI3K\u03b3","score":0.7139999866485596},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.906000018119812},{"id":"https://openalex.org/keywords/lipid-exchange","display_name":"lipid exchange","score":0.9079999923706055},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.6840000152587891},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.6869999766349792},{"id":"https://openalex.org/keywords/vasculogenesis","display_name":"vasculogenesis","score":0.8040000200271606},{"id":"https://openalex.org/keywords/phosphoinositide-signaling","display_name":"phosphoinositide signaling","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7566201686859131},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7282212376594543},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6373462677001953},{"id":"https://openalex.org/C60781801","wikidata":"https://www.wikidata.org/wiki/Q1424593","display_name":"Vasculogenesis","level":4,"score":0.5891414284706116},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5064724683761597},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4587664008140564},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.44201499223709106},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36585551500320435},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36136937141418457},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.34190064668655396},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3362390995025635},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.23419415950775146},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21966609358787537},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.2113719880580902},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.1627635657787323}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.28.1_supplement.1000.1","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1000.1","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.1000.1","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G681674736","display_name":null,"funder_award_id":"#58\u20131950-0-014","funder_id":"https://openalex.org/F4320306114","funder_display_name":"U.S. Department of Agriculture"}],"funders":[{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1905140162","https://openalex.org/W656701549","https://openalex.org/W3169447836","https://openalex.org/W2033388875","https://openalex.org/W1999271515","https://openalex.org/W2037833277","https://openalex.org/W3166519609","https://openalex.org/W3171999051","https://openalex.org/W2011627638","https://openalex.org/W2118146357"],"abstract_inverted_index":{"In":[0,86],"several":[1],"studies,":[2],"vitamin":[3],"E":[4],"has":[5],"been":[6],"observed":[7,15],"to":[8,191],"influence":[9],"angiogenesis":[10,39],"and":[11,40,42,65,72,101,127,137,139,184],"vasculogenesis.":[12],"We":[13,167],"recently":[14],"that":[16,121],"the":[17,27,30,44,51,112,141,146,192,196],"phosphorylated":[18],"form":[19],"of":[20,29,46,90,145,186],"\u03b1\u2010tocopherol":[21],"(\u03b1T),":[22],"\u03b1\u2010tocopheryl":[23],"phosphate":[24],"(\u03b1TP),":[25],"increases":[26],"expression":[28,60,108],"vascular":[31],"endothelial":[32],"growth":[33],"factor":[34],"(VEGF),":[35],"which":[36,56,174],"may":[37],"stimulate":[38,178],"vasculogenesis":[41],"enhance":[43],"survival":[45],"cells.":[47],"Here":[48],"we":[49],"investigated":[50],"molecular":[52],"signaling":[53,171],"mechanisms":[54],"by":[55,99,104,125,130,150,173,181,200,209],"\u03b1TP":[57,75,138,163,177],"induces":[58],"VEGF":[59,94,107],"using":[61],"cultured":[62],"THP\u20101":[63],"monocytes":[64],"HEK293":[66],"cells":[67],"as":[68],"model":[69],"systems.":[70],"\u03b1T":[71,100,126,136,175],"more":[73,102,128],"so":[74,103,129],"increased":[76],"VEGF\u2010promoter":[77],"activity":[78,96,144,180],"in":[79,142],"a":[80,152,169],"phosphatidylinositol\u20103\u2010kinase":[81],"gamma":[82],"(PI3K\u03b3)":[83],"\u2010dependent":[84],"manner.":[85],"contrast,":[87],"after":[88],"over\u2010expression":[89],"PI3K\u03b3":[91,147,179],"and/or":[92,194],"Akt,":[93],"promoter":[95],"is":[97],"inhibited":[98],"\u03b1TP.":[105,131],"PI3K\u03b3\u2010induced":[106],"was":[109,119],"reduced":[110],"when":[111],"human":[113],"tocopherol":[114],"associated":[115],"protein":[116],"1":[117],"(hTAP1/SEC14L2)":[118],"over\u2010expressed,":[120],"could":[122],"be":[123],"reverted":[124],"Recombinant":[132],"hTAP1/hSEC14L2":[133],"binds":[134],"both":[135],"reduces":[140],"vitro":[143],"most":[148],"likely":[149],"forming":[151],"stalled/inactive":[153],"hTAP1/PI3K\u03b3":[154],"heterodimer.":[155,198],"The":[156],"addition":[157],"\u03b1T,":[158],"\u03b2T,":[159],"\u03b3T,":[160],"\u03b4T":[161],"or":[162,176],"differentially":[164],"stimulates":[165],"PI3K\u03b3.":[166],"suggest":[168],"novel":[170],"mechanism":[172],"facilitating":[182],"egress":[183],"presentation":[185],"sequestered":[187],"PI":[188],"from":[189],"hTAP1":[190],"enzyme":[193],"dissociating":[195],"inactive":[197],"Supported":[199,208],"USDA":[201,210],"Contract":[202,211],"#58\u20101950\u20100\u2010014.":[203],"Grant":[204],"Funding":[205],"Source":[206],":":[207],"#58\u20101950\u20100\u2010014":[212]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
