{"id":"https://openalex.org/W1510179025","doi":null,"title":"Expression and downregulation of the GABAergic phenotype in explants of cultured rabbit retina.","display_name":"Expression and downregulation of the GABAergic phenotype in explants of cultured rabbit retina.","publication_year":1996,"publication_date":"1996-05-01","ids":{"openalex":"https://openalex.org/W1510179025","mag":"1510179025","pmid":"https://pubmed.ncbi.nlm.nih.gov/8631623"},"language":"en","primary_location":{"id":"pmid:8631623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8631623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089361326","display_name":"Cheryl L. Rowe-Rendleman","orcid":"https://orcid.org/0000-0002-3024-2356","observed_orcids":["https://orcid.org/0000-0002-3024-2356"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Rowe-Rendleman","raw_affiliation_strings":["Department of Opthalmology and Visual Science, University of Texas, Medical School, Houston 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Opthalmology and Visual Science, University of Texas, Medical School, Houston 77030, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061884784","display_name":"Cheryl K. Mitchell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C K Mitchell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050045865","display_name":"M Habrecht","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Habrecht","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110033380","display_name":"Dianna A. Redburn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D A Redburn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.165,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.85342191,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"37","issue":"6","first_page":"1074","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinal-explant-culture","display_name":"retinal explant culture","score":0.8149999976158142},{"id":"https://openalex.org/keywords/gaba-uptake","display_name":"GABA uptake","score":0.746999979019165},{"id":"https://openalex.org/keywords/horizontal-cells","display_name":"horizontal cells","score":0.8980000019073486},{"id":"https://openalex.org/keywords/amacrine-cells","display_name":"amacrine cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/displaced-amacrine-cells","display_name":"displaced amacrine cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/retinal-development","display_name":"retinal development","score":0.6959999799728394},{"id":"https://openalex.org/keywords/cone-photoreceptors","display_name":"cone photoreceptors","score":0.8500000238418579},{"id":"https://openalex.org/keywords/rabbit-retina","display_name":"rabbit retina","score":0.5989999771118164},{"id":"https://openalex.org/keywords/gaba-immunoreactivity","display_name":"GABA immunoreactivity","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.81740403175354},{"id":"https://openalex.org/C157890192","wikidata":"https://www.wikidata.org/wiki/Q2561978","display_name":"Explant culture","level":3,"score":0.7422803640365601},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6946682929992676},{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.6222372055053711},{"id":"https://openalex.org/C26265296","wikidata":"https://www.wikidata.org/wiki/Q408713","display_name":"Calbindin","level":3,"score":0.5956657528877258},{"id":"https://openalex.org/C2777877921","wikidata":"https://www.wikidata.org/wiki/Q6005532","display_name":"Immunolabeling","level":3,"score":0.5763463973999023},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5340594053268433},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5070135593414307},{"id":"https://openalex.org/C35866371","wikidata":"https://www.wikidata.org/wiki/Q6005502","display_name":"Immunocytochemistry","level":2,"score":0.4532415270805359},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34388917684555054},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.282361775636673},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.23394060134887695},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21209624409675598},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1936054229736328},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19232428073883057},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13428083062171936},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.11933603882789612},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006651","descriptor_name":"Histocytochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012374","descriptor_name":"Rod Cell Outer Segment","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018079","descriptor_name":"Receptors, GABA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D019887","descriptor_name":"Peanut Agglutinin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037102","descriptor_name":"Lectins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064026","descriptor_name":"Calbindins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064030","descriptor_name":"S100 Calcium Binding Protein G","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8631623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8631623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:1510179025","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8631623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1484555822","display_name":"Core Grant for Vision Research","funder_award_id":"P30EY010608","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G8256330886","display_name":"Training Program with Universitiy of Houston","funder_award_id":"T32EY007024","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G8256609218","display_name":"BIOCHEMICAL ANALYSIS OF NEUROTRANSMITTERS","funder_award_id":"R01EY001655","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W20951468","https://openalex.org/W201363424","https://openalex.org/W982130827","https://openalex.org/W1487954084","https://openalex.org/W1530787390","https://openalex.org/W1867857481","https://openalex.org/W1973108213","https://openalex.org/W1979618641","https://openalex.org/W1980350065","https://openalex.org/W1983087457","https://openalex.org/W1985112608","https://openalex.org/W1993000960","https://openalex.org/W1994853736","https://openalex.org/W1998058650","https://openalex.org/W2009313165","https://openalex.org/W2020614844","https://openalex.org/W2021515052","https://openalex.org/W2021739229","https://openalex.org/W2023239530","https://openalex.org/W2024362271","https://openalex.org/W2026768533","https://openalex.org/W2026830722","https://openalex.org/W2031826354","https://openalex.org/W2035688483","https://openalex.org/W2046783889","https://openalex.org/W2055779059","https://openalex.org/W2058630731","https://openalex.org/W2063635108","https://openalex.org/W2067155699","https://openalex.org/W2081983120","https://openalex.org/W2082308689","https://openalex.org/W2086764123","https://openalex.org/W2089336627","https://openalex.org/W2091863239","https://openalex.org/W2112900622"],"related_works":["https://openalex.org/W1985112608","https://openalex.org/W2137554206","https://openalex.org/W2055779059","https://openalex.org/W2064348567","https://openalex.org/W2029228657","https://openalex.org/W2006716158","https://openalex.org/W1986966746","https://openalex.org/W2148095461","https://openalex.org/W2073830299","https://openalex.org/W2413468924"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"study":[2],"the":[3,9,28,39,42,46,65,109,114,125,172,202,208,212,241,265],"morphologic":[4],"and":[5,41,55,60,79,83,94,104,129,151,168,207],"neurochemical":[6,43],"development":[7,44],"of":[8,17,30,38,45,64,101,127,184,192,204,211,234,240],"rabbit":[10,67,76,236],"retina":[11,18,68,77,194],"in":[12,24,27,69,108,118,123,148,158,171,195,218,244,251,262,267],"explant":[13,40],"culture.":[14,119],"METHODS:":[15],"Explants":[16],"from":[19,74,190],"newborn":[20,75,235],"rabbits":[21],"were":[22,49,142],"cultured":[23,221,232],"defined":[25,224],"medium":[26],"absence":[29],"serum":[31],"or":[32],"soluble":[33],"growth":[34],"factors.":[35],"The":[36,198,253],"morphology":[37],"GABAergic":[47,213,242],"system":[48],"examined":[50],"by":[51],"light":[52],"microscopy,":[53],"autoradiography,":[54],"immunohistochemistry":[56],"for":[57],"7":[58,88,146],"days":[59,117,122,147],"compared":[61],"to":[62,87,163,260],"those":[63],"postnatal":[66],"vivo.":[70,196,252],"RESULTS:":[71],"Cultured":[72],"explants":[73,220,233],"develop":[78],"maintain":[80],"well-defined":[81],"plexiform":[82],"cellular":[84,205],"layers":[85,206],"up":[86],"days.":[89],"Exogenous":[90],"3H-gamma-aminobutyric":[91],"acid":[92],"(GABA)":[93],"antibodies":[95,162],"against":[96],"GABA":[97,268],"labeled":[98,139],"a":[99,182,245],"population":[100],"horizontal,":[102],"amacrine":[103,106,169],"displaced":[105],"cells":[107,141,170,258],"ganglion":[110],"cell":[111,136],"layer":[112],"during":[113],"first":[115],"3":[116],"After":[120],"4":[121],"culture,":[124,149],"extent":[126],"uptake":[128,150],"immunolabeling":[130],"was":[131],"diminished":[132],"among":[133],"all":[134],"three":[135],"types,":[137],"but":[138,161],"horizontal":[140,159,167,257],"markedly":[143],"rare.":[144],"At":[145],"GABA-like":[152],"immunoreactivity":[153],"could":[154],"not":[155],"be":[156,216],"detected":[157],"cells,":[160],"calbindin-D":[164],"reacted":[165],"with":[166,248],"appropriate":[173],"retinal":[174,219],"layers.":[175],"Peanut":[176],"agglutinin":[177],"lectin":[178],"binding":[179],"studies":[180],"revealed":[181],"mosaic":[183],"cone":[185],"photoreceptor":[186],"inner":[187],"segments":[188],"indistinguishable":[189],"that":[191,201,230,249,256],"neonatal":[193],"CONCLUSIONS:":[197],"experiments":[199],"show":[200,255],"maturation":[203],"developmental":[209],"expression":[210],"phenotype":[214,243],"can":[215],"observed":[217,250],"under":[222],"chemically":[223],"conditions.":[225],"Histochemical":[226],"evidence":[227],"is":[228],"presented":[229],"indicates":[231],"retinas":[237],"express":[238],"markers":[239],"manner":[246],"consistent":[247],"authors":[254],"continue":[259],"survive":[261],"culture":[263],"after":[264],"diminution":[266],"immunoreactivity.":[269]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}