{"id":"https://openalex.org/W1509996231","doi":"https://doi.org/10.1111/j.1525-139x.2005.18406.x","title":"VITAMIN D IN HEALTH AND DISEASE: Beyond Minerals and Parathyroid Hormone: Role of Active Vitamin D in End\u2010Stage Renal Disease","display_name":"VITAMIN D IN HEALTH AND DISEASE: Beyond Minerals and Parathyroid Hormone: Role of Active Vitamin D in End\u2010Stage Renal Disease","publication_year":2005,"publication_date":"2005-07-01","ids":{"openalex":"https://openalex.org/W1509996231","doi":"https://doi.org/10.1111/j.1525-139x.2005.18406.x","mag":"1509996231","pmid":"https://pubmed.ncbi.nlm.nih.gov/16076353"},"language":"en","primary_location":{"id":"doi:10.1111/j.1525-139x.2005.18406.x","doi":"https://doi.org/10.1111/j.1525-139x.2005.18406.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1525-139x.2005.18406.x","pdf_url":null,"source":{"id":"https://openalex.org/S34122167","display_name":"Seminars in Dialysis","issn_l":"0894-0959","issn":["0894-0959","1525-139X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Dialysis","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008906136","display_name":"Myles Selig Wolf","orcid":"https://orcid.org/0000-0002-1127-1442","observed_orcids":["https://orcid.org/0000-0002-1127-1442"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Myles Wolf","raw_affiliation_strings":["Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA. mswolf@partners.org","Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA. mswolf@partners.org","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041339585","display_name":"Ravi Thadhani","orcid":"https://orcid.org/0000-0001-8315-9938","observed_orcids":["https://orcid.org/0000-0001-8315-9938"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Thadhani","raw_affiliation_strings":["Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008906136"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":3730,"currency":"USD","value_usd":3730},"apc_paid":null,"fwci":0.3499,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.284,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"18","issue":"4","first_page":"302","last_page":"306"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/active-vitamin-d","display_name":"active vitamin D","score":0.8560000061988831},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.8769999742507935},{"id":"https://openalex.org/keywords/secondary-hyperparathyroidism","display_name":"secondary hyperparathyroidism","score":0.9039999842643738},{"id":"https://openalex.org/keywords/paricalcitol","display_name":"paricalcitol","score":0.8569999933242798},{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d3","display_name":"1,25-dihydroxyvitamin D3","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hemodialysis","display_name":"hemodialysis","score":0.8309999704360962},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.7110000252723694},{"id":"https://openalex.org/keywords/hypercalcemia","display_name":"hypercalcemia","score":0.8360000252723694},{"id":"https://openalex.org/keywords/hyperphosphatemia","display_name":"hyperphosphatemia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8923909664154053},{"id":"https://openalex.org/C2778838027","wikidata":"https://www.wikidata.org/wiki/Q3622611","display_name":"Secondary hyperparathyroidism","level":4,"score":0.846785306930542},{"id":"https://openalex.org/C2776036575","wikidata":"https://www.wikidata.org/wiki/Q1641062","display_name":"Hyperphosphatemia","level":3,"score":0.8361061811447144},{"id":"https://openalex.org/C2779524405","wikidata":"https://www.wikidata.org/wiki/Q155746","display_name":"Paricalcitol","level":5,"score":0.8267742395401001},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.7627614140510559},{"id":"https://openalex.org/C2776079296","wikidata":"https://www.wikidata.org/wiki/Q139195","display_name":"Calcitriol","level":3,"score":0.7329341173171997},{"id":"https://openalex.org/C2778063415","wikidata":"https://www.wikidata.org/wiki/Q391744","display_name":"Hemodialysis","level":2,"score":0.7115737795829773},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.675350546836853},{"id":"https://openalex.org/C3019040382","wikidata":"https://www.wikidata.org/wiki/Q476921","display_name":"End stage renal disease","level":3,"score":0.6292485594749451},{"id":"https://openalex.org/C2775945674","wikidata":"https://www.wikidata.org/wiki/Q1344835","display_name":"Hyperparathyroidism","level":2,"score":0.5428987741470337},{"id":"https://openalex.org/C2779740938","wikidata":"https://www.wikidata.org/wiki/Q4138762","display_name":"vitamin D deficiency","level":3,"score":0.516758382320404},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4951273500919342},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39439547061920166},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.33536022901535034},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.22537267208099365}],"mesh":[{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006435","descriptor_name":"Renal Dialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006962","descriptor_name":"Hyperparathyroidism, Secondary","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006962","descriptor_name":"Hyperparathyroidism, Secondary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006962","descriptor_name":"Hyperparathyroidism, Secondary","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D010281","descriptor_name":"Parathyroid Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1525-139x.2005.18406.x","doi":"https://doi.org/10.1111/j.1525-139x.2005.18406.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1525-139x.2005.18406.x","pdf_url":null,"source":{"id":"https://openalex.org/S34122167","display_name":"Seminars in Dialysis","issn_l":"0894-0959","issn":["0894-0959","1525-139X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Dialysis","raw_type":"journal-article"},{"id":"pmid:16076353","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16076353","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in dialysis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W187304924","https://openalex.org/W1768768381","https://openalex.org/W1958413320","https://openalex.org/W1964616785","https://openalex.org/W1968691321","https://openalex.org/W1973164863","https://openalex.org/W1973775872","https://openalex.org/W1973835767","https://openalex.org/W1974079318","https://openalex.org/W1977531987","https://openalex.org/W1979268971","https://openalex.org/W1983032812","https://openalex.org/W1989640819","https://openalex.org/W1991976493","https://openalex.org/W1993111552","https://openalex.org/W1994057975","https://openalex.org/W1994163486","https://openalex.org/W1997341767","https://openalex.org/W2000145095","https://openalex.org/W2000458563","https://openalex.org/W2003162718","https://openalex.org/W2005112962","https://openalex.org/W2006344193","https://openalex.org/W2011382235","https://openalex.org/W2015858614","https://openalex.org/W2018429484","https://openalex.org/W2018536479","https://openalex.org/W2025589168","https://openalex.org/W2028302756","https://openalex.org/W2030174339","https://openalex.org/W2031731549","https://openalex.org/W2033162676","https://openalex.org/W2049428559","https://openalex.org/W2055923382","https://openalex.org/W2061769844","https://openalex.org/W2064935896","https://openalex.org/W2065133740","https://openalex.org/W2067017612","https://openalex.org/W2068698599","https://openalex.org/W2074381462","https://openalex.org/W2075394310","https://openalex.org/W2076520195","https://openalex.org/W2081385953","https://openalex.org/W2086883857","https://openalex.org/W2095173028","https://openalex.org/W2095483193","https://openalex.org/W2097221830","https://openalex.org/W2097889785","https://openalex.org/W2099353808","https://openalex.org/W2102185935","https://openalex.org/W2103694292","https://openalex.org/W2107094270","https://openalex.org/W2109082501","https://openalex.org/W2109351611","https://openalex.org/W2119846536","https://openalex.org/W2119984866","https://openalex.org/W2123365090","https://openalex.org/W2126433244","https://openalex.org/W2127560186","https://openalex.org/W2129877713","https://openalex.org/W2130445180","https://openalex.org/W2135402159","https://openalex.org/W2147487489","https://openalex.org/W2148625316","https://openalex.org/W2154002086","https://openalex.org/W2156828729","https://openalex.org/W2163182278","https://openalex.org/W2164290357","https://openalex.org/W2167960918","https://openalex.org/W2322088784","https://openalex.org/W2325704874","https://openalex.org/W2338451374","https://openalex.org/W2416514262","https://openalex.org/W2416898592","https://openalex.org/W2465692541","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1988779242","https://openalex.org/W2113356410","https://openalex.org/W2137743950","https://openalex.org/W2339029941","https://openalex.org/W2899620352","https://openalex.org/W2321884553","https://openalex.org/W2803738284","https://openalex.org/W3201988635","https://openalex.org/W1778691949","https://openalex.org/W2093581257"],"abstract_inverted_index":{"Secondary":[0],"hyperparathyroidism":[1,29],"is":[2,12,33],"a":[3,116,124,128],"common":[4],"complication":[5],"of":[6,18,27,37,78,110,119,132,147,155,165],"end-stage":[7],"renal":[8],"disease":[9],"(ESRD)":[10],"that":[11,74,114,126,176],"often":[13],"treated":[14],"with":[15,171],"activated":[16],"forms":[17],"intravenous":[19,134],"vitamin":[20,60,68,92,135,156],"D.":[21],"The":[22,100],"natural":[23],"course":[24],"and":[25,40,81,123,149],"treatment":[26],"secondary":[28],"in":[30,45,104],"hemodialysis":[31,97,111,179],"patients":[32],"punctuated":[34],"by":[35],"episodes":[36,55],"hypercalcemia,":[38],"hyperphosphatemia,":[39],"increased":[41,51],"calcium-phosphate":[42],"product,":[43],"which":[44],"previous":[46],"studies":[47,73,109],"were":[48,145],"linked":[49],"to":[50,59,65,159],"mortality.":[52],"Historically":[53],"these":[54,166],"have":[56],"been":[57],"attributed":[58],"D,":[61],"leading":[62],"some":[63],"authorities":[64],"favor":[66],"decreased":[67],"D":[69,93,136,157],"use.":[70],"However,":[71],"the":[72,76,143,160],"examined":[75],"impact":[77,178],"mineral":[79,148],"levels":[80],"parathyroid":[82],"hormone":[83],"(PTH)":[84],"on":[85,96,174],"survival":[86,117,130,162],"did":[87],"not":[88],"consistently":[89],"account":[90],"for":[91],"therapy":[94],"itself":[95],"patient":[98],"survival.":[99],"current":[101],"review":[102],"examines":[103],"detail":[105],"two":[106],"recent":[107],"large-scale":[108],"patients:":[112],"one":[113],"demonstrated":[115,127],"advantage":[118,131],"paricalcitol":[120],"over":[121],"calcitriol":[122],"second":[125],"significant":[129],"any":[133],"formulation":[137],"versus":[138],"none.":[139],"In":[140],"both":[141],"studies,":[142],"effects":[144],"independent":[146],"PTH":[150],"levels,":[151],"suggesting":[152],"\"nontraditional\"":[153],"actions":[154,168],"contributed":[158],"observed":[161],"advantage.":[163],"Several":[164],"nontraditional":[167],"are":[169],"reviewed":[170],"an":[172],"emphasis":[173],"those":[175],"might":[177],"outcomes.":[180]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
