{"id":"https://openalex.org/W1509859425","doi":null,"title":"Muscle metaboreflex control of coronary blood flow and ventricular contractility during dynamic exercise in normal and heart failure conditions","display_name":"Muscle metaboreflex control of coronary blood flow and ventricular contractility during dynamic exercise in normal and heart failure conditions","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W1509859425","mag":"1509859425"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.wayne.edu:oa_dissertations-1209","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wayne.edu/oa_dissertations/210","pdf_url":"https://digitalcommons.wayne.edu/oa_dissertations/210","source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wayne State University Dissertations","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.wayne.edu/oa_dissertations/210","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031770522","display_name":"Matthew Coutsos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Matthew Coutsos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5031770522"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muscle-metaboreflex","display_name":"muscle metaboreflex","score":0.9959999918937683},{"id":"https://openalex.org/keywords/coronary-blood-flow","display_name":"coronary blood flow","score":0.9490000009536743},{"id":"https://openalex.org/keywords/coronary-vasoconstriction","display_name":"coronary vasoconstriction","score":0.8320000171661377},{"id":"https://openalex.org/keywords/left-ventricular-contractility","display_name":"left ventricular contractility","score":0.9190000295639038},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9049999713897705},{"id":"https://openalex.org/keywords/dynamic-exercise","display_name":"dynamic exercise","score":0.8489999771118164},{"id":"https://openalex.org/keywords/alpha-1-adrenergic-blockade","display_name":"alpha-1 adrenergic blockade","score":0.972000002861023},{"id":"https://openalex.org/keywords/prazosin","display_name":"prazosin","score":0.925000011920929},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.8240000009536743},{"id":"https://openalex.org/keywords/preload-recruitable-stroke-work","display_name":"preload recruitable stroke work","score":0.8560000061988831}],"concepts":[{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7784785032272339},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7543684244155884},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.7121502757072449},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6898521184921265},{"id":"https://openalex.org/C48277249","wikidata":"https://www.wikidata.org/wiki/Q1406926","display_name":"Preload","level":3,"score":0.6692816615104675},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6536540985107422},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.6524157524108887},{"id":"https://openalex.org/C123576724","wikidata":"https://www.wikidata.org/wiki/Q1299082","display_name":"Afterload","level":3,"score":0.6213641166687012},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.5058004856109619},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.4929320812225342},{"id":"https://openalex.org/C2909076160","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Coronary vasodilator","level":3,"score":0.42681077122688293},{"id":"https://openalex.org/C2776157398","wikidata":"https://www.wikidata.org/wiki/Q497232","display_name":"Coronary circulation","level":3,"score":0.4108465313911438},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.40655362606048584}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.wayne.edu:oa_dissertations-1209","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wayne.edu/oa_dissertations/210","pdf_url":"https://digitalcommons.wayne.edu/oa_dissertations/210","source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wayne State University Dissertations","raw_type":"dissertation"},{"id":"mag:1509859425","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=1209&context=oa_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.wayne.edu:oa_dissertations-1209","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wayne.edu/oa_dissertations/210","pdf_url":"https://digitalcommons.wayne.edu/oa_dissertations/210","source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wayne State University Dissertations","raw_type":"dissertation"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1509859425.pdf","grobid_xml":"https://content.openalex.org/works/W1509859425.grobid-xml"},"referenced_works_count":114,"referenced_works":["https://openalex.org/W7718591","https://openalex.org/W13920266","https://openalex.org/W82986423","https://openalex.org/W91998247","https://openalex.org/W139774506","https://openalex.org/W160513299","https://openalex.org/W1488574749","https://openalex.org/W1562799989","https://openalex.org/W1606656196","https://openalex.org/W1824736859","https://openalex.org/W1875819283","https://openalex.org/W1907866259","https://openalex.org/W1967720231","https://openalex.org/W1971905141","https://openalex.org/W1972764472","https://openalex.org/W1977824667","https://openalex.org/W1978550729","https://openalex.org/W1981558476","https://openalex.org/W1984731234","https://openalex.org/W1991198634","https://openalex.org/W1993441727","https://openalex.org/W1993675056","https://openalex.org/W1997131918","https://openalex.org/W1998627539","https://openalex.org/W2005407033","https://openalex.org/W2006166108","https://openalex.org/W2006223122","https://openalex.org/W2006763427","https://openalex.org/W2012220093","https://openalex.org/W2013865516","https://openalex.org/W2019727492","https://openalex.org/W2020380044","https://openalex.org/W2027268907","https://openalex.org/W2028225976","https://openalex.org/W2028982689","https://openalex.org/W2032790428","https://openalex.org/W2034721936","https://openalex.org/W2036705178","https://openalex.org/W2039120849","https://openalex.org/W2044267482","https://openalex.org/W2045116163","https://openalex.org/W2047081460","https://openalex.org/W2049023692","https://openalex.org/W2049972637","https://openalex.org/W2052278934","https://openalex.org/W2053616140","https://openalex.org/W2056453954","https://openalex.org/W2057543175","https://openalex.org/W2057590600","https://openalex.org/W2063481915","https://openalex.org/W2066020583","https://openalex.org/W2081544739","https://openalex.org/W2083550830","https://openalex.org/W2083773011","https://openalex.org/W2093998492","https://openalex.org/W2095038529","https://openalex.org/W2103575900","https://openalex.org/W2110373537","https://openalex.org/W2112275686","https://openalex.org/W2114846271","https://openalex.org/W2114876661","https://openalex.org/W2116035231","https://openalex.org/W2118488318","https://openalex.org/W2118986537","https://openalex.org/W2120337309","https://openalex.org/W2132190220","https://openalex.org/W2135032956","https://openalex.org/W2137515021","https://openalex.org/W2141372451","https://openalex.org/W2141536801","https://openalex.org/W2141987212","https://openalex.org/W2143479480","https://openalex.org/W2143540423","https://openalex.org/W2143703067","https://openalex.org/W2146150343","https://openalex.org/W2148455277","https://openalex.org/W2148625185","https://openalex.org/W2149773905","https://openalex.org/W2150512485","https://openalex.org/W2150624447","https://openalex.org/W2151802250","https://openalex.org/W2153298916","https://openalex.org/W2155306834","https://openalex.org/W2157973908","https://openalex.org/W2158486075","https://openalex.org/W2165670017","https://openalex.org/W2169169073","https://openalex.org/W2169192932","https://openalex.org/W2169231252","https://openalex.org/W2172993914","https://openalex.org/W2174297323","https://openalex.org/W2176489849","https://openalex.org/W2176637169","https://openalex.org/W2197729830","https://openalex.org/W2256662442","https://openalex.org/W2259491809","https://openalex.org/W2262501216","https://openalex.org/W2266319401","https://openalex.org/W2288772145","https://openalex.org/W2291355287","https://openalex.org/W2292784958","https://openalex.org/W2311648757","https://openalex.org/W2320966627","https://openalex.org/W2335037890","https://openalex.org/W2344994787","https://openalex.org/W2398995882","https://openalex.org/W2405202980","https://openalex.org/W2410960762","https://openalex.org/W2415480273","https://openalex.org/W2418461269","https://openalex.org/W2422323383","https://openalex.org/W2460344936","https://openalex.org/W2472368056","https://openalex.org/W3174415375"],"related_works":["https://openalex.org/W2288772145","https://openalex.org/W2157479120","https://openalex.org/W2304661232","https://openalex.org/W2045116163","https://openalex.org/W2093998492","https://openalex.org/W7718591","https://openalex.org/W2148625185","https://openalex.org/W2890862473","https://openalex.org/W3175227217","https://openalex.org/W2114876661"],"abstract_inverted_index":{"Muscle":[0],"metaboreflex":[1,220,263],"activation":[2,181,221],"during":[3,126,174,180,200,232],"dynamic":[4],"exercise":[5,176],"induces":[6],"a":[7,17],"substantial":[8],"increase":[9,19,28,59,123,265],"in":[10,20,29,72,102,107,117,208,236,269],"cardiac":[11,30,55,124,146],"work":[12,31,169],"and":[13,25,69,99,110,137,141,153,165,173,179,211,217,240,271],"oxygen":[14],"demand":[15],"via":[16],"significant":[18],"heart":[21,53,127,139,229,272],"rate,":[22],"ventricular":[23,67,104,162,267],"contractility":[24,106,268],"afterload.":[26],"This":[27],"should":[32],"cause":[33],"coronary":[34,41,50,73,92,96,113,155,253],"metabolic":[35],"vasodilation.":[36],"However,":[37],"little":[38],"if":[39],"any":[40],"vasodilation":[42,93],"is":[43,83],"observed":[44,204],"due":[45,63],"to":[46,64,84,122,264],"concomitant":[47],"sympathetically":[48],"induced":[49],"vasoconstriction.":[51],"In":[52,197,228],"failure,":[54],"output":[56,147],"does":[57],"not":[58],"with":[60,219],"MMA":[61,257],"presumably":[62],"impaired":[65],"left":[66,103,266],"contractility,":[68],"large":[70],"decreases":[71],"vascular":[74,156],"conductance":[75,157],"are":[76],"observed.":[77],"The":[78],"purpose":[79],"of":[80,91,161,182,261],"this":[81,112],"dissertation":[82],"determine":[85],"whether":[86,111],"the":[87,119,183,234,252,259],"muscle":[88,184,262],"metaboreflex-induced":[89],"restraint":[90],"functionally":[94],"limits":[95,258],"blood":[97,150],"flow":[98,151],"suppresses":[100],"increases":[101,207,235],"(LV)":[105],"normal":[108,270],"dogs":[109,134],"vasoconstriction":[114,254],"could":[115],"explain":[116],"part,":[118],"reduced":[120],"ability":[121,260],"performance":[125],"failure":[128,230,273],"conditions.":[129,274],"We":[130,249],"used":[131],"chronically":[132],"instrumented":[133],"(n=9,":[135],"control":[136,198],"n=7,":[138],"failure)":[140],"measured":[142],"arterial":[143],"pressure":[144,163],"(MAP),":[145],"(CO),":[148],"circumflex":[149],"(CBF),":[152],"calculated":[154],"(CVC),":[158],"maximal":[159],"derivative":[160],"(dp/dt),":[164],"preload":[166],"recruitable":[167],"stroke":[168],"(PRSW)":[170],"at":[171],"rest":[172],"mild":[175],"(2mph)":[177],"before":[178],"metaboreflex.":[185],"Experiments":[186],"were":[187,242],"repeated":[188],"after":[189,245],"systemic":[190],"alpha-1":[191,201,226,246],"adrenergic":[192,247],"blockade":[193,202],"(prazosin":[194],"50-100":[195],"\u03bcg/kg).":[196],"studies":[199],"we":[203],"significantly":[205,243],"greater":[206,244],"CVC,":[209,238],"CBF":[210],"PRSW,":[212],"as":[213,215],"well":[214],"CO":[216],"dP/dtmax,":[218],"vs.":[222],"those":[223],"seen":[224],"without":[225],"blockade.":[227,248],"experiments":[231],"MMA,":[233],"CBF,":[237],"CO,":[239],"+dP/dtmax":[241],"conclude":[250],"that":[251],"elicited":[255],"by":[256]},"counts_by_year":[],"updated_date":"2026-09-16T18:09:00.828671","created_date":"2016-06-24T00:00:00"}
