{"id":"https://openalex.org/W1509856372","doi":"https://doi.org/10.1172/jci106022","title":"Permeability-increasing activity in hereditary angioneurotic edema plasma","display_name":"Permeability-increasing activity in hereditary angioneurotic edema plasma","publication_year":1969,"publication_date":"1969-04-01","ids":{"openalex":"https://openalex.org/W1509856372","doi":"https://doi.org/10.1172/jci106022","mag":"1509856372","pmid":"https://pubmed.ncbi.nlm.nih.gov/5813121","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/322269"},"language":"en","primary_location":{"id":"doi:10.1172/jci106022","doi":"https://doi.org/10.1172/jci106022","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci106022","pdf_url":"http://www.jci.org/articles/view/106022/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/106022/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111696189","display_name":"Virginia H. Donaldson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2799501412","display_name":"St. Vincent Charity Hospital","ror":"https://ror.org/00dbcz291","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799501412"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Virginia H. Donaldson","raw_affiliation_strings":["From the Shriners Burns Institute and Department of Medicine , University of Cincinnati College of Medicine , Cincinnati , Ohio 45219 ; the","Case Western Re-serve University and the Heart Association of Northeastern Ohio on leave from the Universidade Federal de Minais, Belo Horizonte, Brazil","Case Western Reserve University School of Medicine, Cleveland, Ohio 44106; and the Department of Pediatrics,","From the Shriners Burns Institute and Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45219; the laboratories of the Research Division of","Harvard Medical School and Children's Hospital, Boston, Massachusetts 02115","St. Vincent Charity Hospital, Cleveland, Ohio; the Department of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Shriners Burns Institute and Department of Medicine , University of Cincinnati College of Medicine , Cincinnati , Ohio 45219 ; the","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Case Western Re-serve University and the Heart Association of Northeastern Ohio on leave from the Universidade Federal de Minais, Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Case Western Reserve University School of Medicine, Cleveland, Ohio 44106; and the Department of Pediatrics,","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"From the Shriners Burns Institute and Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45219; the laboratories of the Research Division of","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Harvard Medical School and Children's Hospital, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"St. Vincent Charity Hospital, Cleveland, Ohio; the Department of Medicine,","institution_ids":["https://openalex.org/I2799501412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045639353","display_name":"Oscar D. Ratnoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2799501412","display_name":"St. Vincent Charity Hospital","ror":"https://ror.org/00dbcz291","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799501412"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oscar D. Ratnoff","raw_affiliation_strings":["Case Western Re-serve University and the Heart Association of Northeastern Ohio on leave from the Universidade Federal de Minais, Belo Horizonte, Brazil","Case Western Reserve University School of Medicine, Cleveland, Ohio 44106; and the Department of Pediatrics,","From the Shriners Burns Institute and Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45219; the laboratories of the Research Division of","Harvard Medical School and Children's Hospital, Boston, Massachusetts 02115","St. Vincent Charity Hospital, Cleveland, Ohio; the Department of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Re-serve University and the Heart Association of Northeastern Ohio on leave from the Universidade Federal de Minais, Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Case Western Reserve University School of Medicine, Cleveland, Ohio 44106; and the Department of Pediatrics,","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"From the Shriners Burns Institute and Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45219; the laboratories of the Research Division of","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Harvard Medical School and Children's Hospital, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"St. Vincent Charity Hospital, Cleveland, Ohio; the Department of Medicine,","institution_ids":["https://openalex.org/I2799501412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079383826","display_name":"Wilmar Dias da Silva","orcid":"https://orcid.org/0000-0001-5109-3081","observed_orcids":["https://orcid.org/0000-0001-5109-3081"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2799501412","display_name":"St. Vincent Charity Hospital","ror":"https://ror.org/00dbcz291","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799501412"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wilmar Dias Da Silva","raw_affiliation_strings":["Case Western Re-serve University and the Heart Association of Northeastern Ohio on leave from the Universidade Federal de Minais, Belo Horizonte, Brazil","Case Western Reserve University School of Medicine, Cleveland, Ohio 44106; and the Department of Pediatrics,","From the Shriners Burns Institute and Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45219; the laboratories of the Research Division of","Harvard Medical School and Children's Hospital, Boston, Massachusetts 02115","St. Vincent Charity Hospital, Cleveland, Ohio; the Department of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Re-serve University and the Heart Association of Northeastern Ohio on leave from the Universidade Federal de Minais, Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Case Western Reserve University School of Medicine, Cleveland, Ohio 44106; and the Department of Pediatrics,","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"From the Shriners Burns Institute and Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45219; the laboratories of the Research Division of","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Harvard Medical School and Children's Hospital, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"St. Vincent Charity Hospital, Cleveland, Ohio; the Department of Medicine,","institution_ids":["https://openalex.org/I2799501412"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111433586","display_name":"Fred S. Rosen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2799501412","display_name":"St. Vincent Charity Hospital","ror":"https://ror.org/00dbcz291","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799501412"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred S. Rosen","raw_affiliation_strings":["From the Shriners Burns Institute and Department of Medicine , University of Cincinnati College of Medicine , Cincinnati , Ohio 45219 ; the","Case Western Re-serve University and the Heart Association of Northeastern Ohio on leave from the Universidade Federal de Minais, Belo Horizonte, Brazil","Case Western Reserve University School of Medicine, Cleveland, Ohio 44106; and the Department of Pediatrics,","From the Shriners Burns Institute and Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45219; the laboratories of the Research Division of","Harvard Medical School and Children's Hospital, Boston, Massachusetts 02115","St. Vincent Charity Hospital, Cleveland, Ohio; the Department of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Shriners Burns Institute and Department of Medicine , University of Cincinnati College of Medicine , Cincinnati , Ohio 45219 ; the","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Case Western Re-serve University and the Heart Association of Northeastern Ohio on leave from the Universidade Federal de Minais, Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Case Western Reserve University School of Medicine, Cleveland, Ohio 44106; and the Department of Pediatrics,","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"From the Shriners Burns Institute and Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45219; the laboratories of the Research Division of","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Harvard Medical School and Children's Hospital, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"St. Vincent Charity Hospital, Cleveland, Ohio; the Department of Medicine,","institution_ids":["https://openalex.org/I2799501412"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":12.4835,"has_fulltext":true,"cited_by_count":139,"citation_normalized_percentile":{"value":0.99038462,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"48","issue":"4","first_page":"642","last_page":"653"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hereditary-angioedema","display_name":"hereditary angioedema","score":0.996999979019165},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8009999990463257},{"id":"https://openalex.org/keywords/bradykinin","display_name":"bradykinin","score":0.7879999876022339},{"id":"https://openalex.org/keywords/uterine-contraction","display_name":"uterine contraction","score":0.7609999775886536},{"id":"https://openalex.org/keywords/skin-permeability","display_name":"skin permeability","score":0.7310000061988831},{"id":"https://openalex.org/keywords/trypsin-inactivation","display_name":"trypsin inactivation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/c1-esterase","display_name":"C1 esterase","score":0.7580000162124634},{"id":"https://openalex.org/keywords/kallikrein-kinin-system","display_name":"kallikrein-kinin system","score":0.7089999914169312},{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.5389999747276306},{"id":"https://openalex.org/keywords/plasma-enzymes","display_name":"plasma enzymes","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C2779591629","wikidata":"https://www.wikidata.org/wiki/Q24745328","display_name":"Bradykinin","level":3,"score":0.8938036561012268},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.682244062423706},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.6801101565361023},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.647363543510437},{"id":"https://openalex.org/C2776246183","wikidata":"https://www.wikidata.org/wiki/Q421924","display_name":"Kinin","level":4,"score":0.5941976308822632},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.5862103700637817},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5447479486465454},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5233815908432007},{"id":"https://openalex.org/C2777261171","wikidata":"https://www.wikidata.org/wiki/Q418750","display_name":"Esterase","level":3,"score":0.46082910895347595},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.4540759027004242},{"id":"https://openalex.org/C2777788586","wikidata":"https://www.wikidata.org/wiki/Q2096745","display_name":"Hereditary angioedema","level":2,"score":0.4499571621417999},{"id":"https://openalex.org/C2779121184","wikidata":"https://www.wikidata.org/wiki/Q1166142","display_name":"Erythema","level":2,"score":0.41774576902389526},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36890313029289246},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34109342098236084},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3308652639389038},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2617484927177429},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2537382245063782},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16631421446800232},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000799","descriptor_name":"Angioedema","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000799","descriptor_name":"Angioedema","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000799","descriptor_name":"Angioedema","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004950","descriptor_name":"Esterases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010452","descriptor_name":"Peptide Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci106022","doi":"https://doi.org/10.1172/jci106022","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci106022","pdf_url":"http://www.jci.org/articles/view/106022/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:322269","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/322269","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:5813121","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5813121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci106022","doi":"https://doi.org/10.1172/jci106022","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci106022","pdf_url":"http://www.jci.org/articles/view/106022/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320306493","display_name":"Abbott Laboratories","ror":"https://ror.org/0052svj16"},{"id":"https://openalex.org/F4320309475","display_name":"Northwestern University","ror":"https://ror.org/000e0be47"},{"id":"https://openalex.org/F4320309680","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83"},{"id":"https://openalex.org/F4320310281","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1509856372.pdf","grobid_xml":"https://content.openalex.org/works/W1509856372.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W178665079","https://openalex.org/W199362828","https://openalex.org/W222515578","https://openalex.org/W1497280552","https://openalex.org/W1522956225","https://openalex.org/W1613268704","https://openalex.org/W1628159879","https://openalex.org/W1912649770","https://openalex.org/W1938281021","https://openalex.org/W1952779275","https://openalex.org/W1964899349","https://openalex.org/W1967446411","https://openalex.org/W1971501265","https://openalex.org/W1978451044","https://openalex.org/W1991473086","https://openalex.org/W1999035016","https://openalex.org/W2008162901","https://openalex.org/W2010175077","https://openalex.org/W2013023407","https://openalex.org/W2051880735","https://openalex.org/W2056406773","https://openalex.org/W2066179164","https://openalex.org/W2068579363","https://openalex.org/W2070927293","https://openalex.org/W2081371249","https://openalex.org/W2086085225","https://openalex.org/W2087926948","https://openalex.org/W2102613564","https://openalex.org/W2160274908","https://openalex.org/W2160746542","https://openalex.org/W2222427183","https://openalex.org/W2258208993","https://openalex.org/W2297358582","https://openalex.org/W2314231620","https://openalex.org/W2321234878","https://openalex.org/W2324225876","https://openalex.org/W2337219537","https://openalex.org/W2341799587","https://openalex.org/W2397523915","https://openalex.org/W2409126026","https://openalex.org/W2409788788","https://openalex.org/W2411375359","https://openalex.org/W2418670398"],"related_works":["https://openalex.org/W1624971945","https://openalex.org/W2075082475","https://openalex.org/W1992443159","https://openalex.org/W1912649770","https://openalex.org/W1978451044","https://openalex.org/W2068579363","https://openalex.org/W2471471983","https://openalex.org/W2095237202","https://openalex.org/W1497280552","https://openalex.org/W2002380239"],"abstract_inverted_index":{"Plasma":[0],"from":[1,68,72,97],"persons":[2],"with":[3,46,147],"hereditary":[4,125],"angioneurotic":[5,126],"edema":[6,127],"readily":[7],"developed":[8],"the":[9,18,40,77,92,109,113,118,157],"capacity":[10],"to":[11,16,22,51,116,155],"increase":[12],"vascular":[13,60],"permeability":[14,61,119],"and":[15,54,86,121],"induce":[17],"isolated":[19],"rat":[20],"uterus":[21],"contract.":[23],"Both":[24],"activities":[25,110,123],"resided":[26],"in":[27,62,108,124,145,151],"a":[28,35],"small,":[29],"heat-stable":[30],"molecule":[31],"that":[32,91],"was":[33],"apparently":[34],"polypeptide.":[36],"Crude":[37],"preparations":[38,75],"of":[39,70,76],"polypeptide":[41,78,93,158],"were":[42,129],"inactivated":[43],"during":[44],"incubation":[45],"trypsin.":[47],"They":[48],"also":[49,80],"failed":[50],"produce":[52],"pain":[53],"erythema,":[55],"but":[56],"caused":[57],"markedly":[58],"increased":[59],"human":[63],"skin.":[64],"These":[65],"characteristics":[66],"differ":[67],"those":[69],"bradykinin,":[71],"which":[73],"crude":[74],"could":[79],"be":[81],"distinguished":[82],"by":[83],"electrophoretic":[84],"mobility":[85],"paper":[87],"chromatographic":[88],"behavior.":[89],"Proof":[90],"is":[94],"truly":[95],"different":[96],"bradykinin":[98],"must":[99],"await":[100],"its":[101],"further":[102],"purification.":[103],"Histamine":[104],"played":[105],"no":[106],"role":[107],"observed.":[111],"Although":[112],"enzymes":[114,137],"functioning":[115],"release":[117,156],"factor":[120],"kinin":[122],"plasma":[128,136],"not":[130],"clearly":[131],"defined,":[132],"one":[133],"or":[134,150],"more":[135],"other":[138],"than":[139],"C'1":[140,148],"esterase":[141,149],"presumably":[142],"participated":[143],"either":[144],"conjunction":[146],"pari":[152],"passu":[153],"events":[154],"mediating":[159],"these":[160],"activities.":[161]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
