{"id":"https://openalex.org/W1509815229","doi":"https://doi.org/10.4049/jimmunol.148.11.3405","title":"Characterization and sequencing of a 40-amino-acid peptide from human thyroglobulin inducing experimental autoimmune thyroiditis","display_name":"Characterization and sequencing of a 40-amino-acid peptide from human thyroglobulin inducing experimental autoimmune thyroiditis","publication_year":1992,"publication_date":"1992-06-01","ids":{"openalex":"https://openalex.org/W1509815229","doi":"https://doi.org/10.4049/jimmunol.148.11.3405","mag":"1509815229","pmid":"https://pubmed.ncbi.nlm.nih.gov/1588039"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.148.11.3405","doi":"https://doi.org/10.4049/jimmunol.148.11.3405","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.148.11.3405","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080514577","display_name":"B. Texier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B Texier","raw_affiliation_strings":["INSERM U. 283, H\u00f4pital Cochin , Paris,","INSERM U. 283, H\u00f4pital Cochin, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U. 283, H\u00f4pital Cochin , Paris,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210092774"]},{"raw_affiliation_string":"INSERM U. 283, H\u00f4pital Cochin, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210092774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014046009","display_name":"Catherine Bedin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C B\u00e9din","raw_affiliation_strings":["INSERM U. 283, H\u00f4pital Cochin , Paris,","INSERM U. 283, H\u00f4pital Cochin, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U. 283, H\u00f4pital Cochin , Paris,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210092774"]},{"raw_affiliation_string":"INSERM U. 283, H\u00f4pital Cochin, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210092774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108107887","display_name":"Ha\u00efwen Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"H Tang","raw_affiliation_strings":["INSERM U. 283, H\u00f4pital Cochin , Paris,","INSERM U. 283, H\u00f4pital Cochin, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U. 283, H\u00f4pital Cochin , Paris,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210092774"]},{"raw_affiliation_string":"INSERM U. 283, H\u00f4pital Cochin, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210092774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021912565","display_name":"Luc Camoin","orcid":"https://orcid.org/0000-0002-1230-4787","observed_orcids":["https://orcid.org/0000-0002-1230-4787"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"L Camoin","raw_affiliation_strings":["INSERM U. 283, H\u00f4pital Cochin , Paris,","INSERM U. 283, H\u00f4pital Cochin, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U. 283, H\u00f4pital Cochin , Paris,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210092774"]},{"raw_affiliation_string":"INSERM U. 283, H\u00f4pital Cochin, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210092774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054185948","display_name":"Christine Laurent\u2010Winter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C Laurent-Winter","raw_affiliation_strings":["INSERM U. 283, H\u00f4pital Cochin , Paris,","INSERM U. 283, H\u00f4pital Cochin, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U. 283, H\u00f4pital Cochin , Paris,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210092774"]},{"raw_affiliation_string":"INSERM U. 283, H\u00f4pital Cochin, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210092774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110189013","display_name":"J Charreire","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J Charreire","raw_affiliation_strings":["INSERM U. 283, H\u00f4pital Cochin , Paris,","INSERM U. 283, H\u00f4pital Cochin, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U. 283, H\u00f4pital Cochin , Paris,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210092774"]},{"raw_affiliation_string":"INSERM U. 283, H\u00f4pital Cochin, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210092774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":3.44,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.92308416,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"148","issue":"11","first_page":"3405","last_page":"3411"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.725600004196167,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.725600004196167,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.12409999966621399,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.03920000046491623,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroglobulin","display_name":"thyroglobulin","score":0.8629999756813049},{"id":"https://openalex.org/keywords/experimental-autoimmune-thyroiditis","display_name":"experimental autoimmune thyroiditis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/autoantigens","display_name":"autoantigens","score":0.5339999794960022},{"id":"https://openalex.org/keywords/porcine-thyroglobulin","display_name":"porcine thyroglobulin","score":0.8479999899864197},{"id":"https://openalex.org/keywords/tryptic-fragments","display_name":"tryptic fragments","score":0.8009999990463257},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.8109999895095825},{"id":"https://openalex.org/keywords/peptide-immunization","display_name":"peptide immunization","score":0.6970000267028809},{"id":"https://openalex.org/keywords/hydrophobic-peptides","display_name":"hydrophobic peptides","score":0.675000011920929},{"id":"https://openalex.org/keywords/sequence-homology","display_name":"sequence homology","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C2778835679","wikidata":"https://www.wikidata.org/wiki/Q412228","display_name":"Thyroglobulin","level":3,"score":0.8401914834976196},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.6780216097831726},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.669489324092865},{"id":"https://openalex.org/C2776362883","wikidata":"https://www.wikidata.org/wiki/Q187842","display_name":"Autoimmune thyroiditis","level":4,"score":0.6513110995292664},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.5550636053085327},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.555057942867279},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.48372963070869446},{"id":"https://openalex.org/C2778696486","wikidata":"https://www.wikidata.org/wiki/Q11835644","display_name":"Thyroiditis","level":3,"score":0.4618816077709198},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.4602230191230774},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.4495497941970825},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4387643039226532},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41883525252342224},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4006536602973938},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38995257019996643},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2838250398635864},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1882997751235962},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008808","descriptor_name":"Mice, Inbred CBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013954","descriptor_name":"Thyroglobulin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013954","descriptor_name":"Thyroglobulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013967","descriptor_name":"Thyroiditis, Autoimmune","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013967","descriptor_name":"Thyroiditis, Autoimmune","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.148.11.3405","doi":"https://doi.org/10.4049/jimmunol.148.11.3405","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.148.11.3405","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:1588039","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1588039","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2134795974","https://openalex.org/W2005768107","https://openalex.org/W2138590651","https://openalex.org/W1994916615","https://openalex.org/W2141377520","https://openalex.org/W2024127159","https://openalex.org/W1608755119","https://openalex.org/W2058726650","https://openalex.org/W7097643069","https://openalex.org/W1992929292"],"abstract_inverted_index":{"We":[0],"previously":[1],"demonstrated":[2],"that:":[3],"a)":[4],"a":[5,104,109,118,127,213,236],"cytotoxic":[6],"T":[7],"cell":[8],"hybridoma":[9],"(HTC2)":[10],"was":[11,78,141,153],"able":[12,142],"to":[13,89,125,133,143,171,174,188,233],"induce":[14],"lysis":[15],"of":[16,59,67,99,111,117,121,136,215,224,227],"syngeneic":[17],"macrophages":[18],"pulsed":[19],"with":[20,108,182],"either":[21],"porcine":[22],"thyroglobulin":[23,113,229],"(pTg)":[24],"or":[25,92,167,173],"the":[26,64,68,81,100,154,159,165,205,222,225,228,240],"tryptic":[27],"fragments":[28],"(TF)":[29],"from":[30,71,196,239],"pTg":[31,43,72,122,156,166,172],"less":[32,73],"than":[33,74],"10":[34,75],"kDa":[35,76],"(M(r))":[36],"and":[37,80,231],"that":[38,134],"b)":[39],"these":[40],"low":[41],"M(r)":[42,77,214],"TF":[44,69],"included":[45],"pathogenic":[46],"epitopes":[47],"because":[48],"their":[49,87],"injection":[50],"into":[51],"CBA/J":[52,148],"mice":[53,149,180,197],"induces":[54],"thyroid":[55,150],"lymphocytic":[56,145,160],"infiltration":[57],"typical":[58],"experimental":[60,244],"autoimmune":[61,245],"thyroiditis.":[62,246],"Therefore":[63],"biochemical":[65],"analysis":[66],"preparation":[70],"undertaken":[79],"characterized":[82],"peptides":[83,102],"were":[84,162,176,191],"tested":[85],"for":[86],"ability":[88],"be":[90],"recognized":[91],"not":[93],"by":[94,204],"HTC2":[95],"cells.":[96],"The":[97,115],"sequencing":[98],"selected":[101],"showed":[103],"70%":[105],"sequence":[106,120,238],"homology":[107],"portion":[110,135],"human":[112],"(hTg).":[114],"lack":[116],"published":[119],"led":[123],"us":[124],"synthesize":[126],"40-amino":[128],"acid":[129],"peptide":[130,140,190,211],"(F40D)":[131],"similar":[132,163],"hTg.":[137],"This":[138,208],"F40D":[139,189,206],"generate":[144],"infiltrations":[146,161],"in":[147,164,179,194,198],"glands,":[151],"as":[152],"native":[155],"molecule.":[157],"Although":[158],"F40D-immunized":[168],"mice,":[169],"auto-antibodies":[170],"hTg":[175,241],"only":[177],"detectable":[178],"immunized":[181],"pTg.":[183],"In":[184],"contrast,":[185],"autoantibodies":[186],"levels":[187],"significantly":[192],"increased":[193],"serum":[195],"which":[199],"EAT":[200],"had":[201],"been":[202],"induced":[203],"peptide.":[207],"highly":[209],"hydrophobic":[210],"shows":[212],"4,492":[216],"kDa;":[217],"it":[218],"is":[219],"located":[220],"at":[221],"end":[223],"second-third":[226],"molecule":[230,242],"up":[232],"now":[234],"represents":[235],"unique":[237],"inducing":[243]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
