{"id":"https://openalex.org/W1509604932","doi":"https://doi.org/10.3233/jad-2014-132057","title":"A New Paradigm for the Treatment of Alzheimer's Disease: Targeting Vascular Activation","display_name":"A New Paradigm for the Treatment of Alzheimer's Disease: Targeting Vascular Activation","publication_year":2014,"publication_date":"2014-04-23","ids":{"openalex":"https://openalex.org/W1509604932","doi":"https://doi.org/10.3233/jad-2014-132057","mag":"1509604932","pmid":"https://pubmed.ncbi.nlm.nih.gov/24503617"},"language":"en","primary_location":{"id":"doi:10.3233/jad-2014-132057","doi":"https://doi.org/10.3233/jad-2014-132057","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-2014-132057","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088789109","display_name":"Paula Grammas","orcid":"https://orcid.org/0000-0002-2636-3550","observed_orcids":["https://orcid.org/0000-0002-2636-3550"]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paula Grammas","raw_affiliation_strings":["Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX, USA","Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA","Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX, USA","institution_ids":["https://openalex.org/I926076166"]},{"raw_affiliation_string":"Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA","institution_ids":["https://openalex.org/I926076166"]},{"raw_affiliation_string":"Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX, USA","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024330134","display_name":"Joseph M. Martinez","orcid":"https://orcid.org/0000-0001-9024-4209","observed_orcids":["https://orcid.org/0000-0001-9024-4209"]},"institutions":[{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Martinez","raw_affiliation_strings":["Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA","institution_ids":["https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002612394","display_name":"Alma C. Sanchez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alma Sanchez","raw_affiliation_strings":["Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA","institution_ids":["https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091297684","display_name":"Xiangling Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiangling Yin","raw_affiliation_strings":["Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA","institution_ids":["https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084450707","display_name":"Jarred Riley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jarred Riley","raw_affiliation_strings":["Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA","institution_ids":["https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111465125","display_name":"Dylan Gay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dylan Gay","raw_affiliation_strings":["Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA","institution_ids":["https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068231235","display_name":"Katherine Desobry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Desobry","raw_affiliation_strings":["Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA","institution_ids":["https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023711354","display_name":"Debjani Tripathy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debjani Tripathy","raw_affiliation_strings":["Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA","institution_ids":["https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101040613","display_name":"Jinhua Luo","orcid":"https://orcid.org/0000-0003-0796-186X","observed_orcids":["https://orcid.org/0000-0003-0796-186X"]},"institutions":[{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinhua Luo","raw_affiliation_strings":["Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA","institution_ids":["https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014308363","display_name":"Marianne Evola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marianne Evola","raw_affiliation_strings":["Texas Tech University Office of the Vice President for Research, Lubbock, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Tech University Office of the Vice President for Research, Lubbock, TX, USA","institution_ids":["https://openalex.org/I12315562"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049960946","display_name":"Alice M. Young","orcid":"https://orcid.org/0000-0002-0077-137X","observed_orcids":["https://orcid.org/0000-0002-0077-137X"]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alice Young","raw_affiliation_strings":["Texas Tech University Office of the Vice President for Research, Lubbock, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Tech University Office of the Vice President for Research, Lubbock, TX, USA","institution_ids":["https://openalex.org/I12315562"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088789109"],"corresponding_institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"],"apc_list":null,"apc_paid":null,"fwci":5.3157,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.95915954,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"40","issue":"3","first_page":"619","last_page":"630"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/vascular-activation","display_name":"vascular activation","score":0.8820000290870667}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7840080261230469},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6172186136245728},{"id":"https://openalex.org/C2779490328","wikidata":"https://www.wikidata.org/wiki/Q417542","display_name":"Sunitinib","level":3,"score":0.5520690083503723},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5150689482688904},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.476149320602417},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4156486988067627},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40607258677482605},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3773029148578644},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.340676486492157},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29322755336761475},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2235700488090515},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20898762345314026},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1853194534778595},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.14953842759132385},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077210","descriptor_name":"Sunitinib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000933","descriptor_name":"Antifibrinolytic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001362","descriptor_name":"Avoidance Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001362","descriptor_name":"Avoidance Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001808","descriptor_name":"Blood Vessels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011930","descriptor_name":"Reaction Time","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011930","descriptor_name":"Reaction Time","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D024483","descriptor_name":"Vitamin K 3","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3233/jad-2014-132057","doi":"https://doi.org/10.3233/jad-2014-132057","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-2014-132057","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},{"id":"pmid:24503617","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24503617","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's disease : JAD","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7900000214576721,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G253186564","display_name":null,"funder_award_id":"AG-020569","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3114311027","display_name":null,"funder_award_id":"AG028367","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4128411614","display_name":"Vascular inflammation and neurotoxicity in aging brain","funder_award_id":"R01AG028367","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5172100271","display_name":"Is There a Link Between Alzheimer's and Atheroclerosis","funder_award_id":"R01AG020569","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W31917496","https://openalex.org/W197140406","https://openalex.org/W1562276199","https://openalex.org/W1615217034","https://openalex.org/W1967375871","https://openalex.org/W1973276273","https://openalex.org/W1977960636","https://openalex.org/W1980748384","https://openalex.org/W1983349802","https://openalex.org/W1986968958","https://openalex.org/W1994259160","https://openalex.org/W1994491528","https://openalex.org/W2005204638","https://openalex.org/W2013818100","https://openalex.org/W2017020667","https://openalex.org/W2025944561","https://openalex.org/W2036661577","https://openalex.org/W2037904566","https://openalex.org/W2042902316","https://openalex.org/W2047704857","https://openalex.org/W2050737600","https://openalex.org/W2057042201","https://openalex.org/W2075564007","https://openalex.org/W2083448891","https://openalex.org/W2084675121","https://openalex.org/W2086336187","https://openalex.org/W2091976642","https://openalex.org/W2096410114","https://openalex.org/W2102493638","https://openalex.org/W2105503070","https://openalex.org/W2127799354","https://openalex.org/W2140131793","https://openalex.org/W2146417688","https://openalex.org/W2149450071","https://openalex.org/W2153484787","https://openalex.org/W2157665412","https://openalex.org/W2159442683","https://openalex.org/W2165503155","https://openalex.org/W2165596981","https://openalex.org/W2599367511"],"related_works":["https://openalex.org/W2313835379","https://openalex.org/W3157274197","https://openalex.org/W2165329538","https://openalex.org/W2054909426","https://openalex.org/W7038534428","https://openalex.org/W71878406","https://openalex.org/W2045219086","https://openalex.org/W196329826","https://openalex.org/W4406051005","https://openalex.org/W3131931076"],"abstract_inverted_index":{"No":[0],"disease-modifying":[1],"therapies":[2],"are":[3,30,202],"currently":[4],"available":[5],"for":[6,59,228],"Alzheimer's":[7],"disease":[8],"(AD),":[9],"a":[10,66,210],"neurodegenerative":[11],"disorder":[12],"that":[13,98],"affects":[14],"more":[15],"than":[16],"36":[17],"million":[18],"people":[19],"worldwide.":[20],"Although":[21],"cardiovascular":[22],"risk":[23],"factors":[24,44],"such":[25],"as":[26,33,65,140,173,175,209],"hypertension":[27],"and":[28,84,108,120,198],"diabetes":[29],"increasingly":[31],"implicated":[32],"contributing":[34],"to":[35,224],"the":[36,40,49,60,90,104,229],"development":[37],"of":[38,126,132,154,163,187,206,231],"AD,":[39,183],"mechanisms":[41,189],"whereby":[42],"these":[43,133],"influence":[45],"pathological":[46],"processes":[47],"in":[48,69,76,99,146,158,161,181,190,218],"AD":[50,70,79,101,148,191,196],"brain":[51,155],"have":[52],"not":[53],"been":[54],"defined.":[55],"Here":[56],"we":[57],"propose,":[58],"first":[61],"time,":[62],"vascular":[63,91,130],"activation":[64,92,180],"relevant":[67],"mechanism":[68],"pathogenesis.":[71,192],"We":[72],"explore":[73],"this":[74,219,232],"hypothesis":[75],"two":[77],"transgenic":[78],"animal":[80,102,149],"models:":[81],"AD2576APPSwe":[82],"(AD2576)":[83],"LaFerla":[85],"3xTg":[86],"(3xTgAD)":[87],"mice":[88],"using":[89],"inhibitor":[93],"sunitinib.":[94,169],"Our":[95],"data":[96],"show":[97],"both":[100,147],"models,":[103],"cerebrovasculature":[105],"is":[106,166],"activated":[107],"overexpresses":[109],"amyloid":[110],"beta,":[111,118],"thrombin,":[112],"tumor":[113],"necrosis":[114],"factor":[115],"alpha,":[116],"interleukin-1":[117],"interleukin-6,":[119],"matrix":[121],"metalloproteinase":[122],"9.":[123],"Oral":[124],"administration":[125],"sunitinib":[127,136],"significantly":[128],"reduces":[129],"expression":[131,162],"proteins.":[134],"Furthermore,":[135],"improves":[137],"cognitive":[138],"function,":[139],"assessed":[141],"by":[142,168],"several":[143],"behavioral":[144],"paradigms,":[145],"models.":[150],"Finally,":[151],"oxidant":[152],"injury":[153],"endothelial":[156],"cells":[157],"culture,":[159],"resulting":[160],"inflammatory":[164],"proteins,":[165],"mitigated":[167],"The":[170],"current":[171],"data,":[172],"well":[174],"published":[176],"studies":[177],"showing":[178],"cerebrovascular":[179],"human":[182],"support":[184],"further":[185],"exploration":[186],"vascular-based":[188],"New":[193],"thinking":[194],"about":[195],"pathogenesis":[197],"novel,":[199],"effective":[200],"treatments":[201],"urgently":[203],"needed.":[204],"Identification":[205],"\"vascular":[207],"activation\"":[208],"heretofore":[211],"unexplored":[212],"target":[213],"could":[214],"stimulate":[215],"translational":[216],"investigations":[217],"newly":[220],"defined":[221],"area,":[222],"leading":[223],"innovative":[225],"therapeutic":[226],"approaches":[227],"treatment":[230],"devastating":[233],"disease.":[234]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
