{"id":"https://openalex.org/W1509595387","doi":"https://doi.org/10.1111/j.1532-5415.2008.02122.x","title":"Systematic Review of Measures of Clinical Significance Employed in Randomized Controlled Trials of Drugs for Dementia","display_name":"Systematic Review of Measures of Clinical Significance Employed in Randomized Controlled Trials of Drugs for Dementia","publication_year":2009,"publication_date":"2009-01-31","ids":{"openalex":"https://openalex.org/W1509595387","doi":"https://doi.org/10.1111/j.1532-5415.2008.02122.x","mag":"1509595387","pmid":"https://pubmed.ncbi.nlm.nih.gov/19187414"},"language":"en","primary_location":{"id":"doi:10.1111/j.1532-5415.2008.02122.x","doi":"https://doi.org/10.1111/j.1532-5415.2008.02122.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1532-5415.2008.02122.x","pdf_url":null,"source":{"id":"https://openalex.org/S204183829","display_name":"Journal of the American Geriatrics Society","issn_l":"0002-8614","issn":["0002-8614","1532-5415"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Geriatrics Society","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027169145","display_name":"Frank Molnar","orcid":"https://orcid.org/0000-0001-5798-0159","observed_orcids":["https://orcid.org/0000-0001-5798-0159","https://orcid.org/0000-0002-5262-4865"]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I4210145570","display_name":"Bruy\u00e8re","ror":"https://ror.org/05bznkw77","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210145570"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Frank J. Molnar","raw_affiliation_strings":["Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada","From the\n*Clinical Epidemiology Program, Ottawa, Health Research Institute\u2021Division of Geriatric Medicine, Department of Internal Medcine","University of Ottawa\n\t\t\t\t\t\t\u2225Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada\u2020\u00c9lisabeth-Bruy\u00e8re Research Institute, Ottawa, Ontario, Canada","\u00a7Clinical Trials Research Group, Biomedical Ethics Unit, McGill University, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"From the\n*Clinical Epidemiology Program, Ottawa, Health Research Institute\u2021Division of Geriatric Medicine, Department of Internal Medcine","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"University of Ottawa\n\t\t\t\t\t\t\u2225Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada\u2020\u00c9lisabeth-Bruy\u00e8re Research Institute, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931","https://openalex.org/I4210145570"]},{"raw_affiliation_string":"\u00a7Clinical Trials Research Group, Biomedical Ethics Unit, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091717122","display_name":"Malcolm Man\u2010Son\u2010Hing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I4210145570","display_name":"Bruy\u00e8re","ror":"https://ror.org/05bznkw77","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210145570"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Malcolm Man\u2010Son\u2010Hing","raw_affiliation_strings":["From the\n*Clinical Epidemiology Program, Ottawa, Health Research Institute\u2021Division of Geriatric Medicine, Department of Internal Medcine; University of Ottawa\n\t\t\t\t\t\t\u2225Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada\u2020E\u0301lisabeth-Bruye\u0300re Research Institute, Ottawa, Ontario, Canada; and\n\t\t\t\t\t\t\u00a7Clinical Trials Research Group, Biomedical Ethics Unit, McGill University, Montreal, Quebec, Canada","From the\n*Clinical Epidemiology Program, Ottawa, Health Research Institute\u2021Division of Geriatric Medicine, Department of Internal Medcine","University of Ottawa\n\t\t\t\t\t\t\u2225Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada\u2020\u00c9lisabeth-Bruy\u00e8re Research Institute, Ottawa, Ontario, Canada","\u00a7Clinical Trials Research Group, Biomedical Ethics Unit, McGill University, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the\n*Clinical Epidemiology Program, Ottawa, Health Research Institute\u2021Division of Geriatric Medicine, Department of Internal Medcine; University of Ottawa\n\t\t\t\t\t\t\u2225Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada\u2020E\u0301lisabeth-Bruye\u0300re Research Institute, Ottawa, Ontario, Canada; and\n\t\t\t\t\t\t\u00a7Clinical Trials Research Group, Biomedical Ethics Unit, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I153718931","https://openalex.org/I5023651"]},{"raw_affiliation_string":"From the\n*Clinical Epidemiology Program, Ottawa, Health Research Institute\u2021Division of Geriatric Medicine, Department of Internal Medcine","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"University of Ottawa\n\t\t\t\t\t\t\u2225Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada\u2020\u00c9lisabeth-Bruy\u00e8re Research Institute, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931","https://openalex.org/I4210145570"]},{"raw_affiliation_string":"\u00a7Clinical Trials Research Group, Biomedical Ethics Unit, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065187538","display_name":"Dean A. Fergusson","orcid":"https://orcid.org/0000-0002-3389-2485","observed_orcids":["https://orcid.org/0000-0002-3389-2485"]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I4210145570","display_name":"Bruy\u00e8re","ror":"https://ror.org/05bznkw77","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210145570"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Dean Fergusson","raw_affiliation_strings":["From the\n*Clinical Epidemiology Program, Ottawa, Health Research Institute\u2021Division of Geriatric Medicine, Department of Internal Medcine; University of Ottawa\n\t\t\t\t\t\t\u2225Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada\u2020E\u0301lisabeth-Bruye\u0300re Research Institute, Ottawa, Ontario, Canada; and\n\t\t\t\t\t\t\u00a7Clinical Trials Research Group, Biomedical Ethics Unit, McGill University, Montreal, Quebec, Canada","From the\n*Clinical Epidemiology Program, Ottawa, Health Research Institute\u2021Division of Geriatric Medicine, Department of Internal Medcine","University of Ottawa\n\t\t\t\t\t\t\u2225Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada\u2020\u00c9lisabeth-Bruy\u00e8re Research Institute, Ottawa, Ontario, Canada","\u00a7Clinical Trials Research Group, Biomedical Ethics Unit, McGill University, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the\n*Clinical Epidemiology Program, Ottawa, Health Research Institute\u2021Division of Geriatric Medicine, Department of Internal Medcine; University of Ottawa\n\t\t\t\t\t\t\u2225Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada\u2020E\u0301lisabeth-Bruye\u0300re Research Institute, Ottawa, Ontario, Canada; and\n\t\t\t\t\t\t\u00a7Clinical Trials Research Group, Biomedical Ethics Unit, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I153718931","https://openalex.org/I5023651"]},{"raw_affiliation_string":"From the\n*Clinical Epidemiology Program, Ottawa, Health Research Institute\u2021Division of Geriatric Medicine, Department of Internal Medcine","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"University of Ottawa\n\t\t\t\t\t\t\u2225Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada\u2020\u00c9lisabeth-Bruy\u00e8re Research Institute, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931","https://openalex.org/I4210145570"]},{"raw_affiliation_string":"\u00a7Clinical Trials Research Group, Biomedical Ethics Unit, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4760,"currency":"USD","value_usd":4760},"apc_paid":null,"fwci":1.3535,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.73898305,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"57","issue":"3","first_page":"536","last_page":"546"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.5619999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.5619999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.263700008392334,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.06650000065565109,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clinical-significance","display_name":"clinical significance","score":0.9150000214576721},{"id":"https://openalex.org/keywords/minimal-clinically-important-difference","display_name":"minimal clinically important difference","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cholinesterase-inhibitors","display_name":"cholinesterase inhibitors","score":0.9020000100135803},{"id":"https://openalex.org/keywords/memantine","display_name":"memantine","score":1.0},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9919999837875366},{"id":"https://openalex.org/keywords/vascular-dementia","display_name":"vascular dementia","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mixed-dementia","display_name":"mixed dementia","score":0.8220000267028809},{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":1.0},{"id":"https://openalex.org/keywords/outcome-measures","display_name":"outcome measures","score":0.7820000052452087},{"id":"https://openalex.org/keywords/patient-perspectives","display_name":"patient perspectives","score":0.6439999938011169},{"id":"https://openalex.org/keywords/informed-consent","display_name":"informed consent","score":0.8209999799728394},{"id":"https://openalex.org/keywords/sample-size-calculation","display_name":"sample size determination","score":0.6809999942779541},{"id":"https://openalex.org/keywords/consort","display_name":"CONSORT","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8372673988342285},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.74456787109375},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.7192758321762085},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6551192402839661},{"id":"https://openalex.org/C2779484449","wikidata":"https://www.wikidata.org/wiki/Q412189","display_name":"Memantine","level":4,"score":0.5483803749084473},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.544907808303833},{"id":"https://openalex.org/C502991105","wikidata":"https://www.wikidata.org/wiki/Q5133849","display_name":"Clinical research","level":2,"score":0.4377070665359497},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4355927109718323},{"id":"https://openalex.org/C2777952318","wikidata":"https://www.wikidata.org/wiki/Q583908","display_name":"Vascular dementia","level":4,"score":0.4191463589668274},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.41001784801483154},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.377139151096344},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3744245171546936},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18759891390800476},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018697","descriptor_name":"Nootropic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018697","descriptor_name":"Nootropic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018697","descriptor_name":"Nootropic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018697","descriptor_name":"Nootropic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1532-5415.2008.02122.x","doi":"https://doi.org/10.1111/j.1532-5415.2008.02122.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1532-5415.2008.02122.x","pdf_url":null,"source":{"id":"https://openalex.org/S204183829","display_name":"Journal of the American Geriatrics Society","issn_l":"0002-8614","issn":["0002-8614","1532-5415"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Geriatrics Society","raw_type":"journal-article"},{"id":"pmid:19187414","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19187414","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Geriatrics Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1546179578","https://openalex.org/W1575078744","https://openalex.org/W1583848026","https://openalex.org/W1963583371","https://openalex.org/W1968557278","https://openalex.org/W1983870506","https://openalex.org/W1986215651","https://openalex.org/W1993480970","https://openalex.org/W1997886955","https://openalex.org/W2007237295","https://openalex.org/W2030079540","https://openalex.org/W2035910895","https://openalex.org/W2039534020","https://openalex.org/W2047095305","https://openalex.org/W2052011640","https://openalex.org/W2052091788","https://openalex.org/W2055298140","https://openalex.org/W2057679568","https://openalex.org/W2064887457","https://openalex.org/W2067457311","https://openalex.org/W2092356280","https://openalex.org/W2109464535","https://openalex.org/W2112899715","https://openalex.org/W2115455636","https://openalex.org/W2121579366","https://openalex.org/W2128767446","https://openalex.org/W2137646375","https://openalex.org/W2140517044","https://openalex.org/W2156220037","https://openalex.org/W2157407871","https://openalex.org/W2163186438","https://openalex.org/W2168891350","https://openalex.org/W2775750683","https://openalex.org/W3216169949","https://openalex.org/W7065317169"],"related_works":["https://openalex.org/W2965100217","https://openalex.org/W2393239188","https://openalex.org/W2394014176","https://openalex.org/W2014792393","https://openalex.org/W1988395535","https://openalex.org/W1767261720","https://openalex.org/W48976734","https://openalex.org/W2360149492","https://openalex.org/W3178684802","https://openalex.org/W2128478833"],"abstract_inverted_index":{"The":[0,156,180],"ability":[1],"to":[2,20,49,73,76,205,212,216,348,375],"define":[3],"thresholds":[4,198],"for":[5,57,63,82,199,279,311],"the":[6,22,34,39,70,141,150,169,206,260,280,296,315,318,352,377],"clinical":[7,45,58,102,151,162,185,200,221,228,247,293,356,368],"significance":[8,59,103,152,163,186,229,294,369],"(clinical":[9],"importance)":[10],"of":[11,42,101,116,122,153,161,182,184,208,227,246,282,292,295,317,324,355,365,367,379],"outcome":[12,25,325],"measures":[13,26,100,160,183,226,326,354,366],"in":[14,107,127,168,220,252,328,358,372],"dementia":[15,108,143,238,329,359],"drug":[16,64,109,144,239],"research":[17,253],"is":[18,47,242,370],"critical":[19],"determining":[21],"changes":[23,176],"on":[24,90,177,314,334],"that":[27,244],"patients":[28],"and":[29,36,81,92,125,136,175,211,224,235,268,274,350],"families":[30],"would":[31],"consider":[32,288,308,343],"worth":[33,37],"cost":[35],"risking":[38],"side":[40],"effects":[41],"medications":[43,86],"(i.e.,":[44],"importance":[46,248,357],"central":[48,204],"informed":[50],"consent":[51],"when":[52],"starting":[53],"such":[54,258,380],"medications).":[55],"Thresholds":[56],"are":[60,72,336],"also":[61],"required":[62],"trial":[65,209,218],"sample":[66],"size":[67],"calculation":[68],"(if":[69],"studies":[71],"be":[74,88,94],"powered":[75],"detect":[77],"clinically":[78,320],"important":[79,321],"difference)":[80],"decisions":[83,213],"regarding":[84,197,214],"whether":[85,215],"should":[87,93,287,307,342],"accepted":[89],"formularies":[91],"funded.":[95],"To":[96,300],"better":[97],"understand":[98],"what":[99],"have":[104,230],"been":[105,232],"employed":[106,327],"research,":[110],"a":[111,165,345,381],"systematic":[112],"review":[113,266,349],"was":[114],"performed":[115],"double-blind":[117],"randomized":[118],"controlled":[119],"trials":[120],"(RCTs)":[121],"cholinesterase":[123],"inhibitors":[124],"memantine":[126],"subjects":[128],"with":[129],"Alzheimer's":[130,170],"disease,":[131],"vascular":[132],"dementia,":[133,135],"mixed":[134],"mild":[137],"cognitive":[138],"impairment.":[139],"Of":[140],"57":[142],"RCTs":[145],"reviewed,":[146],"only":[147],"46%":[148],"discussed":[149],"their":[154],"results.":[155],"most":[157],"commonly":[158],"cited":[159],"were":[164,187],"4-point":[166],"change":[167],"Disease":[171],"Assessment":[172],"Scale--Cognitive":[173],"Subscale":[174],"global":[178],"scales.":[179],"majority":[181],"opinion":[188],"based.":[189],"Only":[190],"one":[191],"study":[192],"empirically":[193],"measured":[194],"patient":[195],"perspective":[196],"significance.":[201],"Despite":[202],"being":[203],"interpretation":[207],"results":[210],"employ":[217],"findings":[219],"practice,":[222],"patient-":[223],"caregiver-centered":[225],"not":[231],"adequately":[233],"studied":[234],"integrated":[236],"into":[237],"RCTs.":[240],"It":[241],"recommended":[243],"discussions":[245],"receive":[249],"greater":[250],"emphasis":[251],"standards":[254],"published":[255],"by":[256],"organizations":[257],"as":[259],"CONSORT":[261],"group":[262],"(http://www.consort-statement.org).":[263],"Drug":[264,275],"formulary":[265],"committees":[267],"licensing":[269],"agencies":[270,306,341],"(e.g.,":[271],"U.S.":[272],"Food":[273],"Administration,":[276],"European":[277],"Agency":[278],"Evaluation":[281],"Medicinal":[283],"Products,":[284],"Health":[285],"Canada)":[286],"requiring":[289],"an":[290],"assessment":[291],"drugs":[297],"they":[298],"review.":[299],"move":[301],"this":[302,373],"field":[303],"forward,":[304],"funding":[305,340],"initiating":[309],"requests":[310],"proposals":[312],"focused":[313],"determination":[316],"minimally":[319],"difference":[322],"(MCID)":[323],"research.":[330,360],"Once":[331],"empirical":[332],"data":[333],"MCIDs":[335],"available,":[337],"then":[338],"these":[339],"supporting":[344],"consensus":[346,382],"conference":[347],"select":[351],"optimal":[353],"A":[361],"preliminary":[362],"organizational":[363],"framework":[364],"presented":[371],"article":[374],"facilitate":[376],"work":[378],"forum.":[383]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}