{"id":"https://openalex.org/W1509546154","doi":null,"title":"Optimized conditions for chelation of yttrium-90-DOTA immunoconjugates.","display_name":"Optimized conditions for chelation of yttrium-90-DOTA immunoconjugates.","publication_year":1998,"publication_date":"1998-12-01","ids":{"openalex":"https://openalex.org/W1509546154","mag":"1509546154","pmid":"https://pubmed.ncbi.nlm.nih.gov/9867151"},"language":"en","primary_location":{"id":"pmid:9867151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9867151","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043106959","display_name":"David L. Kukis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D L Kukis","raw_affiliation_strings":["Department of Internal Medicine, University of California Davis Medical Center, Sacramento, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of California Davis Medical Center, Sacramento, USA","institution_ids":["https://openalex.org/I4210160527"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111607459","display_name":"Sally J. DeNardo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S J DeNardo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113460761","display_name":"Gerald L. DeNardo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G L DeNardo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046589665","display_name":"Robert T. O\u02bcDonnell","orcid":"https://orcid.org/0000-0002-7708-3700","observed_orcids":["https://orcid.org/0000-0002-7708-3700"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R T O'Donnell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084747504","display_name":"Claude F. Meares","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C F Meares","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.476,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.91039312,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"39","issue":"12","first_page":"2105","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13561","display_name":"Chemical Reactions and Isotopes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/yttrium-90","display_name":"yttrium-90","score":0.9769999980926514},{"id":"https://openalex.org/keywords/dota","display_name":"DOTA","score":0.7419999837875366},{"id":"https://openalex.org/keywords/immunoconjugates","display_name":"immunoconjugates","score":0.8610000014305115},{"id":"https://openalex.org/keywords/chelation-kinetics","display_name":"chelation kinetics","score":0.7739999890327454},{"id":"https://openalex.org/keywords/radioimmunotherapy","display_name":"radioimmunotherapy","score":0.7680000066757202},{"id":"https://openalex.org/keywords/ammonium-acetate-buffer","display_name":"ammonium acetate buffer","score":0.8619999885559082},{"id":"https://openalex.org/keywords/ph-effect","display_name":"pH effect","score":0.6069999933242798},{"id":"https://openalex.org/keywords/temperature-effects","display_name":"temperature effects","score":0.9559999704360962},{"id":"https://openalex.org/keywords/product-yield","display_name":"product yield","score":0.515999972820282},{"id":"https://openalex.org/keywords/radiopharmacy","display_name":"radiopharmacy","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C2779931791","wikidata":"https://www.wikidata.org/wiki/Q161515","display_name":"DOTA","level":3,"score":0.9471089243888855},{"id":"https://openalex.org/C2778556491","wikidata":"https://www.wikidata.org/wiki/Q1660173","display_name":"Immunoconjugate","level":4,"score":0.941912055015564},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8295570015907288},{"id":"https://openalex.org/C2776146153","wikidata":"https://www.wikidata.org/wiki/Q7281276","display_name":"Radioimmunotherapy","level":4,"score":0.7645372152328491},{"id":"https://openalex.org/C197404232","wikidata":"https://www.wikidata.org/wiki/Q319827","display_name":"Chelation","level":2,"score":0.7227393388748169},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.5328472256660461},{"id":"https://openalex.org/C531131001","wikidata":"https://www.wikidata.org/wiki/Q941","display_name":"Yttrium","level":3,"score":0.46374306082725525},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.4500919282436371},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.13959264755249023},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.13213545083999634},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10740435123443604},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C2779851234","wikidata":"https://www.wikidata.org/wiki/Q50690","display_name":"Oxide","level":2,"score":0.0},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002021","descriptor_name":"Buffers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006571","descriptor_name":"Heterocyclic Compounds","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D006571","descriptor_name":"Heterocyclic Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006573","descriptor_name":"Heterocyclic Compounds, 1-Ring","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007202","descriptor_name":"Indicators and Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015021","descriptor_name":"Yttrium Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016499","descriptor_name":"Radioimmunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9867151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9867151","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},{"id":"mag:1509546154","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9867151","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2149237283","display_name":"Translational Multimodality \" Antibody\" Therapy","funder_award_id":"P01CA047829","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1485533072","https://openalex.org/W1833904054","https://openalex.org/W1840723921","https://openalex.org/W1938266859","https://openalex.org/W2025758025","https://openalex.org/W2042369848","https://openalex.org/W2045844438","https://openalex.org/W2057058036","https://openalex.org/W2057995332","https://openalex.org/W2060519872","https://openalex.org/W2074580909","https://openalex.org/W2079554499","https://openalex.org/W2082574034","https://openalex.org/W2092172351","https://openalex.org/W2093329885","https://openalex.org/W2103260526","https://openalex.org/W2119037600","https://openalex.org/W2125589864","https://openalex.org/W2169216073","https://openalex.org/W2409871655","https://openalex.org/W2433586781","https://openalex.org/W2531174521"],"related_works":["https://openalex.org/W323366277","https://openalex.org/W2068853704","https://openalex.org/W2067073802","https://openalex.org/W2096254814","https://openalex.org/W2099087672","https://openalex.org/W2029086462","https://openalex.org/W2109581986","https://openalex.org/W2306849869","https://openalex.org/W1968102366","https://openalex.org/W2098947579"],"abstract_inverted_index":{"UNLABELLED:":[0],"Radioimmunotherapy":[1],"(RIT)":[2],"with":[3,21,56,132,140,155],"90Y-labeled":[4,281],"immunoconjugates":[5,29,58,282],"has":[6],"shown":[7],"promise":[8],"in":[9,82,85,99,128,182,296],"clinical":[10],"trials.":[11],"The":[12,76,112,260,278,286],"macrocyclic":[13],"chelating":[14],"agent":[15],"1,4,7,10-tetraazacyclododecane-N,N',N\",N\"'-tetraacetic":[16],"acid":[17],"(DOTA)":[18],"binds":[19],"90Y":[20,34,174,272,297],"extraordinary":[22],"stability,":[23],"minimizing":[24],"the":[25,69,156,162,167,203,216,302],"toxicity":[26],"of":[27,33,91,114,145,159,164,173,252,263,271,275,280,288,307],"90Y-DOTA":[28,39,57,289,308],"arising":[30],"from":[31,206],"loss":[32],"to":[35,59,68,102,170,210,257],"bone.":[36],"However,":[37],"reported":[38],"immunoconjugate":[40,77],"product":[41,248],"yields":[42,51],"have":[43],"been":[44],"typically":[45],"only":[46,196],"<":[47],"or":[48],"=50%.":[49],"Improved":[50],"are":[52],"needed":[53],"for":[54],"RIT":[55,298],"be":[60],"practical.":[61],"METHODS:":[62],"(S)":[63],"2-[p-(bromoacetamido)benzyl]-DOTA":[64],"(BAD)":[65],"was":[66,80,119,153,187,195,254,266,283],"conjugated":[67],"monoclonal":[70,276],"antibody":[71],"Lym-1":[72],"via":[73],"2-iminothiolane":[74],"(2IT).":[75],"product,":[78],"2IT-BAD-Lym-1,":[79],"labeled":[81],"excess":[83],"yttrium":[84],"various":[86],"buffers":[87,101],"over":[88],"a":[89,135,246],"range":[90],"concentrations":[92],"and":[93,126,134,235,304],"pH.":[94],"Kinetic":[95],"studies":[96],"were":[97,124,222],"performed":[98],"selected":[100],"estimate":[103],"radiolabeling":[104,122,130,220],"reaction":[105,117,204,226],"times":[106],"under":[107,177,243],"prospective":[108,178],"radiopharmacy":[109,179],"labeling":[110,180,241],"conditions.":[111],"effect":[113],"temperature":[115,205],"on":[116],"kinetics":[118],"examined.":[120],"Optimal":[121,219],"conditions":[123,181,221,291],"identified":[125,223],"used":[127],"eight":[129,240],"experiments":[131,242],"2IT-BAD-Lym-1":[133],"second":[136],"immunoconjugate,":[137],"DOTA-peptide-chimeric":[138],"L6,":[139],"248-492":[141],"MBq":[142,268],"(6.7-13.3":[143],"mCi)":[144,270],"90Y.":[146],"RESULTS:":[147],"Ammonium":[148],"acetate":[149,186,231],"buffer":[150],"(0.5":[151],"M)":[152],"associated":[154],"highest":[157],"uptake":[158],"yttrium.":[160],"On":[161],"basis":[163],"kinetic":[165],"data,":[166],"time":[168],"required":[169],"chelate":[171],"94%":[172],"(four":[175],"half-times)":[176],"0.5":[183,228],"M":[184,229],"ammonium":[185,230],"17-148":[188],"min":[189,198],"at":[190,199],"pH":[191,200,233],"6.5,":[192],"but":[193],"it":[194,300],"1-10":[197],"7.5.":[201],"Raising":[202],"25":[207],"degrees":[208,212,237],"C":[209,213],"37":[211,236],"markedly":[214],"increased":[215],"chelation":[217,290],"rate.":[218],"as:":[224],"30-min":[225],"time,":[227],"buffer,":[232],"7-7.5":[234],"C.":[238],"In":[239],"optimal":[244],"conditions,":[245],"mean":[247],"yield":[249],"(+/-":[250],"s.d.)":[251],"91%+/-8%":[253],"achieved,":[255],"comparable":[256],"iodination":[258],"yields.":[259],"specific":[261],"activity":[262],"final":[264],"products":[265],"74-130":[267],"(2.0-3.5":[269],"per":[273],"mg":[274],"antibody.":[277],"immunoreactivity":[279],"100%+/-11%.":[284],"CONCLUSION:":[285],"optimization":[287],"represents":[292],"an":[293],"important":[294],"advance":[295],"because":[299],"facilitates":[301],"dependable":[303],"cost-effective":[305],"preparation":[306],"pharmaceuticals.":[309]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
