{"id":"https://openalex.org/W1509529455","doi":"https://doi.org/10.4049/jimmunol.152.4.1888","title":"Acute inflammatory activity of the S100 protein CP-10. Activation of neutrophils in vivo and in vitro.","display_name":"Acute inflammatory activity of the S100 protein CP-10. Activation of neutrophils in vivo and in vitro.","publication_year":1994,"publication_date":"1994-02-01","ids":{"openalex":"https://openalex.org/W1509529455","doi":"https://doi.org/10.4049/jimmunol.152.4.1888","mag":"1509529455","pmid":"https://pubmed.ncbi.nlm.nih.gov/8120396"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.152.4.1888","doi":"https://doi.org/10.4049/jimmunol.152.4.1888","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.152.4.1888","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034905753","display_name":"Jannine M. Devery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801241159","display_name":"The Heart Research Institute","ror":"https://ror.org/046fa4y88","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801241159"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"J M Devery","raw_affiliation_strings":["The Immunology Group, Heart Research Institute , Camperdown","Immunology Group, Heart Research Institute, Camperdown, NSW Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Immunology Group, Heart Research Institute , Camperdown","institution_ids":["https://openalex.org/I2801241159"]},{"raw_affiliation_string":"Immunology Group, Heart Research Institute, Camperdown, NSW Australia","institution_ids":["https://openalex.org/I2801241159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021189214","display_name":"Nicholas J. C. King","orcid":"https://orcid.org/0000-0002-3877-9772","observed_orcids":["https://orcid.org/0000-0002-3877-9772"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2801241159","display_name":"The Heart Research Institute","ror":"https://ror.org/046fa4y88","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801241159"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"N J C King","raw_affiliation_strings":["Department of Pathology, Sydney University , Sydney ,","Immunology Group, Heart Research Institute, Camperdown, NSW Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Sydney University , Sydney ,","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"Immunology Group, Heart Research Institute, Camperdown, NSW Australia","institution_ids":["https://openalex.org/I2801241159"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027864103","display_name":"C L Geczy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801241159","display_name":"The Heart Research Institute","ror":"https://ror.org/046fa4y88","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801241159"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"C L Geczy","raw_affiliation_strings":["The Immunology Group, Heart Research Institute , Camperdown","Immunology Group, Heart Research Institute, Camperdown, NSW Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Immunology Group, Heart Research Institute , Camperdown","institution_ids":["https://openalex.org/I2801241159"]},{"raw_affiliation_string":"Immunology Group, Heart Research Institute, Camperdown, NSW Australia","institution_ids":["https://openalex.org/I2801241159"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.2739,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.78201748,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"152","issue":"4","first_page":"1888","last_page":"1897"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophil-activation","display_name":"neutrophil activation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/neutrophil-chemotaxis","display_name":"neutrophil chemotaxis","score":0.8849999904632568},{"id":"https://openalex.org/keywords/l-selectin","display_name":"L-selectin","score":0.7919999957084656},{"id":"https://openalex.org/keywords/neutrophil-adhesion","display_name":"neutrophil adhesion","score":0.7379999756813049},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.5509999990463257},{"id":"https://openalex.org/keywords/superoxide-production","display_name":"superoxide production","score":0.7149999737739563},{"id":"https://openalex.org/keywords/acute-inflammation","display_name":"acute inflammation","score":0.5080000162124634},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.48899999260902405},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.828000009059906},{"id":"https://openalex.org/keywords/chemotactic-peptide","display_name":"chemotactic peptide","score":0.609000027179718},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.7663512229919434},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.762939453125},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6213380694389343},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5927062034606934},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5666373372077942},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5321456789970398},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.416897714138031},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3012448251247406},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28746965527534485},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1317540407180786},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002630","descriptor_name":"Chemotactic Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009418","descriptor_name":"S100 Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D040501","descriptor_name":"Calgranulin A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.152.4.1888","doi":"https://doi.org/10.4049/jimmunol.152.4.1888","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.152.4.1888","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:8120396","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8120396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1608239929","https://openalex.org/W2089127153","https://openalex.org/W1950981769","https://openalex.org/W4241101873","https://openalex.org/W2157271860","https://openalex.org/W2034744996","https://openalex.org/W1968705250","https://openalex.org/W2059447844","https://openalex.org/W4229849139","https://openalex.org/W1880127774"],"abstract_inverted_index":{"The":[0,75,130,167],"murine":[1,15,88,137,154,176],"S100":[2],"chemotactic":[3,12,37,131,211],"protein":[4],"of":[5,24,42,66,81,86,92,99,105,113,133,169,191,209],"m.w.":[6],"10,000":[7],"termed":[8],"(CP-10),":[9],"has":[10],"potent":[11],"activity":[13,132],"for":[14,160],"and":[16,32,39,83,181],"human":[17,157],"myeloid":[18],"cells.":[19],"We":[20],"examined":[21,174],"the":[22,43,87,188,192,200,203,207],"ability":[23],"a":[25,210],"synthetic":[26],"CP-10":[27,71,93,114,134,149,170,202],"hinge":[28],"region":[29],"peptide":[30,72,94,115,135],"CP-10(42-55)":[31],"rCP-10":[33,67],"to":[34,59,122,184,206],"act":[35],"as":[36],"agents":[38],"induce":[40],"expression":[41],"adhesion":[44],"molecule":[45],"Mac-1":[46],"(CD":[47],"11b/CD":[48],"18)":[49],"in":[50,140,171],"vivo.":[51],"Maximal":[52],"neutrophil":[53],"(PMN)":[54],"accumulation":[55],"occurred":[56],"between":[57],"2":[58],"8":[60],"h":[61],"after":[62,110],"mouse":[63],"footpad":[64],"injection":[65,112],"(10(-7)":[68],"M)":[69],"or":[70,152,156,163],"(10(-6)":[73],"M).":[74],"infiltrating":[76],"PMN":[77,139],"expressed":[78,102],"high":[79,103],"levels":[80,85,104],"Mac-1,":[82],"low":[84],"L-selectin":[89],"Mel-14.":[90],"Injection":[91],"i.p.":[95,111],"also":[96,143],"induced":[97],"infiltration":[98],"PMNs":[100],"that":[101,199],"Mac-1.":[106],"Cell":[107],"suspensions":[108],"obtained":[109],"could":[116],"be":[117,185],"significantly":[118],"inhibited":[119,144],"from":[120],"adhering":[121],"fibrinogen-coated":[123],"plates":[124],"when":[125],"incubated":[126],"with":[127,179],"anti-Mac-1":[128,146],"antibody.":[129,147],"toward":[136],"inflammatory":[138,155],"vitro":[141],"was":[142,173,182],"by":[145],"Neither":[148],"analogue":[150],"stimulated":[151],"primed":[153],"blood":[158,194],"neutrophils":[159],"superoxide":[161],"production":[162],"granular":[164],"enzyme":[165],"release.":[166],"localization":[168],"vivo":[172],"using":[175],"footpads":[177],"injected":[178],"LPS":[180],"found":[183],"concentrated":[186],"around":[187],"endothelial":[189],"cells":[190],"small":[193],"vessels.":[195],"This":[196],"distribution":[197],"suggests":[198],"accumulated":[201],"may":[204],"contribute":[205],"generation":[208],"gradient.":[212]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2016-06-24T00:00:00"}