{"id":"https://openalex.org/W1509500531","doi":"https://doi.org/10.1186/1471-2407-5-78","title":"Cancer cell adaptation to chemotherapy","display_name":"Cancer cell adaptation to chemotherapy","publication_year":2005,"publication_date":"2005-07-18","ids":{"openalex":"https://openalex.org/W1509500531","doi":"https://doi.org/10.1186/1471-2407-5-78","mag":"1509500531","pmid":"https://pubmed.ncbi.nlm.nih.gov/16026610","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1199589"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2407-5-78","doi":"https://doi.org/10.1186/1471-2407-5-78","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-5-78","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-5-78","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-5-78","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004556147","display_name":"Federica Di Nicolantonio","orcid":"https://orcid.org/0000-0001-9618-2010","observed_orcids":["https://orcid.org/0000-0001-9618-2010"]},"institutions":[{"id":"https://openalex.org/I2802802402","display_name":"Queen Alexandra Hospital","ror":"https://ror.org/04rha3g10","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802802402","https://openalex.org/I4210090003"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Federica Di Nicolantonio","raw_affiliation_strings":["Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth PO6 3LY, UK. federicadn@hotmail.com","Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth PO6 3LY, UK. federicadn@hotmail.com","institution_ids":["https://openalex.org/I2802802402"]},{"raw_affiliation_string":"Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth, UK","institution_ids":["https://openalex.org/I2802802402"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111008182","display_name":"Stuart J. Mercer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802802402","display_name":"Queen Alexandra Hospital","ror":"https://ror.org/04rha3g10","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802802402","https://openalex.org/I4210090003"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stuart J Mercer","raw_affiliation_strings":["Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","Queen Alexandra Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","institution_ids":["https://openalex.org/I2802802402"]},{"raw_affiliation_string":"Queen Alexandra Hospital","institution_ids":["https://openalex.org/I2802802402"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019392501","display_name":"Louise A. Knight","orcid":"https://orcid.org/0000-0003-1431-197X","observed_orcids":["https://orcid.org/0000-0003-1431-197X"]},"institutions":[{"id":"https://openalex.org/I2802802402","display_name":"Queen Alexandra Hospital","ror":"https://ror.org/04rha3g10","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802802402","https://openalex.org/I4210090003"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Louise A Knight","raw_affiliation_strings":["Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","Queen Alexandra Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","institution_ids":["https://openalex.org/I2802802402"]},{"raw_affiliation_string":"Queen Alexandra Hospital","institution_ids":["https://openalex.org/I2802802402"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035655842","display_name":"Francis Guy Gabriel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802802402","display_name":"Queen Alexandra Hospital","ror":"https://ror.org/04rha3g10","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802802402","https://openalex.org/I4210090003"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Francis G Gabriel","raw_affiliation_strings":["Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","Queen Alexandra Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","institution_ids":["https://openalex.org/I2802802402"]},{"raw_affiliation_string":"Queen Alexandra Hospital","institution_ids":["https://openalex.org/I2802802402"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110450774","display_name":"Pauline A. Whitehouse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802802402","display_name":"Queen Alexandra Hospital","ror":"https://ror.org/04rha3g10","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802802402","https://openalex.org/I4210090003"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pauline A Whitehouse","raw_affiliation_strings":["Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","Queen Alexandra Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","institution_ids":["https://openalex.org/I2802802402"]},{"raw_affiliation_string":"Queen Alexandra Hospital","institution_ids":["https://openalex.org/I2802802402"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sanjay Sharma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802802402","display_name":"Queen Alexandra Hospital","ror":"https://ror.org/04rha3g10","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802802402","https://openalex.org/I4210090003"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sanjay Sharma","raw_affiliation_strings":["Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","Queen Alexandra Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","institution_ids":["https://openalex.org/I2802802402"]},{"raw_affiliation_string":"Queen Alexandra Hospital","institution_ids":["https://openalex.org/I2802802402"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108201303","display_name":"Augusta Fernando","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802802402","display_name":"Queen Alexandra Hospital","ror":"https://ror.org/04rha3g10","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802802402","https://openalex.org/I4210090003"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Augusta Fernando","raw_affiliation_strings":["Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","Queen Alexandra Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","institution_ids":["https://openalex.org/I2802802402"]},{"raw_affiliation_string":"Queen Alexandra Hospital","institution_ids":["https://openalex.org/I2802802402"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053202299","display_name":"Sharon Glaysher","orcid":"https://orcid.org/0000-0002-9584-0621","observed_orcids":["https://orcid.org/0000-0002-9584-0621"]},"institutions":[{"id":"https://openalex.org/I2802802402","display_name":"Queen Alexandra Hospital","ror":"https://ror.org/04rha3g10","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802802402","https://openalex.org/I4210090003"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sharon Glaysher","raw_affiliation_strings":["Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","Queen Alexandra Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","institution_ids":["https://openalex.org/I2802802402"]},{"raw_affiliation_string":"Queen Alexandra Hospital","institution_ids":["https://openalex.org/I2802802402"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103210472","display_name":"Silvana Di Palma","orcid":"https://orcid.org/0000-0003-0155-1771","observed_orcids":["https://orcid.org/0000-0003-0155-1771"]},"institutions":[{"id":"https://openalex.org/I2802802402","display_name":"Queen Alexandra Hospital","ror":"https://ror.org/04rha3g10","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802802402","https://openalex.org/I4210090003"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Silvana Di Palma","raw_affiliation_strings":["Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","Queen Alexandra Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","institution_ids":["https://openalex.org/I2802802402"]},{"raw_affiliation_string":"Queen Alexandra Hospital","institution_ids":["https://openalex.org/I2802802402"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103416208","display_name":"Penny Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802802402","display_name":"Queen Alexandra Hospital","ror":"https://ror.org/04rha3g10","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802802402","https://openalex.org/I4210090003"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Penny Johnson","raw_affiliation_strings":["Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","Queen Alexandra Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","institution_ids":["https://openalex.org/I2802802402"]},{"raw_affiliation_string":"Queen Alexandra Hospital","institution_ids":["https://openalex.org/I2802802402"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055778417","display_name":"Shaw S. Somers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802802402","display_name":"Queen Alexandra Hospital","ror":"https://ror.org/04rha3g10","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802802402","https://openalex.org/I4210090003"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shaw S Somers","raw_affiliation_strings":["Department of Surgery, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","Queen Alexandra Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","institution_ids":["https://openalex.org/I2802802402"]},{"raw_affiliation_string":"Queen Alexandra Hospital","institution_ids":["https://openalex.org/I2802802402"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027407598","display_name":"Simon K. C. Toh","orcid":"https://orcid.org/0000-0001-5110-2371","observed_orcids":["https://orcid.org/0000-0001-5110-2371"]},"institutions":[{"id":"https://openalex.org/I2802802402","display_name":"Queen Alexandra Hospital","ror":"https://ror.org/04rha3g10","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802802402","https://openalex.org/I4210090003"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simon Toh","raw_affiliation_strings":["Department of Surgery, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","Queen Alexandra Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","institution_ids":["https://openalex.org/I2802802402"]},{"raw_affiliation_string":"Queen Alexandra Hospital","institution_ids":["https://openalex.org/I2802802402"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111483854","display_name":"Bernie Higgins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63072094","display_name":"University of Portsmouth","ror":"https://ror.org/03ykbk197","country_code":"GB","type":"education","lineage":["https://openalex.org/I63072094"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bernie Higgins","raw_affiliation_strings":["Department of Mathematics and Statistics, University of Portsmouth, Buckingham Building, Lion Terrace, Portsmouth, PO1 3HE, UK","Department of Mathematics and Statistics, University of Portsmouth, Buckingham Building, Lion Terrace, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, University of Portsmouth, Buckingham Building, Lion Terrace, Portsmouth, PO1 3HE, UK","institution_ids":["https://openalex.org/I63072094"]},{"raw_affiliation_string":"Department of Mathematics and Statistics, University of Portsmouth, Buckingham Building, Lion Terrace, UK","institution_ids":["https://openalex.org/I63072094"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alan Lamont","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800288755","display_name":"Southend University Hospital NHS Foundation Trust","ror":"https://ror.org/05fa42p74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800288755"]},{"id":"https://openalex.org/I4210093966","display_name":"Southend Hospital","ror":"https://ror.org/00p2x3741","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800288755","https://openalex.org/I4210093966"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alan Lamont","raw_affiliation_strings":["Department of Radiotherapy and Oncology, Southend Hospital, Prittlewell Chase, Westcliff-on-Sea, Essex, SS0 0RY, UK","Department of Radiotherapy and Oncology, Southend Hospital, Prittlewell Chase, Westcliff-on-Sea, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy and Oncology, Southend Hospital, Prittlewell Chase, Westcliff-on-Sea, Essex, SS0 0RY, UK","institution_ids":["https://openalex.org/I2800288755","https://openalex.org/I4210093966"]},{"raw_affiliation_string":"Department of Radiotherapy and Oncology, Southend Hospital, Prittlewell Chase, Westcliff-on-Sea, UK","institution_ids":["https://openalex.org/I4210093966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040773766","display_name":"T. Gulliford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166773","display_name":"St. Mary's Hospital","ror":"https://ror.org/05x8xdg58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210090003","https://openalex.org/I4210166773"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tim Gulliford","raw_affiliation_strings":["Department of Radiotherapy and Oncology, St Mary's Hospital, Milton Road, Portsmouth, PO3 6AD, UK","Department of Radiotherapy and Oncology, St Mary's Hospital, Portsmouth, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy and Oncology, St Mary's Hospital, Milton Road, Portsmouth, PO3 6AD, UK","institution_ids":["https://openalex.org/I4210166773"]},{"raw_affiliation_string":"Department of Radiotherapy and Oncology, St Mary's Hospital, Portsmouth, UK","institution_ids":["https://openalex.org/I4210166773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069442538","display_name":"Jeremy Hurren","orcid":"https://orcid.org/0000-0003-0959-9155","observed_orcids":["https://orcid.org/0000-0003-0959-9155"]},"institutions":[{"id":"https://openalex.org/I2802802402","display_name":"Queen Alexandra Hospital","ror":"https://ror.org/04rha3g10","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802802402","https://openalex.org/I4210090003"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jeremy Hurren","raw_affiliation_strings":["Department of Surgery, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","Queen Alexandra Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","institution_ids":["https://openalex.org/I2802802402"]},{"raw_affiliation_string":"Queen Alexandra Hospital","institution_ids":["https://openalex.org/I2802802402"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113573569","display_name":"Constantinos Yiangou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802802402","display_name":"Queen Alexandra Hospital","ror":"https://ror.org/04rha3g10","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802802402","https://openalex.org/I4210090003"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Constantinos Yiangou","raw_affiliation_strings":["Department of Surgery, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","Queen Alexandra Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","institution_ids":["https://openalex.org/I2802802402"]},{"raw_affiliation_string":"Queen Alexandra Hospital","institution_ids":["https://openalex.org/I2802802402"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014188852","display_name":"Ian A. Cree","orcid":"https://orcid.org/0000-0001-5007-9456","observed_orcids":["https://orcid.org/0000-0001-5007-9456"]},"institutions":[{"id":"https://openalex.org/I2802802402","display_name":"Queen Alexandra Hospital","ror":"https://ror.org/04rha3g10","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802802402","https://openalex.org/I4210090003"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Ian A Cree","raw_affiliation_strings":["Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","Queen Alexandra Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK","institution_ids":["https://openalex.org/I2802802402"]},{"raw_affiliation_string":"Queen Alexandra Hospital","institution_ids":["https://openalex.org/I2802802402"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5014188852"],"corresponding_institution_ids":["https://openalex.org/I2802802402"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":4.3105,"has_fulltext":true,"cited_by_count":133,"citation_normalized_percentile":{"value":0.94513501,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"5","issue":"1","first_page":"78","last_page":"78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.017100000753998756,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.8970000147819519},{"id":"https://openalex.org/keywords/multidrug-resistance-gene-1","display_name":"multidrug resistance gene 1","score":0.8539999723434448},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9850000143051147},{"id":"https://openalex.org/keywords/topoisomerase-ii-alpha","display_name":"TOP2A","score":0.9409999847412109},{"id":"https://openalex.org/keywords/topotecan","display_name":"topotecan","score":0.8769999742507935},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.8889999985694885},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9539999961853027},{"id":"https://openalex.org/keywords/epirubicin","display_name":"epirubicin","score":0.9779999852180481},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9710000157356262},{"id":"https://openalex.org/keywords/irinotecan","display_name":"irinotecan","score":0.9869999885559082},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.5109999775886536},{"id":"https://openalex.org/keywords/ovarian-carcinoma","display_name":"ovarian carcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8550000190734863},{"id":"https://openalex.org/keywords/esophageal-cancer","display_name":"esophageal cancer","score":0.9200000166893005},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.6629999876022339},{"id":"https://openalex.org/keywords/resistance-gene-expression","display_name":"resistance gene expression","score":0.5730000138282776},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.7533825039863586},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6355586647987366},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5583422780036926},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.5173146724700928},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.48889508843421936},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3509882092475891},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17213502526283264},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.10454171895980835}],"mesh":[{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004358","descriptor_name":"Drug Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015251","descriptor_name":"Epirubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019772","descriptor_name":"Topotecan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1471-2407-5-78","doi":"https://doi.org/10.1186/1471-2407-5-78","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-5-78","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-5-78","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:95709","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1199589","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1199589","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1199589","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"Text"},{"id":"pmid:16026610","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16026610","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cancer","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unito.it:2318/127007","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2318/127007","pdf_url":"https://iris.unito.it/bitstream/2318/127007/1/2005_DiNicolantonio_BMC_Cancer_Article.pdf","source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:cefcfe6e423c4cfd9ffa9f123f33f832","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/cefcfe6e423c4cfd9ffa9f123f33f832","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cancer, Vol 5, Iss 1, p 78 (2005)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2407-5-78","doi":"https://doi.org/10.1186/1471-2407-5-78","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-5-78","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-5-78","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1509500531.pdf","grobid_xml":"https://content.openalex.org/works/W1509500531.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1488985726","https://openalex.org/W1515049248","https://openalex.org/W1515560162","https://openalex.org/W1577577364","https://openalex.org/W1767428601","https://openalex.org/W1855651608","https://openalex.org/W1928936189","https://openalex.org/W1933433305","https://openalex.org/W1941056101","https://openalex.org/W1943747111","https://openalex.org/W1969455020","https://openalex.org/W1972756957","https://openalex.org/W1975888461","https://openalex.org/W1978628753","https://openalex.org/W1980132014","https://openalex.org/W1982531566","https://openalex.org/W1984328540","https://openalex.org/W1993875123","https://openalex.org/W1996853671","https://openalex.org/W2003776328","https://openalex.org/W2004172747","https://openalex.org/W2006434892","https://openalex.org/W2009408345","https://openalex.org/W2015055491","https://openalex.org/W2018588892","https://openalex.org/W2065915399","https://openalex.org/W2067697523","https://openalex.org/W2075733574","https://openalex.org/W2089949728","https://openalex.org/W2100688168","https://openalex.org/W2106636644","https://openalex.org/W2110790042","https://openalex.org/W2116846790","https://openalex.org/W2124140776","https://openalex.org/W2138311952","https://openalex.org/W2138440094","https://openalex.org/W2147723172","https://openalex.org/W2155140832","https://openalex.org/W2168168277","https://openalex.org/W2296462761","https://openalex.org/W2345653340","https://openalex.org/W2398133785","https://openalex.org/W2409469058","https://openalex.org/W2468131549","https://openalex.org/W4236530034"],"related_works":["https://openalex.org/W2013284605","https://openalex.org/W1537586392","https://openalex.org/W2261909656","https://openalex.org/W4415486468","https://openalex.org/W2031982181","https://openalex.org/W2035253718","https://openalex.org/W1556571873","https://openalex.org/W1982417455","https://openalex.org/W2079827858","https://openalex.org/W3009613168"],"abstract_inverted_index":{"BACKGROUND:":[0],"Tumor":[1],"resistance":[2,64,148,219,301],"to":[3,50,62,88,110,128,175,194,260,263,289,294,324,329],"chemotherapy":[4,159,295],"may":[5,226,296],"be":[6,261],"present":[7,245],"at":[8],"the":[9,22,63,130,144,168,236,264,278,283,290,306,326],"beginning":[10],"of":[11,21,43,65,74,115,146,167,189,202,218,235,238,287,300,308],"treatment,":[12,15,239],"develop":[13],"during":[14],"or":[16,113,221,312],"become":[17],"apparent":[18],"on":[19,305],"re-treatment":[20],"patient.":[23],"The":[24,252],"mechanisms":[25,302],"involved":[26],"are":[27,40,244,322],"usually":[28],"inferred":[29],"from":[30,71],"experiments":[31],"with":[32,277],"cell":[33,101],"lines,":[34],"as":[35],"studies":[36],"in":[37,99,143,177,196,199,204,223,229,246,282],"tumor-derived":[38],"cells":[39,48],"difficult.":[41],"Studies":[42],"human":[44,230],"tumors":[45,73,207],"show":[46],"that":[47,58,216,241,317],"adapt":[49],"chemotherapy,":[51],"but":[52,267],"it":[53],"has":[54],"been":[55],"largely":[56],"assumed":[57],"clonal":[59],"selection":[60],"leads":[61],"recurrent":[66],"tumors.":[67,211],"METHODS:":[68],"Cells":[69],"derived":[70],"47":[72],"breast,":[75],"ovarian,":[76],"esophageal,":[77],"and":[78,81,97,120,160,182,208,240,248,285,315],"colorectal":[79,206],"origin":[80],"16":[82,116],"paired":[83,136],"esophageal":[84,137],"biopsies":[85],"were":[86],"exposed":[87],"anticancer":[89],"agents":[90],"(cisplatin;":[91],"5-fluorouracil;":[92],"epirubicin;":[93],"doxorubicin;":[94],"paclitaxel;":[95],"irinotecan":[96],"topotecan)":[98],"short-term":[100],"culture":[102],"(6":[103],"days).":[104],"Real-time":[105],"quantitative":[106],"PCR":[107],"was":[108,123,126,140,162],"used":[109,127,255],"measure":[111],"up-":[112],"down-regulation":[114,188,201,222],"different":[117],"resistance/target":[118],"genes,":[119],"when":[121],"tissue":[122],"available,":[124],"immunohistochemistry":[125],"assess":[129],"protein":[131],"levels.":[132],"RESULTS:":[133],"In":[134],"8/16":[135],"biopsies,":[138],"there":[139,268],"an":[141],"increase":[142],"expression":[145,166],"multi-drug":[147],"gene":[149],"1":[150],"(MDR1)":[151],"following":[152],"epirubicin":[153],"+":[154,156],"cisplatin":[155],"5-fluorouracil":[157],"(ECF)":[158],"this":[161],"accompanied":[163],"by":[164,256],"increased":[165],"MDR-1":[169],"encoded":[170],"protein,":[171],"P-gp.":[172],"Following":[173],"exposure":[174],"doxorubicin":[176],"vitro,":[178,197],"13/14":[179],"breast":[180],"carcinomas":[181,185],"9/12":[183],"ovarian":[184,210],"showed":[186],">2-fold":[187],"topoisomerase":[190],"IIalpha":[191],"(TOPOIIalpha).":[192],"Exposure":[193],"topotecan":[195],"resulted":[198],">4-fold":[200],"TOPOIIalpha":[203],"6/7":[205],"8/10":[209],"CONCLUSION:":[212],"This":[213],"study":[214],"suggests":[215,316],"up-regulation":[217],"genes":[220,225],"target":[224],"occur":[227],"rapidly":[228],"solid":[231],"tumors,":[232,274],"within":[233],"days":[234],"start":[237],"similar":[242],"changes":[243],"pre-":[247],"post-chemotherapy":[249],"biopsy":[250],"material.":[251],"molecular":[253],"processes":[254],"each":[257],"tumor":[258,309],"appear":[259],"linked":[262],"drug":[265],"used,":[266],"is":[269,303],"also":[270],"heterogeneity":[271],"between":[272],"individual":[273,313],"even":[275],"those":[276],"same":[279,291],"histological":[280],"type,":[281],"pattern":[284],"magnitude":[286],"response":[288,327],"drugs.":[292],"Adaptation":[293],"explain":[297],"why":[298],"prediction":[299],"difficult":[304],"basis":[307],"type":[310],"alone":[311],"markers,":[314],"more":[318],"complex":[319],"predictive":[320],"methods":[321],"required":[323],"improve":[325],"rates":[328],"chemotherapy.":[330]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}