{"id":"https://openalex.org/W1509117909","doi":null,"title":"Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure.","display_name":"Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure.","publication_year":2001,"publication_date":"2001-07-15","ids":{"openalex":"https://openalex.org/W1509117909","mag":"1509117909","pmid":"https://pubmed.ncbi.nlm.nih.gov/11454677"},"language":"en","primary_location":{"id":"pmid:11454677","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11454677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Y Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y Wang","raw_affiliation_strings":["The Johns Hopkins Oncology Center, Bunting-Blaustein Cancer Research Building, Baltimore, Maryland 21231, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Johns Hopkins Oncology Center, Bunting-Blaustein Cancer Research Building, Baltimore, Maryland 21231, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018033166","display_name":"Wendy L. Devereux","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Devereux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046028725","display_name":"Patrick M. Woster","orcid":"https://orcid.org/0000-0002-9471-1916","observed_orcids":["https://orcid.org/0000-0002-9471-1916"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P M Woster","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073262248","display_name":"Tracy Murray Stewart","orcid":"https://orcid.org/0000-0001-8679-6414","observed_orcids":["https://orcid.org/0000-0001-8679-6414"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T M Stewart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111837763","display_name":"A. Hacker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Hacker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5076964907","display_name":"Robert A. Casero","orcid":"https://orcid.org/0000-0001-5653-3306","observed_orcids":["https://orcid.org/0000-0001-5653-3306"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R A Casero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.9431,"has_fulltext":false,"cited_by_count":241,"citation_normalized_percentile":{"value":0.94947189,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"61","issue":"14","first_page":"5370","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyamine-oxidase","display_name":"polyamine oxidase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/polyamine-catabolism","display_name":"polyamine catabolism","score":0.9160000085830688},{"id":"https://openalex.org/keywords/polyamine-analogues","display_name":"polyamine analogues","score":0.6949999928474426},{"id":"https://openalex.org/keywords/enzyme-induction","display_name":"enzyme induction","score":0.703000009059906},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.7549999952316284},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.7379999756813049},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.4269999861717224}],"concepts":[{"id":"https://openalex.org/C2781188418","wikidata":"https://www.wikidata.org/wiki/Q3450498","display_name":"Polyamine oxidase","level":4,"score":0.9225146770477295},{"id":"https://openalex.org/C2780115381","wikidata":"https://www.wikidata.org/wiki/Q421959","display_name":"Polyamine","level":2,"score":0.8675971031188965},{"id":"https://openalex.org/C2776109719","wikidata":"https://www.wikidata.org/wiki/Q424597","display_name":"Spermine","level":3,"score":0.6719153523445129},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.609302818775177},{"id":"https://openalex.org/C2777497464","wikidata":"https://www.wikidata.org/wiki/Q418834","display_name":"Spermidine","level":3,"score":0.58323073387146},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5826303958892822},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5233356356620789},{"id":"https://openalex.org/C2777167505","wikidata":"https://www.wikidata.org/wiki/Q410190","display_name":"Putrescine","level":3,"score":0.5015697479248047},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.4405451714992523},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.42961469292640686},{"id":"https://openalex.org/C189482833","wikidata":"https://www.wikidata.org/wiki/Q869146","display_name":"cDNA library","level":4,"score":0.4205203652381897},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3008398413658142},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1387387216091156}],"mesh":[{"descriptor_ui":"D000097667","descriptor_name":"Polyamine Oxidase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000587","descriptor_name":"Oxidoreductases Acting on CH-NH Group Donors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000587","descriptor_name":"Oxidoreductases Acting on CH-NH Group Donors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011073","descriptor_name":"Polyamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011073","descriptor_name":"Polyamines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:11454677","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11454677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.334.7022","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.334.7022","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerres.aacrjournals.org/content/61/14/5370.full.pdf","raw_type":"text"},{"id":"mag:1509117909","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11454677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3775430996","display_name":"Re-expression of Aberrantly Silenced Genes Induced by Polyamine Analogues","funder_award_id":"R01CA051085","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6941127517","display_name":"SPORE in Lung Cancer","funder_award_id":"P50CA058184","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8486618507","display_name":"ANTINEOPLASTIC POLYAMINE ANALOGUES","funder_award_id":"R01CA085509","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1513041781","https://openalex.org/W1524663237","https://openalex.org/W1964646682","https://openalex.org/W1982970127","https://openalex.org/W1987290568","https://openalex.org/W1990899055","https://openalex.org/W1992732908","https://openalex.org/W1994388625","https://openalex.org/W1999032956","https://openalex.org/W2023093923","https://openalex.org/W2042397686","https://openalex.org/W2044177020","https://openalex.org/W2061756752","https://openalex.org/W2074285803","https://openalex.org/W2116879291","https://openalex.org/W2132969874","https://openalex.org/W2137355756","https://openalex.org/W2145555194","https://openalex.org/W2281124822","https://openalex.org/W2464830172"],"related_works":["https://openalex.org/W2006628846","https://openalex.org/W2115258133","https://openalex.org/W2222551960","https://openalex.org/W2141334533","https://openalex.org/W1997545617","https://openalex.org/W2008245453","https://openalex.org/W4400248923","https://openalex.org/W1995303070","https://openalex.org/W2043975563","https://openalex.org/W2345020700"],"abstract_inverted_index":{"Mammalian":[0],"polyamine":[1,17,164,186,197],"catabolism":[2,187],"is":[3,31,73,159],"under":[4],"the":[5,13,23,59,100,180,183,195],"control":[6],"of":[7,28,41,47,54,70,81,103,118,131,138,145,182,185],"two":[8],"enzymes,":[9],"spermidine/spermine":[10],"N1-acetyltransferase":[11],"and":[12,25,141,191],"flavin":[14],"adenine":[15],"dinucleotide-dependent":[16],"oxidase":[18,90,97],"(PAO).":[19],"In":[20,51],"this":[21,55,71,104],"study,":[22],"cloning":[24],"initial":[26],"characterization":[27],"human":[29],"PAO":[30,65,68,101,106,139,146,158,168],"reported.":[32],"A":[33],"1894-bp":[34],"cDNA":[35,56],"with":[36,64],"an":[37],"open":[38],"reading":[39],"frame":[40],"1668-bp":[42],"codes":[43],"for":[44],"a":[45,78,87,94,119,142,174],"protein":[46,63],"555":[48],"amino":[49],"acids.":[50],"vitro":[52],"transcription/translation":[53],"clone":[57,72,169],"produces":[58],"expected":[60],"M(r)":[61],"61,900":[62],"activity.":[66,147],"The":[67,167],"activity":[69,102],"inhibited":[74],"by":[75],"MDL":[76],"72,527,":[77],"specific":[79,88,95],"inhibitor":[80],"mammalian":[82],"PAO.":[83],"However,":[84,115],"neither":[85],"pargyline,":[86],"monoamine":[89],"inhibitor,":[91,98],"nor":[92],"semicarbazide,":[93],"diamine":[96],"inhibits":[99],"clone.":[105],"has":[107],"been":[108],"referred":[109],"to":[110,128,163,194],"as":[111],"being":[112],"constitutively":[113],"expressed.":[114],"24-h":[116],"exposure":[117],"non-small":[120],"cell":[121,124,156],"lung":[122],"carcinoma":[123],"line,":[125],"NCI":[126],"H157,":[127],"10":[129],"microM":[130],"N1,N\"-bis(ethyl)norspermine":[132],"results":[133,149],"in":[134,152,161,188,192],"approximately":[135],"5-fold":[136],"induction":[137,144],"mRNA":[140],">3-fold":[143],"These":[148],"demonstrate":[150],"that":[151],"at":[153],"least":[154],"one":[155],"type,":[157],"up-regulated":[160],"response":[162,193],"analogue":[165],"exposure.":[166],"described":[170],"here":[171],"should":[172],"provide":[173],"useful":[175],"tool,":[176],"which":[177],"will":[178],"facilitate":[179],"dissection":[181],"role":[184],"normal":[189],"growth":[190],"antitumor":[196],"analogues.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
