{"id":"https://openalex.org/W1508943512","doi":"https://doi.org/10.21236/ada447539","title":"PSES - A Novel Prostate Specific Chimeric Enhancer for Prostate Cancer Gene Therapy","display_name":"PSES - A Novel Prostate Specific Chimeric Enhancer for Prostate Cancer Gene Therapy","publication_year":2005,"publication_date":"2005-02-01","ids":{"openalex":"https://openalex.org/W1508943512","doi":"https://doi.org/10.21236/ada447539","mag":"1508943512"},"language":"en","primary_location":{"id":"doi:10.21236/ada447539","doi":"https://doi.org/10.21236/ada447539","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada447539","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},"volume":null,"type":"report","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111365848","display_name":"Chinghai H. Kao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Chinghai Kao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111365848"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-specific-antigen","display_name":"prostate-specific antigen","score":0.5849999785423279},{"id":"https://openalex.org/keywords/prostate-specific-membrane-antigen","display_name":"prostate-specific membrane antigen","score":0.9649999737739563},{"id":"https://openalex.org/keywords/trail","display_name":"TRAIL","score":0.5799999833106995},{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.8220000267028809},{"id":"https://openalex.org/keywords/bh3-domain","display_name":"BH3 domain","score":0.8309999704360962},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.44999998807907104},{"id":"https://openalex.org/keywords/cell-permeable-peptide","display_name":"cell-permeable peptide","score":0.7419999837875366},{"id":"https://openalex.org/keywords/tumor-cell-killing","display_name":"tumor cell killing","score":0.4410000145435333}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8199614882469177},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.7592672109603882},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.6286220550537109},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5802498459815979},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.5172598958015442},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4773557186126709},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4252961277961731},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.39158451557159424},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34358540177345276},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34056442975997925},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2964091897010803},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28413450717926025},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12525656819343567},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08528569340705872}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.21236/ada447539","doi":"https://doi.org/10.21236/ada447539","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada447539","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},{"id":"pmh:ADA447539","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA447539","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC","raw_type":"Text"},{"id":"pmh:ADA454853","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA454853","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC","raw_type":"Text"},{"id":"pmh:ADA471728","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA471728","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC","raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8100000023841858,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1831598597","https://openalex.org/W1983376387","https://openalex.org/W2114941806","https://openalex.org/W2121435941","https://openalex.org/W2162044353","https://openalex.org/W2413062221"],"related_works":["https://openalex.org/W2121435941","https://openalex.org/W2054952331","https://openalex.org/W1983080805","https://openalex.org/W1493821990","https://openalex.org/W2320432216","https://openalex.org/W2034324302","https://openalex.org/W2789304324","https://openalex.org/W4213207974","https://openalex.org/W1992655681","https://openalex.org/W2790339668"],"abstract_inverted_index":{"Recently":[0],"we":[1,104],"identified":[2],"two":[3],"prostate-specific":[4],"enhancers,":[5],"AREc3":[6,25],"and":[7,12,16,26,45,100,122,139,164,173],"PSME(del2),":[8],"from":[9],"PSA":[10],"gene":[11,14],"PSMA":[13],"respectively,":[15],"generated":[17],"a":[18,40,71,83,132,161,166],"chemic":[19],"promoter,":[20],"called":[21,80],"PSES,":[22],"by":[23],"combining":[24],"PSME(del2).":[27],"The":[28],"goal":[29],"of":[30,68,120,157,183],"this":[31],"research":[32],"is":[33],"to":[34,38,46,63,109,178],"use":[35],"AREc3/PSME(del2)or":[36],"PSES":[37],"develop":[39],"prostate-restricted":[41],"replicative":[42],"adenovirus":[43],"(PRRA)":[44],"arm":[47],"PrRRA":[48],"with":[49,107,160],"an":[50],"apoptosis":[51],"inducer,":[52],"TRAIL":[53,108,124,163],"(tumor":[54],"necrosis":[55],"factor-related":[56],"apoptosis-inducing":[57],"ligand).":[58],"We":[59,152],"constructed":[60,77],"3":[61],"PRRAs-according":[62],"our":[64,113],"original":[65,114],"proposal.":[66],"None":[67],"them":[69],"demonstrated":[70,131],"good":[72],"prostate":[73,92,118,150,175],"specificity.":[74],"We,":[75],"then,":[76],"another":[78],"PRRA,":[79],"AdE4PSESE1a,":[81],"using":[82],"different":[84],"strategy.":[85],"AdE4PSESE1a":[86,106,121,146,159],"only":[87],"replicated":[88],"in":[89,126,134,143],"PSAIPSMA":[90,127,148],"positive":[91,128,149],"cancer":[93,176],"cells":[94,96,177],"or":[95],"expressing":[97],"adenoviral":[98],"El":[99],"E4":[101],"proteins.":[102],"Then,":[103],"armed":[105],"make":[110],"AD-IU-2":[111],"as":[112],"plan.":[115],"Ad-IU-2":[116,130],"retains":[117],"specificity":[119],"expresses":[123],"on":[125,154],"cells.":[129],"better":[133],"vitro":[135],"cell":[136],"killing":[137,141],"activity":[138,142],"tumor":[140,168],"vivo":[144],"than":[145],"against":[147],"cancers.":[151],"are":[153],"the":[155,180],"process":[156],"arming":[158],"soluble":[162],"creating":[165],"hybrid":[167],"model":[169],"containing":[170],"both":[171],"PSNPSMA-positive":[172],"negative":[174],"test":[179],"therapeutic":[181],"advantage":[182],"TRAIL-armed":[184],"PRRA.":[185]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}