{"id":"https://openalex.org/W1508928576","doi":null,"title":"Short- and long-term neuronal plasticity in hippocampal CA1 region of rat","display_name":"Short- and long-term neuronal plasticity in hippocampal CA1 region of rat","publication_year":2010,"publication_date":"2010-06-14","ids":{"openalex":"https://openalex.org/W1508928576","mag":"1508928576"},"language":"en","primary_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/22185","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/22185","pdf_url":"http://hdl.handle.net/2077/22185","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2077/22185","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102088511","display_name":"Fen\u2010Sheng Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fen\u2010Sheng Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5102088511"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.8489999771118164},{"id":"https://openalex.org/keywords/hippocampal-ca1","display_name":"hippocampal CA1","score":0.9409999847412109},{"id":"https://openalex.org/keywords/short-term-synaptic-plasticity","display_name":"short-term plasticity","score":0.8370000123977661},{"id":"https://openalex.org/keywords/paired-pulse-facilitation","display_name":"paired-pulse facilitation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/paired-pulse-depression","display_name":"paired-pulse depression","score":0.9980000257492065},{"id":"https://openalex.org/keywords/long-term-potentiation","display_name":"long-term potentiation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/long-term-depression","display_name":"long-term depression","score":0.9959999918937683},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.8949999809265137},{"id":"https://openalex.org/keywords/nr2a","display_name":"NR2A","score":0.7369999885559082},{"id":"https://openalex.org/keywords/nr2b","display_name":"NR2B","score":0.9959999918937683},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.5669999718666077},{"id":"https://openalex.org/keywords/ampa-receptors","display_name":"AMPA receptors","score":0.6209999918937683},{"id":"https://openalex.org/keywords/excitatory-postsynaptic-potentials","display_name":"excitatory postsynaptic potentials","score":0.8790000081062317},{"id":"https://openalex.org/keywords/release-probability","display_name":"release probability","score":0.5830000042915344},{"id":"https://openalex.org/keywords/developmental-plasticity","display_name":"developmental plasticity","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6533364653587341},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.6177490949630737},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6151486039161682},{"id":"https://openalex.org/C79186407","wikidata":"https://www.wikidata.org/wiki/Q472074","display_name":"Plasticity","level":2,"score":0.6008325815200806},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.5507019758224487},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5041922330856323},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2715841829776764},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1357530653476715},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:gupea.ub.gu.se:2077/22185","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/22185","pdf_url":"http://hdl.handle.net/2077/22185","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"mag:1508928576","doi":null,"is_oa":false,"landing_page_url":"https://gupea.ub.gu.se/bitstream/2077/22185/1/gupea_2077_22185_1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/22185","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/22185","pdf_url":"http://hdl.handle.net/2077/22185","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1508928576.pdf","grobid_xml":"https://content.openalex.org/works/W1508928576.grobid-xml"},"referenced_works_count":162,"referenced_works":["https://openalex.org/W180788233","https://openalex.org/W950082919","https://openalex.org/W1500186234","https://openalex.org/W1555596939","https://openalex.org/W1567528708","https://openalex.org/W1576462562","https://openalex.org/W1591958019","https://openalex.org/W1594322774","https://openalex.org/W1601000163","https://openalex.org/W1608821495","https://openalex.org/W1609834322","https://openalex.org/W1613388116","https://openalex.org/W1666284247","https://openalex.org/W1733248925","https://openalex.org/W1793612468","https://openalex.org/W1798409403","https://openalex.org/W1802355730","https://openalex.org/W1826560869","https://openalex.org/W1859494833","https://openalex.org/W1955943544","https://openalex.org/W1962539779","https://openalex.org/W1965176956","https://openalex.org/W1966499883","https://openalex.org/W1967745586","https://openalex.org/W1968763273","https://openalex.org/W1970160370","https://openalex.org/W1970792572","https://openalex.org/W1970938545","https://openalex.org/W1972270334","https://openalex.org/W1972384396","https://openalex.org/W1972585252","https://openalex.org/W1973436856","https://openalex.org/W1973592745","https://openalex.org/W1975356184","https://openalex.org/W1975462660","https://openalex.org/W1975543142","https://openalex.org/W1976175452","https://openalex.org/W1979169606","https://openalex.org/W1979565874","https://openalex.org/W1980774236","https://openalex.org/W1982270009","https://openalex.org/W1983381504","https://openalex.org/W1983923341","https://openalex.org/W1983956991","https://openalex.org/W1986246844","https://openalex.org/W1989773017","https://openalex.org/W1990294595","https://openalex.org/W1990969569","https://openalex.org/W1991779336","https://openalex.org/W1993372975","https://openalex.org/W1996088954","https://openalex.org/W1997568797","https://openalex.org/W1998955447","https://openalex.org/W1999576398","https://openalex.org/W1999772445","https://openalex.org/W2008888935","https://openalex.org/W2009944441","https://openalex.org/W2010463725","https://openalex.org/W2014148866","https://openalex.org/W2014611177","https://openalex.org/W2015757121","https://openalex.org/W2017201962","https://openalex.org/W2019016101","https://openalex.org/W2020216347","https://openalex.org/W2020622209","https://openalex.org/W2021024875","https://openalex.org/W2021897528","https://openalex.org/W2023013885","https://openalex.org/W2023573333","https://openalex.org/W2023654689","https://openalex.org/W2025801062","https://openalex.org/W2028594041","https://openalex.org/W2030035704","https://openalex.org/W2031739172","https://openalex.org/W2031811225","https://openalex.org/W2033897148","https://openalex.org/W2035499517","https://openalex.org/W2036137643","https://openalex.org/W2036488650","https://openalex.org/W2038556096","https://openalex.org/W2040521599","https://openalex.org/W2041662644","https://openalex.org/W2043036883","https://openalex.org/W2046388858","https://openalex.org/W2049511526","https://openalex.org/W2052515926","https://openalex.org/W2053794249","https://openalex.org/W2054203244","https://openalex.org/W2055568369","https://openalex.org/W2055775269","https://openalex.org/W2056607057","https://openalex.org/W2057605801","https://openalex.org/W2060038665","https://openalex.org/W2060671316","https://openalex.org/W2061130462","https://openalex.org/W2061405268","https://openalex.org/W2063364623","https://openalex.org/W2064064782","https://openalex.org/W2066478761","https://openalex.org/W2067140282","https://openalex.org/W2067856703","https://openalex.org/W2069204309","https://openalex.org/W2069354675","https://openalex.org/W2070352474","https://openalex.org/W2071019848","https://openalex.org/W2071214963","https://openalex.org/W2072731296","https://openalex.org/W2075603142","https://openalex.org/W2077519653","https://openalex.org/W2077620190","https://openalex.org/W2077758457","https://openalex.org/W2081033522","https://openalex.org/W2082365169","https://openalex.org/W2085846947","https://openalex.org/W2086837225","https://openalex.org/W2087120734","https://openalex.org/W2087157604","https://openalex.org/W2087230364","https://openalex.org/W2088267783","https://openalex.org/W2089413793","https://openalex.org/W2092908224","https://openalex.org/W2094319585","https://openalex.org/W2096424464","https://openalex.org/W2099757754","https://openalex.org/W2102268999","https://openalex.org/W2103312298","https://openalex.org/W2105829350","https://openalex.org/W2109208582","https://openalex.org/W2109909801","https://openalex.org/W2111062311","https://openalex.org/W2111266813","https://openalex.org/W2112927743","https://openalex.org/W2113574370","https://openalex.org/W2116195093","https://openalex.org/W2117664079","https://openalex.org/W2121894651","https://openalex.org/W2122285447","https://openalex.org/W2123067258","https://openalex.org/W2129761500","https://openalex.org/W2129841439","https://openalex.org/W2130302656","https://openalex.org/W2130534913","https://openalex.org/W2140899588","https://openalex.org/W2145547868","https://openalex.org/W2145984134","https://openalex.org/W2146033515","https://openalex.org/W2150242758","https://openalex.org/W2154045630","https://openalex.org/W2154142567","https://openalex.org/W2158425431","https://openalex.org/W2160510653","https://openalex.org/W2160765931","https://openalex.org/W2161998020","https://openalex.org/W2165305160","https://openalex.org/W2167403166","https://openalex.org/W2168558032","https://openalex.org/W2175272720","https://openalex.org/W2199987190","https://openalex.org/W2335948309","https://openalex.org/W2339906229","https://openalex.org/W2518048391","https://openalex.org/W4214891130"],"related_works":["https://openalex.org/W2030035704","https://openalex.org/W1455199701","https://openalex.org/W49877142","https://openalex.org/W2088267783","https://openalex.org/W2064818293","https://openalex.org/W1997824093","https://openalex.org/W1974861286","https://openalex.org/W1987344203","https://openalex.org/W184331644","https://openalex.org/W7154825192"],"abstract_inverted_index":{"The":[0,361,468],"brain":[1],"is":[2,87],"highly":[3],"plastic,":[4],"displaying":[5],"both":[6,326,351,436],"short-":[7],"and":[8,19,29,53,64,84,148,158,179,213,288,309,314,332,359,388,438,496],"long-term":[9,51],"changes,":[10],"resulting":[11],"from":[12,109,118,411],"developmental":[13],"processes":[14,48],"as":[15,17,25,50,208,238],"well":[16],"learning":[18],"memory.":[20],"Moreover,":[21],"short-term":[22,169,424],"plasticity":[23,170,330,384,495],"such":[24,49],"paired":[26,183,285],"pulse":[27,286],"facilitation":[28],"depression":[30,54],"(PPF,":[31],"PPD)":[32],"have":[33],"long":[34],"been":[35],"used":[36,237,302],"to":[37,68,174,187,206,232,303,329,335,345,355,415,421,486,493],"monitor":[38,233],"the":[39,69,144,172,257,261,266,368,393,452,457,494,502],"presynaptic":[40,188,280],"versus":[41],"postsynaptic":[42,164,369,458],"changes":[43,446],"occurring":[44],"during":[45],"more":[46],"lasting":[47,296],"potentiation":[52,425],"(LTP,":[55],"LTD).":[56],"Many":[57],"issues":[58],"remain":[59],"unresolved,":[60],"e.g.":[61,282],"how":[62,90],"PPF":[63,178],"PPD":[65],"are":[66,461],"related":[67],"probabilistic":[70],"features":[71],"of":[72,101,161,221,260,275,290,317,357,374,392,426,435,477],"synaptic":[73,102,145,193,211,276,383,445],"transmission,":[74],"an":[75,209,422,480],"issue":[76,396],"which":[77,203],"has":[78,270],"also":[79,462],"methodological":[80],"aspects.":[81],"Regarding":[82],"LTP":[83,313,358],"LTD,":[85],"it":[86],"still":[88],"uncertain":[89],"Ca2+":[91,347,365,454],"via":[92,156,371],"NMDA":[93],"receptors":[94,308,324],"(NMDA-R)":[95],"produces":[96],"either":[97,231],"increases":[98],"or":[99,184,236,306],"decreases":[100],"strength.\\nExperiments":[103],"were":[104,116,131,152,253,301,310],"performed":[105],"on":[106,312,451],"hippocampal":[107],"slices":[108],"1-21":[110],"day-old":[111],"Sprague-Dawley":[112],"rats.":[113],"Intracellular":[114],"recordings":[115,130],"obtained":[117,132],"visually":[119],"identified":[120],"CA1":[121,197],"pyramidal":[122],"cells":[123,198],"using":[124,181,340],"whole-cell":[125],"patch":[126],"clamp":[127],"technique.":[128],"Extracellular":[129],"under":[133,278],"low":[134],"magnification":[135],"optical":[136],"resolution":[137],"by":[138,227,385,400,409,430,464,473],"assessing":[139],"field":[140],"potentials":[141,165],"evoked":[142],"in":[143,154,171,196,250,456,497],"layer.":[146],"AMPA-R":[147],"NMDA-R":[149,299,337,404,487],"mediated":[150],"responses":[151,428],"assessed":[153],"parallel":[155],"early":[157],"late":[159],"measurements":[160,274],"composite":[162],"excitatory":[163],"(EPSPs).\\nI":[166],"first":[167,267],"examined":[168],"millisecond":[173],"second":[175,258],"range,":[176],"including":[177],"PPD,":[180],"weak":[182],"multiple":[185],"stimuli":[186],"afferents":[189],"(minimal":[190],"stimulation).":[191],"Excitatory":[192],"currents":[194],"(EPSCs)":[195],"revealed":[199],"a":[200,216,239,341,378,401,431,474],"strength":[201],"dependence,":[202],"was":[204,225,320,397,406],"hard":[205],"explain":[207],"isolated":[210,336],"phenomenon,":[212],"so":[214],"suggesting":[215],"role":[217],"for":[218,241,256,265,272],"unreliable":[219,279],"activation":[220,405],"afferents.":[222],"This":[223,269,395,419],"idea":[224],"supported":[226],"CA3":[228,251],"cell":[229],"recording,":[230],"axonal":[234],"activity":[235],"model":[240],"near":[242],"threshold":[243],"spike":[244],"generation.":[245],"Action":[246],"potential":[247],"firing":[248],"thresholds":[249],"cells/axons":[252],"significantly":[254],"lower":[255],"pulses":[259],"paired-pulse":[262,416],"stimulation":[263,413,417],"than":[264],"pulses.":[268],"consequences":[271],"interpreting":[273],"parameters":[277],"activation;":[281],"release":[283],"probability,":[284],"ratio":[287],"coefficient":[289],"variation.\\nThe":[291],"subsequent":[292],"work":[293],"involved":[294],"longer":[295],"plasticity.":[297],"Subunit-specific":[298],"antagonists":[300],"target":[304],"NR2A-":[305],"NR2B-containing":[307],"tested":[311],"two":[315],"forms":[316],"LTD.":[318,360],"It":[319],"found":[321],"that":[322,350,364,443],"NR2A-containing":[323],"dominate,":[325],"with":[327,479],"respect":[328],"induction":[331,356,466],"their":[333],"contribution":[334],"responses.":[338],"Experiments":[339],"lowered":[342],"Mg2+":[343],"concentration":[344,455],"amplify":[346],"entry":[348],"demonstrated":[349],"subunit":[352],"types":[353,373],"contributed":[354],"data":[362],"suggest":[363,442],"influx":[366],"into":[367],"spine":[370,459],"different":[372],"NMDA-Rs":[375],"makes":[376],"up":[377],"\u201cfinal":[379],"common":[380],"pathway\u201d,":[381],"controlling":[382],"its":[386],"magnitude":[387],"temporal":[389],"pattern,":[390],"regardless":[391],"source.":[394],"further":[398],"interrogated":[399],"protocol":[402],"where":[403],"suddenly":[407],"increased":[408],"switching":[410],"single-pulse":[412],"(SPS)":[414],"(PPS).":[418],"led":[420],"initial":[423],"AMPA":[427,437],"followed":[429],"slowly":[432],"developing":[433],"LTD":[434],"NMDA.":[439],"These":[440],"results":[441,469],"NMDA-dependent":[444],"do":[447],"not":[448],"only":[449],"depend":[450],"instantaneous":[453],"but":[460],"influenced":[463],"prior":[465],"events.":[467],"can":[470,500],"be":[471],"described":[472],"modified":[475],"BCM-model":[476],"metaplasticity":[478],"activity-dependent":[481],"sliding":[482],"threshold.":[483],"In":[484],"addition":[485],"driven":[488],"processes,":[489],"passive":[490],"relaxation":[491],"contributes":[492],"some":[498],"cases":[499],"outbalance":[501],"active":[503],"control.":[504]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
