{"id":"https://openalex.org/W150881044","doi":null,"title":"DENDRITIC CELLS, RAPAMYCIN AND TRANSPLANT TOLERANCE","display_name":"DENDRITIC CELLS, RAPAMYCIN AND TRANSPLANT TOLERANCE","publication_year":2005,"publication_date":"2005-04-28","ids":{"openalex":"https://openalex.org/W150881044","mag":"150881044"},"language":"de","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:7276","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/7276/1/tanert_etd2005.pdf","pdf_url":"http://d-scholarship.pitt.edu/7276/1/tanert_etd2005.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/7276/1/tanert_etd2005.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050405497","display_name":"Timu\u00e7in Taner","orcid":"https://orcid.org/0000-0003-0641-2930","observed_orcids":["https://orcid.org/0000-0003-0641-2930"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Timu\u00e7in Taner","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0641-2930","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5050405497"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.04439999908208847,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9639999866485596},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":1.0},{"id":"https://openalex.org/keywords/transplantation-tolerance","display_name":"transplantation tolerance","score":0.9929999709129333},{"id":"https://openalex.org/keywords/organ-transplantation","display_name":"organ transplantation","score":0.5770000219345093},{"id":"https://openalex.org/keywords/dendritic-cell-maturation","display_name":"dendritic cell maturation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/antigen-uptake","display_name":"antigen uptake","score":0.5659999847412109},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.8939999938011169},{"id":"https://openalex.org/keywords/t-cell-anergy","display_name":"T cell anergy","score":0.9010000228881836},{"id":"https://openalex.org/keywords/alloantigen-presentation","display_name":"alloantigen presentation","score":0.7039999961853027},{"id":"https://openalex.org/keywords/cardiac-allograft-survival","display_name":"cardiac allograft survival","score":0.7689999938011169},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8379999995231628},{"id":"https://openalex.org/keywords/tolerogenic-dendritic-cells","display_name":"tolerogenic dendritic cells","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C200315206","wikidata":"https://www.wikidata.org/wiki/Q4733146","display_name":"Allorecognition","level":4,"score":0.8248472213745117},{"id":"https://openalex.org/C2777921159","wikidata":"https://www.wikidata.org/wiki/Q32089","display_name":"Sirolimus","level":2,"score":0.5789878368377686},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5691224336624146},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5442713499069214},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.5137184858322144},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48514804244041443},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.46793147921562195},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45610174536705017},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.4496014714241028},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.42172694206237793},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4216857850551605},{"id":"https://openalex.org/C83464605","wikidata":"https://www.wikidata.org/wiki/Q575296","display_name":"Antigen presentation","level":4,"score":0.42164182662963867},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39681434631347656},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3227294087409973},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:7276","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/7276/1/tanert_etd2005.pdf","pdf_url":"http://d-scholarship.pitt.edu/7276/1/tanert_etd2005.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:150881044","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/7276/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:7276","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/7276/1/tanert_etd2005.pdf","pdf_url":"http://d-scholarship.pitt.edu/7276/1/tanert_etd2005.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W150881044.pdf","grobid_xml":"https://content.openalex.org/works/W150881044.grobid-xml"},"referenced_works_count":203,"referenced_works":["https://openalex.org/W67546116","https://openalex.org/W183179568","https://openalex.org/W248089139","https://openalex.org/W1490721606","https://openalex.org/W1504809230","https://openalex.org/W1514093767","https://openalex.org/W1521187592","https://openalex.org/W1523435579","https://openalex.org/W1533596330","https://openalex.org/W1533878687","https://openalex.org/W1534496719","https://openalex.org/W1534709281","https://openalex.org/W1538328989","https://openalex.org/W1562592996","https://openalex.org/W1568945049","https://openalex.org/W1572004867","https://openalex.org/W1572210960","https://openalex.org/W1578114463","https://openalex.org/W1581554632","https://openalex.org/W1582077486","https://openalex.org/W1595217065","https://openalex.org/W1599851165","https://openalex.org/W1610653714","https://openalex.org/W1616716935","https://openalex.org/W1630218117","https://openalex.org/W1651589626","https://openalex.org/W1713856372","https://openalex.org/W1751630725","https://openalex.org/W1754391675","https://openalex.org/W1796142965","https://openalex.org/W1836092290","https://openalex.org/W1851301117","https://openalex.org/W1863217888","https://openalex.org/W1880220168","https://openalex.org/W1882142355","https://openalex.org/W1896731228","https://openalex.org/W1939229836","https://openalex.org/W1941619275","https://openalex.org/W1942198241","https://openalex.org/W1949206767","https://openalex.org/W1960538598","https://openalex.org/W1961222220","https://openalex.org/W1961232072","https://openalex.org/W1965981615","https://openalex.org/W1967994686","https://openalex.org/W1969797237","https://openalex.org/W1970047038","https://openalex.org/W1971056717","https://openalex.org/W1971895216","https://openalex.org/W1972758309","https://openalex.org/W1974301628","https://openalex.org/W1974618020","https://openalex.org/W1974696160","https://openalex.org/W1976726113","https://openalex.org/W1976830389","https://openalex.org/W1980720313","https://openalex.org/W1981817625","https://openalex.org/W1984034950","https://openalex.org/W1984673216","https://openalex.org/W1986729547","https://openalex.org/W1988050497","https://openalex.org/W1991139368","https://openalex.org/W1991298036","https://openalex.org/W1991562873","https://openalex.org/W1994263397","https://openalex.org/W1996518557","https://openalex.org/W1997055154","https://openalex.org/W2000286082","https://openalex.org/W2001009931","https://openalex.org/W2004275733","https://openalex.org/W2005454345","https://openalex.org/W2006031703","https://openalex.org/W2006559495","https://openalex.org/W2006772331","https://openalex.org/W2007265487","https://openalex.org/W2007491742","https://openalex.org/W2008999841","https://openalex.org/W2010665897","https://openalex.org/W2012461372","https://openalex.org/W2014616379","https://openalex.org/W2014616709","https://openalex.org/W2015407598","https://openalex.org/W2015744457","https://openalex.org/W2018603240","https://openalex.org/W2018798721","https://openalex.org/W2019291297","https://openalex.org/W2019458815","https://openalex.org/W2020179858","https://openalex.org/W2021428880","https://openalex.org/W2021588424","https://openalex.org/W2022850278","https://openalex.org/W2024839583","https://openalex.org/W2026237749","https://openalex.org/W2026351725","https://openalex.org/W2030019992","https://openalex.org/W2035799558","https://openalex.org/W2043796257","https://openalex.org/W2046842929","https://openalex.org/W2049158627","https://openalex.org/W2051502229","https://openalex.org/W2051658534","https://openalex.org/W2051907403","https://openalex.org/W2052143222","https://openalex.org/W2054083392","https://openalex.org/W2054729047","https://openalex.org/W2062286567","https://openalex.org/W2062512887","https://openalex.org/W2062952469","https://openalex.org/W2063287577","https://openalex.org/W2064353818","https://openalex.org/W2064661688","https://openalex.org/W2065907531","https://openalex.org/W2067773447","https://openalex.org/W2072549025","https://openalex.org/W2072845025","https://openalex.org/W2074572906","https://openalex.org/W2075421237","https://openalex.org/W2076412822","https://openalex.org/W2076436122","https://openalex.org/W2076899204","https://openalex.org/W2078450673","https://openalex.org/W2078725645","https://openalex.org/W2080154277","https://openalex.org/W2082400158","https://openalex.org/W2086291966","https://openalex.org/W2090008825","https://openalex.org/W2090168014","https://openalex.org/W2090500286","https://openalex.org/W2090640877","https://openalex.org/W2091420555","https://openalex.org/W2092995823","https://openalex.org/W2094373273","https://openalex.org/W2095083502","https://openalex.org/W2095751049","https://openalex.org/W2097096084","https://openalex.org/W2098578564","https://openalex.org/W2099712159","https://openalex.org/W2100446366","https://openalex.org/W2100656607","https://openalex.org/W2101781154","https://openalex.org/W2102689053","https://openalex.org/W2103370207","https://openalex.org/W2104959557","https://openalex.org/W2107140931","https://openalex.org/W2108794906","https://openalex.org/W2110276942","https://openalex.org/W2110443482","https://openalex.org/W2111695773","https://openalex.org/W2112506009","https://openalex.org/W2116372484","https://openalex.org/W2116716017","https://openalex.org/W2117395989","https://openalex.org/W2117547641","https://openalex.org/W2118463883","https://openalex.org/W2122304580","https://openalex.org/W2124249502","https://openalex.org/W2124376809","https://openalex.org/W2124971003","https://openalex.org/W2126397566","https://openalex.org/W2127959346","https://openalex.org/W2128390662","https://openalex.org/W2129456806","https://openalex.org/W2129585918","https://openalex.org/W2131635315","https://openalex.org/W2132608384","https://openalex.org/W2132830324","https://openalex.org/W2132929600","https://openalex.org/W2133696426","https://openalex.org/W2135277567","https://openalex.org/W2136706405","https://openalex.org/W2136992496","https://openalex.org/W2138961639","https://openalex.org/W2139557613","https://openalex.org/W2141286193","https://openalex.org/W2144700815","https://openalex.org/W2145015209","https://openalex.org/W2145594595","https://openalex.org/W2146326458","https://openalex.org/W2148222156","https://openalex.org/W2148619935","https://openalex.org/W2150564865","https://openalex.org/W2151296838","https://openalex.org/W2152172202","https://openalex.org/W2155874006","https://openalex.org/W2157278565","https://openalex.org/W2158770157","https://openalex.org/W2160215044","https://openalex.org/W2161792071","https://openalex.org/W2162361110","https://openalex.org/W2162415302","https://openalex.org/W2164047987","https://openalex.org/W2165344718","https://openalex.org/W2165590978","https://openalex.org/W2166676682","https://openalex.org/W2167234191","https://openalex.org/W2167897482","https://openalex.org/W2170293184","https://openalex.org/W2171398137","https://openalex.org/W2343246332","https://openalex.org/W2792966232","https://openalex.org/W4313305992","https://openalex.org/W4313343356","https://openalex.org/W7096186325"],"related_works":["https://openalex.org/W2072845025","https://openalex.org/W2019832508","https://openalex.org/W2027563916","https://openalex.org/W153537846","https://openalex.org/W2387977819","https://openalex.org/W2408715756","https://openalex.org/W1918052238","https://openalex.org/W2106575829","https://openalex.org/W3205727459","https://openalex.org/W2145178056"],"abstract_inverted_index":{"Dendritic":[0],"cells":[1,8,209],"(DC)":[2],"are":[3],"uniquely":[4],"well-equipped,":[5],"professional":[6],"antigen-presenting":[7],"(APC),":[9],"with":[10,114],"the":[11,40,115,126,134,271,275,296,304],"ability":[12],"to":[13,29,97,179,207,225,243,246,285],"initiate":[14],"and":[15,25,37,42,64,118,138,156,166,185,228,291],"regulate":[16],"immune":[17],"responses.":[18],"In":[19],"transplantation,":[20],"DC":[21,116,153,194,212,290,308],"of":[22,45,128,143,176,205,213,237,264,278,299,306,312],"both":[23,159],"donor":[24],"host":[26,214],"origin":[27],"contribute":[28],"graft":[30,232,265],"rejection":[31],"by":[32,190,210],"inducing":[33],"T":[34,83,139,187,197,208],"cell":[35,84,140,188,198],"activation":[36,137],"proliferation,":[38],"via":[39],"direct":[41],"indirect":[43],"pathways":[44],"allorecognition,":[46],"respectively.":[47],"Evidence":[48],"has":[49],"also":[50,302],"accumulated,":[51],"however,":[52],"that":[53,75,150,203,274,292],"DC,":[54,171],"particularly":[55],"in":[56,107,130,160,167,173,217,250,253,261,283],"an":[57,254],"immature":[58],"state,":[59],"can":[60,280,294],"promote":[61],"tolerance":[62],"induction":[63],"prolong":[65,229],"organ":[66,230],"allograft":[67],"survival.":[68,233,266],"Rapamycin":[69],"is":[70,76,95],"a":[71,247],"potent":[72],"immunosuppressant":[73],"pro-drug":[74],"well-recognized":[77],"for":[78,270],"its":[79,100,286],"inhibitory":[80,287],"effects":[81,101,288],"on":[82,89,92,102,133,289],"proliferation.":[85],"Despite":[86],"extensive":[87],"research":[88],"rapamycin's":[90],"impact":[91],"lymphocytes,":[93],"little":[94],"known":[96],"date":[98],"regarding":[99],"DC.":[103,146,191,300],"The":[104],"central":[105],"hypothesis":[106],"these":[108,238],"studies":[109,268],"was":[110],"that,":[111],"rapamycin":[112,151,180,279,293],"interferes":[113],"maturation":[117,158],"enhances":[119],"their":[120],"tolerogenic":[121,297],"potential.":[122],"We":[123],"first":[124,272],"analyzed":[125],"influence":[127],"rapamycin,":[129],"pharmacologically-relevant":[131],"concentrations,":[132],"maturation,":[135],"functional":[136],"stimulatory":[141],"potential":[142,305],"murine":[144],"myeloid":[145],"Herein":[147],"we":[148,201],"show":[149],"targets":[152],"antigen":[154],"(Ag)-uptake":[155],"IL-4-mediated":[157],"vitro":[161],"(in":[162,169],"bone":[163],"marrow-derived":[164],"DC),":[165],"vivo":[168,174,218],"freshly-isolated":[170],"following":[172],"administration":[175],"rapamycin).":[177],"Exposure":[178],"impairs":[181],"inflammatory":[182],"cytokine":[183],"production":[184],"effective":[186],"stimulation":[189],"Furthermore,":[192,257],"rapamycin-treated":[193,307],"induce":[195,223],"Ag-specific":[196,255],"anergy.":[199],"Next,":[200],"determined":[202],"presentation":[204],"alloAgs":[206],"rapamycin-pretreated":[211],"origin,":[215],"under":[216],"(pre-transplant)":[219],"steady-state":[220],"conditions,":[221],"could":[222],"hyporesponsiveness":[224],"subsequent":[226],"challenge":[227],"(heart)":[231],"A":[234],"single":[235],"infusion":[236,259],"cells,":[239],"seven":[240],"days":[241],"prior":[242],"transplant,":[244],"led":[245],"significant":[248],"improvement":[249],"transplant":[251,313],"outcome":[252],"manner.":[256],"repeated":[258],"resulted":[260],"marked":[262],"prolongation":[263],"These":[267],"demonstrate,":[269],"time,":[273],"immunosuppressive":[276],"action":[277],"be":[281],"ascribed,":[282],"part,":[284],"potentiate":[295],"properties":[298],"They":[301],"reveal":[303],"as":[309],"therapeutic":[310],"vectors":[311],"tolerance.":[314]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
