{"id":"https://openalex.org/W150854593","doi":null,"title":"Rosuvastatin slows the development of diastolic dysfunction in calcific aortic stenosis.","display_name":"Rosuvastatin slows the development of diastolic dysfunction in calcific aortic stenosis.","publication_year":2012,"publication_date":"2012-07-01","ids":{"openalex":"https://openalex.org/W150854593","mag":"150854593","pmid":"https://pubmed.ncbi.nlm.nih.gov/22953672"},"language":"en","primary_location":{"id":"pmid:22953672","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22953672","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of heart valve disease","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014732595","display_name":"Lu\u00eds M. Moura","orcid":"https://orcid.org/0000-0003-4258-8650","observed_orcids":["https://orcid.org/0000-0003-4258-8650"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Luis M Moura","raw_affiliation_strings":["Department of Medicine, Oporto School of Medicine, University of Oporto, Portugal. luismoura@med.up.pt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Oporto School of Medicine, University of Oporto, Portugal. luismoura@med.up.pt","institution_ids":["https://openalex.org/I182534213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012434354","display_name":"Sandra Ramos","orcid":"https://orcid.org/0000-0001-5788-1679","observed_orcids":["https://orcid.org/0000-0001-5788-1679"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandra F Ramos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041318172","display_name":"Steen Dalby Kristensen","orcid":"https://orcid.org/0000-0002-0112-0181","observed_orcids":["https://orcid.org/0000-0002-0112-0181"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steen D Kristensen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016901394","display_name":"Fausto Jos\u00e9 Pinto","orcid":"https://orcid.org/0000-0002-8034-4529","observed_orcids":["https://orcid.org/0000-0002-8034-4529"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fausto J Pinto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004152661","display_name":"Isabel M Barros","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isabel M Barros","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5027657424","display_name":"Francisco Rocha\u2010Gon\u00e7alves","orcid":"https://orcid.org/0000-0002-9068-9547","observed_orcids":["https://orcid.org/0000-0002-9068-9547"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francisco Rocha-Gon\u00e7alves","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2064,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.59042342,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"21","issue":"4","first_page":"463","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.7285000085830688,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.7285000085830688,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.22920000553131104,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rosuvastatin","display_name":"rosuvastatin","score":0.996999979019165},{"id":"https://openalex.org/keywords/calcific-aortic-stenosis","display_name":"calcific aortic stenosis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/diastolic-dysfunction","display_name":"diastolic dysfunction","score":0.8980000019073486},{"id":"https://openalex.org/keywords/left-ventricular-diastolic-function","display_name":"left ventricular diastolic function","score":0.9100000262260437},{"id":"https://openalex.org/keywords/isovolumic-relaxation-time","display_name":"isovolumic relaxation time","score":0.8610000014305115},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.8700000047683716},{"id":"https://openalex.org/keywords/statin-therapy","display_name":"statin therapy","score":0.8149999976158142},{"id":"https://openalex.org/keywords/tissue-doppler-imaging","display_name":"tissue Doppler imaging","score":0.7509999871253967},{"id":"https://openalex.org/keywords/e-a-ratio","display_name":"E/A ratio","score":0.6570000052452087},{"id":"https://openalex.org/keywords/e-e-ratio","display_name":"E/e' ratio","score":0.9440000057220459},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9760200381278992},{"id":"https://openalex.org/C2780499067","wikidata":"https://www.wikidata.org/wiki/Q415159","display_name":"Rosuvastatin","level":2,"score":0.8936124444007874},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7866330742835999},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7237789630889893},{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.6787259578704834},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.6062757968902588},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.1481388807296753}],"mesh":[{"descriptor_ui":"D000068718","descriptor_name":"Rosuvastatin Calcium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003971","descriptor_name":"Diastole","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004452","descriptor_name":"Echocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005464","descriptor_name":"Fluorobenzenes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020097","descriptor_name":"Natriuretic Peptide, Brain","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D054144","descriptor_name":"Heart Failure, Diastolic","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D054144","descriptor_name":"Heart Failure, Diastolic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D054144","descriptor_name":"Heart Failure, Diastolic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmid:22953672","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22953672","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of heart valve disease","raw_type":"Clinical Trial"},{"id":"pmh:oai:pure.atira.dk:publications/3aee8751-355c-4ad5-8e8a-e6b82c550c6f","doi":null,"is_oa":false,"landing_page_url":"https://pure.au.dk/portal/en/publications/3aee8751-355c-4ad5-8e8a-e6b82c550c6f","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Moura, L M, Ramos, S F, Kristensen, S D, Pinto, F J, Barros, I M, Rocha-Gon\u00e7alves, F & L\u00f8fgren, B 2012, 'Rosuvastatin slows the development of diastolic dysfunction in calcific aortic stenosis', Journal of Heart Valve Disease, vol. 21, no. 4, pp. 463-72.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repositorio.ulisboa.pt:10451/35327","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10451/35327","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"mag:150854593","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22953672","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1921637439","https://openalex.org/W1968035285","https://openalex.org/W1976791051","https://openalex.org/W1978805635","https://openalex.org/W1979235316","https://openalex.org/W1997859168","https://openalex.org/W2000009174","https://openalex.org/W2004943709","https://openalex.org/W2009936845","https://openalex.org/W2009992710","https://openalex.org/W2015795623","https://openalex.org/W2017188640","https://openalex.org/W2017850911","https://openalex.org/W2030044261","https://openalex.org/W2034562813","https://openalex.org/W2037876625","https://openalex.org/W2039182800","https://openalex.org/W2043353709","https://openalex.org/W2048919425","https://openalex.org/W2049783070","https://openalex.org/W2054436867","https://openalex.org/W2055653999","https://openalex.org/W2058869291","https://openalex.org/W2063982755","https://openalex.org/W2068875409","https://openalex.org/W2069693007","https://openalex.org/W2079007437","https://openalex.org/W2082385280","https://openalex.org/W2097303291","https://openalex.org/W2103636227","https://openalex.org/W2106214890","https://openalex.org/W2112050863","https://openalex.org/W2116507628","https://openalex.org/W2117330772","https://openalex.org/W2122202708","https://openalex.org/W2122601000","https://openalex.org/W2134855279","https://openalex.org/W2135412352","https://openalex.org/W2138402059","https://openalex.org/W2158295026","https://openalex.org/W2161411353","https://openalex.org/W2167045683","https://openalex.org/W2328937331"],"related_works":["https://openalex.org/W2115020538","https://openalex.org/W7097857141","https://openalex.org/W959763216","https://openalex.org/W2361408896","https://openalex.org/W1798444782","https://openalex.org/W2088172530","https://openalex.org/W2030044261","https://openalex.org/W2008115427","https://openalex.org/W7166432006","https://openalex.org/W4214640849"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIM":[2],"OF":[3],"THE":[4],"STUDY:":[5],"The":[6,77,257],"study":[7,100,110,223,264],"aims":[8],"were":[9,57,94,229],"to":[10,32,306,313],"test":[11],"the":[12,17,34,99,109,233,238,273,289,296,308],"effect":[13],"of":[14,19,36,42,122,227,259,265,275,291,298],"rosuvastatin":[15,59,125,270],"on":[16],"progression":[18,274],"left":[20],"ventricular":[21],"(LV)":[22],"diastolic":[23,43,79,133,276],"function":[24,80,134,317],"in":[25,45,232,237,278,301],"patients":[26,128,267],"with":[27,54,71,124],"aortic":[28],"stenosis":[29],"(AS),":[30],"and":[31,101,196],"evaluate":[33],"use":[35],"beta-natriuretic-peptide":[37],"(BNP)":[38],"as":[39,140],"a":[40,67,130],"marker":[41],"dysfunction":[44,277],"this":[46,260],"condition.":[47],"METHODS:":[48],"Sixty-one":[49],"hypercholesterolemic,":[50],"consecutive":[51],"new":[52],"referrals":[53],"moderate":[55,279],"AS":[56,280],"administered":[58],"(Crestor)":[60],"20":[61],"mg/day":[62],"for":[63],"18":[64],"months,":[65],"while":[66],"further":[68],"60":[69],"subjects":[70,97,137],"normal":[72],"cholesterol":[73],"levels":[74,93,226],"remained":[75],"untreated.":[76],"LV":[78],"was":[81],"determined":[82],"using":[83,283],"conventional":[84],"Doppler":[85,88],"echocardiography,":[86],"tissue":[87],"imaging":[89],"(TDI);":[90],"BNP":[91,228],"plasma":[92,225,292],"monitored":[95],"when":[96,281],"entered":[98],"then":[102],"assessed":[103,282],"prospectively":[104],"at":[105,222],"six-month":[106],"intervals":[107],"until":[108],"end.":[111],"RESULTS:":[112],"After":[113],"an":[114,143],"18-month":[115],"(mean":[116],"73":[117],"+/-":[118,150,154,161,165,175,179,186,190,201,205,212,216],"24":[119],"weeks)":[120],"period":[121],"treatment":[123,271,300],"(Tx":[126,148,173,199],"group),":[127,139],"showed":[129,268],"significantly":[131,230],"better":[132],"than":[135,236],"untreated":[136],"(uTx":[138],"indicated":[141],"by":[142,288],"isovolumic":[144],"relaxation":[145],"time":[146],"(IVRT)":[147],"102.0":[149],"42.8":[151],"versus":[152,163,177,188,203,214,248],"97.2":[153],"19.1;":[155],"p":[156,168,181,193,207,218,253],"<":[157,219],"0.001;":[158],"uTx":[159,184,210,239],"99.7":[160],"21.7":[162],"95.2":[164],"21.8":[166],"ms;":[167],"=":[169,182,194,208,254],"0.032),":[170],"E/A":[171],"ratio":[172,198],"1.0":[174],"0.6":[176],"0.9":[178,189],"0.3,":[180],"0.52;":[183],"1.2":[185,213],"0.40":[187],"0.30":[191],"versus,":[192],"0.006),":[195],"E/E'":[197],"11.4":[200,204],"1.5":[202],"1.8,":[206],"0.19;":[209],"15.4":[211],"12.3":[215],"1.5,":[217],"0.001).":[220],"Similarly,":[221],"end,":[224],"lower":[231],"Tx":[234],"group":[235,240],"[median":[241],"(1st-3rd":[242],"quartiles):":[243],"37.0":[244],"pg/ml":[245,250],"(20.1-65.2":[246],"pg/ml)":[247],"57.1":[249],"(46.9-98.2":[251],"pg/ml);":[252],"0.017].":[255],"CONCLUSION:":[256],"results":[258],"prospective":[261],"follow":[262],"up":[263],"asymptomatic":[266],"that":[269],"delays":[272],"hemodynamic":[284],"echocardiographic":[285],"parameters":[286],"or":[287],"release":[290],"physiological":[293],"markers.":[294],"Hence,":[295],"benefits":[297],"statin":[299],"AS,":[302],"which":[303],"are":[304],"known":[305],"affect":[307],"valve":[309],"endothelium,":[310],"also":[311],"extend":[312],"changes":[314],"affecting":[315],"myocardial":[316],"itself.":[318]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
