{"id":"https://openalex.org/W1508325619","doi":"https://doi.org/10.1016/s0021-9258(17)41784-4","title":"Inositol 1,4,5,6-tetrakisphosphate is phosphorylated in rat liver by a 3-kinase that is distinct from inositol 1,4,5-trisphosphate 3-kinase.","display_name":"Inositol 1,4,5,6-tetrakisphosphate is phosphorylated in rat liver by a 3-kinase that is distinct from inositol 1,4,5-trisphosphate 3-kinase.","publication_year":1994,"publication_date":"1994-02-01","ids":{"openalex":"https://openalex.org/W1508325619","doi":"https://doi.org/10.1016/s0021-9258(17)41784-4","mag":"1508325619","pmid":"https://pubmed.ncbi.nlm.nih.gov/8308002"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(17)41784-4","doi":"https://doi.org/10.1016/s0021-9258(17)41784-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)41784-4","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(17)41784-4","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061887843","display_name":"Andrew Craxton","orcid":"https://orcid.org/0000-0002-5957-9251","observed_orcids":["https://orcid.org/0000-0002-5957-9251"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Craxton","raw_affiliation_strings":["Inositol Lipid Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inositol Lipid Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036027763","display_name":"Christoph\u00e9 Erneux","orcid":"https://orcid.org/0000-0002-0773-8206","observed_orcids":["https://orcid.org/0000-0002-0773-8206"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Erneux","raw_affiliation_strings":["Inositol Lipid Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inositol Lipid Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013107971","display_name":"Stephen B. Shears","orcid":"https://orcid.org/0000-0001-7309-8916","observed_orcids":["https://orcid.org/0000-0001-7309-8916"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.B. Shears","raw_affiliation_strings":["Inositol Lipid Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inositol Lipid Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.0242,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.86884419,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"269","issue":"6","first_page":"4337","last_page":"4342"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inositol-1-4-5-trisphosphate-3-kinase","display_name":"inositol 1,4,5-trisphosphate 3-kinase","score":0.9079999923706055},{"id":"https://openalex.org/keywords/inositol-1-3-4-trisphosphate","display_name":"inositol 1,3,4-trisphosphate","score":0.7749999761581421},{"id":"https://openalex.org/keywords/inositol-polyphosphate-metabolism","display_name":"inositol polyphosphate metabolism","score":0.6510000228881836},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.4819999933242798},{"id":"https://openalex.org/keywords/isoenzymes","display_name":"isozymes","score":0.7900000214576721},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.5659999847412109},{"id":"https://openalex.org/keywords/cdna-clones","display_name":"cDNA clones","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.8979241251945496},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5880172252655029},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5347643494606018},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5256803035736084},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46822187304496765},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35075902938842773},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16553068161010742}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007295","descriptor_name":"Inositol Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017853","descriptor_name":"Phosphotransferases (Alcohol Group Acceptor)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0021-9258(17)41784-4","doi":"https://doi.org/10.1016/s0021-9258(17)41784-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)41784-4","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:8308002","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8308002","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/56079","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/56079","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of biological chemistry, 269 (6","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(17)41784-4","doi":"https://doi.org/10.1016/s0021-9258(17)41784-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)41784-4","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W23453243","https://openalex.org/W181110245","https://openalex.org/W1484360204","https://openalex.org/W1485488844","https://openalex.org/W1487444379","https://openalex.org/W1494062829","https://openalex.org/W1509560911","https://openalex.org/W1558610458","https://openalex.org/W1559021450","https://openalex.org/W1562922570","https://openalex.org/W1588492473","https://openalex.org/W1622773889","https://openalex.org/W1900249688","https://openalex.org/W1954233493","https://openalex.org/W1997093700","https://openalex.org/W1999482021","https://openalex.org/W2013420237","https://openalex.org/W2018225424","https://openalex.org/W2058449890","https://openalex.org/W2167294419","https://openalex.org/W2325631407","https://openalex.org/W2336512389","https://openalex.org/W2338831915"],"related_works":["https://openalex.org/W1605382755","https://openalex.org/W2415331531","https://openalex.org/W2050315409","https://openalex.org/W2000584059","https://openalex.org/W1512142615","https://openalex.org/W2056258610","https://openalex.org/W1516463671","https://openalex.org/W2004919905","https://openalex.org/W1976781991","https://openalex.org/W1540416564"],"abstract_inverted_index":{"Liver":[0],"homogenates":[1],"phosphorylated":[2,46,86],"inositol":[3,7,28,47,64,83,92,131,137,141,156,167],"1,4,5,6-tetrakisphosphate":[4,48,84,126,138],"exclusively":[5],"to":[6,26,59,101],"1,3,4,5,6-pentakisphosphate.":[8],"Approximately":[9],"30%":[10],"of":[11,21,152,155],"this":[12],"phosphorylating":[13,54],"activity":[14,38,44],"was":[15,32,39,128],"associated":[16],"with":[17],"the":[18,22,27,42],"particulate":[19],"fraction":[20],"cell,":[23],"in":[24,99],"contrast":[25,100],"3,4,5,6-tetrakisphosphate":[29,93],"1-kinase,":[30],"which":[31],"90%":[33],"soluble.":[34],"This":[35],"soluble":[36,43],"1-kinase":[37,74],"resolved":[40,145],"from":[41,159],"that":[45,82],"by":[49,63,88,130,146,176],"anion-exchange":[50,147],"chromatography.":[51,148],"The":[52],"two":[53,153,171],"activities":[55,173],"were":[56,144],"also":[57],"found":[58],"be":[60],"differentially":[61],"inhibited":[62,129],"1,3,4-trisphosphate":[65],"(IC50":[66],"for":[67,73],"3-kinase":[68,127,139,143,158,172],">":[69],"100":[70],"microM;":[71],"IC50":[72],"<":[75],"1":[76,134],"microM).":[77,135],"Thus,":[78,169],"we":[79],"have":[80],"demonstrated":[81],"is":[85,94],"directly":[87],"a":[89],"3-kinase,":[90],"and":[91,115,140,161],"not":[95,165],"an":[96],"obligatory":[97],"intermediate,":[98],"one":[102],"previous":[103],"model":[104],"(Oliver,":[105],"K.":[106],"G.,":[107],"Putney,":[108],"J.":[109,113,120],"W.,":[110],"Jr.,":[111],"Obie,":[112],"F.,":[114],"Shears,":[116],"S.":[117],"B.":[118],"(1992)":[119],"Biol.":[121],"Chem.":[122],"267,":[123],"21528-21534).":[124],"Inositol":[125],"1,3,4,6-tetrakisphosphate":[132],"(IC50,":[133],"Soluble":[136],"1,4,5-trisphosphate":[142,157],"Furthermore,":[149],"cDNA":[150],"clones":[151],"isozymes":[154],"rat":[160],"human":[162],"brain":[163],"did":[164],"phosphorylate":[166],"1,4,5,6-tetrakisphosphate.":[168],"these":[170],"are":[174],"performed":[175],"distinct":[177],"enzymes.":[178]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
