{"id":"https://openalex.org/W15082049","doi":null,"title":"Abstract 14394: Reduction of Myocardial Perfusion During Acute Hyperglycemia Is More Marked in the Presence of Insulin Resistance: A Noninvasive Bedside Evaluation Using Vasodilator Myocardial Contrast Echocardiography","display_name":"Abstract 14394: Reduction of Myocardial Perfusion During Acute Hyperglycemia Is More Marked in the Presence of Insulin Resistance: A Noninvasive Bedside Evaluation Using Vasodilator Myocardial Contrast Echocardiography","publication_year":2011,"publication_date":"2011-11-22","ids":{"openalex":"https://openalex.org/W15082049","mag":"15082049"},"language":"en","primary_location":{"id":"mag:15082049","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/circ.124.suppl_21.A14394","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null},"volume":null,"type":"conference-abstract","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061114305","display_name":"Sahar S. Abdelmoneim","orcid":"https://orcid.org/0000-0003-0995-8795","observed_orcids":["https://orcid.org/0000-0003-0995-8795"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sahar S. Abdelmoneim","raw_affiliation_strings":["Cardiovascular Medicine, Mayo Clinic, Rochester, MN"],"raw_orcid":"https://orcid.org/0000-0003-0995-8795","affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009429813","display_name":"Mary E. Hagen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary E. Hagen","raw_affiliation_strings":["Cardiovascular Medicine, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051173490","display_name":"Edward Mendrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Mendrick","raw_affiliation_strings":["Cardiovascular Medicine, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068466173","display_name":"Vishwanath Pattan","orcid":"https://orcid.org/0000-0002-7077-8331","observed_orcids":["https://orcid.org/0000-0002-7077-8331"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vishwanath Pattan","raw_affiliation_strings":["Endocrine and Metabolism, Mayo Clinic, Rochester, MN"],"raw_orcid":"https://orcid.org/0000-0002-7077-8331","affiliations":[{"raw_affiliation_string":"Endocrine and Metabolism, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075339591","display_name":"Benjamin Wong","orcid":"https://orcid.org/0000-0003-2258-7925","observed_orcids":["https://orcid.org/0000-0003-2258-7925"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Wong","raw_affiliation_strings":["Cardiovascular Medicine, Mayo Clinic, Rochester, MN"],"raw_orcid":"https://orcid.org/0000-0003-2258-7925","affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005493907","display_name":"Barbara Norby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara Norby","raw_affiliation_strings":["Cardiovascular Medicine, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057014138","display_name":"Tamara Roberson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamara Roberson","raw_affiliation_strings":["Endocrine and Metabolism, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine and Metabolism, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004739053","display_name":"Troy Szydel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Troy Szydel","raw_affiliation_strings":["Endocrine and Metabolism, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine and Metabolism, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043696489","display_name":"Rita Basu","orcid":"https://orcid.org/0000-0002-7827-9422","observed_orcids":["https://orcid.org/0000-0002-7827-9422"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rita Basu","raw_affiliation_strings":["Endocrine and Metabolism, Mayo Clinic, Rochester, MN"],"raw_orcid":"https://orcid.org/0000-0002-7827-9422","affiliations":[{"raw_affiliation_string":"Endocrine and Metabolism, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102733833","display_name":"Ananda Basu","orcid":"https://orcid.org/0000-0003-4166-6741","observed_orcids":["https://orcid.org/0000-0003-4166-6741"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ananda Basu","raw_affiliation_strings":["Endocrine and Metabolism, Mayo Clinic, Rochester, MN"],"raw_orcid":"https://orcid.org/0000-0003-4166-6741","affiliations":[{"raw_affiliation_string":"Endocrine and Metabolism, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025608840","display_name":"Sharon L. Mulvagh","orcid":"https://orcid.org/0000-0002-7377-4053","observed_orcids":["https://orcid.org/0000-0002-7377-4053"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon L. Mulvagh","raw_affiliation_strings":["Cardiovascular Medicine, Mayo Clinic, Rochester, MN"],"raw_orcid":"https://orcid.org/0000-0002-7377-4053","affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"124","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.15309999883174896,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.017999999225139618,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9380000233650208},{"id":"https://openalex.org/keywords/acute-hyperglycemia","display_name":"acute hyperglycemia","score":0.9570000171661377},{"id":"https://openalex.org/keywords/myocardial-blood-flow","display_name":"myocardial blood flow","score":0.8740000128746033},{"id":"https://openalex.org/keywords/coronary-flow-reserve","display_name":"coronary flow reserve","score":0.9950000047683716},{"id":"https://openalex.org/keywords/myocardial-perfusion","display_name":"myocardial perfusion","score":0.9110000133514404},{"id":"https://openalex.org/keywords/hyperinsulinemic-euglycemic-clamp","display_name":"hyperinsulinemic-euglycemic clamp","score":0.8109999895095825},{"id":"https://openalex.org/keywords/glucose-infusion-rate","display_name":"glucose infusion rate","score":0.8270000219345093},{"id":"https://openalex.org/keywords/non-diabetic-patients","display_name":"non-diabetic patients","score":0.6399999856948853},{"id":"https://openalex.org/keywords/regadenoson-stress","display_name":"regadenoson stress","score":0.8920000195503235}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9155497550964355},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6819800138473511},{"id":"https://openalex.org/C2778707443","wikidata":"https://www.wikidata.org/wiki/Q3936479","display_name":"Coronary flow reserve","level":3,"score":0.6518575549125671},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.604789674282074},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5925084352493286},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5451436042785645},{"id":"https://openalex.org/C2909076160","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Coronary vasodilator","level":3,"score":0.5170005559921265},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.4962618947029114},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.46346867084503174},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.446049302816391},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.41870784759521484},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3565834164619446}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:15082049","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/circ.124.suppl_21.A14394","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7300000190734863}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1975730119","https://openalex.org/W2350169745","https://openalex.org/W3012518916","https://openalex.org/W1998949258","https://openalex.org/W2089853691","https://openalex.org/W2523231913","https://openalex.org/W2000263989","https://openalex.org/W3136613854","https://openalex.org/W1999669982","https://openalex.org/W1986520743","https://openalex.org/W1997224652","https://openalex.org/W2571821948","https://openalex.org/W2465887328","https://openalex.org/W1977716709","https://openalex.org/W2071110069","https://openalex.org/W2470447090","https://openalex.org/W2233087823","https://openalex.org/W2059720659","https://openalex.org/W2368188617","https://openalex.org/W1985074117"],"abstract_inverted_index":{"Background:":[0],"The":[2],"effect":[3],"of":[4,20,82,193,224,232],"insulin":[5,226],"resistance":[6,227],"(IR)":[7],"on":[8,25,60],"coronary":[9,31,239],"perfusion":[10],"in":[11,42,117,234,248],"humans":[12],"is":[13],"poorly":[14],"studied.":[15],"We":[16,49],"evaluated":[17],"the":[18,222,230],"association":[19],"IR":[21,56],"during":[22,66,128,165],"acute":[23,166,220],"hyperglycemia":[24,167],"myocardial":[26,38,137,235],"blood":[27,86,138,236],"flow":[28,32,237,240],"(MBF)":[29],"and":[30,75,99,127,150,159,202,238],"reserve":[33,161,241],"(CFR)":[34],"as":[35,242],"measured":[36],"by":[37,245],"contrast":[39],"echocardiography":[40],"(MCE)":[41],"nondiabetic":[43],"volunteers":[44],"Methods:":[47],"prospectively":[50],"enrolled":[51],"19":[52],"[5":[53],"males]":[54],"nondiabetics.":[55,249],"status":[57],"was":[58,78,112],"based":[59],"glucose":[61,87],"infusion":[62],"rate":[63],"(GIR,":[64],"mg/kg/min)":[65],"euglycemic":[67,95],"hormone":[68],"clamp":[69],"[somatostatin,":[70],"replacement":[71],"glucagon,":[72],"growth":[73],"hormone,":[74],"insulin].":[76],"Glucose":[77],"infused":[79],"for":[80],"total":[81],"4":[83],"hrs":[84],"(arterialized":[85],"(BG)":[88],"monitored":[89],"every":[90],"10":[91],"min)":[92],"to":[93,135],"achieve":[94],"(BG":[96,101],"95\u00b1":[97],"6.8mg/dl)":[98],"hyperglycemic":[100],"233":[102],"\u00b1":[103,180,184,195],"18":[104],"mg/dl)":[105],"states.":[106],"For":[107],"each":[108],"glycemic":[109],"state,":[110],"MCE":[111,247],"done":[113],"(Definity:":[114],"1.3":[115],"ml":[116],"60":[118],"cc":[119],"0.9%":[120],"saline":[121],"at":[122,125],"200":[123],"ml/hr;)":[124],"rest":[126],"stress":[129],"(regadenoson":[130],"400":[131],"ug":[132],"IV":[133],"bolus)":[134],"measure":[136],"volume":[139],"(A":[140],"dB);":[141],"microbubble":[142],"velocity":[143],"(\u03b2":[144],"sec":[145],"-1":[146],");":[147],"MBF":[148,171,201],"(dB/sec);":[149],"CFR":[151,158,178,203],"Results:":[154],"Stress":[156],"MBF,":[157],"\u03b2":[160],"were":[162,204,210],"significantly":[163,205],"reduced":[164],"vs.":[168,174,182],"euglycemia":[169],"[stress":[170],"4.5\u00b1":[172],"2.1":[173],"5.5\u00b1":[175],"2.5,":[176],"P=0.040,":[177],"2.07":[179],"0.89":[181],"3.2":[183],"1.3,":[185],"P":[186],"Figure":[187],".":[188],"Using":[189],"a":[190],"threshold":[191],"GIR":[192],"5.5":[194],"3.3":[196],"mg/kg/min":[197],"(median":[198],"5":[199],"mg/kg/min),":[200],"differentiated,":[206],"although,":[207],"clinical":[208],"characteristics":[209],"not":[211],",":[212],"Table":[213],"Conclusions:":[217],"During":[219],"hyperglycemia,":[221],"degree":[223],"underlying":[225],"correlates":[228],"with":[229],"magnitude":[231],"reduction":[233],"determined":[243],"noninvasively":[244],"vasodilator":[246]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2025-10-27T00:00:00"}