{"id":"https://openalex.org/W1508006484","doi":null,"title":"Refined tools to define hazelnut and peanut allergy in children","display_name":"Refined tools to define hazelnut and peanut allergy in children","publication_year":2007,"publication_date":"2007-11-01","ids":{"openalex":"https://openalex.org/W1508006484","mag":"1508006484"},"language":"en","primary_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/23522","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/23522","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.library.uu.nl/handle/1874/23522","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079705061","display_name":"Annebeth E. Flinterman","orcid":"https://orcid.org/0000-0002-8655-0497","observed_orcids":["https://orcid.org/0000-0002-8655-0497"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Annebeth E. Flinterman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8655-0497","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5079705061"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hazelnut-allergy","display_name":"hazelnut allergy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/peanut-allergy","display_name":"peanut allergy","score":1.0},{"id":"https://openalex.org/keywords/food-allergy-diagnosis","display_name":"food allergy diagnosis","score":0.7680000066757202},{"id":"https://openalex.org/keywords/double-blind-placebo-controlled-food-challenge","display_name":"double-blind placebo-controlled food challenge","score":0.9150000214576721},{"id":"https://openalex.org/keywords/oral-food-challenge","display_name":"oral food challenge","score":0.7580000162124634},{"id":"https://openalex.org/keywords/ige-sensitization","display_name":"IgE sensitization","score":0.8450000286102295},{"id":"https://openalex.org/keywords/peanut-allergens","display_name":"peanut allergens","score":0.8050000071525574},{"id":"https://openalex.org/keywords/allergen-immunotherapy","display_name":"allergen immunotherapy","score":0.7229999899864197},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.7580000162124634},{"id":"https://openalex.org/keywords/t-cell-epitopes","display_name":"T cell epitopes","score":0.9390000104904175},{"id":"https://openalex.org/keywords/ige-epitopes","display_name":"IgE epitopes","score":0.9259999990463257},{"id":"https://openalex.org/keywords/b-cell-response","display_name":"B cell response","score":0.6690000295639038},{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":0.6700000166893005},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.6800000071525574},{"id":"https://openalex.org/keywords/parental-anxiety","display_name":"parental anxiety","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C2778012357","wikidata":"https://www.wikidata.org/wiki/Q7157933","display_name":"Peanut allergy","level":4,"score":0.8735219836235046},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7862128019332886},{"id":"https://openalex.org/C2776027960","wikidata":"https://www.wikidata.org/wiki/Q769815","display_name":"Food allergy","level":3,"score":0.6811444163322449},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.649250328540802},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.5860678553581238},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5141780376434326},{"id":"https://openalex.org/C2780510475","wikidata":"https://www.wikidata.org/wiki/Q186752","display_name":"Allergen","level":3,"score":0.5010037422180176},{"id":"https://openalex.org/C2775933838","wikidata":"https://www.wikidata.org/wiki/Q168800","display_name":"Anaphylaxis","level":3,"score":0.49701574444770813},{"id":"https://openalex.org/C2777917907","wikidata":"https://www.wikidata.org/wiki/Q272436","display_name":"Hay fever","level":3,"score":0.48763933777809143},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.4609189033508301},{"id":"https://openalex.org/C2780596994","wikidata":"https://www.wikidata.org/wiki/Q769479","display_name":"Oral allergy syndrome","level":4,"score":0.43687704205513},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4323109984397888},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3988259732723236},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.07788804173469543}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:dspace.library.uu.nl:1874/23522","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/23522","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/23522","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/23522","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:1508006484","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/23522","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/23522","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/23522","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"},{"display_name":"Zero hunger","score":0.40450000762939453,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":195,"referenced_works":["https://openalex.org/W95590845","https://openalex.org/W283264256","https://openalex.org/W290066869","https://openalex.org/W1504546383","https://openalex.org/W1525120429","https://openalex.org/W1582598578","https://openalex.org/W1653134186","https://openalex.org/W1761962232","https://openalex.org/W1783440668","https://openalex.org/W1925752674","https://openalex.org/W1931782913","https://openalex.org/W1941442833","https://openalex.org/W1944657476","https://openalex.org/W1964427077","https://openalex.org/W1968195665","https://openalex.org/W1968323951","https://openalex.org/W1970468974","https://openalex.org/W1970640947","https://openalex.org/W1970880716","https://openalex.org/W1973776145","https://openalex.org/W1975456044","https://openalex.org/W1975619580","https://openalex.org/W1975792234","https://openalex.org/W1976006475","https://openalex.org/W1976635930","https://openalex.org/W1977800771","https://openalex.org/W1978348694","https://openalex.org/W1978388952","https://openalex.org/W1979179151","https://openalex.org/W1981210226","https://openalex.org/W1981698967","https://openalex.org/W1983057058","https://openalex.org/W1984562450","https://openalex.org/W1986203176","https://openalex.org/W1987494349","https://openalex.org/W1987571936","https://openalex.org/W1988066089","https://openalex.org/W1988580681","https://openalex.org/W1989040407","https://openalex.org/W1989728270","https://openalex.org/W1989802197","https://openalex.org/W1990253099","https://openalex.org/W1990258895","https://openalex.org/W1991894933","https://openalex.org/W1992153121","https://openalex.org/W1992658087","https://openalex.org/W1995339672","https://openalex.org/W1995889207","https://openalex.org/W1998078318","https://openalex.org/W2000279446","https://openalex.org/W2000831686","https://openalex.org/W2002807391","https://openalex.org/W2005335541","https://openalex.org/W2006208839","https://openalex.org/W2009566241","https://openalex.org/W2009746313","https://openalex.org/W2011000046","https://openalex.org/W2017415480","https://openalex.org/W2017778900","https://openalex.org/W2018472993","https://openalex.org/W2019168895","https://openalex.org/W2019743243","https://openalex.org/W2020538616","https://openalex.org/W2021676941","https://openalex.org/W2023610121","https://openalex.org/W2023870565","https://openalex.org/W2025628543","https://openalex.org/W2025786019","https://openalex.org/W2026313549","https://openalex.org/W2026795128","https://openalex.org/W2028064677","https://openalex.org/W2028915073","https://openalex.org/W2029379074","https://openalex.org/W2029661050","https://openalex.org/W2031676223","https://openalex.org/W2032611208","https://openalex.org/W2033751720","https://openalex.org/W2033913511","https://openalex.org/W2034785481","https://openalex.org/W2035045405","https://openalex.org/W2036632318","https://openalex.org/W2040950480","https://openalex.org/W2041594259","https://openalex.org/W2041939173","https://openalex.org/W2043120247","https://openalex.org/W2046741942","https://openalex.org/W2046759597","https://openalex.org/W2050629446","https://openalex.org/W2050806871","https://openalex.org/W2052022547","https://openalex.org/W2052338519","https://openalex.org/W2052875649","https://openalex.org/W2053432732","https://openalex.org/W2056088575","https://openalex.org/W2056399846","https://openalex.org/W2058034600","https://openalex.org/W2058951284","https://openalex.org/W2059372582","https://openalex.org/W2063096720","https://openalex.org/W2063201619","https://openalex.org/W2063720477","https://openalex.org/W2065504830","https://openalex.org/W2067313879","https://openalex.org/W2070356198","https://openalex.org/W2071297908","https://openalex.org/W2073524152","https://openalex.org/W2074191073","https://openalex.org/W2075756062","https://openalex.org/W2076278773","https://openalex.org/W2077325346","https://openalex.org/W2078178846","https://openalex.org/W2078772364","https://openalex.org/W2079208358","https://openalex.org/W2082558314","https://openalex.org/W2082761273","https://openalex.org/W2083980508","https://openalex.org/W2084652317","https://openalex.org/W2085383312","https://openalex.org/W2086500471","https://openalex.org/W2087399836","https://openalex.org/W2087735313","https://openalex.org/W2088716050","https://openalex.org/W2089346000","https://openalex.org/W2089736491","https://openalex.org/W2090029451","https://openalex.org/W2092564708","https://openalex.org/W2093280923","https://openalex.org/W2094157366","https://openalex.org/W2095604884","https://openalex.org/W2095959961","https://openalex.org/W2098084575","https://openalex.org/W2098388862","https://openalex.org/W2100042048","https://openalex.org/W2104009953","https://openalex.org/W2104802908","https://openalex.org/W2107431762","https://openalex.org/W2108254924","https://openalex.org/W2108757802","https://openalex.org/W2109373419","https://openalex.org/W2110372259","https://openalex.org/W2111901567","https://openalex.org/W2111967756","https://openalex.org/W2113739450","https://openalex.org/W2114435349","https://openalex.org/W2117810644","https://openalex.org/W2118532682","https://openalex.org/W2118658391","https://openalex.org/W2118832804","https://openalex.org/W2119538799","https://openalex.org/W2119908538","https://openalex.org/W2123758536","https://openalex.org/W2123994079","https://openalex.org/W2126849374","https://openalex.org/W2127285081","https://openalex.org/W2127984467","https://openalex.org/W2129330033","https://openalex.org/W2130017988","https://openalex.org/W2130614990","https://openalex.org/W2136735111","https://openalex.org/W2136848239","https://openalex.org/W2137516648","https://openalex.org/W2138298580","https://openalex.org/W2139551965","https://openalex.org/W2140806800","https://openalex.org/W2141111918","https://openalex.org/W2142155502","https://openalex.org/W2142758173","https://openalex.org/W2147280137","https://openalex.org/W2151978148","https://openalex.org/W2153042751","https://openalex.org/W2153592178","https://openalex.org/W2154897087","https://openalex.org/W2156000592","https://openalex.org/W2157119191","https://openalex.org/W2157876150","https://openalex.org/W2158676116","https://openalex.org/W2159061261","https://openalex.org/W2161870183","https://openalex.org/W2162176602","https://openalex.org/W2162668960","https://openalex.org/W2165898725","https://openalex.org/W2166289280","https://openalex.org/W2166930439","https://openalex.org/W2168365842","https://openalex.org/W2169834341","https://openalex.org/W2170036507","https://openalex.org/W2171596920","https://openalex.org/W2172027284","https://openalex.org/W2327922071","https://openalex.org/W2395525054","https://openalex.org/W2418134111","https://openalex.org/W2593244680","https://openalex.org/W2785012502","https://openalex.org/W3135773419","https://openalex.org/W4253220851"],"related_works":["https://openalex.org/W2058044812","https://openalex.org/W623336562","https://openalex.org/W1491135250","https://openalex.org/W2038970459","https://openalex.org/W7018487852","https://openalex.org/W2012158447","https://openalex.org/W1970640947","https://openalex.org/W4387002672","https://openalex.org/W2092588929","https://openalex.org/W2567595886"],"abstract_inverted_index":{"In":[0,57,246],"this":[1],"thesis":[2,151],"the":[3,15,35,39,44,70,111,138,171,175,186,205,215,224,228,236,260,270,277,353,370,388,409,416],"term":[4],"allergy":[5,147,214,233],"is":[6,77,85,141,209,219,221,235,292,311,327,341],"used":[7],"to":[8,81,144,194,243,248,259,274,304,307,318,331,380],"denote":[9],"reactions":[10,20,349],"that":[11,153,169,211,218,241,387,390],"are":[12],"mediated":[13],"by":[14,282,362],"antibody":[16],"IgE.":[17],"Such":[18],"allergic":[19,61,182,263],"usually":[21],"take":[22],"place":[23],"within":[24],"half":[25],"an":[26,157,297,312],"hour":[27],"after":[28,63,101,170],"ingestion":[29],"and":[30,55,83,163,190,199,285],"may":[31,106,124,377,407],"include":[32],"itching":[33],"of":[34,38,43,174,188,227,238,262,279,323,366,373,411,418],"mouth,":[36],"swelling":[37,42],"throat,":[40],"hives,":[41],"face,":[45],"stomach":[46],"ache,":[47],"vomiting,":[48],"diarrhea,":[49],"hay":[50],"fever":[51],"symptoms,":[52],"obstructed":[53],"breathing,":[54],"shock.":[56],"patients":[58],"who":[59,96,116],"develop":[60],"symptoms":[62,100],"eating":[64,102],"certain":[65],"foods,":[66],"IgE":[67,305],"specific":[68,195,216],"for":[69,231,252,329,339,415],"offending":[71],"food":[72,134,140,146],"can":[73,350,359],"be":[74,108,244,332,360,378],"observed,":[75],"which":[76],"called":[78],"sensitization.":[79],"Sensitization":[80],"hazelnut":[82,103,120,162,189,198,213],"peanut":[84,105,122,164,191,200,232,253,283,337,419],"common":[86],"during":[87],"childhood,":[88],"especially":[89],"in":[90,160,197,204,212,302],"children":[91,95,115],"with":[92,137,148,223,401],"eczema.":[93],"However,":[94,265,334],"do":[97,267],"not":[98,268],"have":[99,117,125,256],"or":[104,121],"also":[107,167],"sensitized.":[109,127],"On":[110],"other":[112],"hand,":[113],"young":[114],"never":[118],"eaten":[119],"still":[123],"become":[126],"A":[128],"challenge,":[129,172],"preferably":[130],"a":[131,293,364,375,381,392],"double-blind":[132],"placebo-controlled":[133],"challenge":[135],"(DBPCFC)":[136],"relevant":[139],"then":[142],"indicated":[143],"diagnose":[145],"certainty.":[149],"This":[150,310],"shows":[152],"oral":[154],"challenges":[155],"remain":[156],"important":[158,313],"tool":[159],"ascertaining":[161],"allergy.":[165,420],"It":[166,208],"appears":[168],"regardless":[173],"results,":[176],"parents":[177],"feel":[178],"less":[179],"anxious":[180],"about":[181],"reactions.":[183],"To":[184],"refine":[185],"diagnosis":[187],"allergy,":[192,229,254],"sensitization":[193],"allergens":[196,239,284,338],"has":[201,299],"been":[202,257,300],"studied":[203,301],"challenged":[206],"children.":[207,264],"demonstrated":[210],"allergen":[217],"recognized":[220,240],"associated":[222],"clinical":[225],"severity":[226],"while":[230],"it":[234,316],"number":[237],"seems":[242],"paramount.":[245],"order":[247],"investigate":[249],"possible":[250,286],"therapies":[251],"probiotics":[255,266],"added":[258],"diets":[261],"change":[269],"inadequate":[271],"immune":[272],"response":[273,356,395],"peanut.":[275],"Subsequently":[276],"activation":[278],"T":[280,287,324,393],"cells":[281],"cell":[288,325,355,394],"epitopes":[289,389],"(an":[290],"epitope":[291],"recognition":[294],"site":[295],"on":[296],"allergen)":[298],"relation":[303],"binding":[306,368],"these":[308],"epitopes.":[309,403],"issue":[314],"when":[315],"comes":[317],"developing":[319],"peanut-specific":[320],"immunotherapy.":[321],"Stimulation":[322],"reactivity":[326],"necessary":[328],"immunotherapy":[330,340],"successful.":[333],"using":[335,363],"intact":[336],"too":[342],"dangerous":[343],"at":[344],"present":[345],"because":[346],"severe":[347],"IgE-mediated":[348],"occur.":[351],"If":[352],"B":[354],"(IgE":[357],"reactivity)":[358],"reduced":[361,379],"selection":[365],"non-IgE":[367],"peptides,":[369],"side":[371],"effects":[372],"such":[374],"treatment":[376,417],"considerable":[382],"extent.":[383],"The":[384],"study":[385],"showed":[386],"induced":[391],"were":[396],"indeed":[397],"only":[398],"partially":[399],"overlapping":[400],"IgE-binding":[402],"These":[404],"promising":[405],"results":[406],"allow":[408],"development":[410],"safe":[412],"allergen-specific":[413],"vaccines":[414]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}