{"id":"https://openalex.org/W1507967295","doi":null,"title":"Anti-inflammatory effect of pigment epithelium-derived factor in DBA/2J mice.","display_name":"Anti-inflammatory effect of pigment epithelium-derived factor in DBA/2J mice.","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W1507967295","mag":"1507967295","pmid":"https://pubmed.ncbi.nlm.nih.gov/19247457","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2647972"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2647972","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2647972","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2647972","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Xiaohong Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126000","display_name":"Dean McGee Eye Institute","ror":"https://ror.org/036kn0x67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210126000"]},{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaohong Zhou","raw_affiliation_strings":["Dean McGee Eye Institute, Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dean McGee Eye Institute, Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA","institution_ids":["https://openalex.org/I4210126000","https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100448978","display_name":"Feng Li","orcid":"https://orcid.org/0000-0003-2795-1693","observed_orcids":["https://orcid.org/0000-0003-2795-1693"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Feng Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086069157","display_name":"Li Kong","orcid":"https://orcid.org/0000-0002-3415-0520","observed_orcids":["https://orcid.org/0000-0002-3415-0520"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Kong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030299442","display_name":"James Chodosh","orcid":"https://orcid.org/0000-0002-7463-1599","observed_orcids":["https://orcid.org/0000-0002-7463-1599"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Chodosh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101634721","display_name":"Wei Cao","orcid":"https://orcid.org/0000-0002-2755-7023","observed_orcids":["https://orcid.org/0000-0002-2755-7023"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Cao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1883,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.89941619,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"15","issue":null,"first_page":"438","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pigment-epithelium-derived-factor","display_name":"pigment epithelium-derived factor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.8600000143051147},{"id":"https://openalex.org/keywords/retinal-ganglion-cell-loss","display_name":"retinal ganglion cell death","score":0.9679999947547913},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8690000176429749},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8550000190734863},{"id":"https://openalex.org/keywords/dba-2j-mice","display_name":"DBA/2J mice","score":0.9359999895095825},{"id":"https://openalex.org/keywords/adeno-associated-virus","display_name":"adeno-associated virus","score":0.8349999785423279},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9200000166893005},{"id":"https://openalex.org/keywords/il-18","display_name":"IL-18","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.9890000224113464},{"id":"https://openalex.org/keywords/optic-nerve","display_name":"optic nerve","score":0.8700000047683716},{"id":"https://openalex.org/keywords/vision-loss","display_name":"vision loss","score":0.6370000243186951},{"id":"https://openalex.org/keywords/retinitis","display_name":"retinal inflammation","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C52237779","wikidata":"https://www.wikidata.org/wiki/Q18030441","display_name":"PEDF","level":3,"score":0.9468412399291992},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8786665201187134},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.7232966423034668},{"id":"https://openalex.org/C2778024200","wikidata":"https://www.wikidata.org/wiki/Q2346242","display_name":"Retinal pigment epithelium","level":3,"score":0.5748945474624634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5390369892120361},{"id":"https://openalex.org/C2777624874","wikidata":"https://www.wikidata.org/wiki/Q927337","display_name":"Retinal ganglion cell","level":3,"score":0.45418843626976013},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3703087866306305},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3268580734729767},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3264102339744568},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.31237882375717163},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.3120272159576416}],"mesh":[{"descriptor_ui":"D000099174","descriptor_name":"Pigment Epithelium-Derived Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005904","descriptor_name":"Glial Fibrillary Acidic Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008811","descriptor_name":"Mice, Inbred DBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009412","descriptor_name":"Nerve Fibers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009900","descriptor_name":"Optic Nerve","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014792","descriptor_name":"Visual Acuity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015843","descriptor_name":"Serpins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015843","descriptor_name":"Serpins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015843","descriptor_name":"Serpins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020382","descriptor_name":"Interleukin-18","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:2647972","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2647972","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"pmid:19247457","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19247457","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.434.868","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.434.868","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.molvis.org/molvis/v15/a44/mv-v15-a44-zhou.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.791.2779","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.791.2779","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/6e/41/mv-v15-438.PMC2647972.pdf","raw_type":"text"},{"id":"mag:1507967295","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19247457","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2647972","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2647972","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1854954188","display_name":"Core Grant for Vision Research","funder_award_id":"P30EY012190","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G3948148410","display_name":"Mentoring Vision Research In Oklahoma","funder_award_id":"P20RR017703","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G652684929","display_name":"PEDF and Photoreceptor Protection: A Naked DNA Approach","funder_award_id":"R03EY014427","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W60487933","https://openalex.org/W139826761","https://openalex.org/W146768185","https://openalex.org/W1525118283","https://openalex.org/W1531501691","https://openalex.org/W1532907291","https://openalex.org/W1574402411","https://openalex.org/W1583737662","https://openalex.org/W1965794824","https://openalex.org/W1969005256","https://openalex.org/W1970925827","https://openalex.org/W1971884595","https://openalex.org/W1973772529","https://openalex.org/W1973817146","https://openalex.org/W1987876121","https://openalex.org/W1995169973","https://openalex.org/W2004831648","https://openalex.org/W2012629169","https://openalex.org/W2019132331","https://openalex.org/W2022209206","https://openalex.org/W2049448622","https://openalex.org/W2050548455","https://openalex.org/W2051953793","https://openalex.org/W2055820698","https://openalex.org/W2055878329","https://openalex.org/W2057266151","https://openalex.org/W2058547675","https://openalex.org/W2059407857","https://openalex.org/W2062322287","https://openalex.org/W2065092171","https://openalex.org/W2068232370","https://openalex.org/W2076358107","https://openalex.org/W2084646891","https://openalex.org/W2085451942","https://openalex.org/W2089338590","https://openalex.org/W2089853352","https://openalex.org/W2093168164","https://openalex.org/W2106116627","https://openalex.org/W2111608717","https://openalex.org/W2112215733","https://openalex.org/W2113843341","https://openalex.org/W2126605806","https://openalex.org/W2134769368","https://openalex.org/W2138339712","https://openalex.org/W2141754801","https://openalex.org/W2142405486","https://openalex.org/W2143481850","https://openalex.org/W2159315829","https://openalex.org/W2160256074","https://openalex.org/W2163925135","https://openalex.org/W2166602064","https://openalex.org/W4295065557"],"related_works":["https://openalex.org/W7098570229","https://openalex.org/W7096250879","https://openalex.org/W1756806485","https://openalex.org/W2413356529","https://openalex.org/W2113743403","https://openalex.org/W3199386796","https://openalex.org/W2383355417","https://openalex.org/W2008975983","https://openalex.org/W2076771890","https://openalex.org/W2032416536"],"abstract_inverted_index":{"PURPOSE:":[0],"Glaucoma":[1],"is":[2,17,29,48],"the":[3,63,73,117,166,192,225,247,267],"second":[4],"leading":[5],"cause":[6,11],"of":[7,12,27,34,39,66,70,79,88,119,127,142,171,179,197,208,249,255,260,269],"blindness.":[8],"The":[9,177,257],"ultimate":[10],"vision":[13,215,240],"loss":[14,207,238],"in":[15,68,72,110,116,122,165,191,203,224,242],"glaucoma":[16,35],"thought":[18],"to":[19,124,266],"be":[20],"retinal":[21,111],"ganglion":[22],"cell":[23],"(RGC)":[24],"death.":[25,272],"Neuroprotection":[26],"RGC":[28,71,102,209,237,271],"therefore":[30],"an":[31,76],"important":[32],"goal":[33],"therapy.":[36],"Several":[37],"lines":[38],"evidence":[40],"suggest":[41],"that":[42],"pigment":[43],"epithelium":[44],"derived":[45],"factor":[46,55,182],"(PEDF)":[47],"a":[49,263],"potent":[50],"anti-angiogenic,":[51],"neuroprotective,":[52],"and":[53,103,137,144,168,185,194,210,217,221,227,234,239,251,253],"anti-inflammatory":[54,258],"for":[56],"neurons.":[57],"In":[58],"this":[59],"study,":[60],"we":[61],"examined":[62,131],"potential":[64],"role":[65],"PEDF":[67,128,143,162,201,232,261],"protection":[69,107],"DBA/2J":[74,83,120,172,198,243],"mouse,":[75],"animal":[77],"model":[78],"inherited":[80],"glaucoma.":[81],"METHODS:":[82],"mice":[84,121,173,205],"at":[85],"two":[86],"months":[87],"age":[89,190],"were":[90,108,129],"transfected":[91],"intravitreally":[92],"with":[93,175,189],"adeno-associated":[94],"virus":[95],"(AAV)-PEDF":[96],"or":[97],"AAV-green":[98],"fluorescent":[99],"protein":[100,148,163],"(AAV-GFP).":[101],"nerve":[104,196,211],"fiber":[105,212],"layer":[106],"evaluated":[109],"cross":[112],"sections.":[113],"Biochemical":[114],"alterations":[115],"retinas":[118],"response":[123],"intravitreal":[125],"transfection":[126,202],"also":[130],"by":[132,152,158],"reverse":[133],"transcriptase":[134],"PCR":[135],"(RT-PCR)":[136],"western":[138],"blot.":[139],"Cellular":[140],"localization":[141],"glial":[145],"fibrillary":[146],"acidic":[147],"(GFAP)":[149],"was":[150,156],"determined":[151,157],"immunohistochemistry.":[153],"Visual":[154],"acuity":[155],"optomotor":[159],"testing.":[160],"RESULTS:":[161],"levels":[164],"retina":[167,193,226],"optic":[169,195,228],"nerves":[170],"declined":[174],"age.":[176],"expression":[178,223],"tumor":[180],"necrosis":[181],"(TNF),":[183],"GFAP,":[184],"interleukin-18":[186],"(IL-18)":[187],"increased":[188],"mice.":[199],"Intravitreal":[200],"DBS/2J":[204],"reduced":[206,218],"layer,":[213],"delayed":[214],"loss,":[216],"TNF,":[219],"IL-18,":[220,252],"GFAP":[222],"nerve.":[229],"CONCLUSIONS:":[230],"Transduced":[231],"potently":[233],"efficaciously":[235],"reduces":[236],"decline":[241],"mice,":[244],"possibly":[245],"via":[246],"reduction":[248],"TNF":[250],"downregulation":[254],"GFAP.":[256],"effect":[259],"represents":[262],"novel":[264],"approach":[265],"prevention":[268],"glaucomatous":[270]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}