{"id":"https://openalex.org/W150790485","doi":"https://doi.org/10.1016/s0021-9258(19)88705-7","title":"Identification of the prostacyclin receptor by use of [15-3H1]19-(3-azidophenyl)-20-norisocarbacyclin, an irreversible specific photoaffinity probe.","display_name":"Identification of the prostacyclin receptor by use of [15-3H1]19-(3-azidophenyl)-20-norisocarbacyclin, an irreversible specific photoaffinity probe.","publication_year":1992,"publication_date":"1992-10-01","ids":{"openalex":"https://openalex.org/W150790485","doi":"https://doi.org/10.1016/s0021-9258(19)88705-7","mag":"150790485","pmid":"https://pubmed.ncbi.nlm.nih.gov/1400351"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(19)88705-7","doi":"https://doi.org/10.1016/s0021-9258(19)88705-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)88705-7","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(19)88705-7","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057261704","display_name":"Seiji Ito","orcid":"https://orcid.org/0000-0002-0942-1624","observed_orcids":["https://orcid.org/0000-0002-0942-1624"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Ito","raw_affiliation_strings":["Department of Cell Biology, Osaka Bioscience Institute, Suita Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Osaka Bioscience Institute, Suita Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027301316","display_name":"Hitoshi Hashimoto","orcid":"https://orcid.org/0000-0001-6548-4016","observed_orcids":["https://orcid.org/0000-0001-6548-4016"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Hashimoto","raw_affiliation_strings":["Department of Cell Biology, Osaka Bioscience Institute, Suita Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Osaka Bioscience Institute, Suita Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089629096","display_name":"Masahiko Negishi","orcid":"https://orcid.org/0000-0002-2076-8928","observed_orcids":["https://orcid.org/0000-0002-2076-8928"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Negishi","raw_affiliation_strings":["Department of Cell Biology, Osaka Bioscience Institute, Suita Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Osaka Bioscience Institute, Suita Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055447760","display_name":"Mayumi Suzuki","orcid":"https://orcid.org/0000-0003-0655-4760","observed_orcids":["https://orcid.org/0000-0003-0655-4760"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Suzuki","raw_affiliation_strings":["Department of Cell Biology, Osaka Bioscience Institute, Suita Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Osaka Bioscience Institute, Suita Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075365982","display_name":"Hiroshi Koyano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Koyano","raw_affiliation_strings":["Department of Cell Biology, Osaka Bioscience Institute, Suita Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Osaka Bioscience Institute, Suita Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054350731","display_name":"Ry\u014dji Noyori","orcid":"https://orcid.org/0000-0003-0688-8066","observed_orcids":["https://orcid.org/0000-0003-0688-8066"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Noyori","raw_affiliation_strings":["Department of Cell Biology, Osaka Bioscience Institute, Suita Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Osaka Bioscience Institute, Suita Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036189941","display_name":"Atsushi Ichikawa","orcid":"https://orcid.org/0009-0000-2175-2963","observed_orcids":["https://orcid.org/0009-0000-2175-2963"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Ichikawa","raw_affiliation_strings":["Department of Cell Biology, Osaka Bioscience Institute, Suita Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Osaka Bioscience Institute, Suita Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.1902,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.76884678,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"267","issue":"28","first_page":"20326","last_page":"20330"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.5238999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.5238999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.22709999978542328,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.12549999356269836,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostacyclin-receptor","display_name":"prostacyclin receptor","score":0.996999979019165},{"id":"https://openalex.org/keywords/prostacyclin","display_name":"prostacyclin","score":0.9330000281333923},{"id":"https://openalex.org/keywords/photoaffinity-labeling","display_name":"photoaffinity labeling","score":0.902999997138977},{"id":"https://openalex.org/keywords/receptor-binding","display_name":"receptor binding","score":0.5709999799728394},{"id":"https://openalex.org/keywords/gtpgammas","display_name":"GTP gamma S","score":0.7979999780654907},{"id":"https://openalex.org/keywords/receptor-purification","display_name":"receptor purification","score":0.5339999794960022},{"id":"https://openalex.org/keywords/porcine-platelets","display_name":"porcine platelets","score":0.878000020980835},{"id":"https://openalex.org/keywords/iloprost","display_name":"iloprost","score":0.7590000033378601},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.828000009059906}],"concepts":[{"id":"https://openalex.org/C2778581200","wikidata":"https://www.wikidata.org/wiki/Q16943198","display_name":"Photoaffinity labeling","level":3,"score":0.6783046722412109},{"id":"https://openalex.org/C2781128415","wikidata":"https://www.wikidata.org/wiki/Q412050","display_name":"Prostacyclin","level":2,"score":0.652034342288971},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.634033203125},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5284911394119263},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.44370564818382263},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4278213083744049},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3524302840232849},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2123921513557434},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000345","descriptor_name":"Affinity Labels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001386","descriptor_name":"Azides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010777","descriptor_name":"Photochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D011869","descriptor_name":"Radioligand Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011982","descriptor_name":"Receptors, Prostaglandin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012515","descriptor_name":"Mast-Cell Sarcoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016244","descriptor_name":"Guanosine 5'-O-(3-Thiotriphosphate)","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044006","descriptor_name":"Receptors, Epoprostenol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(19)88705-7","doi":"https://doi.org/10.1016/s0021-9258(19)88705-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)88705-7","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:1400351","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1400351","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(19)88705-7","doi":"https://doi.org/10.1016/s0021-9258(19)88705-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)88705-7","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.428600013256073}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.44999998807907104}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W259490105","https://openalex.org/W1484354452","https://openalex.org/W1555809376","https://openalex.org/W1560501087","https://openalex.org/W1604451973","https://openalex.org/W1775749144","https://openalex.org/W1966434299","https://openalex.org/W1966631520","https://openalex.org/W1972859683","https://openalex.org/W2010291027","https://openalex.org/W2018938214","https://openalex.org/W2037619900","https://openalex.org/W2048435001","https://openalex.org/W2052697779","https://openalex.org/W2057591548","https://openalex.org/W2059808149","https://openalex.org/W2068059006","https://openalex.org/W2071596004","https://openalex.org/W2073824580","https://openalex.org/W2076300996","https://openalex.org/W2076991479","https://openalex.org/W2082091333","https://openalex.org/W2095529079","https://openalex.org/W2167859431"],"related_works":["https://openalex.org/W1972859683","https://openalex.org/W2082091333","https://openalex.org/W1966434299","https://openalex.org/W4235493699","https://openalex.org/W2045443221","https://openalex.org/W2091830691","https://openalex.org/W4230186166","https://openalex.org/W2068030576","https://openalex.org/W1993097923","https://openalex.org/W1969744521"],"abstract_inverted_index":{"The":[0,67,91],"prostaglandin":[1],"I":[2],"(PGI2)":[3],"receptor":[4,137,186],"of":[5,57,63,69,93,108,114,119,147,159,201],"mouse":[6],"mastocytoma":[7,36],"P-815":[8],"cells":[9],"was":[10,71,124,139,151],"characterized":[11],"by":[12,75,89,126,141,154],"photo-affinity":[13],"labeling":[14],"with":[15,38,54,132],"the":[16,30,35,94,99,135,157,184,202],"stable":[17,80],"PGI2":[18,81,127,136,170,185,203],"analogue":[19],"[15-3H1]-19-(3-azidophenyl)-20-norisocarbacyclin":[20],"([3H]":[21],"APNIC)":[22],"used":[23],"as":[24],"a":[25,43,50,55,61,85,117,179,193],"potential":[26],"photoaffinity":[27],"probe":[28],"for":[29,134,196],"receptor.":[31,204],"[3H]APNIC":[32,70,155,176],"bound":[33],"to":[34,84,98,166],"membrane":[37,158],"high":[39],"affinity":[40],"and":[41,60,77,83,129,138,187,199],"in":[42,112,156,169],"saturable":[44],"manner.":[45],"Scatchard":[46],"plot":[47],"analysis":[48],"indicated":[49],"single":[51],"binding":[52,68,92],"site":[53],"Kd":[56],"4.7":[58],"nM":[59],"Bmax":[62],"0.58":[64],"pmol/mg":[65],"protein.":[66],"dose":[72],"dependently":[73],"inhibited":[74,125],"APNIC":[76],"iloprost,":[78],"another":[79],"agonist,":[82],"much":[86],"lesser":[87],"extent":[88],"PGE2.":[90],"radioligand":[95],"showed":[96],"sensitivity":[97],"guanine":[100],"nucleotide":[101],"guanosine":[102],"5'-O-(3-thio-triphosphate)":[103],"(GTP":[104],"gamma":[105,143],"S).":[106],"Photolysis":[107],"[3H]APNIC-prelabeled":[109],"membranes":[110,162],"resulted":[111],"incorporation":[113],"radiolabel":[115],"into":[116],"protein":[118,146,180],"approximately":[120,148],"43":[121],"kDa.":[122],"Photolabeling":[123],"agonists":[128],"other":[130],"prostaglandins":[131],"specificity":[133],"modulated":[140],"GTP":[142],"S.":[144],"A":[145],"45":[149],"kDa":[150],"also":[152],"labeled":[153],"porcine":[160],"platelets,":[161],"that":[163,175,181,188],"are":[164],"known":[165],"be":[167,192],"abundant":[168],"receptors.":[171],"These":[172],"results":[173],"demonstrate":[174],"specifically":[177],"labels":[178],"may":[182],"represent":[183],"this":[189],"radioprobe":[190],"will":[191],"useful":[194],"reagent":[195],"further":[197],"characterization":[198],"purification":[200]},"counts_by_year":[{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
